+

WO2006117218A3 - Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache - Google Patents

Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache Download PDF

Info

Publication number
WO2006117218A3
WO2006117218A3 PCT/EP2006/004181 EP2006004181W WO2006117218A3 WO 2006117218 A3 WO2006117218 A3 WO 2006117218A3 EP 2006004181 W EP2006004181 W EP 2006004181W WO 2006117218 A3 WO2006117218 A3 WO 2006117218A3
Authority
WO
WIPO (PCT)
Prior art keywords
serotonin
headache
transport
diagnosis
production
Prior art date
Application number
PCT/EP2006/004181
Other languages
French (fr)
Other versions
WO2006117218A2 (en
Inventor
Sigrid Schuh-Hofer
Arnold Guy
Matthias Richter
Original Assignee
Charite Universitaetsmedizin
Sigrid Schuh-Hofer
Arnold Guy
Matthias Richter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05009822A external-priority patent/EP1728520A1/en
Application filed by Charite Universitaetsmedizin, Sigrid Schuh-Hofer, Arnold Guy, Matthias Richter filed Critical Charite Universitaetsmedizin
Publication of WO2006117218A2 publication Critical patent/WO2006117218A2/en
Publication of WO2006117218A3 publication Critical patent/WO2006117218A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to the use of radiopharmaceuticals which specifically bind the serotonin-transport-protein (SERT) for the production of a diagnostic drug for the diagnosis of headache. The radiopharmaceuticals are tracers, which have the capacity to specifically bind the Serotonin-Transport-Protein in the context of a Positron-Emission-Tomography (PET) or a Single Photon Emission Tomography (SPECT). The present invention further relates to a screening method for identifying substances, which selectively modify the binding of these radiopharmaceuticals to the serotonin transporter. These substances are, e.g. precursors of putative therapeutics for the treatment of headache.
PCT/EP2006/004181 2005-05-04 2006-05-04 Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache WO2006117218A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05009822.7 2005-05-04
EP05009822A EP1728520A1 (en) 2005-05-04 2005-05-04 Use of radiopharmaceutical compounds which are specific binders to serotonine transporters for the preparation of a diagnotic agent for the examination of headache related disorders
US71513905P 2005-09-09 2005-09-09
US60/715,139 2005-09-09

Publications (2)

Publication Number Publication Date
WO2006117218A2 WO2006117218A2 (en) 2006-11-09
WO2006117218A3 true WO2006117218A3 (en) 2007-12-13

Family

ID=36646112

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/004181 WO2006117218A2 (en) 2005-05-04 2006-05-04 Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache

Country Status (1)

Country Link
WO (1) WO2006117218A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116990498B (en) * 2023-09-28 2024-08-09 山东大学齐鲁医院 Application of plasma tryptophan metabolite in diagnosis of migraine in children

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US6165716A (en) * 1995-09-23 2000-12-26 Medical Research Council Screening for disorders of serotonergic dysfunction
US20010047028A1 (en) * 1999-01-28 2001-11-29 Dan Peters Novel azabicyclo derivatives and their use
US20030091505A1 (en) * 2001-10-18 2003-05-15 Jian-Min Fu Tetracyclicazaindoles and indolines having 5-HT activity
US20030149024A1 (en) * 2001-11-28 2003-08-07 Jian-Min Fu Therapeutic compounds
US20040014992A1 (en) * 2000-10-17 2004-01-22 Meltzer Peter C. Compounds with high monoamine transporter affinity

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165716A (en) * 1995-09-23 2000-12-26 Medical Research Council Screening for disorders of serotonergic dysfunction
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US20010047028A1 (en) * 1999-01-28 2001-11-29 Dan Peters Novel azabicyclo derivatives and their use
US20040014992A1 (en) * 2000-10-17 2004-01-22 Meltzer Peter C. Compounds with high monoamine transporter affinity
US20030091505A1 (en) * 2001-10-18 2003-05-15 Jian-Min Fu Tetracyclicazaindoles and indolines having 5-HT activity
US20030149024A1 (en) * 2001-11-28 2003-08-07 Jian-Min Fu Therapeutic compounds

