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WO2007067593A3 - Formulations d'inhibiteur de cetp - Google Patents

Formulations d'inhibiteur de cetp Download PDF

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Publication number
WO2007067593A3
WO2007067593A3 PCT/US2006/046503 US2006046503W WO2007067593A3 WO 2007067593 A3 WO2007067593 A3 WO 2007067593A3 US 2006046503 W US2006046503 W US 2006046503W WO 2007067593 A3 WO2007067593 A3 WO 2007067593A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulations
emulsifyng
self
cetp inhibitors
cetp inhibitor
Prior art date
Application number
PCT/US2006/046503
Other languages
English (en)
Other versions
WO2007067593A2 (fr
Inventor
Agam R Sheth
Bhagwant Rege
Soumojeet Ghosh
Laman L Alani
Craig A Mckelvey
Maria T Cruanes
Original Assignee
Merck & Co Inc
Agam R Sheth
Bhagwant Rege
Soumojeet Ghosh
Laman L Alani
Craig A Mckelvey
Maria T Cruanes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Agam R Sheth, Bhagwant Rege, Soumojeet Ghosh, Laman L Alani, Craig A Mckelvey, Maria T Cruanes filed Critical Merck & Co Inc
Priority to US12/085,745 priority Critical patent/US8486983B2/en
Priority to EP06839075A priority patent/EP1965764B1/fr
Priority to AT06839075T priority patent/ATE516016T1/de
Publication of WO2007067593A2 publication Critical patent/WO2007067593A2/fr
Publication of WO2007067593A3 publication Critical patent/WO2007067593A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une formulation liquide pour administration orale de l'inhibiteur de CETP de formule I qui a une biodisponibilité améliorée comparée à des formulations solides conventionnelles. La formulation comprend l'inhibiteur de CETP, ou un sel pharmaceutiquement acceptable de celui-ci; une huile; et un ou plusieurs tensioactifs non ioniques ayant un bilan lipophile hydrophile (HLB) > 10.
PCT/US2006/046503 2005-12-05 2006-12-05 Formulations d'inhibiteur de cetp WO2007067593A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/085,745 US8486983B2 (en) 2005-12-05 2006-12-05 Self-emulsifying formulations of CETP inhibitors
EP06839075A EP1965764B1 (fr) 2005-12-05 2006-12-05 Formulations d'inhibiteur de cetp
AT06839075T ATE516016T1 (de) 2005-12-05 2006-12-05 Selbstemulgierende formulierungen von cetp- hemmern

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74245105P 2005-12-05 2005-12-05
US60/742,451 2005-12-05

Publications (2)

Publication Number Publication Date
WO2007067593A2 WO2007067593A2 (fr) 2007-06-14
WO2007067593A3 true WO2007067593A3 (fr) 2007-10-25

Family

ID=38123443

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/046503 WO2007067593A2 (fr) 2005-12-05 2006-12-05 Formulations d'inhibiteur de cetp

Country Status (4)

