WO2006039747A2 - Improved blood pump - Google Patents
Improved blood pump Download PDFInfo
- Publication number
- WO2006039747A2 WO2006039747A2 PCT/AU2005/001567 AU2005001567W WO2006039747A2 WO 2006039747 A2 WO2006039747 A2 WO 2006039747A2 AU 2005001567 W AU2005001567 W AU 2005001567W WO 2006039747 A2 WO2006039747 A2 WO 2006039747A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- glassy carbon
- blood pump
- pump
- rotary blood
- impeller
- Prior art date
Links
- 239000008280 blood Substances 0.000 title claims abstract description 34
- 210000004369 blood Anatomy 0.000 title claims abstract description 34
- 229910021397 glassy carbon Inorganic materials 0.000 claims abstract description 68
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 150000002431 hydrogen Chemical class 0.000 claims description 3
- 229910021645 metal ion Inorganic materials 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 239000001307 helium Substances 0.000 claims description 2
- 229910052734 helium Inorganic materials 0.000 claims description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 2
- 239000000463 material Substances 0.000 description 13
- 229910002804 graphite Inorganic materials 0.000 description 5
- 239000010439 graphite Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000000576 coating method Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000002243 precursor Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 239000010936 titanium Substances 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 239000000560 biocompatible material Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000007737 ion beam deposition Methods 0.000 description 2
- 238000005468 ion implantation Methods 0.000 description 2
- 238000001659 ion-beam spectroscopy Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- KXGFMDJXCMQABM-UHFFFAOYSA-N 2-methoxy-6-methylphenol Chemical compound [CH]OC1=CC=CC([CH])=C1O KXGFMDJXCMQABM-UHFFFAOYSA-N 0.000 description 1
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000002194 amorphous carbon material Substances 0.000 description 1
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 1
- 239000003575 carbonaceous material Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 231100000481 chemical toxicant Toxicity 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 229910003472 fullerene Inorganic materials 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000003350 kerosene Substances 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- 229910021396 non-graphitizing carbon Inorganic materials 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- -1 titanium ions Chemical class 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229910001868 water Inorganic materials 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/818—Bearings
- A61M60/824—Hydrodynamic or fluid film bearings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/165—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
- A61M60/178—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/237—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/403—Details relating to driving for non-positive displacement blood pumps
- A61M60/422—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
Definitions
- the present invention relates to an improved implantable blood pump.
- congestive heart failure may have been treated with the use of a blood pump to assist the pumping of blood around the circulatory system of a patient.
- a prior art implantable blood pump is described in US Patent 6,609,883 - Woodard et al. in which the blood pump is primarily fabricated from a titanium or its alloys that may include by weight 6% aluminium and 4% vanadium (Ti-6A1-4V).
- the pump housing of this blood pump is metallic and includes a magnetic drive motor acting on a hydrodynamic impeller within the pump housing. Whilst the material from which the pump is made is biocompatible, one of the disadvantages with this is that titanium is a relatively costly material to machine.
- DLC Diamond-Like Carbon
- the present invention consists of an implantable rotary blood pump including an impeller adapted to rotate within a pump housing, and a motor having at least one stator mounted on or within the pump housing that interacts with magnetised regions in said impeller, characterised in that at least a portion of said pump is made of glassy carbon.
- said housing includes said portion of glassy carbon.
- said impeller includes said portion of glassy carbon.
- said portion of glassy carbon forms a hydrodynamic bearing.
- said portion of glassy carbon is not positioned between stators.
- said portion of glassy carbon is implanted with any one or more of hydrogen, oxygen, helium, carbon, nitrogen or metal ions.
- Preferably said portion of glassy carbon is heat-treated.
- said housing includes an upper portion screwably connected to a lower portion.
- said glassy carbon has a density between 1.40 and 1.60.
- said glassy carbon has a thickness less than 8mm.
- said portion of glassy carbon is covered by an impermeable layer adapted to minimise the egress of bio-toxic compounds.
- Fig. 1 shows a cross-sectional view of a first embodiment of an implantable rotary blood pump in accordance with the present invention
- Fig. 2 shows an enlarged cross-sectional view of a second embodiment of a blade of an impeller for an implantable rotary blood pump in accordance with the present invention
- Fig. 3 shows a cross-sectional view of a third embodiment of an implantable rotary blood pump in accordance with the present invention.
- FIG. 1 A first embodiment of the present invention is shown in Fig. 1.
- an implantable rotary blood pump 13 is shown.
- This blood pump 13 includes an inlet 1 and an outlet 8; an impeller 2 which rotates and propels blood from the inlet 1 using centrifugal propulsion through the pump housing 6 to the outlet 8.
- a motor generates the torque force for rotating the impeller 2.
