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WO2006106336A3 - Amorces de rats - Google Patents

Amorces de rats Download PDF

Info

Publication number
WO2006106336A3
WO2006106336A3 PCT/GB2006/001257 GB2006001257W WO2006106336A3 WO 2006106336 A3 WO2006106336 A3 WO 2006106336A3 GB 2006001257 W GB2006001257 W GB 2006001257W WO 2006106336 A3 WO2006106336 A3 WO 2006106336A3
Authority
WO
WIPO (PCT)
Prior art keywords
development
rat primers
antibodies
rat
primers
Prior art date
Application number
PCT/GB2006/001257
Other languages
English (en)
Other versions
WO2006106336A2 (fr
Inventor
Ralph Adams
Andrew George Popplewell
Patrick Marcel Slocombe
Original Assignee
Ucb Sa
Ralph Adams
Andrew George Popplewell
Patrick Marcel Slocombe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa, Ralph Adams, Andrew George Popplewell, Patrick Marcel Slocombe filed Critical Ucb Sa
Publication of WO2006106336A2 publication Critical patent/WO2006106336A2/fr
Publication of WO2006106336A3 publication Critical patent/WO2006106336A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention concerne des ensembles d'amorces utilisés pour isoler des séquences de régions variables d'anticorps de rats. Cette invention concerne également des anticorps comprenant ces régions qui sont utilisés pour développer des traitements et, en particulier, pour développer des anticorps humanisés.
PCT/GB2006/001257 2005-04-06 2006-04-05 Amorces de rats WO2006106336A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0507044A GB0507044D0 (en) 2005-04-06 2005-04-06 Primers
GB0507044.6 2005-04-06

Publications (2)

Publication Number Publication Date
WO2006106336A2 WO2006106336A2 (fr) 2006-10-12
WO2006106336A3 true WO2006106336A3 (fr) 2007-03-29

Family

ID=34586838

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001257 WO2006106336A2 (fr) 2005-04-06 2006-04-05 Amorces de rats

Country Status (2)

Country Link
GB (1) GB0507044D0 (fr)
WO (1) WO2006106336A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993002191A1 (fr) * 1991-07-16 1993-02-04 The Wellcome Foundation Limited Anticorps humanise contre l'antigene cd18_______________
US6458355B1 (en) * 1998-01-22 2002-10-01 Genentech, Inc. Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
WO2003054016A2 (fr) * 2001-12-21 2003-07-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Procede de clonage de sequences de domaines variables

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993002191A1 (fr) * 1991-07-16 1993-02-04 The Wellcome Foundation Limited Anticorps humanise contre l'antigene cd18_______________
US6458355B1 (en) * 1998-01-22 2002-10-01 Genentech, Inc. Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
WO2003054016A2 (fr) * 2001-12-21 2003-07-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Procede de clonage de sequences de domaines variables

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
"PRIMER DESIGN FOR THE CLONING OF IMMUNOGLOBULIN HEAVY-CHAIN LEADER-VARIABLE REGIONS FROM MOUSE HYBRIDOMA CELLS USING THE PCR", BIOTECHNIQUES, INFORMA LIFE SCIENCES PUBLISHING, WESTBOROUGH, MA, US, vol. 11, no. 2, August 1991 (1991-08-01), pages 152 - 154,156, XP000647450, ISSN: 0736-6205 *
BABCOOK J S ET AL: "A NOVEL STRATEGY FOR GENERATING MONOCLONAL ANTIBODIES FROM SINGLE, ISOLATED LYMPHOCYTES PRODUCING ANTIBODIES OF DEFINED SPECIFICITIES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 93, no. 15, 23 July 1996 (1996-07-23), pages 7843 - 7848, XP000608647, ISSN: 0027-8424 *
COCHET O ET AL: "Intracellular expression and functional properties of an anti-p21Ras scFv derived from a rat hybridoma containing specific lambda and irrelevant kappa light chains.", MOLECULAR IMMUNOLOGY. DEC 1998, vol. 35, no. 17, December 1998 (1998-12-01), pages 1097 - 1110, XP002398950, ISSN: 0161-5890 *
DATABASE Geneseq [online] 22 April 2003 (2003-04-22), "Mouse antibody 5.12.14 heavy chain reverse PCR primer SL002B.", XP002397095, retrieved from EBI accession no. GSN:ABX81392 Database accession no. ABX81392 *
DATABASE Geneseq [online] 8 June 1993 (1993-06-08), "Rat gamma-CH1 constant region probe.", XP002398958, retrieved from EBI accession no. GSN:AAQ35179 Database accession no. AAQ35179 *
DÜBEL S ET AL: "Isolation of IgG antibody Fv-DNA from various mouse and rat hybridoma cell lines using the polymerase chain reaction with a simple set of primers.", JOURNAL OF IMMUNOLOGICAL METHODS. 30 SEP 1994, vol. 175, no. 1, 30 September 1994 (1994-09-30), pages 89 - 95, XP002079907, ISSN: 0022-1759 *
KÜTEMEIER G ET AL: "Rapid isolation of immunoglobulin variable genes from cell lysates of rat hybridomas by polymerase chain reaction.", HYBRIDOMA. FEB 1992, vol. 11, no. 1, February 1992 (1992-02-01), pages 23 - 32, XP008067493, ISSN: 0272-457X *
MAYNARD J ET AL: "ANTIBODY ENGINEERING", ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, ANNUAL REVIEW INCO., PALO ALTO, CA, US, vol. 2, 2000, pages 339 - 376, XP009039750 *
ORLANDI R ET AL: "CLONING IMMUNOGLOBULIN VARIABLE DOMAINS FOR EXPRESSION BY THE POLYMERASE CHAIN REACTION", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 86, no. 10, 1 May 1989 (1989-05-01), pages 3833 - 3837, XP000026475, ISSN: 0027-8424 *
ORUM H ET AL: "Efficient method for constructing comprehensive murine Fab antibody libraries displayed on phage.", NUCLEIC ACIDS RESEARCH. 25 SEP 1993, vol. 21, no. 19, 25 September 1993 (1993-09-25), pages 4491 - 4498, XP000828043, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
WO2006106336A2 (fr) 2006-10-12
GB0507044D0 (en) 2005-05-11

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