WO2007005534A8 - Chemical compounds - Google Patents
Chemical compoundsInfo
- Publication number
- WO2007005534A8 WO2007005534A8 PCT/US2006/025402 US2006025402W WO2007005534A8 WO 2007005534 A8 WO2007005534 A8 WO 2007005534A8 US 2006025402 W US2006025402 W US 2006025402W WO 2007005534 A8 WO2007005534 A8 WO 2007005534A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- directed
- ikk2
- formula
- treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 102100021854 Inhibitor of nuclear factor kappa-B kinase subunit beta Human genes 0.000 abstract 3
- 101710205525 Inhibitor of nuclear factor kappa-B kinase subunit beta Proteins 0.000 abstract 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- VFHUJFBEFDVZPJ-UHFFFAOYSA-N 1h-indole-2-carboxamide Chemical class C1=CC=C2NC(C(=O)N)=CC2=C1 VFHUJFBEFDVZPJ-UHFFFAOYSA-N 0.000 abstract 1
- 101100508533 Drosophila melanogaster IKKbeta gene Proteins 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ563687A NZ563687A (en) | 2005-06-30 | 2006-06-28 | 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[2-(1-methylethyl)-2,3-dihydro-1H-isoindol-5-yl]-1H-indole-7-carboxamide for inhibiting IKK2 (aka IKKbeta) |
EA200800183A EA014083B1 (en) | 2005-06-30 | 2006-06-28 | Novel indole carboxamide derivatives, a pharmaceutical composition comprising thereof and a method for treating thereof |
JP2008519569A JP5059756B2 (en) | 2005-06-30 | 2006-06-28 | Compound |
MX2007016541A MX2007016541A (en) | 2005-06-30 | 2006-06-28 | Chemical compounds. |
EP06785861A EP1896014A4 (en) | 2005-06-30 | 2006-06-28 | Chemical compounds |
BRPI0611674-4A BRPI0611674A2 (en) | 2005-06-30 | 2006-06-28 | chemical compounds |
AU2006266028A AU2006266028B2 (en) | 2005-06-30 | 2006-06-28 | Chemical compounds |
CN2006800304481A CN101247804B (en) | 2005-06-30 | 2006-06-28 | Chemical compounds |
CA002613068A CA2613068A1 (en) | 2005-06-30 | 2006-06-28 | Indole carboxamides as ikk2 inhibitors |
ZA2007/09948A ZA200709948B (en) | 2005-06-30 | 2007-11-19 | Chemical Compounds |
IL187786A IL187786A0 (en) | 2005-06-30 | 2007-11-29 | Chemical compounds |
NO20080457A NO20080457L (en) | 2005-06-30 | 2008-01-24 | Chemical connections |
US13/273,408 US8354406B2 (en) | 2005-06-30 | 2011-10-14 | Chemical compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69525605P | 2005-06-30 | 2005-06-30 | |
US60/695,256 | 2005-06-30 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11931189 A-371-Of-International | 2006-06-28 | ||
US13/273,408 Division US8354406B2 (en) | 2005-06-30 | 2011-10-14 | Chemical compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2007005534A2 WO2007005534A2 (en) | 2007-01-11 |
WO2007005534A3 WO2007005534A3 (en) | 2007-04-26 |
WO2007005534A8 true WO2007005534A8 (en) | 2008-01-17 |
Family
ID=37605008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/025402 WO2007005534A2 (en) | 2005-06-30 | 2006-06-28 | Chemical compounds |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1896014A4 (en) |
JP (1) | JP5059756B2 (en) |
KR (1) | KR20080021077A (en) |
CN (1) | CN101247804B (en) |
AR (1) | AR055343A1 (en) |
AU (1) | AU2006266028B2 (en) |
BR (1) | BRPI0611674A2 (en) |
CA (1) | CA2613068A1 (en) |
EA (1) | EA014083B1 (en) |
IL (1) | IL187786A0 (en) |
MA (1) | MA29566B1 (en) |
MX (1) | MX2007016541A (en) |
NO (1) | NO20080457L (en) |
NZ (1) | NZ563687A (en) |
PE (1) | PE20070173A1 (en) |
TW (1) | TWI380973B (en) |
UA (1) | UA99699C2 (en) |
WO (1) | WO2007005534A2 (en) |
ZA (1) | ZA200709948B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
PE20060748A1 (en) * | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | INDOLCARBOXAMIDE DERIVATIVES AS KINASE INHIBITORS IKK2 |
GB0525164D0 (en) * | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
US20080293802A1 (en) * | 2005-12-16 | 2008-11-27 | Smithline Beecham Corporation | Chemical Compounds |