- the motor is formed by the interaction of stators 5 axially mounted within the pump housing 6 interacting with magnetic regions in the impeller 2.
- the impeller 2 is hydrodynamically suspended on a fluid bearing formed by a restriction gap 9 between each of the four blades 3 of impeller 2 and the inner wall of the pump housing 6.
- the four blades 3 are joined together by struts 4 in a substantially square configuration.
- the housing 6 is entirely comprised of glassy carbon.
- Glassy carbon is generally a class of non-graphitizing carbon and has relatively increased strength and hardness characteristics when compared to ordinary graphite.
- Glassy carbon generally includes linkages of small graphite like regions and has a lustrous surface and homogenous structure resembling glass.
- Glassy carbon may be produced using precursor materials such as cellulose, kerosene, palm oil or a thermosetting resin such as phenolic resin and sucrose with polyvinylidene chloride.
- the preparation of glassy carbon involves subjecting the organic precursors to a series of heat treatments at temperatures up to 3000 0 C.
- non-graphitizing carbons are impermeable to gases and are chemically extremely inert, including those which have been prepared at very high temperatures.
- the rates of oxidation of certain glassy carbons in oxygen, carbon dioxide or water vapour are lower than those of any other carbon making them ideally suited to applications in implantable medical devices.
- glassy carbon typically contains more than 90% sp 2 hydridised carbon atoms, with less than 10 at.% hydrogen.
- Glassy carbon may typically have a hardness of ⁇ 20GPa and a preferred hardness range of between 5 - 15 GPa.
- glassy carbon is generally understood to be composed of a high proportion of fullerene-related structures which contain varying ratios of pentagonal and hexagonal components, depending on the heat treatment to which the structures were exposed during manufacture. Sheet and ribbon-like components may also be contained within the glassy carbon structure.
- glassy carbon can be moulded into solid shapes. It can also be applied as a coating and impregnated into graphite, and a range of other materials.
- Glassy carbon may also contain a plurality of pores of about 20-50 A diameter. The diameter of the pores may be varied depending on the treatment when the glassy carbon is formed. Glassy carbon has many properties that make it suitable for use with blood pumps and these include: relatively low density and high corrosion resistance, when compared to metals; and relatively high strength, and low fluid permeability, when compared to plastics.
- glassy carbon within this specification includes vitreous carbon.
- Glassy carbon is relatively amorphous and generally shows little or no signs of crystallinity.
- Glassy carbon may exhibit no or few diffraction peaks and only an amorphous halo when viewed by x-ray diffraction.
- the glassy carbon may include a low level of relatively small crystals.
- Most graphites excluding HOPG and pyrolytic graphite) exhibit considerable porosity whereas glassy carbon is relatively denser. As a consequence, glassy carbon lacks the porosity of other types of graphite.
- Glassy carbon may be ultrasonically cleaned without significant damage and machined to tight tolerances using laser ablation.
- the preferred thickness of any pump component made from glassy carbon is less than 8mm. This is due to the method of manufacturing the glassy carbon.
- a precursor resin is formed by moulding.
- the moulded resin is then heat-treated to a temperature generally greater than 1000 0 C.
- the temperature of the treatment process may be modulated or reduced to create a material with a lower electrical conductivity.
- the treatment of heat may preferably be carried out under high pressure.
- the resulting glassy carbon is relatively easy to machine and polish, if post-process dimensional adjustments are required.
- Glassy carbon generally has a high electrical conductivity or a low resistivity, which may be generally undesirable in certain applications.
- Glassy carbon may be modified with ion implantation to reduce the electrical conductivity by creating insulating regions within the surface of the material.
- hydrogen, oxygen, carbon, nitrogen or metal ions may be used for this ion implantation.
- the electrical conductivity may also be reduced by minimising the pyrolysis temperature as used in the preparation of the material from its pursors.
- the housing 6 may include an upper portion screwably connected to a lower portion. These portions may both be constructed of glassy carbon.
- Fig. 2 shows a second embodiment of the present invention wherein a section of the blade 3 of an impeller 2 for an implantable rotary blood pump is shown.
- Blade 3 includes a layer of glassy carbon 7, which encapsulates a permanent magnet 11.
- Permanent magnets 11 are constructed of generally bio-toxic material. In use, it is necessary to prevent the bio-toxic material from contacting the blood in the pump. Additionally, it is important to note that glassy carbons are slightly fluid permeable and as such bio-toxic compounds may degrade and release toxic chemicals or compounds in a patient's circulatory system.
- the glassy carbon layer 7 of the blade 3 is coated in an impermeable barrier 12a to block, stop or greatly impede the eluting or release of bio-toxic compounds or chemicals into the patient's blood stream.
- a similar barrier 12b also encapsulates, coat and seal the permanent magnet 11.
