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WO2007092190A3 - Procedes et compositions permettant de moduler l'activite du recepteur du sphingosine-1-phosphate (s1p) - Google Patents

Procedes et compositions permettant de moduler l'activite du recepteur du sphingosine-1-phosphate (s1p) Download PDF

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Publication number
WO2007092190A3
WO2007092190A3 PCT/US2007/002353 US2007002353W WO2007092190A3 WO 2007092190 A3 WO2007092190 A3 WO 2007092190A3 US 2007002353 W US2007002353 W US 2007002353W WO 2007092190 A3 WO2007092190 A3 WO 2007092190A3
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Prior art keywords
compositions
phosphate
methods
receptor activity
modulating sphingosine
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PCT/US2007/002353
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English (en)
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WO2007092190A2 (fr
Inventor
Hongfeng Deng
Ghotas Evindar
Malcolm J Kavarana
Barry Morgan
Ashis K Saha
Alexander L Satz
Original Assignee
Praecis Pharm Inc
Hongfeng Deng
Ghotas Evindar
Malcolm J Kavarana
Barry Morgan
Ashis K Saha
Alexander L Satz
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Application filed by Praecis Pharm Inc, Hongfeng Deng, Ghotas Evindar, Malcolm J Kavarana, Barry Morgan, Ashis K Saha, Alexander L Satz filed Critical Praecis Pharm Inc
Priority to EP07763628A priority Critical patent/EP1981837A2/fr
Priority to JP2008554260A priority patent/JP2009526053A/ja
Publication of WO2007092190A2 publication Critical patent/WO2007092190A2/fr
Publication of WO2007092190A3 publication Critical patent/WO2007092190A3/fr

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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Abstract

La présente invention concerne des composés qui modulent l'activité du récepteur du récepteur du SIPI, l'utilisation de ces composés pour traiter des états associés à la signalisation par le récepteur du SIPI et des compositions pharmaceutiques comprenant ces composés.
PCT/US2007/002353 2006-02-06 2007-01-30 Procedes et compositions permettant de moduler l'activite du recepteur du sphingosine-1-phosphate (s1p) WO2007092190A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07763628A EP1981837A2 (fr) 2006-02-06 2007-01-30 Procedes et compositions permettant de moduler l'activite du recepteur du sphingosine-1-phosphate (s1p)
JP2008554260A JP2009526053A (ja) 2006-02-06 2007-01-30 スフィンゴシン−１−リン酸−（ｓ１ｐ）受容体活性を調節するための方法および組成物

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US11/349,069 US20060223866A1 (en) 2004-08-13 2006-02-06 Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
US11/349,069 2006-02-06

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WO2007092190A3 true WO2007092190A3 (fr) 2007-11-29

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US8580841B2 (en) 2008-07-23 2013-11-12 Arena Pharmaceuticals, Inc. Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
US9126932B2 (en) 2008-07-23 2015-09-08 Arena Pharmaceuticals, Inc. Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
US9522133B2 (en) 2008-07-23 2016-12-20 Arena Pharmaceuticals, Inc. Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
US8415484B2 (en) 2008-08-27 2013-04-09 Arena Pharmaceuticals, Inc. Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
US9108969B2 (en) 2008-08-27 2015-08-18 Arena Pharmaceuticals, Inc. Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
US8853419B2 (en) 2010-01-27 2014-10-07 Arena Pharmaceuticals, Inc. Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
US9175320B2 (en) 2010-01-27 2015-11-03 Arena Pharmaceuticals, Inc. Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
US9447041B2 (en) 2010-01-27 2016-09-20 Arena Pharmaceuticals, Inc. Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
US11555015B2 (en) 2018-09-06 2023-01-17 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders

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US20060223866A1 (en) 2006-10-05
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EP1981837A2 (fr) 2008-10-22
WO2007092190A2 (fr) 2007-08-16

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