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WO2007003398A3 - Elektrodenanordnung, deren verwendung sowie verfahren zu deren herstellung - Google Patents

Elektrodenanordnung, deren verwendung sowie verfahren zu deren herstellung Download PDF

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Publication number
WO2007003398A3
WO2007003398A3 PCT/EP2006/006459 EP2006006459W WO2007003398A3 WO 2007003398 A3 WO2007003398 A3 WO 2007003398A3 EP 2006006459 W EP2006006459 W EP 2006006459W WO 2007003398 A3 WO2007003398 A3 WO 2007003398A3
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WO
WIPO (PCT)
Prior art keywords
electrode assembly
similar
production
zone
biological cell
Prior art date
Application number
PCT/EP2006/006459
Other languages
English (en)
French (fr)
Other versions
WO2007003398A2 (de
Inventor
Dirk Zimmermann
Ernst Bamberg
Ulrich Zimmermann
Original Assignee
Max Planck Gesellschaft
Univ Wuerzburg J Maximilians
Dirk Zimmermann
Ernst Bamberg
Ulrich Zimmermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Univ Wuerzburg J Maximilians, Dirk Zimmermann, Ernst Bamberg, Ulrich Zimmermann filed Critical Max Planck Gesellschaft
Priority to EP06776116A priority Critical patent/EP1899724A2/de
Priority to US11/922,971 priority patent/US20100038247A1/en
Publication of WO2007003398A2 publication Critical patent/WO2007003398A2/de
Publication of WO2007003398A3 publication Critical patent/WO2007003398A3/de

Links

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685—Microneedles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Electromagnetism (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Sustainable Development (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

Die Erfindung betrifft eine Elektrodenanordnung (10) für elektrophysiologische Untersuchungen biologischer Zellen (Z) und dergleichen. Die Elektrodenanordnung (10) weist einen Kontaktbereich (40k) zum Kontaktieren der Elektrodenanordnung (10) mit einer biologischen Zelle (Z) oder dergleichen, sowie einen Anschlussbereich (40A) zur externen elektrischen Kontaktierung der Elektrodenanordnung (10) auf. Der Kontaktbereich (40K) ist mit einer oder einer Mehrzahl Elektrodenspitzen (40s) ausgebildet, die sich vom Anschlussbereich (40a) her erstrecken und eine geometrische Gestalt aufweisen, die im Betrieb ein ansonsten zerstörungsfreies Eindringen in eine biologische Zelle (Z) oder dergleichen über deren Membran (M) in das Zellinnere (I) erlaubt.
PCT/EP2006/006459 2005-07-01 2006-07-03 Elektrodenanordnung, deren verwendung sowie verfahren zu deren herstellung WO2007003398A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06776116A EP1899724A2 (de) 2005-07-01 2006-07-03 Elektrodenanordnung, deren verwendung sowie verfahren zu deren herstellung
US11/922,971 US20100038247A1 (en) 2005-07-01 2006-07-03 Electrode Assembly, Use Thereof, and Method for the Production Thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005030859A DE102005030859A1 (de) 2005-07-01 2005-07-01 Elektrodenanordnung, deren Verwendung sowie Verfahren zu deren Herstellung
DE102005030859.7 2005-07-01

Publications (2)

Publication Number Publication Date
WO2007003398A2 WO2007003398A2 (de) 2007-01-11
WO2007003398A3 true WO2007003398A3 (de) 2007-03-15

Family

ID=37027789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/006459 WO2007003398A2 (de) 2005-07-01 2006-07-03 Elektrodenanordnung, deren verwendung sowie verfahren zu deren herstellung

Country Status (4)

