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WO2007002851A3 - Thermally-processed cocoa products useful for vascular health improvement - Google Patents

Thermally-processed cocoa products useful for vascular health improvement Download PDF

Info

Publication number
WO2007002851A3
WO2007002851A3 PCT/US2006/025422 US2006025422W WO2007002851A3 WO 2007002851 A3 WO2007002851 A3 WO 2007002851A3 US 2006025422 W US2006025422 W US 2006025422W WO 2007002851 A3 WO2007002851 A3 WO 2007002851A3
Authority
WO
WIPO (PCT)
Prior art keywords
thermally
products useful
health improvement
vascular health
cocoa products
Prior art date
Application number
PCT/US2006/025422
Other languages
French (fr)
Other versions
WO2007002851A2 (en
Inventor
Harold H Schmitz
Catherine L Kwik-Uribe
John F Hammerstone
Mark A Kelm
Rebecca J Robbins
Original Assignee
Mars Inc
Harold H Schmitz
Catherine L Kwik-Uribe
John F Hammerstone
Mark A Kelm
Rebecca J Robbins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mars Inc, Harold H Schmitz, Catherine L Kwik-Uribe, John F Hammerstone, Mark A Kelm, Rebecca J Robbins filed Critical Mars Inc
Priority to MX2007016272A priority Critical patent/MX2007016272A/en
Priority to CA002611849A priority patent/CA2611849A1/en
Priority to EP06785869A priority patent/EP1896442A2/en
Priority to JP2008520292A priority patent/JP2009501161A/en
Priority to AU2006263666A priority patent/AU2006263666A1/en
Publication of WO2007002851A2 publication Critical patent/WO2007002851A2/en
Publication of WO2007002851A3 publication Critical patent/WO2007002851A3/en
Priority to IL188073A priority patent/IL188073A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/0003—Processes of manufacture not relating to composition or compounding ingredients
    • A23G1/0006—Processes specially adapted for manufacture or treatment of cocoa or cocoa products
    • A23G1/0009—Manufacture or treatment of liquids, creams, pastes, granules, shreds or powders
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/56—Liquid products; Solid products in the form of powders, flakes or granules for making liquid products, e.g. for making chocolate milk, drinks and the products for their preparation, pastes for spreading or milk crumb
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Food Science & Technology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Medical Informatics (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)

Abstract

The invention relates to compositions containing polyphenols such as flavanols, procyanidins, and derivatives thereof obtainable by thermally treating the polyphenols in an aqueous solution, and to compositions comprising epimers of flavanols, procyanidins, and derivatives thereof, and methods of therapeutic or prophylactic treatment of NO-responsive diseases or disorders using the same. The invention also relates to thermally-processed cocoa powders and cocoa extracts characterized by an altered monomelic and oligomeric profile where the total amount of epicatechin and catechin is unchanged, where new dimers are present, and where oligomers higher than the trimers are absent.
PCT/US2006/025422 2005-06-29 2006-06-29 Thermally-processed cocoa products useful for vascular health improvement WO2007002851A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
MX2007016272A MX2007016272A (en) 2005-06-29 2006-06-29 Thermally-processed cocoa products useful for vascular health improvement.
CA002611849A CA2611849A1 (en) 2005-06-29 2006-06-29 Thermally-processed cocoa products useful for vascular health improvement
EP06785869A EP1896442A2 (en) 2005-06-29 2006-06-29 Thermally-processed cocoa products useful for vascular health improvement
JP2008520292A JP2009501161A (en) 2005-06-29 2006-06-29 Heat treated cocoa products useful for improving vascular health
AU2006263666A AU2006263666A1 (en) 2005-06-29 2006-06-29 Thermally-processed cocoa products useful for vascular health improvement
IL188073A IL188073A0 (en) 2005-06-29 2007-12-12 Thermally-processed cocoa products useful for vascular health improvement

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69536105P 2005-06-29 2005-06-29
US60/695,361 2005-06-29

Publications (2)

Publication Number Publication Date
WO2007002851A2 WO2007002851A2 (en) 2007-01-04
WO2007002851A3 true WO2007002851A3 (en) 2007-03-01

Family

ID=37596059

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/025422 WO2007002851A2 (en) 2005-06-29 2006-06-29 Thermally-processed cocoa products useful for vascular health improvement

