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WO2007009187A1 - Complement nutritionnel contenant un polyphenol et un probiotique - Google Patents

Complement nutritionnel contenant un polyphenol et un probiotique Download PDF

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Publication number
WO2007009187A1
WO2007009187A1 PCT/AU2006/001028 AU2006001028W WO2007009187A1 WO 2007009187 A1 WO2007009187 A1 WO 2007009187A1 AU 2006001028 W AU2006001028 W AU 2006001028W WO 2007009187 A1 WO2007009187 A1 WO 2007009187A1
Authority
WO
WIPO (PCT)
Prior art keywords
food additive
food
product
polyphenol
additive according
Prior art date
Application number
PCT/AU2006/001028
Other languages
English (en)
Inventor
Suzanne Keith
Original Assignee
Tarac Technologies Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2005903899A external-priority patent/AU2005903899A0/en
Application filed by Tarac Technologies Pty Ltd filed Critical Tarac Technologies Pty Ltd
Publication of WO2007009187A1 publication Critical patent/WO2007009187A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C13/00—Cream; Cream preparations; Making thereof
    • A23C13/12—Cream preparations
    • A23C13/16—Cream preparations containing, or treated with, microorganisms, enzymes, or antibiotics; Sour cream
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C17/00—Buttermilk; Buttermilk preparations
    • A23C17/02—Buttermilk; Buttermilk preparations containing, or treated with, microorganisms or enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a food or nutritional supplement composition
  • Biologically active polyphenols are powerful antioxidants. It is known that there are overall health benefits from antioxidant-rich foods consumed in the diet. Antioxidants have been associated with a wide range of health benefits including their ability to scavenge free radicals, maintain healthy vision and, perhaps most importantly their ability to improve cardiovascular health, as well as suggested ability to reduce the risk of cancer and improve immune function.
  • antioxidant supplement products to confer the health benefits ascribed to antioxidant products. It is also becoming clear that currently available additive products are not as effective as perhaps they might be.
  • the present invention is addressed to this situation and provides an alternative additive composition to those currently available.
  • catechin and epicatechin the major phenol monomers in red wine
  • catechin and epicatechin proanthocyanidins or tannins
  • current food supplements such as grape seed extracts, which are concentrated sources of polyphenols are poorly absorbed.
  • proanthocyanidin polymers which cannot be absorbed through the wall of the small intestine because of their high molecular weight, are open to degradation by colonic microflora into lower molecular weight metabolites.
  • the inventors of the present invention propose that the beneficial health effects to be obtained from polyphenol products may be enhanced by increasing the bioavailability of the active substances obtained from metabolism of polyphenols.
  • a food additive composition including a polyphenol in combination with a probiotic.
  • Probiotics are an important part of the complex world of foods that are good for health. Probiotics are foods that contain live bacteria. It is the bacteria and metabolites which they produce that give these probiotics their health promoting properties.
  • probiotics may help the gut prevent an imbalance in which there are too many harmful bacteria.
  • research on probiotics has shown that probiotics may be promising as treatments for a number of diseases and conditions, including lactose intolerance, diarrhea secondary to antibiotic use or E coli infections, other gastrointestinal infections, vaginal candidiasis infections, and lactose malabsorption due to chemotherapy.
  • probiotics improve the body's ability to resist intestinal infection.
  • lactobacilli and bifidobacteria The two most common bacterial species added in the production of probiotic foods are lactobacilli and bifidobacteria. There are numerous strains of lactobacilli and bifidobacteria; the main strains thought to have probiotic characteristics are L casei, B lactis, Ljohnsonii, B breve, L bulgaricus, B animalis, L rhamnosus, B infantis, L reuteri, B Iongum, and L acidophilus.
  • probiotic products may be usefully combined with polyphenol products to provide a food additive. Indeed the finding of the inventors may be considered surprising.
  • the role of probiotic products in promoting gut health has often been related to ability of the probiotic to reinforce the intestinal mucosal barrier against deleterious agents, and to reduce the permeability of the gut wall to pathological agents, large molecules and bacteria.
  • Probiotic products are considered to have little or no effect on the main physiological functions of the gut including absorption. It is thus surprising to suggest that a combination of a polyphenol and a probiotic would produce a beneficial effect.
  • composition of the invention has been demonstrated to positively influence indicators of cardiovascular health.
  • a method of improving cardiovascular health in a subject in need thereof consisting of administering to the subject a composition including a probiotic in combination with a polyphenol.
