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WO2007048051A3 - Screening for modulators of metalation pathways for metalloproteins - Google Patents

Screening for modulators of metalation pathways for metalloproteins Download PDF

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Publication number
WO2007048051A3
WO2007048051A3 PCT/US2006/041349 US2006041349W WO2007048051A3 WO 2007048051 A3 WO2007048051 A3 WO 2007048051A3 US 2006041349 W US2006041349 W US 2006041349W WO 2007048051 A3 WO2007048051 A3 WO 2007048051A3
Authority
WO
WIPO (PCT)
Prior art keywords
metalation
metalloproteins
pathways
modulators
screening
Prior art date
Application number
PCT/US2006/041349
Other languages
French (fr)
Other versions
WO2007048051A2 (en
Inventor
Holden H Thorp
Thomas V O'halloran
Original Assignee
Viamet Pharmaceuticals Inc
Holden H Thorp
Thomas V O'halloran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viamet Pharmaceuticals Inc, Holden H Thorp, Thomas V O'halloran filed Critical Viamet Pharmaceuticals Inc
Priority to EP06826503A priority Critical patent/EP1938107A2/en
Priority to JP2008536870A priority patent/JP2009512454A/en
Priority to US12/090,764 priority patent/US20090075836A1/en
Priority to AU2006304860A priority patent/AU2006304860A1/en
Priority to CA002625282A priority patent/CA2625282A1/en
Publication of WO2007048051A2 publication Critical patent/WO2007048051A2/en
Publication of WO2007048051A3 publication Critical patent/WO2007048051A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention is directed to methods for screening modulators of metalation pathways for the metalation of metalloproteins.
PCT/US2006/041349 2005-10-20 2006-10-20 Screening for modulators of metalation pathways for metalloproteins WO2007048051A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP06826503A EP1938107A2 (en) 2005-10-20 2006-10-20 Screening for modulators of metalyation pathways for metalloproteins
JP2008536870A JP2009512454A (en) 2005-10-20 2006-10-20 Screening method for modulators of metalation pathways of metalloproteins
US12/090,764 US20090075836A1 (en) 2005-10-20 2006-10-20 Screening for modulators of metalation pathways for metalloproteins
AU2006304860A AU2006304860A1 (en) 2005-10-20 2006-10-20 Screening for modulators of metalation pathways for metalloproteins
CA002625282A CA2625282A1 (en) 2005-10-20 2006-10-20 Screening for modulators of metalation pathways for metalloproteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72918305P 2005-10-20 2005-10-20
US60/729,183 2005-10-20

Publications (2)

Publication Number Publication Date
WO2007048051A2 WO2007048051A2 (en) 2007-04-26
WO2007048051A3 true WO2007048051A3 (en) 2007-07-05

Family

ID=37882106

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/041349 WO2007048051A2 (en) 2005-10-20 2006-10-20 Screening for modulators of metalation pathways for metalloproteins

Country Status (6)

Country Link
US (1) US20090075836A1 (en)
EP (1) EP1938107A2 (en)
JP (1) JP2009512454A (en)
AU (1) AU2006304860A1 (en)
CA (1) CA2625282A1 (en)
WO (1) WO2007048051A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403618B1 (en) * 2000-02-15 2002-06-11 Novactyl, Inc. Agent and method for controlling angiogenesis
US20030007973A1 (en) * 2001-06-22 2003-01-09 Lynes Michael A. Methods and compositions for manipulation of the immune response using anti-metallothionein antibody
US20050090430A1 (en) * 1996-05-23 2005-04-28 Bio-Rad Laboratories, Inc. Methods and compositions for diagnosis and treatment of iron misregulation diseases
EP1619499A1 (en) * 2003-04-25 2006-01-25 Takeda Pharmaceutical Company Limited Novel screening method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001555A (en) * 1994-09-23 1999-12-14 The United States Of America As Represented By The Department Of Health And Human Services Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein
US7855167B2 (en) * 1998-02-02 2010-12-21 Odyssey Thera, Inc. In vivo screening of protein-protein interactions with protein-fragment complementation assays
JP4542810B2 (en) * 2003-04-25 2010-09-15 武田薬品工業株式会社 New screening method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050090430A1 (en) * 1996-05-23 2005-04-28 Bio-Rad Laboratories, Inc. Methods and compositions for diagnosis and treatment of iron misregulation diseases
US6403618B1 (en) * 2000-02-15 2002-06-11 Novactyl, Inc. Agent and method for controlling angiogenesis
US20030007973A1 (en) * 2001-06-22 2003-01-09 Lynes Michael A. Methods and compositions for manipulation of the immune response using anti-metallothionein antibody
EP1619499A1 (en) * 2003-04-25 2006-01-25 Takeda Pharmaceutical Company Limited Novel screening method

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
AUDRAIN M A ET AL: "Anti-lactoferrin autoantibodies: relation between epitopes and iron-binding domain.", JOURNAL OF AUTOIMMUNITY AUG 1996, vol. 9, no. 4, August 1996 (1996-08-01), pages 569 - 574, XP002431144, ISSN: 0896-8411 *
CHANGELA ANITA ET AL: "Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR.", SCIENCE (WASHINGTON D C), vol. 301, no. 5638, 5 September 2003 (2003-09-05), pages 1383 - 1387, XP002431143, ISSN: 0036-8075 *
EATON D L: "Effects of various trace metals on the binding of cadmium to rat hepatic metallothionein determined by the Cd/hemoglobin affinity assay.", TOXICOLOGY AND APPLIED PHARMACOLOGY 30 MAR 1985, vol. 78, no. 1, 30 March 1985 (1985-03-30), pages 158 - 162, XP008077474, ISSN: 0041-008X *
FINNEY LYDIA A ET AL: "Transition metal speciation in the cell: Insights from the chemistry of metal ion receptors.", SCIENCE (WASHINGTON D C), vol. 300, no. 5621, 9 May 2003 (2003-05-09), pages 931 - 936, XP002431146, ISSN: 0036-8075 *
FUJII J ET AL: "CHARACTERIZATION OF WILD-TYPE AND AMYOTROPHIC LATERAL SCLEROSIS-RELATED MUTANT CU,ZN-SUPEROXIDE DISMUTASES OVERPRODUCED IN BACULOVIRUS-INFECTED INSECT CELLS", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 64, no. 4, April 1995 (1995-04-01), pages 1456 - 1461, XP008077508, ISSN: 0022-3042 *
GROBLER JA ET AL: "Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 99, no. 10, 14 May 2002 (2002-05-14), pages 6661 - 6666, XP002271568, ISSN: 0027-8424 *
HAYWARD LAWRENCE J ET AL: "Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 3 MAY 2002, vol. 277, no. 18, 3 May 2002 (2002-05-03), pages 15923 - 15931, XP002431142, ISSN: 0021-9258 *
RAE T D ET AL: "Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase", SCIENCE (WASHINGTON D C), vol. 284, no. 5415, 30 April 1999 (1999-04-30), pages 805 - 808, XP002431141, ISSN: 0036-8075 *
TEOH MELISSA L T ET AL: "Leporipoxvirus Cu,Zn-superoxide dismutase (SOD) homologs are catalytically inert decoy proteins that bind copper chaperone for SOD.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 35, 29 August 2003 (2003-08-29), pages 33175 - 33184, XP002431145, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
JP2009512454A (en) 2009-03-26
WO2007048051A2 (en) 2007-04-26
EP1938107A2 (en) 2008-07-02
AU2006304860A1 (en) 2007-04-26
CA2625282A1 (en) 2007-04-26
US20090075836A1 (en) 2009-03-19

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