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WO2007060568A3 - Magnetic sensor device with sample chamber - Google Patents

Magnetic sensor device with sample chamber Download PDF

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Publication number
WO2007060568A3
WO2007060568A3 PCT/IB2006/054217 IB2006054217W WO2007060568A3 WO 2007060568 A3 WO2007060568 A3 WO 2007060568A3 IB 2006054217 W IB2006054217 W IB 2006054217W WO 2007060568 A3 WO2007060568 A3 WO 2007060568A3
Authority
WO
WIPO (PCT)
Prior art keywords
sensor
sensor device
magnetic sensor
excitation wires
sample chamber
Prior art date
Application number
PCT/IB2006/054217
Other languages
French (fr)
Other versions
WO2007060568A2 (en
Inventor
Josephus Arnoldus Henr Kahlman
Haris Duric
Original Assignee
Koninkl Philips Electronics Nv
Josephus Arnoldus Henr Kahlman
Haris Duric
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv, Josephus Arnoldus Henr Kahlman, Haris Duric filed Critical Koninkl Philips Electronics Nv
Publication of WO2007060568A2 publication Critical patent/WO2007060568A2/en
Publication of WO2007060568A3 publication Critical patent/WO2007060568A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G01N15/0656—Investigating concentration of particle suspensions using electric, e.g. electrostatic methods or magnetic methods

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)

Abstract

The invention relates to a magnetic sensor device (10) comprising two excitation wires (11, 13) for the generation of first and second magnetic fields (B1, B2) that dominate in a first and a second investigation region (5a, 5b), respectively. A Giant Magneto-Resistance (GMR) sensor (12) is disposed in the middle between the excitation wires (11, 13) and senses stray fields (B') generated by magnetized beads (2) that are bound in one (5a) of the investigation regions. As the excitation wires (11, 13) are fed with anti-parallel currents (I1, 12), the components of the first and second magnetic fields (B1, B2) in the sensitive direction (D) of the GMR sensor (12) compensate each other in said sensor (12), thus minimizing interferences from crosstalk. A similar cancellation of stray fields (B') is prevented by providing one (5b) of the investigation regions with an exclusion zone that prevents the binding of magnetized beads (2) there.
PCT/IB2006/054217 2005-11-23 2006-11-13 Magnetic sensor device with sample chamber WO2007060568A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05111136 2005-11-23
EP05111136.7 2005-11-23

Publications (2)

Publication Number Publication Date
WO2007060568A2 WO2007060568A2 (en) 2007-05-31
WO2007060568A3 true WO2007060568A3 (en) 2007-09-07

Family

ID=38006560

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/054217 WO2007060568A2 (en) 2005-11-23 2006-11-13 Magnetic sensor device with sample chamber

Country Status (1)

Country Link
WO (1) WO2007060568A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8797028B2 (en) * 2007-10-25 2014-08-05 Koninklijke Philips N.V. Sensor device for target particles in a sample
EP2219033B1 (en) 2008-12-30 2016-05-25 MicroCoat Biotechnologie GmbH Device, instrument and process for detecting magnetically labeled analytes
DE102009047801B4 (en) * 2009-09-30 2014-06-12 Siemens Aktiengesellschaft Flow chamber with cell guide
DE102009047793A1 (en) * 2009-09-30 2011-04-07 Siemens Aktiengesellschaft Flow chamber with GMR sensor and cell guide
EP2616819A1 (en) * 2010-09-17 2013-07-24 Koninklijke Philips Electronics N.V. Magnetic system for particle attraction in a plurality of chambers
DE102013200927A1 (en) * 2013-01-22 2014-07-24 Siemens Aktiengesellschaft Method for enriching and separating cells with concentrations over several logarithmic stages
JP6590915B2 (en) 2014-09-26 2019-10-16 ボーンズ・インコーポレーテッドＢｏｕｒｎｓ，Ｉｎｃｏｒｐｏｒａｔｅｄ System and method for actively balancing / cancelling magnetic interference in magnetic sensors
EP3290938A1 (en) 2016-09-05 2018-03-07 Industrial Technology Research Institute Biomolecule magnetic sensor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005010543A1 (en) * 2003-07-30 2005-02-03 Koninklijke Philips Electronics N.V. On-chip magnetic sensor device with suppressed cross-talk
WO2005010542A2 (en) * 2003-07-30 2005-02-03 Koninklijke Philips Electronics N.V. On-chip magnetic particle sensor with improved snr
WO2005073695A1 (en) * 2004-01-26 2005-08-11 Koninklijke Philips Electronics N.V. Method and device for on-chip magnetic resonance spectroscopy
WO2005116661A1 (en) * 2004-05-24 2005-12-08 Koninklijke Philips Electronics N.V. Magneto-resistive sensor for high sensitivity depth probing

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005010543A1 (en) * 2003-07-30 2005-02-03 Koninklijke Philips Electronics N.V. On-chip magnetic sensor device with suppressed cross-talk
WO2005010542A2 (en) * 2003-07-30 2005-02-03 Koninklijke Philips Electronics N.V. On-chip magnetic particle sensor with improved snr
WO2005073695A1 (en) * 2004-01-26 2005-08-11 Koninklijke Philips Electronics N.V. Method and device for on-chip magnetic resonance spectroscopy
WO2005116661A1 (en) * 2004-05-24 2005-12-08 Koninklijke Philips Electronics N.V. Magneto-resistive sensor for high sensitivity depth probing

Also Published As

Publication number Publication date
WO2007060568A2 (en) 2007-05-31

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