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WO2007061631A3 - Production de glycoproteines a o-glycosylation reduite - Google Patents

Production de glycoproteines a o-glycosylation reduite Download PDF

Info

Publication number
WO2007061631A3
WO2007061631A3 PCT/US2006/043535 US2006043535W WO2007061631A3 WO 2007061631 A3 WO2007061631 A3 WO 2007061631A3 US 2006043535 W US2006043535 W US 2006043535W WO 2007061631 A3 WO2007061631 A3 WO 2007061631A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycosylation
reduced
glycoproteins
production
linked glycosylation
Prior art date
Application number
PCT/US2006/043535
Other languages
English (en)
Other versions
WO2007061631A8 (fr
WO2007061631A2 (fr
Inventor
Piotr Bobrowicz
James W Cook
Warren Kett
Original Assignee
Glycofi Inc
Piotr Bobrowicz
James W Cook
Warren Kett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12/084,591 priority Critical patent/US8206949B2/en
Priority to AU2006316838A priority patent/AU2006316838B2/en
Priority to CA002628725A priority patent/CA2628725A1/fr
Priority to ES06837184.8T priority patent/ES2534465T3/es
Priority to CN2006800425908A priority patent/CN101365783B/zh
Priority to EP06837184.8A priority patent/EP1954815B1/fr
Application filed by Glycofi Inc, Piotr Bobrowicz, James W Cook, Warren Kett filed Critical Glycofi Inc
Priority to JP2008541229A priority patent/JP5284789B2/ja
Publication of WO2007061631A2 publication Critical patent/WO2007061631A2/fr
Publication of WO2007061631A8 publication Critical patent/WO2007061631A8/fr
Publication of WO2007061631A3 publication Critical patent/WO2007061631A3/fr
Priority to US13/484,665 priority patent/US8501438B2/en
Priority to US13/530,768 priority patent/US8795984B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne une méthode destinée à la production de compositions protéinées pauvres en O-glycosylations. Cette méthode consiste à produire la protéine dans des cellules mises en culture en présence d'un inhibiteur d'O-glycosylation induite par la Pmt et/ou en présence d'une ou plusieurs α-1,2-mannosidases.
PCT/US2006/043535 2005-11-15 2006-11-10 Production de glycoproteines a o-glycosylation reduite WO2007061631A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2006316838A AU2006316838B2 (en) 2005-11-15 2006-11-10 Production of glycoproteins with reduced O-glycosylation
CA002628725A CA2628725A1 (fr) 2005-11-15 2006-11-10 Production de glycoproteines a o-glycosylation reduite
ES06837184.8T ES2534465T3 (es) 2005-11-15 2006-11-10 Producción de glucoproteínas con O-glucosilación reducida
CN2006800425908A CN101365783B (zh) 2005-11-15 2006-11-10 具有降低的o-糖基化的糖蛋白的产生
EP06837184.8A EP1954815B1 (fr) 2005-11-15 2006-11-10 Production de glycoproteines a o-glycosylation reduite
US12/084,591 US8206949B2 (en) 2005-11-15 2006-11-10 Production of glycoproteins with reduced O-glycosylation
JP2008541229A JP5284789B2 (ja) 2005-11-15 2006-11-10 Ｏ−グリコシル化を減少している糖タンパク質の生成
US13/484,665 US8501438B2 (en) 2005-11-15 2012-05-31 Production of glycoproteins with reduced O-glycosylation
US13/530,768 US8795984B2 (en) 2005-11-15 2012-06-22 Production of glycoproteins with reduced O-glycosylation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73710805P 2005-11-15 2005-11-15
US60/737,108 2005-11-22

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US12/084,591 A-371-Of-International US8206949B2 (en) 2005-11-15 2006-11-10 Production of glycoproteins with reduced O-glycosylation
US13/484,665 Continuation US8501438B2 (en) 2005-11-15 2012-05-31 Production of glycoproteins with reduced O-glycosylation
US13/530,768 Continuation US8795984B2 (en) 2005-11-15 2012-06-22 Production of glycoproteins with reduced O-glycosylation

Publications (3)

Publication Number Publication Date
WO2007061631A2 WO2007061631A2 (fr) 2007-05-31
WO2007061631A8 WO2007061631A8 (fr) 2008-05-02
WO2007061631A3 true WO2007061631A3 (fr) 2008-10-23

Family

ID=38067716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/043535 WO2007061631A2 (fr) 2005-11-15 2006-11-10 Production de glycoproteines a o-glycosylation reduite

Country Status (8)

