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WO2007052059A3 - Modification de l'equilibre th1/th2 dans des vaccins antigrippaux sous-unitaires avec adjuvants - Google Patents

Modification de l'equilibre th1/th2 dans des vaccins antigrippaux sous-unitaires avec adjuvants Download PDF

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Publication number
WO2007052059A3
WO2007052059A3 PCT/GB2006/004136 GB2006004136W WO2007052059A3 WO 2007052059 A3 WO2007052059 A3 WO 2007052059A3 GB 2006004136 W GB2006004136 W GB 2006004136W WO 2007052059 A3 WO2007052059 A3 WO 2007052059A3
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WO
WIPO (PCT)
Prior art keywords
adjuvants
balance
changing
split influenza
influenza vaccines
Prior art date
Application number
PCT/GB2006/004136
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English (en)
Other versions
WO2007052059A2 (fr
Inventor
Derek O'hagan
Original Assignee
Novartis Vaccines & Diagnostic
Derek O'hagan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37897441&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007052059(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DK06808431.8T priority Critical patent/DK1951300T3/da
Priority to EP06808431A priority patent/EP1951300B1/fr
Priority to US12/092,146 priority patent/US20090047353A1/en
Priority to PL06808431T priority patent/PL1951300T3/pl
Priority to NZ568212A priority patent/NZ568212A/en
Application filed by Novartis Vaccines & Diagnostic, Derek O'hagan filed Critical Novartis Vaccines & Diagnostic
Priority to AT06808431T priority patent/ATE513561T1/de
Priority to CA2628397A priority patent/CA2628397C/fr
Priority to AU2006310340A priority patent/AU2006310340B2/en
Priority to JP2008538421A priority patent/JP5363107B2/ja
Priority to SI200631106T priority patent/SI1951300T1/sl
Publication of WO2007052059A2 publication Critical patent/WO2007052059A2/fr
Publication of WO2007052059A3 publication Critical patent/WO2007052059A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention vise à éviter des composants dans des vaccins sous-unité susceptibles de provoquer une réponse excessive de Th2. L'invention concerne donc une composition immunogène comprenant un antigène antigrippal sous-unitaire et un adjuvant Th1, l'antigène étant de préférence préparé à partir d'un virus cultivé en culture cellulaire (par exemple, exempt de protéines d'oeufs).
PCT/GB2006/004136 2005-11-04 2006-11-06 Modification de l'equilibre th1/th2 dans des vaccins antigrippaux sous-unitaires avec adjuvants WO2007052059A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
SI200631106T SI1951300T1 (sl) 2005-11-04 2006-11-06 Modifikacija TH1/TH2 ravnoteĹľja v cepivih proti gripi iz razgrajenega virusa z adjuvansi
EP06808431A EP1951300B1 (fr) 2005-11-04 2006-11-06 Modification de l'equilibre th1/th2 dans des vaccins antigrippaux sous-unitaires avec adjuvants
US12/092,146 US20090047353A1 (en) 2005-11-04 2006-11-06 Changing th1/th2 balance in split influenza vaccines with adjuvants
PL06808431T PL1951300T3 (pl) 2005-11-04 2006-11-06 Zmiana równowagi TH1/TH2 w szczepionkach typu split przeciwko grypie zawierających adjuwant
NZ568212A NZ568212A (en) 2005-11-04 2006-11-06 Changing Th1/Th2 balance in split influenza vaccines with adjuvants
DK06808431.8T DK1951300T3 (da) 2005-11-04 2006-11-06 Ændring af Th1/Th2-balancen i split-influenzavacciner med adjuvanser
AT06808431T ATE513561T1 (de) 2005-11-04 2006-11-06 Veränderung des th1/th2-gleichgewichts in spalt- grippeimpfstoffen mit adjuvantien
CA2628397A CA2628397C (fr) 2005-11-04 2006-11-06 Modification de l'equilibre th1/th2 dans des vaccins antigrippaux sous-unitaires avec adjuvants
AU2006310340A AU2006310340B2 (en) 2005-11-04 2006-11-06 Changing TH1/TH2 balance in split influenza vaccines with adjuvants
JP2008538421A JP5363107B2 (ja) 2005-11-04 2006-11-06 アジュバントを含むスプリットインフルエンザワクチンにおけるｔｈ１／ｔｈ２バランスの変化

