WO2007066189A3 - Salts, prodrugs and formulations of 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-urea - Google Patents
Salts, prodrugs and formulations of 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-urea Download PDFInfo
- Publication number
- WO2007066189A3 WO2007066189A3 PCT/IB2006/003416 IB2006003416W WO2007066189A3 WO 2007066189 A3 WO2007066189 A3 WO 2007066189A3 IB 2006003416 W IB2006003416 W IB 2006003416W WO 2007066189 A3 WO2007066189 A3 WO 2007066189A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- phenyl
- pyrrolo
- prodrugs
- dichloro
- pyrimidine
- Prior art date
Links
- 239000000651 prodrug Substances 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- VFCRSIORGUNNGT-UHFFFAOYSA-N 1-[5-(4-amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxyphenyl]-3-(2,4-dichlorophenyl)urea Chemical compound COC1=CC=C(C(=O)C=2C3=C(N)N=CN=C3N(C(C)C)C=2)C=C1NC(=O)NC1=CC=C(Cl)C=C1Cl VFCRSIORGUNNGT-UHFFFAOYSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to compounds of the formula (I), or a pharmaceutically acceptable salt, prodrug or hydrates thereof. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74907005P | 2005-12-09 | 2005-12-09 | |
US60/749,070 | 2005-12-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007066189A2 WO2007066189A2 (en) | 2007-06-14 |
WO2007066189A3 true WO2007066189A3 (en) | 2008-08-14 |
Family
ID=38123252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2006/003416 WO2007066189A2 (en) | 2005-12-09 | 2006-11-24 | Salts, prodrugs and formulations of 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-urea |
Country Status (8)
Country | Link |
---|---|
AR (1) | AR058293A1 (en) |
DO (1) | DOP2006000271A (en) |
GT (1) | GT200600496A (en) |
NL (1) | NL2000337A1 (en) |
PE (1) | PE20071037A1 (en) |
TW (1) | TW200733965A (en) |
UY (1) | UY29991A1 (en) |
WO (1) | WO2007066189A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9321772B2 (en) | 2011-09-02 | 2016-04-26 | The Regents Of The University Of California | Substituted pyrazolo[3,4-D]pyrimidines and uses thereof |
US10131668B2 (en) | 2012-09-26 | 2018-11-20 | The Regents Of The University Of California | Substituted imidazo[1,5-a]pYRAZINES for modulation of IRE1 |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2197426A2 (en) * | 2007-10-19 | 2010-06-23 | Abbott GmbH & Co. KG | Solid dispersion product containing n-aryl urea-based compound |
KR20100087170A (en) * | 2007-10-19 | 2010-08-03 | 애보트 게엠베하 운트 콤파니 카게 | Solid dispersion product of n-aryl urea-based drugs |
JP5819195B2 (en) * | 2008-10-16 | 2015-11-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Fusion ring heteroaryl kinase inhibitors |
CA2785716A1 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted pyrrolo-aminopyrimidine compounds |
CA2802541A1 (en) * | 2010-06-23 | 2011-12-29 | Metabolex, Inc. | Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
US20140004192A1 (en) * | 2012-04-13 | 2014-01-02 | Ziopharm Oncology, Inc. | Pharmaceutical formulations of indibulin and uses thereof |
US9611267B2 (en) | 2012-06-13 | 2017-04-04 | Incyte Holdings Corporation | Substituted tricyclic compounds as FGFR inhibitors |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
EP2986610B9 (en) | 2013-04-19 | 2018-10-17 | Incyte Holdings Corporation | Bicyclic heterocycles as fgfr inhibitors |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
MA41551A (en) | 2015-02-20 | 2017-12-26 | Incyte Corp | BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS |
MY197720A (en) | 2015-02-20 | 2023-07-10 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
CN107722012B (en) * | 2016-08-11 | 2020-05-29 | 斯福瑞(南通)制药有限公司 | Process for preparing 4-chloro-7H-pyrrolo [2,3-d ] pyrimidines |
AR111960A1 (en) | 2017-05-26 | 2019-09-04 | Incyte Corp | CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION |
KR20210018265A (en) | 2018-05-04 | 2021-02-17 | 인사이트 코포레이션 | Solid form of FGFR inhibitor and method for preparing same |
EP3788046A1 (en) | 2018-05-04 | 2021-03-10 | Incyte Corporation | Salts of an fgfr inhibitor |
WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
CR20220169A (en) | 2019-10-14 | 2022-10-27 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
AU2020395185A1 (en) | 2019-12-04 | 2022-06-02 | Incyte Corporation | Derivatives of an FGFR inhibitor |
US11897891B2 (en) | 2019-12-04 | 2024-02-13 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
TW202304459A (en) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
TW202313611A (en) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | Tricyclic heterocycles as fgfr inhibitors |
JP2025015449A (en) * | 2023-07-18 | 2025-01-30 | 信越化学工業株式会社 | Composition for solid dispersion, solid dispersion, and method of manufacturing solid dispersion |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0901786A2 (en) * | 1997-08-11 | 1999-03-17 | Pfizer Products Inc. | Solid pharmaceutical dispersions with enhanced bioavailability |
WO2004056830A1 (en) * | 2002-12-19 | 2004-07-08 | Pfizer Products Inc. | Pyrrolopyrimidine derivatives |
-
2006
- 2006-11-24 WO PCT/IB2006/003416 patent/WO2007066189A2/en active Application Filing
- 2006-11-27 NL NL2000337A patent/NL2000337A1/en active Search and Examination
- 2006-12-05 DO DO2006000271A patent/DOP2006000271A/en unknown
- 2006-12-06 UY UY29991A patent/UY29991A1/en not_active Application Discontinuation
- 2006-12-06 PE PE2006001565A patent/PE20071037A1/en not_active Application Discontinuation
- 2006-12-07 AR ARP060105422A patent/AR058293A1/en unknown
- 2006-12-07 GT GT200600496A patent/GT200600496A/en unknown
- 2006-12-08 TW TW095145947A patent/TW200733965A/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0901786A2 (en) * | 1997-08-11 | 1999-03-17 | Pfizer Products Inc. | Solid pharmaceutical dispersions with enhanced bioavailability |
WO2004056830A1 (en) * | 2002-12-19 | 2004-07-08 | Pfizer Products Inc. | Pyrrolopyrimidine derivatives |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9321772B2 (en) | 2011-09-02 | 2016-04-26 | The Regents Of The University Of California | Substituted pyrazolo[3,4-D]pyrimidines and uses thereof |
US10131668B2 (en) | 2012-09-26 | 2018-11-20 | The Regents Of The University Of California | Substituted imidazo[1,5-a]pYRAZINES for modulation of IRE1 |
Also Published As
Publication number | Publication date |
---|---|
PE20071037A1 (en) | 2007-11-19 |
GT200600496A (en) | 2007-07-17 |
WO2007066189A2 (en) | 2007-06-14 |
AR058293A1 (en) | 2008-01-30 |
UY29991A1 (en) | 2007-07-31 |
NL2000337A1 (en) | 2007-06-12 |
DOP2006000271A (en) | 2007-08-15 |
TW200733965A (en) | 2007-09-16 |
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