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WO2006105110A3 - Assay device and methods - Google Patents

Assay device and methods Download PDF

Info

Publication number
WO2006105110A3
WO2006105110A3 PCT/US2006/011322 US2006011322W WO2006105110A3 WO 2006105110 A3 WO2006105110 A3 WO 2006105110A3 US 2006011322 W US2006011322 W US 2006011322W WO 2006105110 A3 WO2006105110 A3 WO 2006105110A3
Authority
WO
WIPO (PCT)
Prior art keywords
analyte
cartridge
assay device
methods
automated
Prior art date
Application number
PCT/US2006/011322
Other languages
French (fr)
Other versions
WO2006105110A2 (en
Inventor
Victor Manneh
Simon Burnell
Khaled A Yamout
Original Assignee
Inverness Medical Switzerland
Victor Manneh
Simon Burnell
Khaled A Yamout
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inverness Medical Switzerland, Victor Manneh, Simon Burnell, Khaled A Yamout filed Critical Inverness Medical Switzerland
Publication of WO2006105110A2 publication Critical patent/WO2006105110A2/en
Publication of WO2006105110A3 publication Critical patent/WO2006105110A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

A system for detecting an analyte includes system a cartridge and a cartridge reader. The system is automated for easy use by a patient at home, or by a health care professional. The system provides a rapid, accurate measurement of an analyte. The cartridge can include a microfluidic assay device can measure an analyte in a small volume of a liquid sample.
PCT/US2006/011322 2005-03-29 2006-03-28 Assay device and methods WO2006105110A2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US66583505P 2005-03-29 2005-03-29
US66586905P 2005-03-29 2005-03-29
US66586705P 2005-03-29 2005-03-29
US66586805P 2005-03-29 2005-03-29
US66583805P 2005-03-29 2005-03-29
US60/665,867 2005-03-29
US60/665,868 2005-03-29
US60/665,869 2005-03-29
US60/665,835 2005-03-29
US60/665,838 2005-03-29

Publications (2)

Publication Number Publication Date
WO2006105110A2 WO2006105110A2 (en) 2006-10-05
WO2006105110A3 true WO2006105110A3 (en) 2009-04-09

Family

ID=37054024

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/011322 WO2006105110A2 (en) 2005-03-29 2006-03-28 Assay device and methods

Country Status (1)

Country Link
WO (1) WO2006105110A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192778B2 (en) 1999-10-06 2007-03-20 Natan Michael J Surface enhanced spectroscopy-active composite nanoparticles
US8497131B2 (en) 1999-10-06 2013-07-30 Becton, Dickinson And Company Surface enhanced spectroscopy-active composite nanoparticles comprising Raman-active reporter molecules
WO2002079764A1 (en) 2001-01-26 2002-10-10 Nanoplex Technologies, Inc. Surface-enhanced spectroscopy-active sandwich nanoparticles
BRPI0713029A2 (en) 2006-06-20 2012-07-17 Amic Ab test device
US20100322824A1 (en) 2007-11-05 2010-12-23 Koninklijke Philips Electronics N.V. Biosensor cartridge
FR2931244A1 (en) * 2008-05-13 2009-11-20 Biosynex Sarl DEVICE FOR DETECTING AT LEAST ONE ELEMENT CONTAINED IN A BLOOD SOLUTION
EP2304445B1 (en) * 2008-07-09 2020-06-10 Micropoint Bioscience Inc Analytical cartridge with fluid flow control
US9040285B2 (en) 2008-12-18 2015-05-26 Koninklijkle Philips N.V. Sensing device for sensing a fluid
US20120149128A1 (en) * 2009-02-23 2012-06-14 Victor Manneh Assays and assay devices
WO2012011074A2 (en) 2010-07-22 2012-01-26 Hach Company Lab-on-a-chip for alkalinity analysis
US9933428B2 (en) 2012-01-10 2018-04-03 Idexx Laboratories, Inc. Immunoassay test slide
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
GB201217390D0 (en) * 2012-09-28 2012-11-14 Agplus Diagnostics Ltd Test device and sample carrier
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
JP2014173934A (en) * 2013-03-07 2014-09-22 Toshiba Corp Semiconductor micro-analysis chip and manufacturing method thereof
US10073091B2 (en) 2014-08-08 2018-09-11 Ortho-Clinical Diagnostics, Inc. Lateral flow assay device
GB201611442D0 (en) 2016-06-30 2016-08-17 Lumiradx Tech Ltd Fluid control
EP3691788A1 (en) * 2017-08-03 2020-08-12 FibroTx OÜ Lateral flow assay and device for skin care application
CN111343919B (en) * 2017-11-21 2023-10-10 Bbb有限公司 biological sensor
WO2020117707A1 (en) * 2018-12-02 2020-06-11 Polymer Technology Systems, Inc. Systems and methods for an e-gating feature in an electrochemical test strip
WO2020196817A1 (en) * 2019-03-28 2020-10-01 国立大学法人愛媛大学 Spectral analysis chip
TW202136735A (en) * 2020-01-13 2021-10-01 英商盧米瑞德克斯英國有限公司 Fluid control in microfluidic devices

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5759866A (en) * 1995-11-15 1998-06-02 Nihon Medi-Physics Co., Ltd. Device and method for assaying biological components in sample
US20030207308A1 (en) * 2000-08-31 2003-11-06 The Regents Of The University Of California Capillary array and related methods
US20030207328A1 (en) * 1996-04-25 2003-11-06 Genicon Sciences Corporation Analyte assay using particulate labels
US20030211564A1 (en) * 2002-05-10 2003-11-13 Suyue Qian Multilayer reagent test strips and methods for using the same to quantify glycated protein in a physiological sample
US6656745B1 (en) * 2000-06-02 2003-12-02 Francis X. Cole Devices and methods for a multi-level, semi-quantitative immunodiffusion assay
US20040018637A1 (en) * 1998-11-23 2004-01-29 Polito Alan J. Method and apparatus for performing a lateral flow assay

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5759866A (en) * 1995-11-15 1998-06-02 Nihon Medi-Physics Co., Ltd. Device and method for assaying biological components in sample
US20030207328A1 (en) * 1996-04-25 2003-11-06 Genicon Sciences Corporation Analyte assay using particulate labels
US20040018637A1 (en) * 1998-11-23 2004-01-29 Polito Alan J. Method and apparatus for performing a lateral flow assay
US6656745B1 (en) * 2000-06-02 2003-12-02 Francis X. Cole Devices and methods for a multi-level, semi-quantitative immunodiffusion assay
US20030207308A1 (en) * 2000-08-31 2003-11-06 The Regents Of The University Of California Capillary array and related methods
US20030211564A1 (en) * 2002-05-10 2003-11-13 Suyue Qian Multilayer reagent test strips and methods for using the same to quantify glycated protein in a physiological sample

Also Published As

Publication number Publication date
WO2006105110A2 (en) 2006-10-05

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