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WO2007010084A3 - Immunostimulatory oligo- and polysaccharides and uses thereof - Google Patents

Immunostimulatory oligo- and polysaccharides and uses thereof Download PDF

Info

Publication number
WO2007010084A3
WO2007010084A3 PCT/FI2006/000256 FI2006000256W WO2007010084A3 WO 2007010084 A3 WO2007010084 A3 WO 2007010084A3 FI 2006000256 W FI2006000256 W FI 2006000256W WO 2007010084 A3 WO2007010084 A3 WO 2007010084A3
Authority
WO
WIPO (PCT)
Prior art keywords
immune response
mannooligosaccharides
type immune
food
polysaccharides
Prior art date
Application number
PCT/FI2006/000256
Other languages
French (fr)
Other versions
WO2007010084A2 (en
Inventor
Johannes Savolainen
Kaisa Nieminen
Original Assignee
Johannes Savolainen
Kaisa Nieminen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI20050757A external-priority patent/FI20050757A0/en
Application filed by Johannes Savolainen, Kaisa Nieminen filed Critical Johannes Savolainen
Publication of WO2007010084A2 publication Critical patent/WO2007010084A2/en
Publication of WO2007010084A3 publication Critical patent/WO2007010084A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to the use of an immunostimulant selected from the group consisting of mannan polysaccharides comprising β-1,2-linked chains, β -1,2-(D)-mannooligosaccharides, and any combination thereof for the preparation of a medicament for treating a mammal, including human, suffering from or susceptible to a condition which can be improved or prevented by inducing a Th1-type, and/or inhibiting a Th2-type immune response. This invention also relates to an immunostimulatory composition comprising at least one component selected from the group consisting of mannan polysaccharides comprising β -1,2-linked chains and β -1,2-(D)-mannooligosaccharides; and a carrier. This invention further relates to a food comprising at least one component selected from the group consisting of mannan polysaccharides comprising β -1,2-linked chains and β -1,2-(D) mannooligosaccharides and use of mannan polysaccharides comprising ß-1,2-linked chains and β -1,2-(D) mannooligosaccharides as a food additive. This invention also relates to a method for inducing of Th1-type immune response comprising administering to a subject the composition of or the food of the invention in an amount effective to induce a Th1-type immune response and a method for inhibition of Th2-type immune response comprising administering to a subject the composition or the food of the invention in an amount effective to partially or completely inhibit development of Th2-type immune response.
PCT/FI2006/000256 2005-07-15 2006-07-17 Immunostimulatory oligo- and polysaccharides and uses thereof WO2007010084A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69938305P 2005-07-15 2005-07-15
US60/699,383 2005-07-15
FI20050757A FI20050757A0 (en) 2005-07-15 2005-07-15 Immunostimulatory oligo- and polysaccharides and uses thereof
FI20050757 2005-07-15

Publications (2)

Publication Number Publication Date
WO2007010084A2 WO2007010084A2 (en) 2007-01-25
WO2007010084A3 true WO2007010084A3 (en) 2007-04-05

Family

ID=37433872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2006/000256 WO2007010084A2 (en) 2005-07-15 2006-07-17 Immunostimulatory oligo- and polysaccharides and uses thereof

Country Status (1)

Country Link
WO (1) WO2007010084A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE068442T2 (en) 2009-07-15 2024-12-28 Nutricia Nv Mixture of non-digestible oligosaccharides for stimulating the immune system
CN102497869B (en) 2009-07-15 2013-11-27 N.V.努特里奇亚 Fucosyllactose as a human milk equivalent non-digestible oligosaccharide with novel functional benefits
FI20115631A0 (en) * 2011-06-21 2011-06-21 Turun Yliopisto IMMUNOSTIMULATORY COMPOUNDS AND USES THEREOF
BR112017000345B1 (en) 2014-07-09 2022-04-26 Cadena Bio, Inc Oligosaccharide compositions, methods for their production and food product
EP4205553A1 (en) 2015-01-26 2023-07-05 DSM Nutritional Products, LLC Oligosaccharide compositions for use animal feed and methods of producing thereof
ES2659648T3 (en) 2015-01-26 2018-03-16 Kaleido Biosciences, Inc. Therapeutic compounds of glycan and related methods thereof
EP3964234A1 (en) 2015-04-23 2022-03-09 Kaleido Biosciences, Inc. Glycan therapeutics and methods of treatment
AU2016378817A1 (en) 2015-12-22 2018-07-19 Turun Yliopisto Immunostimulatory adjuvants and uses thereof
JP2019527213A (en) * 2016-07-13 2019-09-26 カレイド・バイオサイエンシズ・インコーポレイテッド Glycan compositions and methods of use
WO2019014645A1 (en) * 2017-07-13 2019-01-17 Kaleido Biosciences, Inc. Glycan compositions and methods of use
WO2019031961A1 (en) 2017-08-11 2019-02-14 N.V. Nutricia Human milk oligosaccharide for improving immune fitness
EP3703705B1 (en) 2017-11-03 2024-05-15 DSM Nutritional Products, LLC Glucose-containing glycan preparations for use in the treatment of hyperammonaemia
CN112426429B (en) * 2020-11-19 2022-09-27 河南中医药大学 A kind of carbohydrate composition for nourishing yin and nourishing blood for yin and blood deficiency syndrome

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057919A2 (en) * 1999-03-25 2000-10-05 Sapientia Therapeutics Limited Lipid-based artificial particles inducing cell-mediated immunity
WO2003090787A1 (en) * 2002-04-25 2003-11-06 Bundle David R Synthetic anti-candida albicans oligosaccharide based vaccines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057919A2 (en) * 1999-03-25 2000-10-05 Sapientia Therapeutics Limited Lipid-based artificial particles inducing cell-mediated immunity
WO2003090787A1 (en) * 2002-04-25 2003-11-06 Bundle David R Synthetic anti-candida albicans oligosaccharide based vaccines

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
APOSTOLOPOULOS V ET AL: "OXIDATIVE/REDUCTIVE CONJUGATION OF MANNAN TO ANTIGEN SELECTS FOR T1 OR T2 IMMUNE RESPONSES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 92, 1 October 1995 (1995-10-01), pages 10128 - 10132, XP000601312, ISSN: 0027-8424 *
CASSONE ANTONIO: "Immunogenic and immunomodulatory properties of mannoproteins from Candida albicans", CANADIAN JOURNAL OF BOTANY, vol. 73, no. SUPPL. 1 SECT. E-H, 1995, pages S1192 - S1198, XP009075786, ISSN: 0008-4026 *
DAVIS W C ET AL: "USE OF THE MANNAN RECEPTOR TO SELECTIVELY TARGET VACCINE ANTIGENS FOR PROCESSING AND ANTIGEN PRESENTATION THROUGH THE MHC CLASS I AND CLASS II PATHWAYS", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 969, October 2002 (2002-10-01), pages 119 - 125, XP009052421, ISSN: 0077-8923 *
DROMER FRANCOISE ET AL: "Synthetic analogues of beta-1,2 oligomannosides prevent intestinal colonization by the pathogenic yeast Candida albicans", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 46, no. 12, December 2002 (2002-12-01), pages 3869 - 3876, XP002410370, ISSN: 0066-4804 *
JOUAULT T ET AL: "Beta-1,2-linked oligomannosides from Candida albicans act as signals for tumor necrosis factor alpha production.", INFECTION AND IMMUNITY. JUN 1995, vol. 63, no. 6, June 1995 (1995-06-01), pages 2378 - 2381, XP002410371, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
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