- these barriers 12a and 12b may be constructed from gold, zinc, ParaleneTM or similar impermeable coating material.
- FIG. 3 A third embodiment is shown in Fig. 3, a blood pump 13 is shown in an axial flow configuration. Similar numbering has been used in this embodiment as previous embodiments.
- the impeller 2 includes a shaft 103 running along the axis of rotation; an annular ring 102 with hydrodynamic bearings on the upper and lower angular surfaces of the annular ring 102; and a set of blades 3 which join the shaft 103 to the annular ring 102.
- the permanent magnets 11 are encased within the annular ring 102 rather than in the blades 3.
- the stators 5 are also mounted radially in relation to the axis of rotation of the impeller 2 rather than axially as shown in Fig 1.
- this embodiment Whilst the body of housing 6 is primarily ⁇ -6A1-4V, this embodiment includes a member 102 constructed of glassy carbon. This member 102 is mounted on a portion of the housing 6, and in particular over the hydrodynamic bearing regions of the housing 6. This has the effect of creating the hydrodynamic bearings or bearing surfaces out of glassy carbon material and gives the bearing surfaces the benefit of the glassy carbon properties, which may include low friction under contact conditions.
- the member 102 may be disposed so as not to be directly positioned between the stators 5. This positioning of the member 102 allows the glassy carbon to be substantially removed from the electromagnetic path of the motor formed by the pump 13. The positioning of the member 102 outside the electromagnetic path of the motor reduces electromagnetic eddy currents occurring in the glassy carbon and increases the motor efficiency of the pump 13.
- a glassy carbon member may be mounted or disposed on the impeller 2, thereby also providing the benefits of glassy carbon properties to the hydrodynamic bearing regions of the impeller 2.
- One such benefit is that of low friction.
- the third embodiment depicts a pump 13 having a composite structure including a glassy carbon member 102, it should be understood that in other embodiments other components or portions of the pump may be of glassy carbon.
- the blade 3 of the impeller of the abovementioned second embodiment is described as having a magnet 11 substantially encapsulated by glassy carbon 7, in other not shown embodiments other parts of the impeller may wholly be of glassy carbon or a composite of materials including glassy carbon.
- DLC Diamond-Like Carbon
- the present invention described within this specification is directed towards an implantable blood pump at least partially made of glassy carbon.
- DLC can be synthesized as thin films using ion beam deposition or sputter deposition. Depending on the sp 3 to sp 2 hybridization ratio (in some cases exceeding 60%) DLC films can appear transparent, possess high hardness, and be electrically insulating. Some forms of DLC may contain more than 10% hydrogen.
- DLC is also generally unlike glassy carbon in terms of electrical conductivity. Typically, DLC is generally limited to forming thin layers or coatings.
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Mechanical Engineering (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Fluid Mechanics (AREA)
- Physics & Mathematics (AREA)
- External Artificial Organs (AREA)
- Structures Of Non-Positive Displacement Pumps (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2004905862A AU2004905862A0 (en) | 2004-10-11 | Improved Blood Pump | |
AU2004905862 | 2004-10-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006039747A2 true WO2006039747A2 (en) | 2006-04-20 |
WO2006039747A3 WO2006039747A3 (en) | 2006-10-19 |
Family
ID=36148688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU2005/001567 WO2006039747A2 (en) | 2004-10-11 | 2005-10-10 | Improved blood pump |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006039747A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2549113A3 (en) * | 2011-07-20 | 2017-07-26 | Levitronix GmbH | Magnetic rotor and rotation pump with a magnetic rotor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2663534A1 (en) * | 1990-06-22 | 1991-12-27 | Cuilleron J | Artificial cardiac valve |
US5925552A (en) * | 1996-04-25 | 1999-07-20 | Medtronic, Inc. | Method for attachment of biomolecules to medical devices surfaces |
US5945319A (en) * | 1996-04-25 | 1999-08-31 | Medtronic, Inc. | Periodate oxidative method for attachment of biomolecules to medical device surfaces |
US5891506A (en) * | 1996-08-09 | 1999-04-06 | Medtronic, Inc. | Oxidative method for attachment of glycoproteins or glycopeptides to surfaces of medical devices |
JP2000237299A (en) * | 1999-02-18 | 2000-09-05 | Yasuhiro Fukui | Biologically compatible material and method for forming it |
-
2005
- 2005-10-10 WO PCT/AU2005/001567 patent/WO2006039747A2/en active Application Filing
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2549113A3 (en) * | 2011-07-20 | 2017-07-26 | Levitronix GmbH | Magnetic rotor and rotation pump with a magnetic rotor |
Also Published As
Publication number | Publication date |
---|---|
WO2006039747A3 (en) | 2006-10-19 |
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