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WO2006119994A3 - Verfahren zur herstellung von albumin-konjugaten mit einem röntgenkontrastmittel als wirkstoff - Google Patents

Verfahren zur herstellung von albumin-konjugaten mit einem röntgenkontrastmittel als wirkstoff Download PDF

Info

Publication number
WO2006119994A3
WO2006119994A3 PCT/EP2006/004434 EP2006004434W WO2006119994A3 WO 2006119994 A3 WO2006119994 A3 WO 2006119994A3 EP 2006004434 W EP2006004434 W EP 2006004434W WO 2006119994 A3 WO2006119994 A3 WO 2006119994A3
Authority
WO
WIPO (PCT)
Prior art keywords
contrast medium
ray contrast
active substance
albumin conjugates
conjugates
Prior art date
Application number
PCT/EP2006/004434
Other languages
English (en)
French (fr)
Other versions
WO2006119994A2 (de
Inventor
Hansjoerg Sinn
Marcel Muelbaier
Original Assignee
Hansjoerg Sinn
Marcel Muelbaier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hansjoerg Sinn, Marcel Muelbaier filed Critical Hansjoerg Sinn
Priority to EP06724795A priority Critical patent/EP1893242A2/de
Priority to US11/919,683 priority patent/US20090047218A1/en
Priority to CA002607694A priority patent/CA2607694A1/en
Publication of WO2006119994A2 publication Critical patent/WO2006119994A2/de
Publication of WO2006119994A3 publication Critical patent/WO2006119994A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Die vorliegende Erfindung betrifft Röntgenkontrastmittel-Protein-Konjugate und insbesondere Röntgenkontrastmittel-Albumin-Konjugate, Arzneimittel umfassend Röntgenkontrastmittel-Protein-Konjugate, Verfahren zur Herstellung solcher Konjugate sowie deren Verwendung.
PCT/EP2006/004434 2005-05-11 2006-05-11 Verfahren zur herstellung von albumin-konjugaten mit einem röntgenkontrastmittel als wirkstoff WO2006119994A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06724795A EP1893242A2 (de) 2005-05-11 2006-05-11 Verfahren zur herstellung von albumin-konjugaten mit einem röntgenkontrastmittel als wirkstoff
US11/919,683 US20090047218A1 (en) 2005-05-11 2006-05-11 Method for producing albumin conjugates comprising an X-ray contrast medium as the active substance
CA002607694A CA2607694A1 (en) 2005-05-11 2006-05-11 Method for producing albumin conjugates comprising an x-ray contrast medium as the active substance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005021846A DE102005021846A1 (de) 2005-05-11 2005-05-11 Verfahren zur Herstellung von Albumin-Konjugaten mit einem Röntgenkontrastmittel als Wirkstoff
DE102005021846.6 2005-05-11

Publications (2)

Publication Number Publication Date
WO2006119994A2 WO2006119994A2 (de) 2006-11-16
WO2006119994A3 true WO2006119994A3 (de) 2007-03-15

Family

ID=36690071

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/004434 WO2006119994A2 (de) 2005-05-11 2006-05-11 Verfahren zur herstellung von albumin-konjugaten mit einem röntgenkontrastmittel als wirkstoff

Country Status (5)

Country Link
US (1) US20090047218A1 (de)
EP (1) EP1893242A2 (de)
CA (1) CA2607694A1 (de)
DE (1) DE102005021846A1 (de)
WO (1) WO2006119994A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015080984A1 (en) 2013-11-27 2015-06-04 BioPharmX, Inc. Solid oral dosage form for breast symptoms

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883650A (en) * 1988-04-13 1989-11-28 Albert Einstein College Of Medicine - Of Yeshiva University Radioidohippuric acid ester, a conjugate thereof, and methods of making the same
DE19636889A1 (de) * 1996-09-11 1998-03-12 Felix Dr Kratz Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel
US6602989B1 (en) * 2000-05-17 2003-08-05 The Research Foundation Of State University Of New York Synthesis, characterization, and application of pyridylazo bioconjugates as diagnostic and therapeutic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2125188A1 (fr) * 1991-12-04 1993-06-10 Dominique Meyer Nouveau compose macromoleculaire polyamine iode, son procede de preparation et son utilisation comme agent de contraste
US7790141B2 (en) * 2003-08-11 2010-09-07 Pathak Holdings, Llc Radio-opaque compounds, compositions containing same and methods of their synthesis and use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883650A (en) * 1988-04-13 1989-11-28 Albert Einstein College Of Medicine - Of Yeshiva University Radioidohippuric acid ester, a conjugate thereof, and methods of making the same
DE19636889A1 (de) * 1996-09-11 1998-03-12 Felix Dr Kratz Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel
US6602989B1 (en) * 2000-05-17 2003-08-05 The Research Foundation Of State University Of New York Synthesis, characterization, and application of pyridylazo bioconjugates as diagnostic and therapeutic agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DAVIS M-T B ET AL: "A SIMPLE MODIFIED CARBODIIMIDE METHOD FOR CONJUGATION OF SMALL-MOLECULAR-WEIGHT COMPOUNDS TO IMMUNOGLOBULIN G WITH MINIMAL PROTEIN CROSSLINKING", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 116, no. 2, 1981, pages 402 - 407, XP008061171, ISSN: 0003-2697 *
STEHLE G ET AL: "The loading rate determines tumor targeting properties of methotrexate-albumin conjugates in rats", ANTI-CANCER DRUGS, RAPID COMMUNICATIONS, OXFORD, GB, vol. 8, no. 7, August 1997 (1997-08-01), pages 677 - 685, XP009029047, ISSN: 0959-4973 *
WUNDER A ET AL: "Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 170, no. 9, 1 May 2003 (2003-05-01), pages 4793 - 4801, XP002371816, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
DE102005021846A1 (de) 2006-11-16
EP1893242A2 (de) 2008-03-05
US20090047218A1 (en) 2009-02-19
WO2006119994A2 (de) 2006-11-16
CA2607694A1 (en) 2006-11-16
DE102005021846A8 (de) 2007-03-08

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