  • the polyphenol product is derived from natural sources.
  • the polyphenol product is derived from grape seed, apple and pear, green tea or cocoa extracts.
  • the polyphenol product is a proanthocyanidin rich product.
  • composition of the invention is administered on a regular basis, most preferably on a daily basis.
  • a single dose of a composition in accordance with the invention contains from 0.5-2.5g of polyphenol product in combination with a probiotic component.
  • Grape seed extract is a complex mixture of proanthocyanidin monomers (primarily catechin and epicatechin), dimers, trimers and larger species.
  • gut bacteria metabolise the polymers present in the GSE 1 assisted by the presence of the probiotic.
  • the effect of the composition on vascular health compares favourably to any effect resulting from administration of either the polyphenol product alone or the probiotic alone.
  • composition of the invention is not proposed as a mere admixture having the known health benefits of the components of the composition, but rather it is proposed that the composition exhibits effects beyond that which would be expected from the known properties of the various components. A hitherto unsuspected interaction between the components and the subject is thus proposed.
  • probiotic product is yogurt, although probiotic products may also be found in sour cream, buttermilk, powdered milk, and frozen desserts. Probiotics may also be supplied as supplements in tablet, capsule, and freeze-dried preparations.
  • the composition of the invention may be supplied in the form of a food product incorporating the components of the composition.
  • the composition of the invention may be incorporated into a dairy food, for example, yoghurt product or a milk or other dairy product.
  • the composition of the invention may be supplied in other food products.
  • the composition of the invention may be supplied in tablet, capsule or powder form, either alone or additionally incorporating other desirable products, for example vitamin and mineral supplements.
  • Figure 1 illustrates flow mediated dilation responses to consumption of grape seed extract in cordial against a control
  • Figure 2 illustrates flow mediated dilation responses to consumption of grape seed extract in yoghurt containing probiotics against a control
  • Figure 3 illustrates flow mediated dilation responses to consumption of grape seed extract in milk against a control
  • Figure 4 represents phenolic acids measured in urine samples following ingestion of foods containing polyphenols in the form of grape seed extract.
  • FMD flow mediated dilation
  • 2g of GSE were administered in different food matrices (yoghurt, milk) and in cordial to 4 subjects and subsequent measurements of flow mediated dilation taken. After a 3-day low polyphenol period, these individuals randomly took 2g of GSE in the food or cordial in the fasting state and had blood samples taken and flow mediated dilatation (FMD) assessed at 0 (fasting), 1 , 2, 4, 8 and 24 hours. Subjects continued to fast until 4 hours after the consumption of the test foods and followed the low-polyphenol diet until the intervention period was completed. Subjects also completed control days in which the same food or cordial was taken without GSE and exactly the same protocol was followed (i.e. each subject had a total of 48 blood samples and ultrasounds on 8 separate days).
  • FMD flow mediated dilatation
  • Each testing phase was separated by a minimum of a 1 week washout period.
  • Urine was collected for measurement of phenolic acids over 5 12 hour time periods: free living, after a 3 day low polyphenol period, 0-12 hours after GSE (or control) ingestion, 12-24, 24-36, 36-48 hours. Plasma catechin and epicatechin were also measured at each time point.
  • FIG. 1 illustrates graphically the results obtained from the incorporation of GSE alone in cordial. In this context cordial serves as a neutral food medium. It can be seen that the GSE mediates the post prandial drop observed in FMD.
  • the food matrix appeared to influence the FMD responses with the blunting of FMD drop being most evident when GSE was consumed in yoghurt, that is when a combination of polyphenols and probiotics were consumed.
  • the combination provided significant improvements where compared with ingestion of polyphenol without an accompanying probiotic component.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Botany (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une composition d'additif alimentaire comprenant un polyphénol, tel qu'un produit à base de polyphénol dérivé du pépin de raisin, de la pomme, de la poire, du thé vert ou d'extraits de cacao, associé à un probiotique, tel qu'un probiotique choisi parmi les espèces lactobacilli et bifidobacteria. L'invention concerne également un produit alimentaire ou un aliment de consommation courante contenant cet additif alimentaire. L'invention concerne également un procédé visant à améliorer la santé cardiovasculaire par l'administration de la composition de complément alimentaire au sujet.
PCT/AU2006/001028 2005-07-22 2006-07-20 Complement nutritionnel contenant un polyphenol et un probiotique WO2007009187A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2005903899A AU2005903899A0 (en) 2005-07-22 Nutritional Supplement
AU2005903899 2005-07-22