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ACTON P D ET AL: "Quantification of serotonin transporters in nonhuman primates using 123IADAM and single photon emission tomography", JOURNAL OF NUCLEAR MEDICINE, vol. 42, no. 10, October 2001 (2001-10-01), & 48TH ANNUAL MEETING OF THE SOCIETY OF NUCLEAR MEDICINE; TORONTO, ONTARIO, CANADA; JUNE 23-27, 2001, pages 1556 - 1562, XP002369625, ISSN: 0161-5505 *
DUCROS A ET AL: "The Genetics of Migraine", LANCET NEUROLOGY, LANCET PUBLISHING GROUP, LONDON, GB, vol. 1, no. 5, September 2002 (2002-09-01), pages 285 - 293, XP004811296, ISSN: 1474-4422 *
HESSE S ET AL: "Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders", NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, PERGAMON PRESS LTD, XX, vol. 28, no. 6, October 2004 (2004-10-01), pages 547 - 563, XP004621916, ISSN: 0149-7634 *
LIN KUN-JU ET AL: "Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography.", JOURNAL OF NUCLEAR MEDICINE : OFFICIAL PUBLICATION, SOCIETY OF NUCLEAR MEDICINE. APR 2004, vol. 45, no. 4, April 2004 (2004-04-01), pages 673 - 681, XP002369624, ISSN: 0161-5505 *
UEBELHACK R ET AL: "P.1.094 Reduction of the brain <123>I-ADAM binding isrelated to the plasma drug level in amitriptyline treated subjects", EUROPEAN NEUROPSYCHOPHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, AMSTERDAM, NL, vol. 14, October 2004 (2004-10-01), pages S214 - S215, XP004990010, ISSN: 0924-977X *

Also Published As

Publication number Publication date
WO2006117218A2 (en) 2006-11-09

Similar Documents

Publication Publication Date Title
WO2009052970A3 (en) Compounds for use in imaging, diagnosing, and/or treatment of diseases of the central nervous system or of tumors
WO2007010534A3 (en) Imaging protocols
EP2217945A4 (en) Single photon emission computed tomography (spect) system for cardiac imaging
CL2011000237A1 (en) Compounds suitable for labeling or already labeled with 18f, epiridine derivatives, benzodiazepine peripheral receptor ligand for imaging diagnosis by positron emission topography (pet); pharmaceutical composition; Pharmaceutical kit
WO2008098112A3 (en) Positron emission tomography imaging method
IL183878A0 (en) Positron emission tomography imaging method
GB0718967D0 (en) Peptide imaging agents
BRPI1010261A2 (en) in vivo imaging agent and method, precursor compound, methods for preparing a precursor compound and in vivo imaging agent, and for diagnosing a condition, kit, cassette, and radiopharmaceutical composition.
WO2009038795A3 (en) Positron emission tomography probes for imaging immune activation and selected cancers
IL211526A0 (en) Compounds and methods for 18f labeled agents, compositions comprising such compounds and their use for diagnostic imaging
PH12013500270A1 (en) Peptide radiotracer compositions
WO2009018088A3 (en) Imaging of alpha-synuclein
WO2010096426A8 (en) Compounds, compositions, methods of synthesis, and methods of treatment
WO2007148083A3 (en) Stabilisation of radiopharmaceutical precursors
BRPI0919551A2 (en) in vivo imaging agent and method, precursor compound, kit, cassette, radiopharmaceutical composition, and methods for preparing the in vivo imaging agent and for diagnosing a condition
WO2009013358A3 (en) Polysaccharides grafted by polyamines for the preparation of radiopharmaceutical compositions
WO2006117218A3 (en) Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache
FI20050271A0 (en) Odontological computed tomography imaging
WO2012042062A3 (en) Marker sequences for multiple sclerosis and use thereof
WO2012040138A3 (en) Choline analogs as radiotracer
TN2009000233A1 (en) Radiolabelling via fluorination of aziridines
PH12013501017A1 (en) Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system
WO2007137135A3 (en) Rotenone analogs: method of preparation and use
NZ591824A (en) Butyrylcholinesterase ligands as diagnostic tools and treatment for deseases of the nervous system
WO2009055922A8 (en) Labeled iodinated tropane formulation

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

NENP Non-entry into the national phase

Ref country code: RU

WWW Wipo information: withdrawn in national office

Country of ref document: RU

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06742800

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 06742800

Country of ref document: EP

Kind code of ref document: A2

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载