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WO2006119284A3 - Composes aromatiques conjugues utilise a des fins diagnostiques et therapeutiques - Google Patents

Composes aromatiques conjugues utilise a des fins diagnostiques et therapeutiques Download PDF

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Publication number
WO2006119284A3
WO2006119284A3 PCT/US2006/016824 US2006016824W WO2006119284A3 WO 2006119284 A3 WO2006119284 A3 WO 2006119284A3 US 2006016824 W US2006016824 W US 2006016824W WO 2006119284 A3 WO2006119284 A3 WO 2006119284A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
resonance
immune
enhance
compositions
Prior art date
Application number
PCT/US2006/016824
Other languages
English (en)
Other versions
WO2006119284A2 (fr
Inventor
Lee Roy Morgan
Original Assignee
Dekk Tec Inc
Morgan Lee R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dekk Tec Inc, Morgan Lee R filed Critical Dekk Tec Inc
Priority to EP06758930A priority Critical patent/EP1888053A2/fr
Priority to CA002606599A priority patent/CA2606599A1/fr
Priority to BRPI0612330-9A priority patent/BRPI0612330A2/pt
Priority to JP2008510132A priority patent/JP2008540428A/ja
Priority to AU2006242244A priority patent/AU2006242244A1/en
Priority to MX2007013762A priority patent/MX2007013762A/es
Publication of WO2006119284A2 publication Critical patent/WO2006119284A2/fr
Publication of WO2006119284A3 publication Critical patent/WO2006119284A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/78—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C251/80—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/82—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of rings other than six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des composés, des compositions et des méthodes permettant d'utiliser ces composés et ces compositions dans le traitement de maladies hyperprolifératives, notamment des maladies précancéreuses et cancéreuses. Dans un mode de réalisation, ces composés contiennent des composés modulant la résonance qui peuvent être utilisés dans lesdites méthodes en tant qu'agent de couplage capable d'interagir avec le système immunitaire afin de surveiller ou de stimuler la fonction immunitaire. Ces modulateurs de résonance présentent des propriétés électromagnétiques inhérentes qui attirent les cellules immunes vers une zone cible sur laquelle l'agent modulant la résonance a été appliqué. Les propriétés électromagnétiques (telles que l'amplitude de tension) de la zone cible sont modifiées en présence du modulateur de résonance et servent d'indicateur de la fonction immune. Un stimulus externe (tel qu'un champ magnétique électromagnétique appliqué) peut également être appliqué au modulateur de résonance afin d'améliorer sa stimulation immune et ses propriétés d'attraction. L'invention décrit des exemples particuliers de modulateurs de résonance et ces substances possèdent généralement des moments dipolaires intramoléculaires de résonance qui sont capables d'interaction électrostatique des environnements biologiques. Dans certains exemples, les composés s'agrègent sur des sites d'action thérapeutique afin d'améliorer l'activité thérapeutique. Dans d'autres exemples, les composés stimulent la production de plaquettes.
PCT/US2006/016824 2005-05-04 2006-05-03 Composes aromatiques conjugues utilise a des fins diagnostiques et therapeutiques WO2006119284A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP06758930A EP1888053A2 (fr) 2005-05-04 2006-05-03 Composes aromatiques conjugues utilise a des fins diagnostiques et therapeutiques
CA002606599A CA2606599A1 (fr) 2005-05-04 2006-05-03 Composes aromatiques conjugues utilise a des fins diagnostiques et therapeutiques
BRPI0612330-9A BRPI0612330A2 (pt) 2005-05-04 2006-05-03 compostos aromÁticos conjugados para diagnàsticos e terapia
JP2008510132A JP2008540428A (ja) 2005-05-04 2006-05-03 診断と治療のための共役芳香族化合物
AU2006242244A AU2006242244A1 (en) 2005-05-04 2006-05-03 Conjugated aromatic compounds for diagnosis and therapy
MX2007013762A MX2007013762A (es) 2005-05-04 2006-05-03 Compuestos aromaticos conjugados para diagnostico y terapia.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67808905P 2005-05-04 2005-05-04
US60/678,089 2005-05-04

Publications (2)

Publication Number Publication Date
WO2006119284A2 WO2006119284A2 (fr) 2006-11-09
WO2006119284A3 true WO2006119284A3 (fr) 2007-01-11

