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WO2006038107A3 - Method for inhibiting fibrogenesis by an rhdecorin-fc fusion protein - Google Patents

Method for inhibiting fibrogenesis by an rhdecorin-fc fusion protein Download PDF

Info

Publication number
WO2006038107A3
WO2006038107A3 PCT/IB2005/002999 IB2005002999W WO2006038107A3 WO 2006038107 A3 WO2006038107 A3 WO 2006038107A3 IB 2005002999 W IB2005002999 W IB 2005002999W WO 2006038107 A3 WO2006038107 A3 WO 2006038107A3
Authority
WO
WIPO (PCT)
Prior art keywords
rhdecorin
fusion protein
decorin
lifetime
amino acids
Prior art date
Application number
PCT/IB2005/002999
Other languages
French (fr)
Other versions
WO2006038107A2 (en
Inventor
Mengsu Yang
Hsiang-Fu Kung
Yaou Zhang
Celina S M Cheng
Pik Yuen Cheung
Original Assignee
Mengsu Yang
Hsiang-Fu Kung
Yaou Zhang
Celina S M Cheng
Pik Yuen Cheung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mengsu Yang, Hsiang-Fu Kung, Yaou Zhang, Celina S M Cheng, Pik Yuen Cheung filed Critical Mengsu Yang
Priority to CN2005800371903A priority Critical patent/CN101115839B/en
Publication of WO2006038107A2 publication Critical patent/WO2006038107A2/en
Publication of WO2006038107A3 publication Critical patent/WO2006038107A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to methods for inhibiting liver fibrogenesis in vitro and/or in vivo with directly administered recombinant rhDecorin and rhDecorin-Fc fusion protein. In one embodiment a linker is provided between Decorin and the Fc hinge fragment to form a fusion protein which increases the biologic activity of Decorin and increases the ability to bind to TGF-ß and extends the lifetime of decorin in serum, where the Fc hinge fragment is a modified form of Fc involving the replacement of four N-terminal amino acids with ten different amino acids which extends the lifetime of the Decorin-Fc protein by 50%.
PCT/IB2005/002999 2004-08-30 2005-07-18 Method for inhibiting fibrogenesis by an rhdecorin-fc fusion protein WO2006038107A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2005800371903A CN101115839B (en) 2004-08-30 2005-07-18 Method of inhibiting fibrogenesis by rhDecorin-Fc fusion protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92915904A 2004-08-30 2004-08-30
US10/929,159 2004-08-30

Publications (2)

Publication Number Publication Date
WO2006038107A2 WO2006038107A2 (en) 2006-04-13
WO2006038107A3 true WO2006038107A3 (en) 2006-08-31

Family

ID=36142914

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/002999 WO2006038107A2 (en) 2004-08-30 2005-07-18 Method for inhibiting fibrogenesis by an rhdecorin-fc fusion protein

Country Status (2)

Country Link
CN (1) CN101115839B (en)
WO (1) WO2006038107A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021000155A (en) 2018-07-03 2021-05-12 Catalent Pharma Solutions Llc Multifunctional protein molecules comprising decorin and use thereof.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072100A2 (en) * 2003-02-07 2004-08-26 The Regents Of The University Of California Nell peptide expression systems and bone formation activity of nell peptide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583103A (en) * 1988-06-28 1996-12-10 La Jolla Cancer Research Foundation Inhibition of transforming growth factor beta activity
CN1216913C (en) * 2002-07-10 2005-08-31 清华大学 Human interleukin-17 receptor sampling molecule fusion protein and coding gene and expression cell line

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072100A2 (en) * 2003-02-07 2004-08-26 The Regents Of The University Of California Nell peptide expression systems and bone formation activity of nell peptide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JONSSON M. ET AL.: "Initiation of the Decorin Glycosaminoglycan Chain in the Endoplasmic Reticulum-Golgi Intermediate Compartment", J. BIOL. CHEM., vol. 278, no. 24, 13 June 2003 (2003-06-13), pages 21415 - 21420 *

Also Published As

Publication number Publication date
CN101115839B (en) 2011-05-04
CN101115839A (en) 2008-01-30
WO2006038107A2 (en) 2006-04-13

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