WO2006119598A3 - Transdermal device for the slow delivery of an omega-3-fatty acid, optionally in combination with a hmg coa reductase inhibitor - Google Patents
Transdermal device for the slow delivery of an omega-3-fatty acid, optionally in combination with a hmg coa reductase inhibitor Download PDFInfo
- Publication number
- WO2006119598A3 WO2006119598A3 PCT/BR2006/000090 BR2006000090W WO2006119598A3 WO 2006119598 A3 WO2006119598 A3 WO 2006119598A3 BR 2006000090 W BR2006000090 W BR 2006000090W WO 2006119598 A3 WO2006119598 A3 WO 2006119598A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- omega
- optionally
- combination
- fatty acid
- coa reductase
- Prior art date
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 2
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 title 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
- 229940012843 omega-3 fatty acid Drugs 0.000 title 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 4
- 235000012000 cholesterol Nutrition 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Device for slow liberation via transdermal process of a medicine for reducing an excess of cholesterol and method of production of a transdermic device, which is characterized by a bi-laminate device comprising a flexible macromolecular matrix (2) providing a thickness from 0,15 to 0,6 cm and a surface from 10 to 100 square cm and a posterior coating (1) on one side which allows a considerable reduction (more than 15 times) of the doses to be administered in the treatment of an excess of cholesterol; the macromolecular matrix contains and liberates in a continuous way for a period between 1 to 4 months from 0,05 to 0,18% per day of its total weight of Omega-3 follyocid and / or statin by its surface in contact with the patient's skin without being necessarily the device to be adhered in a fix and permanent way to his / her skin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0501708 BRPI0501708A (en) | 2005-05-10 | 2005-05-10 | transdermal slow-release device for an excess cholesterol drug and method of producing a transdermal device |
| BRPI0501708-4 | 2005-05-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2006119598A2 WO2006119598A2 (en) | 2006-11-16 |
| WO2006119598A3 true WO2006119598A3 (en) | 2007-03-01 |
Family
ID=37396906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/BR2006/000090 WO2006119598A2 (en) | 2005-05-10 | 2006-05-10 | Transdermal device for the slow delivery of an omega-3-fatty acid, optionally in combination with a hmg coa reductase inhibitor |
Country Status (2)
| Country | Link |
|---|---|
| BR (1) | BRPI0501708A (en) |
| WO (1) | WO2006119598A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2940116B1 (en) | 2008-12-22 | 2012-07-06 | Philippe Perovitch | FORMULATION FOR THE ADMINISTRATION OF HYPOLIPEMIC BY ORAL TRANS-MUCOSAL |
| US9107983B2 (en) | 2010-10-27 | 2015-08-18 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising statins |
| US8877221B2 (en) | 2010-10-27 | 2014-11-04 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same |
| US9308190B2 (en) | 2011-06-06 | 2016-04-12 | Warsaw Orthopedic, Inc. | Methods and compositions to enhance bone growth comprising a statin |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3325130A1 (en) * | 1983-06-29 | 1985-01-03 | Pierre-Richard Nizza Dick | PHARMACEUTICAL COMPOSITION FOR APPLICATION TO THE SKIN BASED ON ESSENTIAL FATTY ACIDS AND DEVICE CONTAINING THIS |
| EP0965340A1 (en) * | 1996-12-23 | 1999-12-22 | Nippon Suisan Kaisha, Ltd. | Dermatologic preparation |
| WO2002038196A2 (en) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Plaster with skincare substances |
-
2005
- 2005-05-10 BR BRPI0501708 patent/BRPI0501708A/en not_active Application Discontinuation
-
2006
- 2006-05-10 WO PCT/BR2006/000090 patent/WO2006119598A2/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3325130A1 (en) * | 1983-06-29 | 1985-01-03 | Pierre-Richard Nizza Dick | PHARMACEUTICAL COMPOSITION FOR APPLICATION TO THE SKIN BASED ON ESSENTIAL FATTY ACIDS AND DEVICE CONTAINING THIS |
| EP0965340A1 (en) * | 1996-12-23 | 1999-12-22 | Nippon Suisan Kaisha, Ltd. | Dermatologic preparation |
| WO2002038196A2 (en) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Plaster with skincare substances |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006119598A2 (en) | 2006-11-16 |
| BRPI0501708A (en) | 2007-05-02 |
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