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WO2006127712A3 - Compositions and methods for inducing, stimulating and directing neuronal growth - Google Patents

Compositions and methods for inducing, stimulating and directing neuronal growth Download PDF

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Publication number
WO2006127712A3
WO2006127712A3 PCT/US2006/019925 US2006019925W WO2006127712A3 WO 2006127712 A3 WO2006127712 A3 WO 2006127712A3 US 2006019925 W US2006019925 W US 2006019925W WO 2006127712 A3 WO2006127712 A3 WO 2006127712A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
stimulating
inducing
neuronal growth
Prior art date
Application number
PCT/US2006/019925
Other languages
French (fr)
Other versions
WO2006127712A2 (en
Inventor
G Tayhas R Palmore
Hyun-Kon Song
Original Assignee
Univ Brown
G Tayhas R Palmore
Hyun-Kon Song
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brown, G Tayhas R Palmore, Hyun-Kon Song filed Critical Univ Brown
Publication of WO2006127712A2 publication Critical patent/WO2006127712A2/en
Publication of WO2006127712A3 publication Critical patent/WO2006127712A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Provided are nerve growth guidance devices, compositions and methods for inducing, enhancing and stimulating neuronal growth and for repair and regeneration of damaged nerves in both the central nervous system and the peripheral nervous system of mammals. The compositions are composed of cationic, aromatic polyheterocyclic substrates electrostatically bound by with anionically charged dopants able to append alone or through a linker nerve growth guidance cues. The compositions may be formed into devices and used in methods for stimulating nerve growth or nerve regeneration.
PCT/US2006/019925 2005-05-23 2006-05-23 Compositions and methods for inducing, stimulating and directing neuronal growth WO2006127712A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68369305P 2005-05-23 2005-05-23
US60/683,693 2005-05-23

Publications (2)

Publication Number Publication Date
WO2006127712A2 WO2006127712A2 (en) 2006-11-30
WO2006127712A3 true WO2006127712A3 (en) 2007-03-08

Family

ID=37452750

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/019925 WO2006127712A2 (en) 2005-05-23 2006-05-23 Compositions and methods for inducing, stimulating and directing neuronal growth

Country Status (1)

Country Link
WO (1) WO2006127712A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107740172A (en) * 2017-09-30 2018-02-27 江南大学 A kind of electroactive corrosion-inhibiting coating based on γ polyglutamic acids and preparation method thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2463861B (en) 2008-09-10 2012-09-26 Univ Manchester Medical device
ES2539475T3 (en) * 2010-02-16 2015-07-01 Celluminova Ab Oligothiophene derivatives as molecular probes
ES2470495B1 (en) * 2012-12-19 2015-05-14 Universidad De Castilla La Mancha Materials, methods and devices to stimulate and direct the proliferation and migration of neural progenitors and axonal and dendritic growth
CN105006494B (en) * 2015-06-23 2017-01-04 中国石油大学(北京) There is the wide spectral light detector of polyamino acid combined oxidation indium stannum nanostructured
US20180303974A1 (en) 2015-11-03 2018-10-25 Ariel-University Research And Development Company Ltd. Compositions for regeneration and repair of neural tissue

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902515A (en) * 1988-04-28 1990-02-20 E. I. Dupont De Nemours And Company Polylactide compositions
US20040228823A1 (en) * 2003-05-16 2004-11-18 University Of Nebraska Board Of Regents Cross-linked ionic core micelles
US20060002978A1 (en) * 2004-06-10 2006-01-05 Shea Lonnie D Biodegradable scaffolds and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902515A (en) * 1988-04-28 1990-02-20 E. I. Dupont De Nemours And Company Polylactide compositions
US20040228823A1 (en) * 2003-05-16 2004-11-18 University Of Nebraska Board Of Regents Cross-linked ionic core micelles
US20060002978A1 (en) * 2004-06-10 2006-01-05 Shea Lonnie D Biodegradable scaffolds and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HURTADO ET AL.: "Poly (d,l-lactic acid) macroporous guidance scaffolds seeded with Schwann cells genetically modified to secrete a bi-functional neurotrophin implanted in the completely transfected adult rat thoracic spinal cord", BIOMATERIALS, vol. 27, 2006, pages 430 - 442, XP005148293 *
PATIST ET AL.: "Freeze-dried poly(d,l-lactic acid) macroporous guidance scaffolds impregnated with brain-derived neurotrophic factor in the transfected adult rat thoracic spinal cord", BIOMATERIALS, vol. 25, 2004, pages 1569 - 1582, XP004481689 *
ROSNER B.I. ET AL.: "Rational Design of Contact Guiding, Neurotrophic Matrices for Peripheral Nerve Regeneration", ANN. BIOMED. ENG., vol. 31, no. 11, 2003, pages 1383 - 1401, XP003002481 *
STOKOLS ET AL.: "The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury", BIOMATERIALS, vol. 25, 2004, pages 5839 - 5846, XP004511122 *
XU ET AL.: "Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide conduits", BIOMATERIALS, vol. 24, 2003, pages 2405 - 2412, XP004420032 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107740172A (en) * 2017-09-30 2018-02-27 江南大学 A kind of electroactive corrosion-inhibiting coating based on γ polyglutamic acids and preparation method thereof

Also Published As

Publication number Publication date
WO2006127712A2 (en) 2006-11-30

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