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WO2006118973A3 - Procedes d'utilisation de composes heterocycliques [3.2.0] et de leurs analogues - Google Patents

Procedes d'utilisation de composes heterocycliques [3.2.0] et de leurs analogues Download PDF

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Publication number
WO2006118973A3
WO2006118973A3 PCT/US2006/016104 US2006016104W WO2006118973A3 WO 2006118973 A3 WO2006118973 A3 WO 2006118973A3 US 2006016104 W US2006016104 W US 2006016104W WO 2006118973 A3 WO2006118973 A3 WO 2006118973A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
heterobyclic
compounds
treatment
rectal cancer
Prior art date
Application number
PCT/US2006/016104
Other languages
English (en)
Other versions
WO2006118973A2 (fr
Inventor
Michael Palladino
Barbara Christine Potts
Venkata Rami Reddy Macherla
Saskia Theodora Corn Neuteboom
Original Assignee
Nereus Pharmaceuticals Inc
Michael Palladino
Barbara Christine Potts
Venkata Rami Reddy Macherla
Saskia Theodora Corn Neuteboom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nereus Pharmaceuticals Inc, Michael Palladino, Barbara Christine Potts, Venkata Rami Reddy Macherla, Saskia Theodora Corn Neuteboom filed Critical Nereus Pharmaceuticals Inc
Publication of WO2006118973A2 publication Critical patent/WO2006118973A2/fr
Publication of WO2006118973A3 publication Critical patent/WO2006118973A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur des méthodes de traitement du cancer qui consiste à administrer à un animal une quantité effective d'un point de vue thérapeutique d'un composé hétérocyclique de formule VI. L'animal est un mammifère, de préférence, un être humain ou un rongeur.
PCT/US2006/016104 2005-04-29 2006-04-27 Procedes d'utilisation de composes heterocycliques [3.2.0] et de leurs analogues WO2006118973A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67653305P 2005-04-29 2005-04-29
US60/676,533 2005-04-29

Publications (2)

Publication Number Publication Date
WO2006118973A2 WO2006118973A2 (fr) 2006-11-09
WO2006118973A3 true WO2006118973A3 (fr) 2007-04-19

Family

ID=37308510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/016104 WO2006118973A2 (fr) 2005-04-29 2006-04-27 Procedes d'utilisation de composes heterocycliques [3.2.0] et de leurs analogues

Country Status (1)

Country Link
WO (1) WO2006118973A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176232B2 (en) 2002-06-24 2007-02-13 The Regents Of The University Of California Salinosporamides and methods for use thereof
US7579371B2 (en) 2004-04-30 2009-08-25 Nereus Pharmaceuticals, Inc. Methods of using [3.2.0] heterocyclic compounds and analogs thereof
JP2007535559A (ja) 2004-04-30 2007-12-06 ネレアス ファーマシューティカルズ インコーポレイテッド ［３．２．０］複素環式化合物及びその使用法
CN103230394B (zh) 2004-12-03 2016-04-20 达纳-法伯癌症研究公司 治疗肿瘤性疾病的化合物及其用途
KR20080109071A (ko) 2006-04-06 2008-12-16 니리어스 파마슈티컬즈, 인코퍼레이션 살리노스포라마이드 ａ 및 그의 유도체들의 전합성
US8986971B2 (en) 2006-09-22 2015-03-24 Triphase Research And Development I Corp. Salt formulations for the fermentation of marine microorganisms
WO2008095195A2 (fr) * 2007-02-02 2008-08-07 Nereus Pharmaceuticals, Inc. Formulations lyophilisées de salinosporamide a
BRPI0909661A2 (pt) 2008-03-07 2015-08-11 Nereus Pharmaceuticals Inc Composto e métodos de síntese química e de formação ou preparação de compostos
CA2723465A1 (fr) 2008-05-12 2009-11-19 Nereus Pharmaceuticals, Inc. Derives de salinosporamide a utiliser en tant qu'inhibiteurs des proteasomes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996032105A1 (fr) * 1995-04-12 1996-10-17 President And Fellows Of Harvard College Analogues de lactacystine
WO2004071382A2 (fr) * 2003-02-14 2004-08-26 Bayer Healthcare Ag Heterocycles substitues
US20050288352A1 (en) * 2004-04-30 2005-12-29 Potts Barbara C [3.2.0] Heterocyclic compounds and methods of using the same
WO2006060609A1 (fr) * 2004-12-03 2006-06-08 Honeywell International Inc. Commande par jets de gaz d'une unite inertielle de mesure

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996032105A1 (fr) * 1995-04-12 1996-10-17 President And Fellows Of Harvard College Analogues de lactacystine
WO2004071382A2 (fr) * 2003-02-14 2004-08-26 Bayer Healthcare Ag Heterocycles substitues
US20050288352A1 (en) * 2004-04-30 2005-12-29 Potts Barbara C [3.2.0] Heterocyclic compounds and methods of using the same
WO2006028525A2 (fr) * 2004-04-30 2006-03-16 Nereus Pharmaceuticals, Inc. Composes heterocycliques [3.2.0] et leurs procedes d'utilisation
WO2006060609A1 (fr) * 2004-12-03 2006-06-08 Honeywell International Inc. Commande par jets de gaz d'une unite inertielle de mesure

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WILLIAMS P G ET AL: "New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 70, no. 16, 1 July 2005 (2005-07-01), pages 6196 - 6203, XP002376431, ISSN: 0022-3263 *

Also Published As

Publication number Publication date
WO2006118973A2 (fr) 2006-11-09

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