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WO2006108713A3 - 1-amino-1, 2,3,4-tetrahydro-naphthaline-2-ol derivates as anti-inflammatory agents - Google Patents

1-amino-1, 2,3,4-tetrahydro-naphthaline-2-ol derivates as anti-inflammatory agents Download PDF

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Publication number
WO2006108713A3
WO2006108713A3 PCT/EP2006/003782 EP2006003782W WO2006108713A3 WO 2006108713 A3 WO2006108713 A3 WO 2006108713A3 EP 2006003782 W EP2006003782 W EP 2006003782W WO 2006108713 A3 WO2006108713 A3 WO 2006108713A3
Authority
WO
WIPO (PCT)
Prior art keywords
naphthaline
derivates
tetrahydro
amino
inflammatory agents
Prior art date
Application number
PCT/EP2006/003782
Other languages
German (de)
French (fr)
Other versions
WO2006108713A2 (en
Inventor
Anne Mengel
Konrad Krolikiewicz
Stefan Baeurle
Heike Schaecke
Original Assignee
Schering Ag
Anne Mengel
Konrad Krolikiewicz
Stefan Baeurle
Heike Schaecke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Anne Mengel, Konrad Krolikiewicz, Stefan Baeurle, Heike Schaecke filed Critical Schering Ag
Publication of WO2006108713A2 publication Critical patent/WO2006108713A2/en
Publication of WO2006108713A3 publication Critical patent/WO2006108713A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to poly-substituted tetrahydronaphtalene derivatives of formula (I) and to a method for the production and the use thereof in the form of antiphlogistics.
PCT/EP2006/003782 2005-04-14 2006-04-13 1-amino-1, 2,3,4-tetrahydro-naphthaline-2-ol derivates as anti-inflammatory agents WO2006108713A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005017316.0 2005-04-14
DE102005017316A DE102005017316A1 (en) 2005-04-14 2005-04-14 Tetrahydronaphthalene derivatives, process for their preparation and their use as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
WO2006108713A2 WO2006108713A2 (en) 2006-10-19
WO2006108713A3 true WO2006108713A3 (en) 2006-12-14

Family

ID=36889239

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/003782 WO2006108713A2 (en) 2005-04-14 2006-04-13 1-amino-1, 2,3,4-tetrahydro-naphthaline-2-ol derivates as anti-inflammatory agents

Country Status (8)

Country Link
AR (1) AR053582A1 (en)
DE (1) DE102005017316A1 (en)
DO (1) DOP2006000089A (en)
GT (1) GT200600152A (en)
PE (1) PE20061360A1 (en)
TW (1) TW200716565A (en)
UY (1) UY29482A1 (en)
WO (1) WO2006108713A2 (en)

Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63220242A (en) * 1987-03-10 1988-09-13 Fuji Photo Film Co Ltd Photoresist composition
WO1988008836A2 (en) * 1987-05-15 1988-11-17 Schering Corporation Aryl substituted naphthalene, benzoxepine, benzazepine, benzocycloheptene derivatives
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
EP0579223A1 (en) * 1992-07-17 1994-01-19 Mitsubishi Chemical Corporation Carboxylic acid derivatives having 5 alpha-reductase inhibitory activity
WO1999004778A1 (en) * 1997-07-22 1999-02-04 Eli Lilly And Company Pharmaceutical compounds
WO1999006388A2 (en) * 1997-07-31 1999-02-11 Proteome Sciences Plc. Pharmaceutical compounds isolated from aristolochia taliscana
WO1999037607A1 (en) * 1998-01-27 1999-07-29 Icagen, Inc. Potassium channel inhibitors
WO1999050205A2 (en) * 1998-03-30 1999-10-07 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
WO2000010977A1 (en) * 1998-08-21 2000-03-02 The Scripps Research Institute Catalytic asymmetric aminohydroxylation with amino-substituted heterocycles
JP2000256255A (en) * 1999-03-10 2000-09-19 Kuraray Co Ltd Optical resolution method of (±) -trans-permetholinic acid
WO2001030734A1 (en) * 1999-10-29 2001-05-03 Astrazeneca Ab Novel hydronaphtalene compounds, prepared by a rhodium catalyzed ring opening reaction in the presence of phosphine ligand
WO2003000694A1 (en) * 2001-06-22 2003-01-03 Almirall Prodesfarma S.A. 6-phenyldihydropyrrolopyrimidinedione derivatives
WO2003027061A2 (en) * 2001-09-21 2003-04-03 Eli Lilly And Company Muscarinic agonists
WO2003040107A1 (en) * 2001-09-24 2003-05-15 Bayer Pharmaceuticals Corporation Imidazole-4-carboxamide derivatives, preparation and use thereof for treatment of obesity
WO2003045924A1 (en) * 2001-11-21 2003-06-05 Pharmacia & Upjohn Company Substituted aryl 1,4-pyrazine derivatives
US20030199690A1 (en) * 2002-02-21 2003-10-23 Schering Corporation Process for synthesis of D1 receptor antagonists
WO2004020375A1 (en) * 2002-08-26 2004-03-11 Merck Patent Gmbh Cyclopenta[b]naphthalene derivatives
CN1524835A (en) * 2003-09-12 2004-09-01 中国科学院上海有机化学研究所 Method for Asymmetric Hydroxylation and Double Hydroxylation Using Immobilized Biscinconyl Alkaloid Ligands
WO2005021682A1 (en) * 2003-08-22 2005-03-10 Merck Patent Gmbh Cyclopenta[a]naphthaline derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370056A1 (en) * 1987-07-16 1990-05-30 Byk Gulden Lomberg Chemische Fabrik Gmbh New diazols
US5489584A (en) * 1994-12-29 1996-02-06 Allergan, Inc. Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63220242A (en) * 1987-03-10 1988-09-13 Fuji Photo Film Co Ltd Photoresist composition
WO1988008836A2 (en) * 1987-05-15 1988-11-17 Schering Corporation Aryl substituted naphthalene, benzoxepine, benzazepine, benzocycloheptene derivatives
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
EP0579223A1 (en) * 1992-07-17 1994-01-19 Mitsubishi Chemical Corporation Carboxylic acid derivatives having 5 alpha-reductase inhibitory activity
WO1999004778A1 (en) * 1997-07-22 1999-02-04 Eli Lilly And Company Pharmaceutical compounds
WO1999006388A2 (en) * 1997-07-31 1999-02-11 Proteome Sciences Plc. Pharmaceutical compounds isolated from aristolochia taliscana
WO1999037607A1 (en) * 1998-01-27 1999-07-29 Icagen, Inc. Potassium channel inhibitors
WO1999050205A2 (en) * 1998-03-30 1999-10-07 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
WO2000010977A1 (en) * 1998-08-21 2000-03-02 The Scripps Research Institute Catalytic asymmetric aminohydroxylation with amino-substituted heterocycles
JP2000256255A (en) * 1999-03-10 2000-09-19 Kuraray Co Ltd Optical resolution method of (±) -trans-permetholinic acid
WO2001030734A1 (en) * 1999-10-29 2001-05-03 Astrazeneca Ab Novel hydronaphtalene compounds, prepared by a rhodium catalyzed ring opening reaction in the presence of phosphine ligand
WO2003000694A1 (en) * 2001-06-22 2003-01-03 Almirall Prodesfarma S.A. 6-phenyldihydropyrrolopyrimidinedione derivatives
WO2003027061A2 (en) * 2001-09-21 2003-04-03 Eli Lilly And Company Muscarinic agonists
WO2003040107A1 (en) * 2001-09-24 2003-05-15 Bayer Pharmaceuticals Corporation Imidazole-4-carboxamide derivatives, preparation and use thereof for treatment of obesity
WO2003045924A1 (en) * 2001-11-21 2003-06-05 Pharmacia & Upjohn Company Substituted aryl 1,4-pyrazine derivatives
US20030199690A1 (en) * 2002-02-21 2003-10-23 Schering Corporation Process for synthesis of D1 receptor antagonists
WO2004020375A1 (en) * 2002-08-26 2004-03-11 Merck Patent Gmbh Cyclopenta[b]naphthalene derivatives
WO2005021682A1 (en) * 2003-08-22 2005-03-10 Merck Patent Gmbh Cyclopenta[a]naphthaline derivatives
CN1524835A (en) * 2003-09-12 2004-09-01 中国科学院上海有机化学研究所 Method for Asymmetric Hydroxylation and Double Hydroxylation Using Immobilized Biscinconyl Alkaloid Ligands

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1983, THIEM, JOACHIM ET AL: "2,6-Dideoxy saccharide glycosides of .alpha.-hydroxy ketones: synthesis and configurational assignment of glycosides with the tetralone substructure of olivomycin", XP002397135, retrieved from STN Database accession no. 1983:215911 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1994, SRIVASTAVA, J. N. ET AL: "Synthesis of 7-methoxy- and 6-methoxytetralino[3,4-c]isocoumarins and 7-methoxy- and 6-methoxytetralino[3,4-c]isoquinolones", XP002397133, retrieved from STN Database accession no. 1994:409135 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2001, FERRAZ, HELENA M. C. ET AL: "The reaction of 1-tetralones with thallium trinitrate supported on clay: ring contraction vs .alpha.-oxidation", XP002397132, retrieved from STN Database accession no. 2001:730084 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2004, PATONAY, TAMAS ET AL: "Synthesis of Racemic and Enantiomerically Enriched .alpha.-Oxyfunctionalized Benzocyclanones and Chromanones by Dimethyldioxirane and Dimethyldioxirane/Mn(III) salen System", XP002397131, retrieved from STN Database accession no. 2004:392983 *
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY , 3(3), 171-6 CODEN: IJCHEI; ISSN: 0971-1627, 1994 *
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY , 12(5), 680-684 CODEN: JOCSET; ISSN: 0103-5053, 2001 *
LIEBIGS ANNALEN DER CHEMIE , (3), 448-61 CODEN: LACHDL; ISSN: 0170-2041, 1983 *
MONATSHEFTE FUER CHEMIE , 135(6), 743-756 CODEN: MOCMB7; ISSN: 0026-9247, 2004 *

Also Published As

Publication number Publication date
WO2006108713A2 (en) 2006-10-19
TW200716565A (en) 2007-05-01
DOP2006000089A (en) 2006-11-15
DE102005017316A1 (en) 2006-10-19
PE20061360A1 (en) 2007-01-26
AR053582A1 (en) 2007-05-09
GT200600152A (en) 2007-03-19
UY29482A1 (en) 2006-10-31

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