Country Link
US (3) US8206949B2 (fr)
EP (1) EP1954815B1 (fr)
JP (1) JP5284789B2 (fr)
CN (1) CN101365783B (fr)
AU (1) AU2006316838B2 (fr)
CA (1) CA2628725A1 (fr)
ES (1) ES2534465T3 (fr)
WO (1) WO2007061631A2 (fr)

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DE60139720D1 (de) * 2000-06-28 2009-10-08 Glycofi Inc Verfahren für die Herstellung modifizierter Glykoproteine
US8206949B2 (en) * 2005-11-15 2012-06-26 Glycofi, Inc. Production of glycoproteins with reduced O-glycosylation
BRPI0711898A2 (pt) * 2006-05-19 2011-12-27 Glycofi Inc composiÇço de proteÍna da eritropoietina substancialmente homogÊnea, composiÇço farmacÊutica, e, mÉtodos de aumentar hematàcrito em um mamÍfero, e de produzir uma composiÇço de eritropoietina
US8637435B2 (en) 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
US20100311122A1 (en) 2008-02-20 2010-12-09 Glycofi, Inc Vectors and yeast strains for protein production
WO2009111183A1 (fr) 2008-03-03 2009-09-11 Glycofi, Inc. Affichage en surface de protéines recombinantes dans des eucaryotes inférieurs
EP2113514A1 (fr) * 2008-05-03 2009-11-04 Westfälische Wilhelms-Universität Münster Procédé de production de glycoprotéines hypoallergéniques dans des plantes mutées ou transgéniques ou des cellules de plantes et plantes mutées ou transgéniques et cellules de plantes destinées à la production de glycoprotéines hypoallergéniques
CN102036974B (zh) * 2008-05-20 2014-07-23 默沙东公司 利用甘露糖基转移酶抑制剂有效生产异源蛋白质
US8067339B2 (en) 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
EP2324121B1 (fr) 2008-08-12 2012-11-07 GlycoFi, Inc. Vecteurs améliorés et souches de levure pour une production de protéine : surexpression de la ca2+-atpase
EP2401378B1 (fr) 2009-02-25 2013-08-14 Merck Sharp & Dohme Corp. Ingénierie métabolique d'une voie d'assimilation du galactose dans la levure glycosynthétisée pichia pastoris
WO2010099195A1 (fr) * 2009-02-26 2010-09-02 Glaxosmithkline Llc. Cellules hôtes et procédés d'utilisation
CN101538318B (zh) * 2009-03-06 2011-11-23 中国人民解放军军事医学科学院生物工程研究所 一种信号肽及其编码基因与应用
ES2784189T3 (es) 2009-03-27 2020-09-23 Academia Sinica Métodos y composiciones para la inmunización contra virus
MX2011010989A (es) * 2009-04-20 2012-02-28 Pfizer Control de glicosilacion de proteina y composiciones y metodos que se refieren a la misma.
EP2427489B1 (fr) 2009-05-07 2015-04-22 Novozymes Biopharma DK A/S Procédé pour limiter la glycosylation à liaison o des anticorps
CA2776392A1 (fr) 2009-10-16 2011-04-21 Merck Sharp & Dohme Corp. Procede de production de proteines dans pichia pastoris exemptes d'activite detectable de liaison croisee a des anticorps diriges contre des antigenes de cellule hote
EP2494030A4 (fr) 2009-10-30 2013-03-27 Merck Sharp & Dohme Procédé de fabrication de protéines thérapeutiques dans la lignée cellulaire pichia pastoris, dépourvue d'activité dipeptidyl aminopeptidase
KR101578137B1 (ko) * 2010-02-02 2015-12-28 삼성전자주식회사 이기종 시스템을 지원하는 이동 단말에서 핸드오버 방법 및 장치
MX2012009349A (es) * 2010-02-10 2013-02-11 Biocon Ltd Metodo para reducir glucosilacion de proteinas, procedimientos y proteinas de los mismos.
AU2011220878A1 (en) 2010-02-24 2012-08-23 Merck Sharp & Dohme Corp. Method for increasing N-glycosylation site occupancy on therapeutic glycoproteins produced in Pichia pastoris
AU2011258425B2 (en) 2010-05-27 2015-12-10 Merck Sharp & Dohme Llc Method for preparing antibodies having improved properties
TWI537385B (zh) 2010-11-04 2016-06-11 中央研究院 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法