Country Link
US (1) US8486983B2 (fr)
EP (1) EP1965764B1 (fr)
AT (1) ATE516016T1 (fr)
WO (1) WO2007067593A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007081571A2 (fr) * 2005-12-30 2007-07-19 Merck & Co., Inc. Inhibiteurs de cetp
US8030359B2 (en) 2006-02-09 2011-10-04 Merck Sharp & Dohme Corp. Polymer formulations of CETP inhibitors
US20100119612A1 (en) * 2007-04-17 2010-05-13 Bend Research, Inc Nanoparticles comprising non-crystalline drug
ES2569660T3 (es) 2007-06-08 2016-05-12 Mannkind Corporation Inhibidores de la IRE-1alfa
JP2011506541A (ja) * 2007-12-17 2011-03-03 ノバルティス アーゲー カルボキシルエステラーゼ１調節を介した高密度リポタンパク質レベルの変換
CA2795750A1 (fr) * 2010-04-07 2011-10-13 Isis Pharmaceuticals, Inc. Modulation de l'expression de cetp
US20120095098A1 (en) * 2010-10-18 2012-04-19 Bhiku Patel Bioavailability Enhancement Delivery System
WO2014009434A1 (fr) 2012-07-11 2014-01-16 Sandoz Ag Système d'administration de médicament auto-microémulsifiant à base d'abiratérone ou d'acétate d'abiratérone
EP2934518B1 (fr) 2012-12-19 2020-02-19 Merck Sharp & Dohme Corp. Inhibiteurs de la cetp spirocycliques
US9376408B2 (en) 2012-12-20 2016-06-28 Merck Sharp & Dohme Corp. Therapeutic thiazolidinone compounds
US9981970B2 (en) 2013-07-30 2018-05-29 Merck Sharp & Dohme Corp. Bicyclic ureas and thiadiazolidine-1, 1-dioxides as CETP inhibitors
EP3054945B1 (fr) 2013-10-10 2018-08-15 Merck Sharp & Dohme Corp. Indolines 3,3'-disubstituées utilisées comme inhibiteurs de la protéine de transfert du cholestérol estérifié
EP3083642B1 (fr) 2013-12-17 2018-09-05 Merck Sharp & Dohme Corp. Isoxazolines bicycliques condensées utilisées comme inhibiteurs de la protéine de transfert du cholestérol estérifié
US10011572B2 (en) 2014-07-29 2018-07-03 Merck Sharp & Dohme Corp. Monocyclic isoxazolines as inhibitors of cholesterol ester transfer protein
JOP20180092A1 (ar) 2017-10-13 2019-04-13 Gilead Sciences Inc مثبطات hiv بروتياز
TW202104210A (zh) 2019-04-17 2021-02-01 美商基利科學股份有限公司 Hiv蛋白酶抑制劑
CN113616614A (zh) * 2021-07-22 2021-11-09 浙江和泽医药科技股份有限公司 一种醋酸阿比特龙软胶囊及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000295A2 (fr) * 2001-06-21 2003-01-03 Pfizer Products Inc. Formulations auto-emulsifiantes d'inhibiteurs de la proteine de transfert du cholesterol esterifie (cetp)
US20030072801A1 (en) * 2001-06-22 2003-04-17 Pfizer Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
WO2005011634A1 (fr) * 2003-08-04 2005-02-10 Pfizer Products Inc. Formes posologiques d'inhibiteurs de la proteine de transfert d'ester de cholesteryle et d'inhibiteurs de la hmg-coa-reductase
WO2006014357A1 (fr) * 2004-07-02 2006-02-09 Merck & Co., Inc. Inhibiteurs de la cetp

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0517412A1 (fr) 1991-06-03 1992-12-09 MERCK SHARP & DOHME LTD. Formulations pharmaceutiques d'une benzodiazepine
GB9405304D0 (en) 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
CN101212966B (zh) 2005-07-01 2012-03-14 默沙东公司 合成cetp抑制剂的方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000295A2 (fr) * 2001-06-21 2003-01-03 Pfizer Products Inc. Formulations auto-emulsifiantes d'inhibiteurs de la proteine de transfert du cholesterol esterifie (cetp)
US20030072801A1 (en) * 2001-06-22 2003-04-17 Pfizer Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
WO2005011634A1 (fr) * 2003-08-04 2005-02-10 Pfizer Products Inc. Formes posologiques d'inhibiteurs de la proteine de transfert d'ester de cholesteryle et d'inhibiteurs de la hmg-coa-reductase
WO2006014357A1 (fr) * 2004-07-02 2006-02-09 Merck & Co., Inc. Inhibiteurs de la cetp

Also Published As

Publication number Publication date
US8486983B2 (en) 2013-07-16
US20090186926A1 (en) 2009-07-23
EP1965764B1 (fr) 2011-07-13
ATE516016T1 (de) 2011-07-15
WO2007067593A2 (fr) 2007-06-14
EP1965764A2 (fr) 2008-09-10

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