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WO2006103666A3 - Polypeptides bid isoles, polynucleotides les codant et anticorps diriges contre ces polypeptides, methodes d'utilisation pour induire l'arret du cycle cellulaire ou l'apoptose - Google Patents

Polypeptides bid isoles, polynucleotides les codant et anticorps diriges contre ces polypeptides, methodes d'utilisation pour induire l'arret du cycle cellulaire ou l'apoptose Download PDF

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Publication number
WO2006103666A3
WO2006103666A3 PCT/IL2006/000393 IL2006000393W WO2006103666A3 WO 2006103666 A3 WO2006103666 A3 WO 2006103666A3 IL 2006000393 W IL2006000393 W IL 2006000393W WO 2006103666 A3 WO2006103666 A3 WO 2006103666A3
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WO
WIPO (PCT)
Prior art keywords
same
cell cycle
cycle arrest
bid
apoptosis
Prior art date
Application number
PCT/IL2006/000393
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English (en)
Other versions
WO2006103666A2 (fr
Inventor
Atan Gross
Rachel Sarig
Iris Kamer
Original Assignee
Yeda Res & Dev
Atan Gross
Rachel Sarig
Iris Kamer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Atan Gross, Rachel Sarig, Iris Kamer filed Critical Yeda Res & Dev
Publication of WO2006103666A2 publication Critical patent/WO2006103666A2/fr
Publication of WO2006103666A3 publication Critical patent/WO2006103666A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un polypeptide BID phosphorylé par PIKK pouvant être utilisé afin d'induire l'arrêt du cycle cellulaire. Elle concerne, plus particulièrement, des polypeptides isolés comprenant une séquence d'acides aminés BID pouvant être utilisée afin d'induire l'arrêt du cycle cellulaire et de traiter des maladies associées à une instabilité génomique. Dans un autre mode de réalisation, elle concerne des polypeptides isolés comprenant une séquence d'acides aminés BID capable d'inhiber la phosphorylation médiée par PIKK de BID endogène pouvant être utilisée afin d'induire l'apoptose et de traiter le cancer.
PCT/IL2006/000393 2005-03-28 2006-03-29 Polypeptides bid isoles, polynucleotides les codant et anticorps diriges contre ces polypeptides, methodes d'utilisation pour induire l'arret du cycle cellulaire ou l'apoptose WO2006103666A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66538305P 2005-03-28 2005-03-28
US60/665,383 2005-03-28

Publications (2)

Publication Number Publication Date
WO2006103666A2 WO2006103666A2 (fr) 2006-10-05
WO2006103666A3 true WO2006103666A3 (fr) 2007-03-08

Family

ID=37053783

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/000393 WO2006103666A2 (fr) 2005-03-28 2006-03-29 Polypeptides bid isoles, polynucleotides les codant et anticorps diriges contre ces polypeptides, methodes d'utilisation pour induire l'arret du cycle cellulaire ou l'apoptose

Country Status (1)

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WO (1) WO2006103666A2 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8859723B2 (en) 2010-08-13 2014-10-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US8927500B2 (en) 2012-02-15 2015-01-06 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US9273099B2 (en) 2003-11-05 2016-03-01 President And Fellows Of Harvard College Stabilized alpha helical peptides and uses thereof
US9394336B2 (en) 2008-09-22 2016-07-19 Aileron Therapeutics, Inc. Methods for preparing purified polypeptide compositions
US9522947B2 (en) 2011-10-18 2016-12-20 Aileron Therapeutics, Inc. Peptidomimetic macrocycles

Families Citing this family (23)

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Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
EP2508531B1 (fr) 2007-03-28 2016-10-19 President and Fellows of Harvard College Polypeptides piqués
US10716828B2 (en) 2007-05-02 2020-07-21 Dana-Farber Cancer Institute, Inc. Methods of modulating cellular homeostatic pathways and cellular survival
DE112009000300T5 (de) 2008-02-08 2011-01-20 Aileron Therapeutics, Inc., Cambridge Therapeutische Peptidomimetische Makrocyclen
US20110144306A1 (en) 2008-07-23 2011-06-16 President And Fellows Of Harvard College Ligation of stapled polypeptides
JP5711128B2 (ja) 2008-09-22 2015-04-30 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子
AU2009316288B2 (en) 2008-11-24 2016-05-19 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with improved properties
JP2012515172A (ja) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
WO2010116375A1 (fr) * 2009-04-08 2010-10-14 Yeda Research And Development Co. Ltd. Peptides isolés pour réguler l'apoptose
US9163330B2 (en) 2009-07-13 2015-10-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
CA2774973A1 (fr) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Macrocycles peptidomimetiques
US8957026B2 (en) 2010-09-22 2015-02-17 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
US9487562B2 (en) 2011-06-17 2016-11-08 President And Fellows Of Harvard College Stabilized polypeptides as regulators of RAB GTPase function
PL2920197T3 (pl) 2012-09-26 2021-09-13 President And Fellows Of Harvard College Peptydy zszywane blokowane proliną i ich zastosowania
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
KR20150131244A (ko) 2013-03-13 2015-11-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스테이플드 및 스티치드 폴리펩티드 및 그의 용도
KR20160019547A (ko) 2013-06-14 2016-02-19 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 안정화된 폴리펩티드 인슐린 수용체 조절제
WO2015179635A2 (fr) 2014-05-21 2015-11-26 President And Fellows Of Harvard College Peptides inhibiteurs de ras et leurs utilisations
KR102570210B1 (ko) 2014-09-24 2023-08-23 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 제제
WO2016049359A1 (fr) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
AU2016235424A1 (en) 2015-03-20 2017-10-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2017004548A1 (fr) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques
WO2017044633A1 (fr) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques en tant que modulateurs de mcl-1

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAMER ET AL.: "Proapoptotic BID is an ATM effector in the DNA-Damage Response", CELL, vol. 122, 25 August 2005 (2005-08-25), pages 593 - 603, XP003002484 *
ZINKEL ET AL.: "A role for proapoptotic BID in the DNA-Damage response", CELL, vol. 122, 26 August 2005 (2005-08-26), pages 579 - 591, XP003002485 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9273099B2 (en) 2003-11-05 2016-03-01 President And Fellows Of Harvard College Stabilized alpha helical peptides and uses thereof
US9464115B2 (en) 2003-11-05 2016-10-11 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides and uses thereof
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9527896B2 (en) 2007-01-31 2016-12-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9394336B2 (en) 2008-09-22 2016-07-19 Aileron Therapeutics, Inc. Methods for preparing purified polypeptide compositions
US8859723B2 (en) 2010-08-13 2014-10-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US9522947B2 (en) 2011-10-18 2016-12-20 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8927500B2 (en) 2012-02-15 2015-01-06 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US9505804B2 (en) 2012-02-15 2016-11-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles

Also Published As

Publication number Publication date
WO2006103666A2 (fr) 2006-10-05

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