PE20081889A1 (en) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | INDOL CARBOXAMIDES AS INHIBITORS OF IKK2 |
ES2490867T3 (en) * | 2008-12-19 | 2014-09-04 | Bristol-Myers Squibb Company | Carbazole and carboline kinase inhibitors |
WO2010102968A1 (en) * | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
MX355943B (en) * | 2013-06-26 | 2018-05-07 | Abbvie Inc | Primary carboxamides as btk inhibitors. |
SG10201903578VA (en) * | 2014-10-24 | 2019-05-30 | Bristol Myers Squibb Co | Indole carboxamides compounds useful as kinase inhibitors |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010022581A (en) * | 1997-08-06 | 2001-03-26 | 피터 지. 스트링거 | 2-Acylaminopropanamines as Tachykinin Receptor Antagonists |
DE19807993A1 (en) | 1998-02-26 | 1999-09-02 | Bayer Ag | Treating tumor necrosis factor mediated inflammatory disease, e.g. arteriosclerosis, using new or known beta-carboline derivatives |
DE19928424A1 (en) | 1999-06-23 | 2000-12-28 | Aventis Pharma Gmbh | New aminoacid residue substituted benzimidazole derivative I(kappa)B-kinase inhibitors, useful for treating NF(kappa)B-related disorders e.g. rheumatoid arthritis, asthma, Alzheimer's disease and cancer |
KR100718830B1 (en) | 1999-06-23 | 2007-05-17 | 사노피-아벤티스 도이칠란트 게엠베하 | Substituted benzimidazole and preparation method thereof |
DE19951360A1 (en) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituted indoles |
GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
WO2001068648A1 (en) | 2000-03-15 | 2001-09-20 | Aventis Pharma Deutschland Gmbh | Substituted beta-carbolines with ikb-kinase inhibiting activity |
EP1134221A1 (en) | 2000-03-15 | 2001-09-19 | Aventis Pharma Deutschland GmbH | Substituted beta-carbolines as lkB kinase inhibitors |
EP1209158A1 (en) | 2000-11-18 | 2002-05-29 | Aventis Pharma Deutschland GmbH | Substituted beta-carbolines |
JP2001278886A (en) * | 2000-03-28 | 2001-10-10 | Dai Ichi Seiyaku Co Ltd | Benzoxazine derivative and medicament containing the same |
US6414013B1 (en) | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
JP4272338B2 (en) | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | Pyridine derivatives |
US6869956B2 (en) | 2000-10-03 | 2005-03-22 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) |
US6960585B2 (en) | 2000-10-03 | 2005-11-01 | Bristol-Myers Squibb Company | Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same |
WO2002030423A1 (en) | 2000-10-12 | 2002-04-18 | Smithkline Beecham Corporation | NF-λB INHIBITORS |
WO2002030353A2 (en) | 2000-10-12 | 2002-04-18 | Smithkline Beecham Corporation | NF-λB INHIBITORS |
AU3980602A (en) | 2000-10-26 | 2002-06-03 | Tularik Inc | Antiinflammation agents |
JP2002193938A (en) | 2000-12-01 | 2002-07-10 | Bayer Ag | 4-arylpyridine derivative |
US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
EP1363993A4 (en) | 2001-02-01 | 2008-11-12 | Bristol Myers Squibb Co | METHODS OF TREATING INFLAMMATORY AND IMMUNE DISEASES USING INHIBITORS OF I$g(k)B KINASE (IKK) |
WO2002094265A1 (en) | 2001-05-24 | 2002-11-28 | Leo Pharma A/S | A method of modulating nf-$g(k)b activity |
ATE442362T1 (en) | 2001-05-24 | 2009-09-15 | Leo Pharma As | PYRIDYLCYANOGUANIDINE COMPOUNDS |
US20030045515A1 (en) | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
US6638679B2 (en) | 2001-07-12 | 2003-10-28 | Kodak Polychrome Graphics, Llc | Photosensitive compositions having mixtures of alkoxy and non-alkoxy diazonium salt containing compounds |
SE0102616D0 (en) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0102617D0 (en) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
US6956052B2 (en) | 2001-09-19 | 2005-10-18 | Pharmacia Corporation | Substituted pyrazolyl compounds for the treatment of inflammation |
EP1438293A2 (en) | 2001-09-19 | 2004-07-21 | Pharmacia Corporation | Substituted pyrazolyl benzenesulfamide compounds for the treatment of inflammation |