CN103534392A (zh) 2010-12-01 2014-01-22 默沙东公司 表面锚定的fc-诱饵抗体展示系统
CA2827732A1 (fr) 2011-02-25 2012-08-30 Merck Sharp & Dohme Corp. Souche de levure pour la production de proteines avec une o-glycosylation modifiee
WO2012115904A2 (fr) * 2011-02-25 2012-08-30 Merck Sharp & Dohme Corp. Production de protéine hybride tnfrii-fc n- et o-sialylée dans la levure
KR20140028013A (ko) 2011-05-25 2014-03-07 머크 샤프 앤드 돔 코포레이션 개선된 특성을 갖는 Fc-함유 폴리펩티드를 제조하는 방법
EP2771477A4 (fr) * 2011-10-27 2015-04-22 Merck Sharp & Dohme Contrôle de l'o-glycosylation dans des eucaryotes inférieurs
WO2013169609A1 (fr) 2012-05-11 2013-11-14 Merck Sharp & Dohme Corp. Système de présentation d'anticorps appât à chaîne légère ancrée en surface
US10683521B2 (en) * 2012-06-19 2020-06-16 Nanyang Technological University Expression construct for sensing cell density and substrate availability and its use in conversion of hydroxycinnamic acids
CA2890048C (fr) 2012-12-03 2022-05-03 Merck Sharp & Dohme Corp. Insuline et analogues d'insuline a base de peptide a partie terminale carboxy (ptc) o-glycosylee
WO2014152100A1 (fr) * 2013-03-15 2014-09-25 Bristol-Myers Squibb Company Procédés de production d'anticorps dans une levure
SG11201510814YA (en) * 2013-07-04 2016-01-28 Novartis Ag O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof
WO2015013116A1 (fr) * 2013-07-25 2015-01-29 Merck Sharp & Dohme Corp. Procédé de réduction de l'étendue d'o-mannosylation de glycoprotéines
EP2871235A1 (fr) * 2013-11-07 2015-05-13 Centre National de la Recherche Scientifique (CNRS) Nouveaux procédés pour produire un hTERT actif
US20150361464A1 (en) * 2014-06-16 2015-12-17 INVISTA North America S.á r.l. Methods, reagents and cells for biosynthesizing compounds
AU2015293949B2 (en) * 2014-07-21 2019-07-25 Teknologian Tutkimuskeskus Vtt Oy Production of glycoproteins with mammalian-like N-glycans in filamentous fungi
CN104198613B (zh) * 2014-09-17 2016-04-06 山东大学 一种分析蛋白o-糖基化位点的方法
WO2020010284A1 (fr) * 2018-07-04 2020-01-09 Cytoimmune Therapeutics, LLC Compositions et méthodes d'immunothérapie ciblant flt3, pd-1 et/ou pd-l1
EP3840582A4 (fr) * 2018-08-21 2022-08-03 Clara Foods Co. Modification de la glycosylation de protéines dans des micro-organismes
WO2024147112A1 (fr) 2023-01-05 2024-07-11 Glycoera Ag Polypeptides glycomodifiés ciblant l'immunoglobuline a et complexes les comprenant
WO2024147113A1 (fr) 2023-01-05 2024-07-11 Glycoera Ag Polypeptides glycomodifiés ciblant des auto-anticorps anti-podocytes et leurs utilisations
WO2024147111A1 (fr) 2023-01-05 2024-07-11 Glycoera Ag Polypeptides glycomodifiés ciblant des auto-anticorps anti-neutrophiles et leurs utilisations
WO2024218743A1 (fr) 2023-04-21 2024-10-24 Glycoera Ag Molécules multifonctionnelles comprenant des glycanes et leurs utilisations

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Also Published As

Publication number Publication date
US20090170159A1 (en) 2009-07-02
US8501438B2 (en) 2013-08-06
WO2007061631A8 (fr) 2008-05-02
EP1954815A2 (fr) 2008-08-13
CN101365783B (zh) 2013-07-17
US8206949B2 (en) 2012-06-26
US20120237973A1 (en) 2012-09-20
AU2006316838B2 (en) 2012-04-12
WO2007061631A2 (fr) 2007-05-31
CN101365783A (zh) 2009-02-11
AU2006316838A1 (en) 2007-05-31
CA2628725A1 (fr) 2007-05-31
ES2534465T3 (es) 2015-04-23
EP1954815A4 (fr) 2010-07-07
JP2009515963A (ja) 2009-04-16
US8795984B2 (en) 2014-08-05
JP5284789B2 (ja) 2013-09-11
US20120322101A1 (en) 2012-12-20
EP1954815B1 (fr) 2015-02-25

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