Publications (1)

Publication Number Publication Date
WO2007009187A1 true WO2007009187A1 (fr) 2007-01-25

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010079104A1 (fr) * 2009-01-07 2010-07-15 Chr. Hansen A/S Additif pour aliment ou eau potable contenant des antioxydants botaniques ainsi que des microorganismes probiotiques
WO2011069987A1 (fr) 2009-12-08 2011-06-16 Nestec S.A. Lait maternisé comprenant des probiotiques et des composants de membrane de globule gras du lait
WO2011105571A1 (fr) 2010-02-26 2011-09-01 三菱化学株式会社 Luminophore d'halogénophosphate et dispositif émetteur de lumière blanche
WO2012114640A1 (fr) 2011-02-25 2012-08-30 三菱化学株式会社 Corps fluorescent à halophosphate et dispositif émetteur de lumière blanche
WO2013190068A1 (fr) * 2012-06-22 2013-12-27 Nestec S.A. Probiotique et polyphénol contre la neurodégénérescence
US20170095442A1 (en) * 2014-05-29 2017-04-06 Jaguar Animal Health, Inc. Methods of Treating Salmonella-Induced Diarrhea in Non-Human Animals
WO2018102658A1 (fr) * 2016-12-02 2018-06-07 Fairlife, Llc Poudre de lait sans lactose et sans brunissement, et procédés de fabrication de celle-ci
US11602553B2 (en) * 2018-06-27 2023-03-14 University Of Florida Research Foundation, Incorporated Composition of lactobacillus and berry extract

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JPH06166626A (ja) * 1992-05-12 1994-06-14 Taiyo Kagaku Co Ltd 生菌粉末
WO1996037113A1 (fr) * 1995-05-26 1996-11-28 Kabushiki Kaisha Yakult Honsha Yaourt contenant du bifidobacterium et procede de production de ce dernier
EP0904784A1 (fr) * 1997-09-22 1999-03-31 N.V. Nutricia Préparation nutritionnelle probiotique
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EP0904784A1 (fr) * 1997-09-22 1999-03-31 N.V. Nutricia Préparation nutritionnelle probiotique
EP1020123A1 (fr) * 1999-01-18 2000-07-19 Sitia-Yomo S.p.A. Boissons comprenant des bactéries lactiques vivantes
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WO2004087893A1 (fr) * 2003-04-04 2004-10-14 Probi Ab Compositions comprenant des souches de lactobacillus plantarum combinees a du tanin et nouvelles souches de lactobacillus plantarum
JP2005046005A (ja) * 2003-06-03 2005-02-24 Yoshiki Katsurayama 茶葉含有食品及び茶葉含有食品の製造方法
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EP1600061A1 (fr) * 2004-05-25 2005-11-30 Cognis IP Management GmbH Compositions buccales et/ou topiques
JP2006034217A (ja) * 2004-07-29 2006-02-09 Torigoe Flour Milling Co Ltd 健康食品
WO2006028164A1 (fr) * 2004-09-10 2006-03-16 Kirin Beer Kabushiki Kaisha Méthode de stabilisation de l’activité antiallergique des bactéries lactiques vis-à-vis de traitements à haute température, et préparations, aliments et boissons stabilisés
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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010079104A1 (fr) * 2009-01-07 2010-07-15 Chr. Hansen A/S Additif pour aliment ou eau potable contenant des antioxydants botaniques ainsi que des microorganismes probiotiques
US9226521B2 (en) 2009-12-08 2016-01-05 Nestec S.A. Infant formula with probiotics and milk fat globule membrane components
WO2011069987A1 (fr) 2009-12-08 2011-06-16 Nestec S.A. Lait maternisé comprenant des probiotiques et des composants de membrane de globule gras du lait
CN102665428A (zh) * 2009-12-08 2012-09-12 雀巢产品技术援助有限公司 含有益生菌和乳脂肪球膜组分的婴儿配方
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