WO2003035625A1 (en) | 2001-09-19 | 2003-05-01 | Pharmacia Corporation | Substituted indazole compounds for the treatment of inflammation |
CA2460939C (en) | 2001-09-19 | 2008-07-29 | Pharmacia Corporation | Substituted pyrazolyl compounds for the treatment of inflammation |
BR0213734A (en) | 2001-10-30 | 2004-10-19 | Pharmacia Corp | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
WO2003084959A1 (en) | 2002-04-03 | 2003-10-16 | Bristol-Myers Squibb Company | Thiopene-based tricyclic compounds and pharmaceutical compositions comprising same |
AU2003220483A1 (en) | 2002-05-09 | 2003-11-11 | Pharmacia Corporation | Substituted pyrazolyl compounds for the treatment of inflammation |
PL373424A1 (en) | 2002-06-06 | 2005-08-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
GB0217757D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
DE60334386D1 (en) * | 2002-08-09 | 2010-11-11 | Merck Sharp & Dohme | tyrosine kinase inhibitors |
DE10237722A1 (en) | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indole or benzimidazole derivatives for the modulation of IKappaB kinase |
WO2004075846A2 (en) | 2003-02-25 | 2004-09-10 | Bristol-Myers Squibb Company | Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same |
GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
US7176214B2 (en) | 2003-05-21 | 2007-02-13 | Bristol-Myers Squibb Company | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same |
EP1651629A1 (en) | 2003-07-31 | 2006-05-03 | Boehringer Ingelheim Pharmaceuticals Inc. | Substituted benzothiophene compounds and uses thereof |
US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
US7291733B2 (en) | 2003-10-10 | 2007-11-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted tricyclic heterocycles and their uses |
MXPA06003746A (en) | 2003-10-14 | 2006-06-14 | Pharmacia Corp | Substituted pyrazinone compounds for the treatment of inflammation. |
GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
AR050253A1 (en) * | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | COMPOSITE DERIVED FROM INDAZOL CARBOXAMIDE, COMPOSITION THAT INCLUDES IT AND ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT |
CN101060842A (en) * | 2004-09-21 | 2007-10-24 | 葛兰素集团有限公司 | Chemical compounds |
PE20060748A1 (en) * | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | INDOLCARBOXAMIDE DERIVATIVES AS KINASE INHIBITORS IKK2 |
-
2006
- 2006-06-28 AR ARP060102790A patent/AR055343A1/en not_active Application Discontinuation
- 2006-06-28 KR KR1020077030656A patent/KR20080021077A/en not_active Ceased
- 2006-06-28 UA UAA200714940A patent/UA99699C2/en unknown
- 2006-06-28 BR BRPI0611674-4A patent/BRPI0611674A2/en not_active IP Right Cessation
- 2006-06-28 TW TW095123240A patent/TWI380973B/en not_active IP Right Cessation
- 2006-06-28 NZ NZ563687A patent/NZ563687A/en not_active IP Right Cessation
- 2006-06-28 WO PCT/US2006/025402 patent/WO2007005534A2/en active Application Filing
- 2006-06-28 EP EP06785861A patent/EP1896014A4/en not_active Withdrawn
- 2006-06-28 JP JP2008519569A patent/JP5059756B2/en not_active Expired - Fee Related
- 2006-06-28 CN CN2006800304481A patent/CN101247804B/en not_active Expired - Fee Related
- 2006-06-28 EA EA200800183A patent/EA014083B1/en not_active IP Right Cessation
- 2006-06-28 AU AU2006266028A patent/AU2006266028B2/en not_active Ceased
- 2006-06-28 CA CA002613068A patent/CA2613068A1/en not_active Abandoned
- 2006-06-28 PE PE2006000761A patent/PE20070173A1/en not_active Application Discontinuation
- 2006-06-28 MX MX2007016541A patent/MX2007016541A/en active IP Right Grant
-
2007
- 2007-11-19 ZA ZA2007/09948A patent/ZA200709948B/en unknown
- 2007-11-29 IL IL187786A patent/IL187786A0/en unknown
- 2007-12-26 MA MA30513A patent/MA29566B1/en unknown
-
2008
- 2008-01-24 NO NO20080457A patent/NO20080457L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1896014A2 (en) | 2008-03-12 |
AU2006266028A1 (en) | 2007-01-11 |
EP1896014A4 (en) | 2010-07-21 |
