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WO2007046868A3 - Thiazolidine derivatives and their uses as therapeutic agents - Google Patents

Thiazolidine derivatives and their uses as therapeutic agents Download PDF

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Publication number
WO2007046868A3
WO2007046868A3 PCT/US2006/019357 US2006019357W WO2007046868A3 WO 2007046868 A3 WO2007046868 A3 WO 2007046868A3 US 2006019357 W US2006019357 W US 2006019357W WO 2007046868 A3 WO2007046868 A3 WO 2007046868A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agents
thiazolidine derivatives
mammal
formula
disclosed
Prior art date
Application number
PCT/US2006/019357
Other languages
French (fr)
Other versions
WO2007046868A2 (en
Inventor
Jianmin Fu
Shifeng Liu
Original Assignee
Xenon Pharmaceuticals Inc
Jianmin Fu
Shifeng Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc, Jianmin Fu, Shifeng Liu filed Critical Xenon Pharmaceuticals Inc
Publication of WO2007046868A2 publication Critical patent/WO2007046868A2/en
Publication of WO2007046868A3 publication Critical patent/WO2007046868A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where p, K, J, W, V, R2, R3, R4, R4a, R5, R5a and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
PCT/US2006/019357 2005-05-19 2006-05-19 Thiazolidine derivatives and their uses as therapeutic agents WO2007046868A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68292705P 2005-05-19 2005-05-19
US60/682,927 2005-05-19

Publications (2)

Publication Number Publication Date
WO2007046868A2 WO2007046868A2 (en) 2007-04-26
WO2007046868A3 true WO2007046868A3 (en) 2007-07-12

Family

ID=37866350

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/019357 WO2007046868A2 (en) 2005-05-19 2006-05-19 Thiazolidine derivatives and their uses as therapeutic agents

Country Status (1)

Country Link
WO (1) WO2007046868A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007143824A1 (en) * 2006-06-13 2007-12-21 Merck Frosst Canada Ltd. Azacyclopentane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
KR20090047458A (en) 2006-08-08 2009-05-12 사노피-아벤티스 Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, methods of preparation thereof, medicaments comprising these compounds and uses thereof
KR20090040478A (en) 2006-08-24 2009-04-24 노파르티스 아게 2- (pyrazin-2-yl) -thiazole and 2- (1H-pyrazol-3-yl) -thiazole derivatives, and stearoyl-COA desaturase for the treatment of metabolism, cardiovascular and other disorders ( Related Compounds as Scd) Inhibitors
GB0722077D0 (en) 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
WO2010094120A1 (en) 2009-02-17 2010-08-26 Merck Frosst Canada Ltd. Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase
EP2459568A4 (en) 2009-07-28 2013-02-27 Merck Frosst Canada Ltd Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase
CN102482312A (en) 2009-08-26 2012-05-30 赛诺菲 Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
WO2011030312A1 (en) 2009-09-10 2011-03-17 Institut National De La Sante Et De La Recherche Medicale (Inserm) NOVEL INHIBITORS OF STEAROYL-CoA-DESATURASE-1 AND THEIR USES
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120054A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (en) 2011-03-08 2012-09-13 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
EP2683700B1 (en) 2011-03-08 2015-02-18 Sanofi Tetra-substituted oxathiazine derivatives, method for their preparation, their usage as medicament and medicament containing same and its use
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
KR20140084164A (en) 2011-10-15 2014-07-04 제넨테크, 인크. Scd1 antagonists for treating cancer
JP6293127B2 (en) 2012-05-22 2018-03-14 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド Selective inhibitor of undifferentiated cells
WO2016044771A1 (en) * 2014-09-18 2016-03-24 Abbvie Inc. Hat inhibitors and methods for their use
MA46589A (en) 2016-10-24 2019-08-28 Yumanity Therapeutics Inc COMPOUNDS AND USES OF THE LATEST
BR112019013954A2 (en) 2017-01-06 2020-02-11 Yumanity Therapeutics, Inc. METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
US11873298B2 (en) 2017-10-24 2024-01-16 Janssen Pharmaceutica Nv Compounds and uses thereof
SG11202009280RA (en) 2018-03-23 2020-10-29 Yumanity Therapeutics Inc Compounds and uses thereof
US12098146B2 (en) 2019-01-24 2024-09-24 Janssen Pharmaceutica Nv Compounds and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2496104A1 (en) * 1978-03-22 1982-06-18 Roussel Uclaf NOVEL PRODUCTS FROM THE 3- (PIPERIDIN-4-YL) 2H-INDOL-2-ONE SERIES AND PROCESS FOR THEIR PREPARATION
JPH04182481A (en) * 1990-11-19 1992-06-30 Nisshin Flour Milling Co Ltd Rhodanine derivative
WO2001062954A2 (en) * 2000-02-24 2001-08-30 Xenon Genetics, Inc. Stearoyl-coa desaturase to identify triglyceride reducing therapeutic agents
US20030064950A1 (en) * 2001-02-23 2003-04-03 Ntambi James M. Methods for reducing body fat and increasing lean body mass by reducing stearoyl-CoA desaturase 1 activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2496104A1 (en) * 1978-03-22 1982-06-18 Roussel Uclaf NOVEL PRODUCTS FROM THE 3- (PIPERIDIN-4-YL) 2H-INDOL-2-ONE SERIES AND PROCESS FOR THEIR PREPARATION
JPH04182481A (en) * 1990-11-19 1992-06-30 Nisshin Flour Milling Co Ltd Rhodanine derivative
WO2001062954A2 (en) * 2000-02-24 2001-08-30 Xenon Genetics, Inc. Stearoyl-coa desaturase to identify triglyceride reducing therapeutic agents
US20030064950A1 (en) * 2001-02-23 2003-04-03 Ntambi James M. Methods for reducing body fat and increasing lean body mass by reducing stearoyl-CoA desaturase 1 activity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 199232, Derwent World Patents Index; AN 1992-265155, XP002426480 *
F. C. BROWN ET AL: "Rhodanine Derivatives", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 73, 1951, pages 2357 - 2359, XP002426478 *
H. SINGH AHUJA ET AL: "Differential Effects of Rexinoids and Thiazolidinediones on Metabolic Gene Expression in Diabetic Rodents", MOLECULAR PHARMACOLOGY, vol. 59, no. 4, 2001, pages 765 - 773, XP002426477 *
J. TONELLI ET AL: "Mechanisms of Early Insulin-Sensitizing Effects of Thiazolidinediones in Type 2 Diabetes", DIABETES, vol. 53, no. 6, June 2004 (2004-06-01), pages 1621 - 1629, XP002426476 *

Also Published As

Publication number Publication date
WO2007046868A2 (en) 2007-04-26

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