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73402605P 2005-11-04 2005-11-04
US60/734,026 2005-11-04
US81247506P 2006-06-08 2006-06-08
US60/812,475 2006-06-08

Publications (2)

Publication Number Publication Date
WO2007052059A2 WO2007052059A2 (fr) 2007-05-10
WO2007052059A3 true WO2007052059A3 (fr) 2007-08-30

Family

ID=37897441

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/004136 WO2007052059A2 (fr) 2005-11-04 2006-11-06 Modification de l'equilibre th1/th2 dans des vaccins antigrippaux sous-unitaires avec adjuvants

Country Status (12)

Country Link
US (1) US20090047353A1 (fr)
EP (1) EP1951300B1 (fr)
JP (1) JP5363107B2 (fr)
AT (1) ATE513561T1 (fr)
AU (1) AU2006310340B2 (fr)
CA (1) CA2628397C (fr)
CY (1) CY1112895T1 (fr)
DK (1) DK1951300T3 (fr)
NZ (1) NZ568212A (fr)
PL (1) PL1951300T3 (fr)
PT (1) PT1951300E (fr)
WO (1) WO2007052059A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1945252T3 (pl) * 2005-11-04 2013-11-29 Seqirus Uk Ltd Szczepionki zawierające oczyszczone antygeny powierzchniowe otrzymane z wirusów grypy hodowanych w hodowli komórkowej i skwalen jako adiuwant
EP2014279A1 (fr) 2007-06-22 2009-01-14 Pevion Biotech AG Virosomes contenant de l'hémagglutinine dérivée du virus de la grippe produit par les lignées cellulaires; les compositions, les méthodes de production, l'emploi des virosomes
JP5518041B2 (ja) 2008-03-18 2014-06-11 ノバルティス アーゲー インフルエンザウイルスワクチン抗原の調製における改良
JP5642712B2 (ja) 2009-02-10 2014-12-17 ノバルティス アーゲー 少ない量のスクアレンを含むインフルエンザワクチン
EP2207031A1 (fr) * 2009-05-18 2010-07-14 Abbott Biologicals B.V. Test d'adjuvant pour les préparations de vaccins
PL3489211T3 (pl) * 2010-05-12 2020-12-14 Novartis Ag Ulepszone sposoby otrzymywania skwalenu
GB201009273D0 (en) * 2010-06-03 2010-07-21 Glaxosmithkline Biolog Sa Novel vaccine
EP2575818A4 (fr) 2010-06-03 2013-11-06 Pharmacyclics Inc Utilisation d'inhibiteurs de la tyrosine kinase de bruton (btk)
US9821051B1 (en) 2010-10-28 2017-11-21 Seqirus UK Limited Reducing hospitalization in elderly influenza vaccine recipients
WO2014018567A1 (fr) 2012-07-24 2014-01-30 Pharmacyclics, Inc. Mutations associées à la résistance à des inhibiteurs de la tyrosine kinase de bruton (btk)
CN111329989A (zh) 2012-11-02 2020-06-26 药品循环有限责任公司 Tec家族激酶抑制剂辅助疗法
CA2942528A1 (fr) 2014-03-20 2015-09-24 Pharmacyclics Inc. Mutations de phospholipase c gamma 2 et associees aux resistances
WO2016001907A1 (fr) * 2014-07-02 2016-01-07 Prendergast Patrick T Mogroside iv et mogroside v utilisables en tant qu'agonistes/stimulateurs/agents de déblocage des récepteurs toll 4 et adjuvant destiné à être utilisé dans un vaccin humain/animal et pour stimuler l'immunité contre des agents pathologiques
US9815886B2 (en) 2014-10-28 2017-11-14 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
MX2020004151A (es) 2017-10-30 2020-08-13 Takeda Pharmaceuticals Co Detergentes compatibles con el medio ambiente para la inactivacion de virus envueltos en lipidos.

