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WO2006126082A3 - Pyridine [3,4-b] pyrazinones - Google Patents

Pyridine [3,4-b] pyrazinones Download PDF

Info

Publication number
WO2006126082A3
WO2006126082A3 PCT/IB2006/001387 IB2006001387W WO2006126082A3 WO 2006126082 A3 WO2006126082 A3 WO 2006126082A3 IB 2006001387 W IB2006001387 W IB 2006001387W WO 2006126082 A3 WO2006126082 A3 WO 2006126082A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyrazinones
pde
pyridine
inhibitors
compounds
Prior art date
Application number
PCT/IB2006/001387
Other languages
English (en)
Other versions
WO2006126082A2 (fr
Inventor
Alan George Benson
Andrew Simon Bell
David Graham Brown
David Louis Brown
Yvette Marlene Fobian
John Nicholas Freskos
Steven Edward Heasley
Robert Owen Hughes
Eric Jon Jacobsen
Brent Virgil Mischke
John Major Molyneaux
Dafydd Rhys Owen
Michael John Palmer
Christopher Phillips
Jr Donald Joseph Rogier
John Keith Walker
Original Assignee
Pharmacia & Upjohn Co Llc
Alan George Benson
Andrew Simon Bell
David Graham Brown
David Louis Brown
Yvette Marlene Fobian
John Nicholas Freskos
Steven Edward Heasley
Robert Owen Hughes
Eric Jon Jacobsen
Brent Virgil Mischke
John Major Molyneaux
Dafydd Rhys Owen
Michael John Palmer
Christopher Phillips
Jr Donald Joseph Rogier
John Keith Walker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc, Alan George Benson, Andrew Simon Bell, David Graham Brown, David Louis Brown, Yvette Marlene Fobian, John Nicholas Freskos, Steven Edward Heasley, Robert Owen Hughes, Eric Jon Jacobsen, Brent Virgil Mischke, John Major Molyneaux, Dafydd Rhys Owen, Michael John Palmer, Christopher Phillips, Jr Donald Joseph Rogier, John Keith Walker filed Critical Pharmacia & Upjohn Co Llc
Priority to CA002608672A priority Critical patent/CA2608672A1/fr
Publication of WO2006126082A2 publication Critical patent/WO2006126082A2/fr
Publication of WO2006126082A3 publication Critical patent/WO2006126082A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Cette invention concerne des composés, des tautomères de ces composés, et des sels pharmaceutiquement acceptables de ces composés ou tautomères. Ces composés possèdent une structure représentée par la formule (I), dans laquelle R2, X6, Y6, R6 et R8 sont définis dans les pièces descriptives de la demande. Des compositions pharmaceutiques correspondantes, des procédés de traitement, des procédés de synthèse et des intermédiaires sont également divulgués.
PCT/IB2006/001387 2005-05-24 2006-05-17 Pyridine [3,4-b] pyrazinones WO2006126082A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002608672A CA2608672A1 (fr) 2005-05-24 2006-05-17 Pyridine [3,4-b] pyrazinones

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68413905P 2005-05-24 2005-05-24
US60/684,139 2005-05-24

Publications (2)

Publication Number Publication Date
WO2006126082A2 WO2006126082A2 (fr) 2006-11-30
WO2006126082A3 true WO2006126082A3 (fr) 2007-01-25

Family

ID=37056557

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/001387 WO2006126082A2 (fr) 2005-05-24 2006-05-17 Pyridine [3,4-b] pyrazinones

Country Status (2)