Family

ID=36954402

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/016824 WO2006119284A2 (fr) 2005-05-04 2006-05-03 Composes aromatiques conjugues utilise a des fins diagnostiques et therapeutiques

Country Status (9)

Country Link
EP (1) EP1888053A2 (fr)
JP (1) JP2008540428A (fr)
KR (1) KR20080015426A (fr)
CN (1) CN101262859A (fr)
AU (1) AU2006242244A1 (fr)
BR (1) BRPI0612330A2 (fr)
CA (1) CA2606599A1 (fr)
MX (1) MX2007013762A (fr)
WO (1) WO2006119284A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200800145A (en) * 2005-08-26 2008-01-01 Dekk Tec Inc Hydrazone agents to treat cutaneous lesions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732904A (en) * 1984-12-24 1988-03-22 Morgan Lee R Antiestrogenic hydrazones
WO2004078174A1 (fr) * 2003-02-28 2004-09-16 Morgan Lee R Modulateur a resonance pour le diagnostic et la therapie

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3775281D1 (de) 1986-06-16 1992-01-30 Siemens Ag Vorrichtung zur steuerung eines herzschrittmachers mittels impedanzmessung an koerpergeweben.
ATE182624T1 (de) 1990-07-11 1999-08-15 Univ New York Phosphotyrosin phosphatase als neuer rezeptor-typ
WO1994005276A1 (fr) 1992-09-08 1994-03-17 Morgan Lee R Composes cytotoxiques
US5503157A (en) 1995-03-17 1996-04-02 Sramek; Bohumir System for detection of electrical bioimpedance signals
US5968527A (en) 1997-02-27 1999-10-19 Catholic University Of America, The Protection of living systems from the adverse effects of stress
US6190893B1 (en) 1998-09-18 2001-02-20 Massachusetts Institute Of Technology Electroactive materials for stimulation of biological activity of bone marrow stromal cells
WO2001076475A2 (fr) 2000-04-07 2001-10-18 The Johns Hopkins University Detecteur de tumeur de la prostate chez l'homme
NL1018287C2 (nl) 2001-06-14 2002-12-30 Georges Vanroy Inrichting en werkwijze voor het op een levend lichaam aanleggen van een elektromagnetisch veld.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732904A (en) * 1984-12-24 1988-03-22 Morgan Lee R Antiestrogenic hydrazones
WO2004078174A1 (fr) * 2003-02-28 2004-09-16 Morgan Lee R Modulateur a resonance pour le diagnostic et la therapie

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
A.K. JAIN ET AL., INDIAN J.CHEM.SECT.B, vol. 34, no. 12, 1995, pages 1047 - 1052, XP009072490 *
DATABASE XFIRE Beilstein Institut zur Förderung der Chemischen Wissenschaften; XP002399733, Database accession no. 3167386 *
L.ELGUERO ET AL.: "Recherches dans la série des azoles", BULL.SOC.CHIM.FR., 1965, pages 769 - 778, XP009072466 *
LORENZ ET AL., HELV.CHIM.ACTA, vol. 28, 1945, pages 600 - 611, XP009072477 *
RAPPOPORT ET AL., J.CHEM.SOC.B, 1967, pages 898 - 903, XP009072489 *
S. TAKEI ET AL., CHEM. ZENTRALBLATT, vol. 110, no. I, 1939, pages 1183 *
VARRON ET AL., ORG.PREP.PROCED., no. 1, 1969, pages 47 - 49, XP009072462 *
WIZINGER R ET AL: "UEBER XANTHYLOMETHINE", CHEMISCHE BERICHTE, VERLAG CHEMIE GMBH. WEINHEIM, DE, vol. 92, 1959, pages 2309 - 2320, XP001105077, ISSN: 0009-2940 *

Also Published As

Publication number Publication date
KR20080015426A (ko) 2008-02-19
WO2006119284A2 (fr) 2006-11-09
CA2606599A1 (fr) 2006-11-09
BRPI0612330A2 (pt) 2009-01-27
CN101262859A (zh) 2008-09-10
AU2006242244A1 (en) 2006-11-09
MX2007013762A (es) 2008-03-14
JP2008540428A (ja) 2008-11-20
EP1888053A2 (fr) 2008-02-20

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