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WO2007010398A3 - Caveolin-3 and in vitro culture of hepatitis c virus - Google Patents

Caveolin-3 and in vitro culture of hepatitis c virus Download PDF

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Publication number
WO2007010398A3
WO2007010398A3 PCT/IB2006/002565 IB2006002565W WO2007010398A3 WO 2007010398 A3 WO2007010398 A3 WO 2007010398A3 IB 2006002565 W IB2006002565 W IB 2006002565W WO 2007010398 A3 WO2007010398 A3 WO 2007010398A3
Authority
WO
WIPO (PCT)
Prior art keywords
caveolin
hcv
vitro culture
hepatitis
virus
Prior art date
Application number
PCT/IB2006/002565
Other languages
French (fr)
Other versions
WO2007010398A2 (en
Inventor
Marcello Merola
Stefania Crotta
Alessia Bianchi
Original Assignee
Novartis Vaccines & Diagnostic
Marcello Merola
Stefania Crotta
Alessia Bianchi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic, Marcello Merola, Stefania Crotta, Alessia Bianchi filed Critical Novartis Vaccines & Diagnostic
Priority to JP2008522095A priority Critical patent/JP2009513109A/en
Priority to CA002615558A priority patent/CA2615558A1/en
Priority to EP06795507A priority patent/EP1910522A2/en
Publication of WO2007010398A2 publication Critical patent/WO2007010398A2/en
Publication of WO2007010398A3 publication Critical patent/WO2007010398A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24251—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Caveolin-3 has been identified as a cellular factor that associates with HCV protein El and E2, and is proposed as a cellular limiting factor. As an alternative possibility, caveolin-3 may act as a cellular receptor for HCV, acting alongside CD81. In either scenario, cells with increased expression of caveolin-3 will be better suited to the in vitro culture of HCV, and blocking the interaction between caveolin-3 and HCV proteins has therapeutic potential.
PCT/IB2006/002565 2005-07-18 2006-07-18 Caveolin-3 and in vitro culture of hepatitis c virus WO2007010398A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008522095A JP2009513109A (en) 2005-07-18 2006-07-18 In vitro culture of caveolin-3 and hepatitis C virus
CA002615558A CA2615558A1 (en) 2005-07-18 2006-07-18 Caveolin-3 and in vitro culture of hepatitis c virus
EP06795507A EP1910522A2 (en) 2005-07-18 2006-07-18 Caveolin-3 and in vitro culture of hepatitis c virus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70046205P 2005-07-18 2005-07-18
US60/700,462 2005-07-18

Publications (2)

Publication Number Publication Date
WO2007010398A2 WO2007010398A2 (en) 2007-01-25
WO2007010398A3 true WO2007010398A3 (en) 2007-04-19

Family

ID=37547530

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/002565 WO2007010398A2 (en) 2005-07-18 2006-07-18 Caveolin-3 and in vitro culture of hepatitis c virus

Country Status (4)

Country Link
EP (1) EP1910522A2 (en)
JP (1) JP2009513109A (en)
CA (1) CA2615558A1 (en)
WO (1) WO2007010398A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100984735B1 (en) * 2009-05-28 2010-10-01 동국대학교 산학협력단 New concept drug developement for screening drug candidate inhibitor of target protein-protein interaction

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004044182A2 (en) * 2002-11-13 2004-05-27 Washington University Highly permissive cell lines for hepatitis c virus replication
WO2006038129A2 (en) * 2004-10-01 2006-04-13 Novartis Vaccines And Diagnostics Srl Hepatitis c virus replication system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004044182A2 (en) * 2002-11-13 2004-05-27 Washington University Highly permissive cell lines for hepatitis c virus replication
WO2006038129A2 (en) * 2004-10-01 2006-04-13 Novartis Vaccines And Diagnostics Srl Hepatitis c virus replication system

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BLIGHT K J ET AL: "Highly Permissive Cell Line for Subgenomic and Genomic Heptatis C VIrus RNA Replication", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 76, no. 24, December 2002 (2002-12-01), pages 13001 - 13014, XP002984512, ISSN: 0022-538X *
BRAZZOLI MICHELA ET AL: "Intracellular accumulation of hepatitis C virus proteins in a human hepatoma cell line.", JOURNAL OF HEPATOLOGY JAN 2007, vol. 46, no. 1, January 2007 (2007-01-01), pages 53 - 59, XP002418005, ISSN: 0168-8278 *
PIETSCHMANN T ET AL: "Persistent and transient replication of full-length hepatitis C virus genomes in cell culture", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 76, no. 8, April 2002 (2002-04-01), pages 4008 - 4021, XP002377301, ISSN: 0022-538X *
SMART E J ET AL: "Caveolins, liquid-ordered domains, and signal transduction", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 19, no. 11, November 1999 (1999-11-01), pages 7289 - 7304, XP002212531, ISSN: 0270-7306 *
SONG KENNETH S ET AL: "Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells: Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 25, 1996, pages 15160 - 15165, XP002418004, ISSN: 0021-9258 *
TANG ZHAOLAN ET AL: "Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 4, 1996, pages 2255 - 2261, XP002418003, ISSN: 0021-9258 *
ZHONG JIN ET AL: "Robust hepatitis C virus infection in vitro", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, no. 26, June 2005 (2005-06-01), pages 9294 - 9299, XP002418002, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
EP1910522A2 (en) 2008-04-16
WO2007010398A2 (en) 2007-01-25
JP2009513109A (en) 2009-04-02
CA2615558A1 (en) 2007-01-25

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