Country Status (9)

Country Link
EP (1) EP1896442A2 (en)
JP (1) JP2009501161A (en)
CN (1) CN101228148A (en)
AU (1) AU2006263666A1 (en)
CA (1) CA2611849A1 (en)
IL (1) IL188073A0 (en)
MX (1) MX2007016272A (en)
RU (1) RU2008103151A (en)
WO (1) WO2007002851A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2659099A1 (en) 2006-06-15 2007-12-21 Mars, Incorporated Use of cocoa flavanols and procyanidins to improve executive cognitive and cerebral blood flow
AU2007275561B2 (en) * 2006-07-21 2013-12-19 Mars, Incorporated Improvement of arginase levels/activity
US8609174B2 (en) 2006-11-17 2013-12-17 Barry Callebaut Ag Method for producing a soluble cocoa product from cocoa powder
US8372456B2 (en) 2006-11-17 2013-02-12 Barry Callebaut Ag Method for producing a soluble cocoa product from cocoa powder
GB0719544D0 (en) * 2007-10-08 2007-11-14 Barry Callebaut Ag Cocoa extract and use thereof
GB0719542D0 (en) 2007-10-08 2007-11-14 Barry Callebaut Ag Use of cocoa extract
GB0719545D0 (en) * 2007-10-08 2007-11-14 Barry Callebaut Ag Novel use of cocoa extract
GB0724716D0 (en) 2007-12-19 2008-01-30 Barry Callebaut Ag Process
GB0801401D0 (en) * 2008-01-25 2008-03-05 Barry Callebaut Ag Composition
ES2381697T3 (en) * 2008-03-28 2012-05-30 Barry Callebaut Ag Cocoa composition
WO2010092941A1 (en) * 2009-02-16 2010-08-19 株式会社 ブルボン Composition having vasodilation activity, process for producing same, and use of same
MX2012010225A (en) * 2010-03-05 2012-10-01 Mars Inc Palatable beverages and compositions with cocoa extract.
ITRM20110600A1 (en) * 2011-11-14 2013-05-15 Univ Roma USE OF A CATECHIN AND EPICATECHIN MIXTURE FOR THE INHIBITION OF THE PIASTRINIC FUNCTION
JP5868787B2 (en) * 2012-06-08 2016-02-24 長谷川香料株式会社 Taste improving agent for cacao flavored food and drink
JP2017511014A (en) 2014-01-02 2017-04-13 エルジー エレクトロニクス インコーポレイティド Broadcast transmission device, operation method of broadcast transmission device, broadcast reception device, and operation method of broadcast reception device
WO2015184291A1 (en) * 2014-05-30 2015-12-03 Shaklee Corporation Chardonnay grape seed extract
JP6772064B2 (en) * 2014-10-17 2020-10-21 株式会社明治 Functional oral composition containing polyphenols
CN105994863A (en) * 2016-05-12 2016-10-12 昆明杏梓生物科技有限公司 Chocolate product containing astaxanthin and preparing method and application of chocolate product
CN105997984B (en) * 2016-05-13 2021-07-02 合肥迈可罗生物工程有限公司 Application of epicatechin and derivatives thereof in preparation of blood fat reducing medicines
WO2017208058A1 (en) * 2016-06-03 2017-12-07 Casaluker S.A. High polyphenols cocoa powder based products, uses and methods for the manufacture thereof
JP6675429B2 (en) * 2018-02-28 2020-04-01 長谷川香料株式会社 Taste improver for food and drink

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194020B1 (en) * 1996-09-06 2001-02-27 Mars Incorporated Process for preparing food products containing cocoa polyphenols

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194020B1 (en) * 1996-09-06 2001-02-27 Mars Incorporated Process for preparing food products containing cocoa polyphenols

Also Published As

Publication number Publication date
CN101228148A (en) 2008-07-23
EP1896442A2 (en) 2008-03-12
JP2009501161A (en) 2009-01-15
MX2007016272A (en) 2008-03-05
WO2007002851A2 (en) 2007-01-04
RU2008103151A (en) 2009-08-10
AU2006263666A1 (en) 2007-01-04
IL188073A0 (en) 2008-03-20
CA2611849A1 (en) 2007-01-04

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