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WO2006037330A1 - Systeme de pompage et procede permettant de commander un ecoulement fluidique dans un systeme de pompage - Google Patents

Systeme de pompage et procede permettant de commander un ecoulement fluidique dans un systeme de pompage Download PDF

Info

Publication number
WO2006037330A1
WO2006037330A1 PCT/DK2005/000634 DK2005000634W WO2006037330A1 WO 2006037330 A1 WO2006037330 A1 WO 2006037330A1 DK 2005000634 W DK2005000634 W DK 2005000634W WO 2006037330 A1 WO2006037330 A1 WO 2006037330A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
valve
flow path
pumping system
fluid reservoir
Prior art date
Application number
PCT/DK2005/000634
Other languages
English (en)
Inventor
Per Brandt Rasmussen
Original Assignee
Danfoss A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danfoss A/S filed Critical Danfoss A/S
Publication of WO2006037330A1 publication Critical patent/WO2006037330A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features
    • A61M2005/1405—Patient controlled analgesia [PCA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags

Definitions

  • the present invention relates to a pumping system for pumping fluid. More particularly, the present invention relates to a pumping system which is capable of providing various flow rates, such as a 'basal flow rate 1 and a 'bolus flow rate' being larger than the 'basal flow rate'.
  • the system of the present invention is particularly suited for being inserted into an infusion system, such as an implantable infusion system, e.g. for providing insulin for diabetes patients. It is also well suited for providing fluid to an analysis probe.
  • an infusion system such as an implantable infusion system, e.g. for providing insulin for diabetes patients. It is also well suited for providing fluid to an analysis probe.
  • EP 0 039 124 A1 discloses an implantable infusion apparatus having a first flow path establishing a fluid connection between a reservoir and a fluid outlet. It further comprises a second flow path having a valve inserted therein and establishing a fluid connection between the reservoir and the fluid outlet when the valve is in an open position.
  • the first flow path provides a steady fluid flow ('basal flow rate') while the second flow path provides an additional fluid flow when needed ('bolus flow rate').
  • a fluid chamber is positioned in fluid connection with the second flow path.
  • Opening and closing of the valve is controlled by an electrical controller which is connected to a switch button which may be manually activated.
  • valve During normal operation the valve is closed. Fluid is pumped from the reservoir to the fluid outlet via the first flow path. Fluid is also pumped via the second flow path from the reservoir to the fluid chamber which is thereby filled. However, the fluid is prevented from reaching the fluid outlet via the second flow path due to the closed valve.
  • the switch button When a bolus infusion is desired, the switch button is activated causing the valve to open.
  • the pressure built up in the fluid chamber in return presses fluid collected in the fluid chamber towards the fluid outlet via the second flow path.
  • the valve closes after a predetermined time.
  • a pumping system comprising:
  • first switching means being adapted to cooperate with the third flow path in controlling the amount of fluid in the first fluid reservoir, thereby controlling the first valve.
  • the above and other objects are fulfilled by providing a method for controlling a fluid flow in a pumping system, the pumping system comprising a fluid inlet, a fluid outlet, a pump, and a flow path having a valve inserted therein and establishing a fluid connection between the pump and the fluid outlet when the valve is in an open position, the method comprising the steps of:
  • the term 'fluid' should be interpreted as either a liquid or a gas. It may be a drug to be delivered to a patient, e.g. insulin to a person suffering from diabetes, in which case the pumping system of the present invention preferably forms part of an infusion apparatus for continuously providing the drug to the patient.
  • the fluid may be a gas or a liquid which needs to be analysed by an analysis probe.
  • the pumping system of the present invention leads the fluid to the analysis probe.
  • the fluid outlet may, thus, be connected to a catheter for insertion into a patient, or it may be connected to an analysis apparatus or probe.
  • the first flow restrictor preferably has the property of providing a specific desired flow rate for each pressure difference between its upstream and downstream sides.
  • a given flow restrictor inserted into the first flow path will ensure a specific corresponding flow rate through the first flow path.
  • This may be achieved by a piece of capillary tube, e.g. made from glass.
  • the first valve may, e.g., be a pinch valve or a valve of the type comprising a diaphragm which closes against a seat.
  • the first valve is in a closed position, and the pumping system will provide fluid to the fluid outlet via the first flow path only.
  • the first switching means is activated causing the first fluid reservoir to be emptied, which in turn causes the first valve to switch to an open position, thereby allowing fluid to pass through the second flow path. This will increase the overall flow rate of the pumping system, thereby providing more fluid to the fluid outlet.
  • the fi rst valve will again be switched to a closed position, thereby again preventing fluid from flowing through the second flow path.
  • the first valve Since the first fluid reservoir is in fluid contact with the pump it will automatically be filled during operation.
  • the first valve is therefore controlled in a self-regulating manner and without the need for external or internal electrical control systems. This is a great advantage because the controlling of the first valve is thereby very simple.
