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WO2007014338A3 - Single nucleotide polymorphisms associated with susceptibility to cardiovascular disease - Google Patents

Single nucleotide polymorphisms associated with susceptibility to cardiovascular disease Download PDF

Info

Publication number
WO2007014338A3
WO2007014338A3 PCT/US2006/029449 US2006029449W WO2007014338A3 WO 2007014338 A3 WO2007014338 A3 WO 2007014338A3 US 2006029449 W US2006029449 W US 2006029449W WO 2007014338 A3 WO2007014338 A3 WO 2007014338A3
Authority
WO
WIPO (PCT)
Prior art keywords
cardiovascular disease
methods
susceptibility
single nucleotide
nucleotide polymorphisms
Prior art date
Application number
PCT/US2006/029449
Other languages
French (fr)
Other versions
WO2007014338A2 (en
WO2007014338A8 (en
Inventor
Monika Stoll
Gerd Assmann
Helmut Schulte
Werner Kroll
Stephen Schwers
Christoph Petry
Original Assignee
Siemens Medical Solutions Diagnostics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Medical Solutions Diagnostics filed Critical Siemens Medical Solutions Diagnostics
Priority to EP06788815A priority Critical patent/EP1907589A4/en
Publication of WO2007014338A2 publication Critical patent/WO2007014338A2/en
Publication of WO2007014338A8 publication Critical patent/WO2007014338A8/en
Priority to US12/019,651 priority patent/US20080233582A1/en
Publication of WO2007014338A3 publication Critical patent/WO2007014338A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides SNPs, polymorphic variants, and haplotypes associated with cardiovascular disease. The invention also provides methods for detecting the SNPs, polymorphic variants, and haplotypes. The invention also provides methods for determining an individual's genotype with respect to one or more polymorphisms and/or haplotypes associated with cardiovascular disease. The invention further provides methods of determining whether an individual has or is susceptible to development or occurrence of a cardiovascular disease or event. The methods are useful for providing diagnostic and/or prognostic information, selecting therapeutic regimens, etc. The invention further provides reagents and kits for practicing the methods.
PCT/US2006/029449 2005-07-26 2006-07-26 Single nucleotide polymorphisms associated with susceptibility to cardiovascular disease WO2007014338A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06788815A EP1907589A4 (en) 2005-07-26 2006-07-26 INDIVIDUAL NUCLEOTIDE POLYMORPHISMS ASSOCIATED TO CARDIOVASCULAR DISEASES
US12/019,651 US20080233582A1 (en) 2005-07-26 2008-01-25 Single nucleotide polymorphisms associated with susceptibility to cardiovascular disease

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US70276005P 2005-07-26 2005-07-26
US60/702,760 2005-07-26
US70321905P 2005-07-27 2005-07-27
US60/703,219 2005-07-27
US70871905P 2005-08-15 2005-08-15
US60/708,719 2005-08-15
US74240705P 2005-12-05 2005-12-05
US60/742,407 2005-12-05
EPEP06012722.2 2006-06-21
EP06012722 2006-06-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/019,651 Continuation-In-Part US20080233582A1 (en) 2005-07-26 2008-01-25 Single nucleotide polymorphisms associated with susceptibility to cardiovascular disease

Publications (3)

Publication Number Publication Date
WO2007014338A2 WO2007014338A2 (en) 2007-02-01
WO2007014338A8 WO2007014338A8 (en) 2007-04-12
WO2007014338A3 true WO2007014338A3 (en) 2010-05-20

Family

ID=37683999

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/029449 WO2007014338A2 (en) 2005-07-26 2006-07-26 Single nucleotide polymorphisms associated with susceptibility to cardiovascular disease

Country Status (2)

Country Link
EP (1) EP1907589A4 (en)
WO (1) WO2007014338A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2267153A1 (en) * 2009-05-26 2010-12-29 Université Claude Bernard Lyon 1 Identification of netrin-1 receptor unc5c gene mutation in solid cancers
AU2021239861A1 (en) * 2020-03-16 2022-10-06 The University Of North Carolina At Chapel Hill Compositions and methods for the selective detection of tumor-derived viral DNA

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030113725A1 (en) * 2000-04-17 2003-06-19 Small Kersten M. Alpha-2 adrenergic receptor polymorphisms
US20040014059A1 (en) * 1999-01-06 2004-01-22 Choong-Chin Liew Method for the detection of gene transcripts in blood and uses thereof
US20050026169A1 (en) * 2002-12-20 2005-02-03 Applera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2380807A1 (en) * 1999-08-09 2001-04-12 University Of Utah Research Foundation Alterations in the long qt syndrome genes kvlqt1 and scn5a and methods for detecting same
WO2001055314A2 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Digestive system related nucleic acids, proteins and antibodies
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
AU2003290527A1 (en) * 2002-10-17 2004-05-04 Decode Genetics Ehf. Susceptibility gene for myocardial infarction

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014059A1 (en) * 1999-01-06 2004-01-22 Choong-Chin Liew Method for the detection of gene transcripts in blood and uses thereof
US20030113725A1 (en) * 2000-04-17 2003-06-19 Small Kersten M. Alpha-2 adrenergic receptor polymorphisms
US20050026169A1 (en) * 2002-12-20 2005-02-03 Applera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HARA ET AL.: "Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin.", BIOCHIMICA BIOPHYSICA ACTA, vol. 1522, no. 2, 2001, pages 130 - 133, XP004326977, DOI: doi:10.1016/S0167-4781(01)00315-3 *
See also references of EP1907589A4 *

Also Published As

Publication number Publication date
WO2007014338A2 (en) 2007-02-01
EP1907589A4 (en) 2010-11-24
EP1907589A2 (en) 2008-04-09
WO2007014338A8 (en) 2007-04-12

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