Country Link
CA (1) CA2608672A1 (fr)
WO (1) WO2006126082A2 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008012456A (es) * 2006-04-21 2008-10-10 Pfizer Prod Inc Piridin[3,4-b]pirazinonas.
FR2902009B1 (fr) * 2006-06-13 2012-12-07 Bioprojet Soc Civ Utilisation d'un inhibiteur de vasopeptidase pour le traitement de l'hypertension arterielle pulmonaire
BRPI0908569B8 (pt) 2008-03-05 2021-05-25 Merck Patent Gmbh estimuladores de secreção de insulina derivados de piridopirazinonas, seu uso, e composição farmacêutica
JP5767393B2 (ja) 2011-03-31 2015-08-19 ファイザー・インク 新規二環式ピリジノン
WO2012172449A1 (fr) 2011-06-13 2012-12-20 Pfizer Inc. Lactames convenant comme inhibiteurs des bêta-sécrétases
ES2605565T3 (es) 2011-08-31 2017-03-15 Pfizer Inc Compuestos de hexahidropirano [3,4-D][1,3]tiazin-2-amina
CA2872154C (fr) 2012-05-04 2016-08-23 Pfizer Inc. Composes d'hexahydropyrano[3,4-d][1,3]thiazin-2-amine substitues par des heterocycliques a titre d'inhibiteurs d'app, bace1 et bace2
JP2015529239A (ja) 2012-09-20 2015-10-05 ファイザー・インク アルキル置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
WO2014091352A1 (fr) 2012-12-11 2014-06-19 Pfizer Inc. Composés d'hexahydropyrano [3,4-d][1,3]thiazin-2-amine en tant qu'inhibiteurs de bace1
US9403846B2 (en) 2012-12-19 2016-08-02 Pfizer Inc. Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
WO2014125394A1 (fr) 2013-02-13 2014-08-21 Pfizer Inc. Composés hexahydropyrano [3,4-d][1,3] thiazin-2-amine substitués par un hétéroaryle
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
SG11201505878UA (en) 2013-02-19 2015-09-29 Pfizer Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders
EP3052495B1 (fr) 2013-10-04 2019-06-26 Pfizer Inc Nouvelles pyridinones bicycliques utilisées comme modulateurs de gamma-sécrétase
ES2759277T3 (es) 2014-04-01 2020-05-08 Pfizer Cromeno y 1,1a,2,7b-tetrahidrociclopropa[c]cromeno piridopiracinadionionas como moduladores de gamma-secretasa
MX2016013329A (es) 2014-04-10 2017-01-26 Pfizer 2-amino-6-metil-4,4a,5,6-tetrahidropirano[3,4-d][1,3]tiazin-8a(8h )-il-1,3-tiazol-4-ilamidas.
WO2016012896A1 (fr) 2014-07-24 2016-01-28 Pfizer Inc. Composés de pyrazolopyrimidine
ES2733502T3 (es) 2014-08-06 2019-11-29 Pfizer Compuestos de imidazopiridazina
EP3253755B1 (fr) 2015-02-03 2020-08-26 Pfizer Inc Nouveaux pyridopyrazinediones cyclopropabenzofuranyl
KR102426986B1 (ko) 2015-06-17 2022-07-28 화이자 인코포레이티드 삼환형 화합물 및 포스포다이에스터라제 억제제로서 이의 용도
EP3353174A1 (fr) 2015-09-24 2018-08-01 Pfizer Inc N-[2-(3-amino-2,5-diméthyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl]amides utiles comme inhibiteurs de bace
WO2017051276A1 (fr) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(2-amino-6,6-disubstitués-4,4a,5,6-tétrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl)-1,3-thiazol-4-yl]amides
EP3353182A1 (fr) 2015-09-24 2018-08-01 Pfizer Inc Dérivés de tétrahydropyrano[3,4-d][1,3]oxazine et leur utilisation en tant qu'inhibiteurs de bace
CA3015166C (fr) 2016-02-23 2021-08-03 Pfizer Inc. Composes 6,7-dihydro-5 h-pyrazolo [5,1-b] [1,3]oxazine-2-carboxamide
PL3478679T3 (pl) 2016-07-01 2021-10-25 Pfizer Inc. Pochodne 5,7-dihydro-pirolopirydyny do leczenia chorób neurologicznych i neurodegeneracyjnych
PT3642202T (pt) 2017-06-22 2023-02-02 Pfizer Derivados de dihidro-pirrolo-piridina
ES2942837T3 (es) 2018-03-23 2023-06-07 Pfizer Derivados de azaespiro piperazina
EP4297868A4 (fr) 2021-02-23 2025-01-08 Hoth Therapeutics Inc Utilisation d'aprépitant pour le traitement de la maladie d'alzheimer
WO2024118524A1 (fr) 2022-11-28 2024-06-06 Cerevel Therapeutics, Llc Composés d'azaindole et leur utilisation en tant qu'inhibiteurs de phosphodiestérase

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076954A1 (fr) * 2001-03-23 2002-10-03 Smithkline Beecham Corporation Composes utiles en tant qu'inhibiteurs de kinase pour le traitement de maladies hyperproliferantes
US20020147199A1 (en) * 2000-03-14 2002-10-10 Degenhard Marx Process for the treatment of erectile dysfunction and product therefor
EP1364950A1 (fr) * 2001-02-26 2003-11-26 Tanabe Seiyaku Co., Ltd. Derive de pyridopyrimidine ou naphthyridine
WO2004031189A1 (fr) * 2002-09-30 2004-04-15 Bristol-Myers Squibb Pharma Company Pyrazinones pyridino et pyrimidino destinees au traitement de l'anxiete et de la depression

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020147199A1 (en) * 2000-03-14 2002-10-10 Degenhard Marx Process for the treatment of erectile dysfunction and product therefor
EP1364950A1 (fr) * 2001-02-26 2003-11-26 Tanabe Seiyaku Co., Ltd. Derive de pyridopyrimidine ou naphthyridine
WO2002076954A1 (fr) * 2001-03-23 2002-10-03 Smithkline Beecham Corporation Composes utiles en tant qu'inhibiteurs de kinase pour le traitement de maladies hyperproliferantes
WO2004031189A1 (fr) * 2002-09-30 2004-04-15 Bristol-Myers Squibb Pharma Company Pyrazinones pyridino et pyrimidino destinees au traitement de l'anxiete et de la depression

Also Published As

Publication number Publication date
WO2006126082A2 (fr) 2006-11-30
CA2608672A1 (fr) 2006-11-30

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