  • the first reservoir is positioned adjacent to the first valve.
  • the first reservoir when the first reservoir is full, it will press onto the first valve which is thereby closed.
  • the first reservoir when the first reservoir is empty, it will not press onto the first valve which will therefore be open. It should be understood that there will normally be a level of fluid in the first reservoir between 'completely full' and 'completely empty', where the position of the first valve will shift from open to closed or vice versa.
  • the second flow path may further have a second flow restrictor with a second flow restriction inserted therein.
  • the second flow restrictor controls the flow rate through the second flow path when the first valve is in an open position.
  • the second flow restriction is preferably smaller than the first flow restriction. In this case the flow rate through the second flow path will be larger than the flow rate through the first flow path when the first valve is in an open position.
  • the overall flow rate of the pumping system will be on a stable, relatively low level during normal operation when the first valve is in a closed position, and will increase to a higher level when the first valve is switched to an open position.
  • the first fluid reservoir may comprise a bellow which is in fluid connection with the third flow path, so that the bellow is being filled with fluid via the third flow path, thereby causing the first valve to be closed, and wherein the bellow is operatively connected to the first switching means in such a way that activation of the first switching means causes the bellow to be emptied, thereby causing the first valve to be opened.
  • the bellow may form part of a bellow arrangement where the bellow is positioned in a chamber containing a compressible fluid. When the bellow is being filled, the compressible fluid is compressed. When the first switching means is subsequently operated in order to allow passage of fluid via the second flow path, the compressed fluid in the chamber will press fluid out of the bellow and into the second flow path, thereby emptying the bellow, and consequently switching the first valve to an open position.
  • the first fluid reservoir may comprise a cylinder and a piston for pressing fluid out of the cylinder, or it may comprise a cavity and a diaphragm for pressing the fluid out of the cavity.
  • the first switching means may be mechanical, such as means for squeezing the reservoir, thereby pressing the fluid out of the reservoir, or a bellow arrangement as described above.
  • the switching means may be electrical, magnetic, or any other suitable kind of switching means.
  • the pump may comprise a container adapted to contain a fluid and means for pressing the fluid out of the container and into the first flow path.
  • the fluid is provided to the container from the fluid inlet.
  • the container may have walls which are made from an elastomeric material, and the pressing means may in this case be adapted to compress the walls of the container in order to press the fluid out of the container.
  • the pressing means may be very simple mechan ical means, or it may be electrical, magnetic or any other suitable kind of means.
  • the pump may comprise a compressible bellow positioned within the container, in which case the pressing means may be adapted to compress the bellow in order to press the fluid out of the container.
  • This may be a bellow arrangement as the one described above.
  • the pressing means may comprise a spring for compressing the container walls or the bellow.
  • the pump may be any other suitable kind of pump, such as a pump comprising a compressed fluid for providing the drive pressure.
  • the third flow path may comprise a third flow restrictor having a third flow restriction.
  • the third flow restrictor may control the amount of time used for filling the first fluid reservoir.
  • the third flow restriction should be chosen relatively to the first flow restriction, and optionally the second flow restriction, in such a way that fluid will be led to the first fluid reservoir when the first valve is in an open position. Thereby it is ensured that the first fluid reservoir is refilled, thereby ensuring that the first valve is switched to a closed position after a certain time has elapsed.
  • the third flow path may comprise a check valve for allowing fluid from the first fluid reservoir to enter the first flow path via the third flow path.
  • the check valve prevents fluid from flowing in the opposite direction.
  • the check valve is positioned in parallel to a third flow restrictor. In this case fluid will flow from the pump via the third flow restrictor and the third flow path to the first fluid reservoir while filling the first fluid reservoir.
  • the fluid from the first fluid reservoir will pass through the check valve rather than through the third flow restrictor, since the flow restriction in the third flow restrictor will typically be substantially larger than in the check valve. Thereby the first fluid reservoir is emptied much faster than it is filled.
  • the pumping system may further comprise one or more additional flow paths being adapted to provide a flush function to the pumping system.
  • the first flow restriction is so large that it will take a relatively long time to obtain a full throughput through the first flow path. In such cases it may be advantageous to provide a quick flush function in order to obtain a full throughput shortly after the pumping system has been turned on.
  • a fourth flow path having a second valve inserted therein, said fourth flow path establishing a fluid connection between the pump and the fluid outlet when the second valve is in an open position, - a fifth flow path establishing a fluid connection between the pump and a second fluid reservoir, said second fluid reservoir causing the second valve to be in a closed position when the second fluid reservoir is full and in an open position when the second fluid reservoir is empty, and
