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WO2006038007A3 - Inhibitory analogues to block receptors for microbial pathogenic determinants - Google Patents

Inhibitory analogues to block receptors for microbial pathogenic determinants Download PDF

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Publication number
WO2006038007A3
WO2006038007A3 PCT/GB2005/003836 GB2005003836W WO2006038007A3 WO 2006038007 A3 WO2006038007 A3 WO 2006038007A3 GB 2005003836 W GB2005003836 W GB 2005003836W WO 2006038007 A3 WO2006038007 A3 WO 2006038007A3
Authority
WO
WIPO (PCT)
Prior art keywords
microbial pathogenic
inhibitory analogues
block receptors
pathogenic determinants
determinants
Prior art date
Application number
PCT/GB2005/003836
Other languages
French (fr)
Other versions
WO2006038007A2 (en
Inventor
Alastair Sutherland
Original Assignee
Univ Glasgow
Alastair Sutherland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Glasgow, Alastair Sutherland filed Critical Univ Glasgow
Publication of WO2006038007A2 publication Critical patent/WO2006038007A2/en
Publication of WO2006038007A3 publication Critical patent/WO2006038007A3/en
Priority to GB0708711A priority Critical patent/GB2434580A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to inhibitory analogues of virulence factors that are capable of blocking receptors for microbial pathogenic determinants that contribute to disease symptoms, in order to reduce the presence of said symptoms. In particular, it relates to inhibitors that are able to act against the toxic effects of Clostridium difficile.
PCT/GB2005/003836 2004-10-05 2005-10-05 Inhibitory analogues to block receptors for microbial pathogenic determinants WO2006038007A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0708711A GB2434580A (en) 2004-10-05 2007-05-04 Inhibitory analogues to block receptors for microbial pathogenic determinants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0422003.4 2004-10-05
GBGB0422003.4A GB0422003D0 (en) 2004-10-05 2004-10-05 Inhibitory analogues to block receptors for microbial pathogenic determinants

Publications (2)

Publication Number Publication Date
WO2006038007A2 WO2006038007A2 (en) 2006-04-13
WO2006038007A3 true WO2006038007A3 (en) 2006-08-17

Family

ID=33428034

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/003836 WO2006038007A2 (en) 2004-10-05 2005-10-05 Inhibitory analogues to block receptors for microbial pathogenic determinants

Country Status (2)

Country Link
GB (2) GB0422003D0 (en)
WO (1) WO2006038007A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998059053A1 (en) * 1997-06-20 1998-12-30 Queen Mary & Westfield College Immonogenic fragments of toxin a of clostridium difficile
WO2000061761A2 (en) * 1999-04-09 2000-10-19 Techlab, Inc. Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
US20030129198A1 (en) * 1999-04-09 2003-07-10 Wilkins Tracy D. Methods to produce high levels of C. difficile toxins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998059053A1 (en) * 1997-06-20 1998-12-30 Queen Mary & Westfield College Immonogenic fragments of toxin a of clostridium difficile
WO2000061761A2 (en) * 1999-04-09 2000-10-19 Techlab, Inc. Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
US20030129198A1 (en) * 1999-04-09 2003-07-10 Wilkins Tracy D. Methods to produce high levels of C. difficile toxins

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CASTAGLIUOLO IGNAZIO ET AL: "A receptor decoy inhibits the enterotoxic effects of Clostridium difficile Toxin A in rat ileum", GASTROENTEROLOGY, vol. 111, no. 2, 1996, pages 433 - 438, XP002383253, ISSN: 0016-5085 *
KINK J A ET AL: "ANTIBODIES TO RECOMBINANT CLOSTRIDIUM DIFFICILE TOXINS A AND B ARE EFFECTIVE TREATMENT AND PREVENT RELAPSE OF C. DIFFICILE-ASSOCIATED DISEASE IN A HAMSTER MODEL OF INFECTION", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 66, no. 5, 1 May 1998 (1998-05-01), pages 2018 - 2025, XP002912254, ISSN: 0019-9567 *
SAUERBORN MARKUS ET AL: "The C-terminal ligand-binding domain of Clostridium difficile toxin A (TcdA) abrogates TcdA-specific binding to cells and prevents mouse lethality", FEMS MICROBIOLOGY LETTERS, vol. 155, no. 1, 1 October 1997 (1997-10-01), pages 45 - 54, XP002383252, ISSN: 0378-1097 *
WARD STEPHEN J ET AL: "Local and systemic neutralizing antibody responses induced by intranasal immunization with the nontoxic binding domain of toxin A from Clostridium difficile", INFECTION AND IMMUNITY, vol. 67, no. 10, October 1999 (1999-10-01), pages 5124 - 5132, XP002383254, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
WO2006038007A2 (en) 2006-04-13
GB2434580A (en) 2007-08-01
GB0708711D0 (en) 2007-06-20
GB0422003D0 (en) 2004-11-03

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