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WO2006124874A3 - Inhibiteurs de la b-raf kinase - Google Patents

Inhibiteurs de la b-raf kinase Download PDF

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Publication number
WO2006124874A3
WO2006124874A3 PCT/US2006/018885 US2006018885W WO2006124874A3 WO 2006124874 A3 WO2006124874 A3 WO 2006124874A3 US 2006018885 W US2006018885 W US 2006018885W WO 2006124874 A3 WO2006124874 A3 WO 2006124874A3
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WIPO (PCT)
Prior art keywords
inhibitors
raf kinase
raf
dermatologic
hematopoiesis
Prior art date
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PCT/US2006/018885
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English (en)
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WO2006124874A2 (fr
Inventor
Timothy C Gahman
Hengyuan Lang
Robert L Davis
Shawn A Scranton
Original Assignee
Kalypsys Inc
Timothy C Gahman
Hengyuan Lang
Robert L Davis
Shawn A Scranton
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Application filed by Kalypsys Inc, Timothy C Gahman, Hengyuan Lang, Robert L Davis, Shawn A Scranton filed Critical Kalypsys Inc
Publication of WO2006124874A2 publication Critical patent/WO2006124874A2/fr
Publication of WO2006124874A3 publication Critical patent/WO2006124874A3/fr

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
    • C07C225/30—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by two rings
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    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
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Abstract

La présente invention concerne des composés et des méthodes utiles comme inhibiteurs de la B-Raf dans le traitement ou la prévention des cancers, tels que des tumeurs malignes hématologiques et non hématologiques, l'hématopoïèse, les maladies auto-immunes, les états dermatologiques et ophtalmologiques.
PCT/US2006/018885 2005-05-12 2006-05-11 Inhibiteurs de la b-raf kinase WO2006124874A2 (fr)

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US68029105P 2005-05-12 2005-05-12
US68032705P 2005-05-12 2005-05-12
US68029305P 2005-05-12 2005-05-12
US68029205P 2005-05-12 2005-05-12
US68029005P 2005-05-12 2005-05-12
US68028805P 2005-05-12 2005-05-12
US68029405P 2005-05-12 2005-05-12
US60/680,294 2005-05-12
US60/680,290 2005-05-12
US60/680,327 2005-05-12
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US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors

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