  • - second switching means being adapted to cooperate with the fifth flow path in controlling the amount of fluid in the second fluid reservoir, thereby controlling the second valve.
  • the additional flow paths may constitute a system which is more or less identical to the system providing the bolus function, except for the chosen flow restrictors.
  • the remarks set forth above are equally applicable here.
  • the pumping system may further comprise means for preventing opening of the first valve during a predetermined time interval following a previous opening of the first valve.
  • means for preventing opening of the first valve during a predetermined time interval following a previous opening of the first valve In some cases it is desirable to be able to prevent that bolus flows are provided at too close time intervals.
  • the pumping system forms part of an infusion system for delivering insulin to a diabetes patient, the patient needs a steady dose of insulin constantly, and on top of that a bolus dose around a meal time. The patient may, therefore, manually activate the switching means in connection with the consumption of a meal. However, if the patient accidentally activates the switching means twice within a short time interval, e.g.
  • the preventing means may comprise
  • the third valve when the third valve is in a closed position, it is not possible to empty the first fluid reservoir, because the fluid contained therein is prevented from flowing via the third flow path into the first flow path. As long as the first fluid reservoir can not be emptied, the first valve will remain in a closed position, thereby preventing a bolus dose from being delivered to the fluid outlet. Thus, the third valve should be controlled to be in a closed position for a suitable time following the delivery of a bolus dose. As soon as it is again considered suitable or safe to deliver a new bolus dose, the third valve can be switched to an open position, thereby allowing the first fluid reservoir to be emptied upon activation of the first switching means.
  • the means for controlling the third valve may comprise a third fluid reservoir which is in fluid connection with the first fluid reservoir, the third fluid reservoir thereby receiving fluid when the first fluid reservoir is emptied.
  • the third fluid reservoir is adapted to cause the third valve to be in a closed position when the third fluid reservoir is full and in an open position when the third fluid reservoir is empty.
  • the third valve is automatically switched to a closed position when the first fluid reservoir is emptied.
  • the pumping system of the present invention may advantageously form part of an infusion system, preferably an implantable infusion system. Alternatively, it may form part of an analysis system.
  • Fig. 1 shows a pumping system with a bolus function
  • Fig. 2 shows a pumping system with a bolus function and a flush function
  • Fig. 3 shows a pumping system with a bolus function, a flush function and a preventing function.
  • Fig. 1 shows a pumping system according to the present invention.
  • the pumping system comprises a fluid inlet 1 , a fluid outlet 2, and a pump 3.
  • the pump 3 comprises compressible walls 4 made from an elastomeric material and defining a container 5 adapted to contain a fluid to be pumped by the pumping system.
  • a first flow path 6 connects the pump 3 and the fluid outlet 2 via a first flow restrictor 7.
  • the pumping system further comprises a second flow path 8 having a second flow restrictor 9 and a first valve 10 inserted therein. When the first valve 10 is in an open position, the second flow path 8 establishes a fluid connection between the pump 3 and the fluid outlet 2.
  • the second flow path 8 is positioned in parallel to the part of the first flow path 6 having the first flow restrictor 7 inserted therein. If the flow restriction of the second flow restrictor 9 is smaller than the flow restriction of the first flow restrictor 7, a fluid will prefer the second flow path 8 to the first flow path 6 when the first valve 10 is on an open position, and the resulting fluid flow to the fluid outlet 2 will accordingly increase when the first valve 10 is opened.
  • the first valve 10 is operated by means of a third flow path 11 having a first fluid reservoir 12 inserted therein.
  • the first fluid reservoir 12 is positioned adjacent to the first valve 10. Thus, when the first fluid reservoir 12 is full it presses against the first valve 10, thereby closing it. On the other hand, when the first fluid reservoir 12 is empty, it does not press against the first valve 10, which is consequently open.
  • the third flow path 11 further has a third flow restrictor 13 and a first check valve 14 positioned in parallel to each other, and each connecting the third flow path 11 to the first flow path 6.
  • fluid may enter the third flow path 11 via the third flow restrictor 13, and it may leave the third flow path
  • the pumping system of Fig. 1 is preferably operated in the following manner.
  • first fluid reservoir 12 is full and the first valve 10 is in a closed position. Consequently, fluid is pumped from the pump 3 to the fluid outlet 2 via the first flow path 6.
  • a first switching means 15 is activated which causes the first fluid reservoir
  • Fig. 2 shows a pumping system like the one shown in Fig. 1 , and the corresponding parts have been provided with the same reference numerals.
  • the pumping system of Fig. 2 is further provided with a flush function for quickly flushing the system.
  • the flush function is provided by a system of flow paths which is identical to the system of flow paths shown in Fig. 1 and providing the bolus function.
