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WO2007066181A3 - Methods of preparing a vegf-r inhibitor - Google Patents

Methods of preparing a vegf-r inhibitor Download PDF

Info

Publication number
WO2007066181A3
WO2007066181A3 PCT/IB2006/003331 IB2006003331W WO2007066181A3 WO 2007066181 A3 WO2007066181 A3 WO 2007066181A3 IB 2006003331 W IB2006003331 W IB 2006003331W WO 2007066181 A3 WO2007066181 A3 WO 2007066181A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitor
preparing
methods
vegf
compound
Prior art date
Application number
PCT/IB2006/003331
Other languages
French (fr)
Other versions
WO2007066181A2 (en
Inventor
Narubumi Fred Makino
Wolfgang Reinhard Ludwig Notz
Original Assignee
Pfizer Prod Inc
Narubumi Fred Makino
Wolfgang Reinhard Ludwig Notz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Narubumi Fred Makino, Wolfgang Reinhard Ludwig Notz filed Critical Pfizer Prod Inc
Priority to EP06820962A priority Critical patent/EP1963310A2/en
Priority to CA002632384A priority patent/CA2632384A1/en
Priority to JP2008543930A priority patent/JP2009518382A/en
Publication of WO2007066181A2 publication Critical patent/WO2007066181A2/en
Publication of WO2007066181A3 publication Critical patent/WO2007066181A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to methods for preparing a compound of formula (7), which is useful as a modulator and/or inhibitor of protein kinases. The present invention also relates to intermediate compounds useful in the preparation of a compound of formula (7).
PCT/IB2006/003331 2005-12-05 2006-11-20 Methods of preparing a vegf-r inhibitor WO2007066181A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06820962A EP1963310A2 (en) 2005-12-05 2006-11-20 Methods of preparing a vegf-r inhibitor
CA002632384A CA2632384A1 (en) 2005-12-05 2006-11-20 Methods of preparing a vegf-r inhibitor
JP2008543930A JP2009518382A (en) 2005-12-05 2006-11-20 Methods for preparing VEGF-R inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74284705P 2005-12-05 2005-12-05
US60/742,847 2005-12-05

Publications (2)

Publication Number Publication Date
WO2007066181A2 WO2007066181A2 (en) 2007-06-14
WO2007066181A3 true WO2007066181A3 (en) 2007-10-04

Family

ID=37857108

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003331 WO2007066181A2 (en) 2005-12-05 2006-11-20 Methods of preparing a vegf-r inhibitor

Country Status (4)

Country Link
EP (1) EP1963310A2 (en)
JP (1) JP2009518382A (en)
CA (1) CA2632384A1 (en)
WO (1) WO2007066181A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7829574B2 (en) 2008-05-09 2010-11-09 Hutchison Medipharma Enterprises Limited Substituted quinazoline compounds and their use in treating angiogenesis-related diseases
JP6315708B2 (en) * 2015-06-22 2018-04-25 日本電信電話株式会社 Lithium-air secondary battery, method for producing lithium-air secondary battery, and apparatus equipped with lithium-air secondary battery
CN112724110B (en) * 2021-01-13 2021-10-26 广州安岩仁医药科技有限公司 Synthesis method of VEGFR inhibitor furoquintinib and benzofuran intermediate thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137395A1 (en) * 2003-12-23 2005-06-23 Agouron Pharmaceuticals, Inc. Novel quinoline derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137395A1 (en) * 2003-12-23 2005-06-23 Agouron Pharmaceuticals, Inc. Novel quinoline derivatives

Also Published As

Publication number Publication date
CA2632384A1 (en) 2007-06-14
EP1963310A2 (en) 2008-09-03
WO2007066181A2 (en) 2007-06-14
JP2009518382A (en) 2009-05-07

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