Country Link
US (1) US20100038247A1 (de)
EP (1) EP1899724A2 (de)
DE (1) DE102005030859A1 (de)
WO (1) WO2007003398A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007076458A1 (en) * 2005-12-21 2007-07-05 Primegen Biotech Llc Microinjector chip
WO2008076465A1 (en) * 2006-12-21 2008-06-26 Primegen Biotech, Llc Microinjector chip
DE102008009826A1 (de) 2008-02-19 2009-08-20 Max-Planck-Gesellschaft Vorrichtung zur Bestimmung eines elektrophysiologischen Parameters von biologischem Zellmaterial, Verfahren zur Herstellung einer Messelektrode für eine derartige Vorrichtung sowie Verfahren zur Vermessung einer Zelle mithilfe einer derartigen Vorrichtung
WO2009104056A1 (en) * 2008-02-21 2009-08-27 Claus Birger Sorensen Biochip for electrophysiological measurements
DE102008047399A1 (de) * 2008-09-16 2010-04-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Elektrodeneinrichtung, Generatoreinrichtung und Verfahren zur Stromerzeugung durch Membranpotential-Ableitung
WO2010121130A2 (en) 2009-04-16 2010-10-21 President And Fellows Of Harvard College Molecular delivery with nanowires
US20140011691A1 (en) * 2010-10-26 2014-01-09 Arizona Board of Regents, A Body Corporate of the State of Arizona, Acting for and on Behalf of Az. Morphology and protein specific reagents as diagnostics for neurodegenerative diseases
US20150076118A1 (en) * 2013-09-17 2015-03-19 Kangmin Hsia System and Method of Polishing a Surface
US20180169403A1 (en) 2015-01-09 2018-06-21 President And Fellows Of Harvard College Nanowire arrays for neurotechnology and other applications
EP3361242B1 (de) * 2015-10-09 2022-04-27 Sony Semiconductor Solutions Corporation Potenzialmessvorrichtung
DE102017218262B4 (de) 2017-10-12 2019-05-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung einer Vorrichtung zur sensorbasierten Untersuchung biologischer Zellen, hergestellte Vorrichtung und Verwendungen hiervon
FR3099696B1 (fr) * 2019-08-08 2024-02-09 Pkvitality Systeme de surveillance corporelle comprenant une microaiguille
CN113970677B (zh) * 2021-10-09 2023-10-27 上海林海生态技术股份有限公司 生物电化学系统用电极板可靠性的检测方法

Citations (8)

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US4969468A (en) * 1986-06-17 1990-11-13 Alfred E. Mann Foundation For Scientific Research Electrode array for use in connection with a living body and method of manufacture
US5388577A (en) * 1990-06-08 1995-02-14 Boston University Electrode array microchip
WO2000016833A1 (en) * 1998-09-18 2000-03-30 The University Of Utah Research Foundation Surface micromachined microneedles
WO2001052731A1 (en) * 2000-01-21 2001-07-26 Instrumentarium Corporation Medical electrode
US20020028991A1 (en) * 2000-09-01 2002-03-07 Medtronic, Inc. Skin-mounted electrodes with nano spikes
EP1344551A2 (de) * 1995-08-10 2003-09-17 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen Mikroelektroden-Anordnung
EP1488740A1 (de) * 2003-06-17 2004-12-22 Instrumentarium Corporation Einheitlicher Multielektrodenbiopotentialsensor und Herstellungsverfahren desselben.
WO2005117554A2 (en) * 2004-06-01 2005-12-15 California Institute Of Technology Microfabricated neural probes and methods of making same

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Patent Citations (8)

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US4969468A (en) * 1986-06-17 1990-11-13 Alfred E. Mann Foundation For Scientific Research Electrode array for use in connection with a living body and method of manufacture
US5388577A (en) * 1990-06-08 1995-02-14 Boston University Electrode array microchip
EP1344551A2 (de) * 1995-08-10 2003-09-17 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen Mikroelektroden-Anordnung
WO2000016833A1 (en) * 1998-09-18 2000-03-30 The University Of Utah Research Foundation Surface micromachined microneedles
WO2001052731A1 (en) * 2000-01-21 2001-07-26 Instrumentarium Corporation Medical electrode
US20020028991A1 (en) * 2000-09-01 2002-03-07 Medtronic, Inc. Skin-mounted electrodes with nano spikes
EP1488740A1 (de) * 2003-06-17 2004-12-22 Instrumentarium Corporation Einheitlicher Multielektrodenbiopotentialsensor und Herstellungsverfahren desselben.
WO2005117554A2 (en) * 2004-06-01 2005-12-15 California Institute Of Technology Microfabricated neural probes and methods of making same

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Also Published As

Publication number Publication date
WO2007003398A2 (de) 2007-01-11
EP1899724A2 (de) 2008-03-19
US20100038247A1 (en) 2010-02-18
DE102005030859A1 (de) 2007-01-04

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