  • the pumping system of Fig. 2 further comprises a fourth flow path 16 having a second valve 17 and a fourth flow restrictor 18 inserted therein.
  • the fourth flow path 16 establishes a fluid connection between the pump 3 and the fluid outlet 2.
  • the pumping system of Fig. 2 also comprises a fifth flow path 19 having a second fluid reservoir 20 inserted therein.
  • the fifth flow path 19 also has a fifth flow restrictor 21 and a second check valve 22 positioned in parallel to each other, and each establishing a fluid connection between the first flow path 6 and the fifth flow path 21.
  • the pumping system comprises a second switching means 23 adapted to cause the second fluid reservoir 20 to be emptied upon activation.
  • the fifth flow path 19, the second fluid reservoir 20 and the second switching means 23 cooperate in operating the second valve 17 in the same way as the third flow path 11 , the first fluid reservoir 12 and the first switching means 15 cooperate in operating the first valve 10.
  • the flush function of the pumping system of Fig. 2 is preferably operated in the following manner.
  • the second fluid reservoir 20 is full and the second valve 20 is in a closed position, thereby preventing fluid from reaching the fluid outlet 2 via the fourth flow path 19.
  • the second switching means 23 is activated. This has the effect that the second fluid reservoir 20 is emptied, thereby causing the second valve 17 to be switched to an open position.
  • the fluid from the second fluid reservoir 20 enters the first flow path 6 via the fifth flow path 19 and the second check valve 22.
  • fluid is allowed to reach the fluid outlet 2 via the fourth flow path 16 as well as via the first flow path 6, thereby increasing the total fluid flow to the fluid outlet 2.
  • a flush function will typically be desirable during a start-up process where it is advantageous that the possible tubing of the system is filled with the liquid relatively fast. This is particularly useful when the pumping system forms part of an infusion apparatus for delivering a drug to a patient.
  • flow restrictors 7, 18 By choosing flow restrictors 7, 18 with a right flow restriction it is possible to provide a quick flush of the system.
  • the fluid will prefer to go towards the fluid outlet 2 via the fourth flow path 16 rather than via the first flow path 6 when the second valve 17 is in an open position.
  • the fluid flow to fluid outlet 2 is relatively large if only the flow restriction of the fourth flow restrictor 18 is chosen to be sufficiently low. Thereby the pumping system is flushed when the second valve 17 is switched to an open position.
  • Fig. 3 shows a pumping system like the one shown in Fig. 2, and corresponding parts have been provided with the same reference numerals.
  • the pumping system of Fig. 3 further comprises a preventing function for preventing that a bolus dose is delivered within a specific time interval following a previous bolus dose.
  • the preventing function is provided by a system of flow paths inserted in connection with the third flow path 11.
  • the pumping system of Fig. 3 further comprises a third valve 24 inserted in the third flow path 11 in series with the first check valve 14 and in parallel with the third flow restrictor 13.
  • the third valve 24 When the third valve 24 is in an open position, fluid is allowed to flow from the first fluid reservoir 12, via the third flow path 11 , the third valve 24 and the second check valve 14 and into the first flow path 6.
  • the third valve 24 is in a closed position, such a flow is prevented. Therefore, the first fluid reservoir 15 can not be emptied when the third valve 24 is in a closed position, and it is therefore not possible to open the first valve 10 and provide a bolus dose as long as the third valve 24 is in a closed position.
  • the third valve 24 is controlled by means of a fluid chamber 25 positioned adjacent to the third valve 24.
  • the fluid chamber 25 is of a kind which will attempt to push any fluid which is in the fluid chamber 25 out of the fluid chamber 25.
  • the fluid chamber 25 acts on the third valve 24 in such a way that when the fluid chamber 25 is full it causes the third valve 24 to be in a closed position, and when the fluid chamber 25 is empty it causes the third valve 24 to be in an open position.
  • the fluid chamber 25 is in fluid connection with the third flow path 11 via a sixth flow restrictor 26 and a third check valve 27 arranged in parallel to each other.
  • the third check valve 27 allows fluid to pass from the fluid chamber 25 to the third flow path 11, while fluid passing from the third flow path 11 to the fluid chamber 25 must pass via the sixth flow restrictor 26.
  • the preventing function of Fig. 3 is preferably operated in the following manner.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un système de pompage permettant de fournir un débit régulier ainsi qu'un débit de bolus, le cas échéant. Une fonction bolus est commandée de manière simple et autorégulatrice. Un réservoir de fluide en contact fluidique avec une pompe entraîne la fermeture d'une vanne dans un chemin d'écoulement de bolus lorsque ledit réservoir est plein et son ouverture lorsqu'il est vide. La fonction de bolus est activée par vidage du réservoir, et la durée d'ouverture de la vanne est commandée par l'écoulement fluidique vers le réservoir. Le système de pompage peut également comprendre une fonction d'évacuation, et une fonction de prévention empêchant l'activation de la fonction bolus pendant un intervalle de temps spécifique suite à une activation antérieure. Ledit système de pompage comprend enfin une vanne empêchant le réservoir de se vider pendant l'intervalle de temps spécifique.
PCT/DK2005/000634 2004-10-08 2005-10-04 Systeme de pompage et procede permettant de commander un ecoulement fluidique dans un systeme de pompage WO2006037330A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200401542 2004-10-08
DKPA200401542 2004-10-08