NZ563687A (en) | 2011-07-29 |
MX2007016541A (en) | 2008-03-07 |
PE20070173A1 (en) | 2007-03-14 |
ZA200709948B (en) | 2009-03-25 |
BRPI0611674A2 (en) | 2009-04-28 |
TWI380973B (en) | 2013-01-01 |
KR20080021077A (en) | 2008-03-06 |
AR055343A1 (en) | 2007-08-22 |
WO2007005534A2 (en) | 2007-01-11 |
CN101247804B (en) | 2012-09-26 |
UA99699C2 (en) | 2012-09-25 |
CN101247804A (en) | 2008-08-20 |
CA2613068A1 (en) | 2007-01-11 |
EA014083B1 (en) | 2010-08-30 |
IL187786A0 (en) | 2008-08-07 |
NO20080457L (en) | 2008-01-29 |
TW200738588A (en) | 2007-10-16 |
JP2009500338A (en) | 2009-01-08 |
AU2006266028B2 (en) | 2012-03-15 |
JP5059756B2 (en) | 2012-10-31 |
WO2007005534A3 (en) | 2007-04-26 |
EA200800183A1 (en) | 2008-08-29 |
MA29566B1 (en) | 2008-06-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2006034317A3 (en) | Chemical compounds | |
WO2007076286A3 (en) | Chemical compounds | |
WO2007005534A3 (en) | Chemical compounds | |
MX2009010270A (en) | Indole carboxamides as ikk2 inhibitors. | |
TNSN08104A1 (en) | Pyrimidine amide compounds as pgds inhibitors | |
WO2006002434A3 (en) | Novel indazole carboxamides and their use | |
WO2007114848A3 (en) | Chemical compounds | |
MY154895A (en) | Pyrimidine hydrazide compounds as pgds inhibitors | |
WO2007102883A3 (en) | Chemical compounds | |
WO2010018109A3 (en) | Substituted aminotetralines | |
WO2007056219A3 (en) | [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto | |
WO2010018113A3 (en) | Bi-aryl aminotetralines | |
WO2007062318A3 (en) | Chemical compounds | |
WO2008094992A3 (en) | 2-aminopyridine derivatives useful as kinase inhibitors | |
IL187438A0 (en) | Pyrrolopyridine derivatives and pharmaceutical compositions containing the same | |
NZ591426A (en) | P38 map kinase inhibitors | |
WO2009023539A3 (en) | Tetrahydropyridine carboxamide derivatives as trpvl antagonists | |
TW200718424A (en) | Novel compounds of amino sulfonyl derivatives | |
WO2007056163A3 (en) | Aminopyrimidines useful as kinase inhibitors | |
WO2007041130A3 (en) | Deazapurines useful as inhibitors of janus kinases | |
WO2008022286A3 (en) | Small molecule inhibitors of kynurenine-3-monooxygenase | |
WO2010018112A3 (en) | Monoaryl aminotetralines | |
WO2008128009A3 (en) | Aminopyrimidines useful as kinase inhibitors | |
WO2006000371A3 (en) | Pyrimidine derivatives as 11beta-hsd1 inhibitors | |
WO2006110173A3 (en) | Novel compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200680030448.1 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 12007502622 Country of ref document: PH |
|
WWE | Wipo information: entry into national phase |
Ref document number: 563687 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 187786 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 9298/DELNP/2007 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006785861 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 07132380 Country of ref document: CO |
|
WWE | Wipo information: entry into national phase |
Ref document number: MX/a/2007/016541 Country of ref document: MX |
|
ENP | Entry into the national phase |
Ref document number: 2613068 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2008519569 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020077030656 Country of ref document: KR |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006266028 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: DZP2008000045 Country of ref document: DZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 200800183 Country of ref document: EA |
|
WWE | Wipo information: entry into national phase |
Ref document number: a200714940 Country of ref document: UA |
|
ENP | Entry into the national phase |
Ref document number: 2006266028 Country of ref document: AU Date of ref document: 20060628 Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: PI0611674 Country of ref document: BR Kind code of ref document: A2 |