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999027961A1 (fr) * 1997-12-02 1999-06-10 Powderject Vaccines, Inc. Administration transdermique de compositions particulaires de vaccins
WO2001080836A1 (fr) * 2000-04-26 2001-11-01 Biovector Therapeutics Utilisation de vecteurs particulaires dans l'immunomodulation
US20040109874A1 (en) * 1999-11-10 2004-06-10 Powderject Vaccines, Inc. Induction of mucosal immunity by vaccination via the skin route
WO2004075829A2 (fr) * 2003-01-30 2004-09-10 Chiron Corporation Vaccin contre la grippe contenant un adjuvant
WO2004084937A1 (fr) * 2003-03-24 2004-10-07 Intercell Ag Utilisation d'alun et d'un adjuvant induisant une reponse immunitaire du type genere par une th1 pour renforcer des reponses immunitaires
WO2005117958A1 (fr) * 2004-05-28 2005-12-15 Glaxosmithkline Biologicals S.A. Compositions de vaccin comprenant des virosomes et un adjuvant a base de saponine
WO2006060710A2 (fr) * 2004-12-02 2006-06-08 Becton, Dickinson And Company Preparations de vaccins destinees a une administration intradermique, contenant des adjuvants et des agents antigeniques

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08506592A (ja) * 1993-02-19 1996-07-16 スミスクライン・ビーチャム・コーポレイション ３−ｏ−脱アシル化モノホスホリル脂質Ａ含有のインフルエンザワクチン組成物
ES2370937T3 (es) * 1993-09-13 2011-12-23 Protein Sciences Corporation Un método para producir vacunas antigripales polivalentes a base de hemaglutinina.
JP2002537102A (ja) * 1999-02-26 2002-11-05 カイロン コーポレイション 吸着された高分子および微粒子を有するミクロエマルジョン
DE60014076T2 (de) * 1999-04-19 2005-10-13 Glaxosmithkline Biologicals S.A. Adjuvans-zusammensetzung, enthaltend saponin und ein immunstimulatorisches oligonukleotid
GB9923176D0 (en) 1999-09-30 1999-12-01 Smithkline Beecham Biolog Novel composition
US6951754B2 (en) * 2000-04-28 2005-10-04 St. Jude Children's Research Hospital DNA transfection system for the generation of infectious influenza virus
GB0025577D0 (en) * 2000-10-18 2000-12-06 Smithkline Beecham Biolog Vaccine
US20080171063A1 (en) * 2005-03-23 2008-07-17 Glaxosmith Kline Biologicals S.A., A Corporation Novel Composition

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999027961A1 (fr) * 1997-12-02 1999-06-10 Powderject Vaccines, Inc. Administration transdermique de compositions particulaires de vaccins
US20040109874A1 (en) * 1999-11-10 2004-06-10 Powderject Vaccines, Inc. Induction of mucosal immunity by vaccination via the skin route
WO2001080836A1 (fr) * 2000-04-26 2001-11-01 Biovector Therapeutics Utilisation de vecteurs particulaires dans l'immunomodulation
WO2004075829A2 (fr) * 2003-01-30 2004-09-10 Chiron Corporation Vaccin contre la grippe contenant un adjuvant
WO2004084937A1 (fr) * 2003-03-24 2004-10-07 Intercell Ag Utilisation d'alun et d'un adjuvant induisant une reponse immunitaire du type genere par une th1 pour renforcer des reponses immunitaires
WO2005117958A1 (fr) * 2004-05-28 2005-12-15 Glaxosmithkline Biologicals S.A. Compositions de vaccin comprenant des virosomes et un adjuvant a base de saponine
WO2006060710A2 (fr) * 2004-12-02 2006-06-08 Becton, Dickinson And Company Preparations de vaccins destinees a une administration intradermique, contenant des adjuvants et des agents antigeniques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
S. HALPERIN ET AL.: "Safety and immunogenicity of a new influenza virus grown in mammalian cell culture", VACCINE, vol. 16, no. 13, 1998, pages 1331 - 1335, XP002428877 *

Also Published As

Publication number Publication date
PT1951300E (pt) 2011-09-05
CY1112895T1 (el) 2016-04-13
JP2009514842A (ja) 2009-04-09
JP5363107B2 (ja) 2013-12-11
ATE513561T1 (de) 2011-07-15
EP1951300B1 (fr) 2011-06-22
EP1951300A2 (fr) 2008-08-06
AU2006310340A1 (en) 2007-05-10
CA2628397A1 (fr) 2007-05-10
PL1951300T3 (pl) 2012-03-30
NZ568212A (en) 2012-03-30
AU2006310340B2 (en) 2011-02-10
WO2007052059A2 (fr) 2007-05-10
CA2628397C (fr) 2013-08-20
DK1951300T3 (da) 2011-10-03
US20090047353A1 (en) 2009-02-19

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