Publications (1)

Publication Number Publication Date
WO2006037330A1 true WO2006037330A1 (fr) 2006-04-13

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PCT/DK2005/000634 WO2006037330A1 (fr) 2004-10-08 2005-10-04 Systeme de pompage et procede permettant de commander un ecoulement fluidique dans un systeme de pompage

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3351278A1 (fr) * 2017-01-24 2018-07-25 Epic Medical Pte Ltd Appareil de commande de fluides

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3738430A (en) * 1969-08-11 1973-06-12 Factory Mutual Res Corp System and method of fluid flow control utilizing a dynamic shutoff valve
EP0039124A1 (fr) * 1980-03-07 1981-11-04 Infusaid Corporation Appareil de perfusion implantable
US6283944B1 (en) * 1998-04-30 2001-09-04 Medtronic, Inc. Infusion systems with patient-controlled dosage features
WO2003068294A2 (fr) * 2002-02-18 2003-08-21 Danfoss A/S Dispositif d'administration d'un medicament sous forme fluide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3738430A (en) * 1969-08-11 1973-06-12 Factory Mutual Res Corp System and method of fluid flow control utilizing a dynamic shutoff valve
EP0039124A1 (fr) * 1980-03-07 1981-11-04 Infusaid Corporation Appareil de perfusion implantable
US6283944B1 (en) * 1998-04-30 2001-09-04 Medtronic, Inc. Infusion systems with patient-controlled dosage features
WO2003068294A2 (fr) * 2002-02-18 2003-08-21 Danfoss A/S Dispositif d'administration d'un medicament sous forme fluide

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3351278A1 (fr) * 2017-01-24 2018-07-25 Epic Medical Pte Ltd Appareil de commande de fluides

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