WO2006035622A1

WO2006035622A1 - In vivo nerve nutrition factor producing method using alternating high potential and in vivo nerve nutrition factor producing device

Info

Publication number: WO2006035622A1
Application number: PCT/JP2005/017177
Authority: WO
Inventors: Hiroji Yanamoto
Original assignee: Japan Health Sciences Foundation
Priority date: 2004-09-28
Filing date: 2005-09-16
Publication date: 2006-04-06
Also published as: JPWO2006035622A1

Abstract

[PROBLEMS] To provide an in vivo nerve nutrition factor producing method and device using an alternating high potential for accelerating the growth of an immature individual, enhancing the viability of organs, or repairing/enhancing the brain function by producing/increasing growth/nutrition factors within the organism. The production/increase of growth/nutrition factors in an organism can be means for hardly causing organ damage due to an ischemic disease such as cardiac or brain infarction and repairing/enhancing the brain function which is normal or has degraded because of a disease or an injury. [MEANS FOR SOLVING PROBLEMS] An in vivo nerve nutrition factor producing device comprising high-voltage generating means for generating an alternating constant or varying high voltage of an extremely low current from an input power supply and electrifying means for applying the generated high voltage to an organism, characterized in that by applying the generated alternating constant or varying high voltage to the organism by the electrifying means, growth/nutrition factors in the organism are produced/increased.

Description

Specification

In vivo neurotrophic factor production method and in vivo neurotrophic factor production apparatus using alternating high potential

Technical field

The present invention relates to an in vivo neurotrophic factor production method and in vivo neurotrophic factor production apparatus using an alternating high potential. More specifically, the present invention relates to a technique for increasing a neurotrophic factor in a living body by placing the living body in an alternating high electric field and applying a potential stimulus to the living body.

An object of the present invention is to increase neurotrophic factors in vivo. As a result, the viability of central nerves and peripheral nerve cells is enhanced, so that they are protected from cerebral ischemic diseases such as cerebral infarction, neurodegenerative diseases and nerve injury caused by cerebrospinal injury. In addition, the growth of neuronal neurites promotes nerve plasticity and improves cranial nerve functions such as memory. Alternatively, it is possible to improve the decrease in the existing cranial nerve function. That is, an object is to provide an in vivo neurotrophic factor production method and in vivo neurotrophic factor production device using an alternating high potential having these beneficial effects.

Background art

[0002] With a load of AC constant high voltage potential (high potential), the so-called electric field (potential) treatment is to generate an AC constant high electric field and place (contact) the body of the person receiving treatment in the electric field. In the meantime, it is a treatment method that expects therapeutic effects on headache, stiff shoulders, insomnia, chronic constipation, etc. by changing the potential in the body. As an electric field treatment apparatus used for electric field treatment, for example, those described in Patent Documents 1 to 4 are known.

In addition, it has been pointed out that electric field treatment may suppress the progression of hypertension associated with chronic renal failure in rats (see Non-Patent Document 1).

[0003] For neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, spinocerebellar degeneration, muscle atrophy, which is resistant to various drug treatments and often lacks a fundamental treatment Such as lateral sclerosis. In addition, cerebrospinal injury is a pathological condition that shows various neurological dysfunction symptoms due to direct damage to nerves caused by trauma, degenerative diseases, etc., or damage to the nerve transmission pathway. For these symptoms It may be effective to enhance neurotrophic factors that enhance the viability of the vesicles themselves and restore lost neural networks by promoting neurite growth.

Ischemia refers to a state in which the blood supply has been reduced for some reason or a state in which the blood supply has been interrupted, and the blood flow is interrupted, and various injuries appear depending on the time or range. Examples of ischemic diseases include angina pectoris and myocardial infarction that develop when the blood supply to the myocardium decreases, and cerebral infarction that develops when the blood vessels of the brain become obstructed for some reason.

Effective means for protecting heart and brain organs from ischemic diseases such as myocardial infarction or cerebral infarction include the treatment of hypertension, diabetes, hyperlipidemia, fattening, heart disease, etc. that exist as risk factors, or Improvement is important. However, there is no means to effectively protect the body from ischemic disease other than improvement of lifestyle habits and medical treatment of risk factors. Even now, many cases suffer from brain injury or heart injury due to ischemic disease, and many patients suffer from sequelae or die.

On the other hand, a neurotrophic factor is a type of growth 'trophic factor that promotes the maturation of neurons and the extension of neurites at the stage of individual growth and development, and synapses between the central nerves or between the central and peripheral nerves. It is an in vivo molecule that contributes to the formation or formation of the neural network between the cranial nerve 'peripheral nerve and various innervating organs. In the process of neuronal development and differentiation, if there is no neurotrophic factor, the neuron will undergo apoptosis and die, so the presence of the neurotrophic factor in the neurodevelopment stage will help maintain the survival of the neuron. It is important. It is also known that when this factor increases after the end of growth and development, the viability of neurons increases, and it has the effect of protecting neurons from various stresses and diseases.

[0004] By supplying the brain with a drug that can stimulate the growth of nerve cells such as this neurotrophic factor, it is not possible to treat neurodegenerative diseases and repair damaged brain cells. For example, Patent Document 5 describes a pharmaceutical composition containing 1,5-di (pyridine_4_yl) -penta-1,4-gen-1-one and a neurotrophic factor. It has been.

[0005] In order to protect the brain from harmful substances, the blood vessels in the brain and spinal cord cannot pass freely. In addition, there is a mechanism called the blood-brain barrier that allows only selectively incorporated substances to enter the brain. Therefore, a pharmaceutical composition as described in Patent Document 1 administered in vivo cannot reach the brain unless it passes through the blood-brain barrier, and cannot exhibit the growth action of nerve cells. There wasn't.

[0006] One of the neurotrophic factors existing in the brain is brain-derived neurotrophic factor (BDNF).

This factor is thought to contribute to synaptic plasticity by promoting the differentiation of endogenous neural stem cells into neurons and the growth of neurites of immature or mature neurons. It is also known that increasing this factor increases the viability of immature or mature neurons. When this factor is abnormally reduced in the brain, in young neurons, impaired differentiation into neurons, and in mature neurons, neuronal regression and decrease in neurites and synapses, and the resulting neuronal function This can cause a decline in memory and cause depression.

[0007] Patent Document 1: Japanese Patent Laid-Open No. 58-146361

Patent Document 2: JP-A-7-284535

Patent Document 3: Japanese Patent Laid-Open No. 2000-42123

Patent Document 4: Japanese Unexamined Patent Publication No. 2003-126270

Patent Document 5: Special Table 2001—504470

Non-patent document 1: Naoki Miura and 7 others, “Antihypertensive effect of hypertension model animals (Dahl _S rats) under alternating high voltage potential”, Journal of the Japan Veterinary Medical Association, 54, _P 472-475, 2001

Disclosure of the invention

Problems to be solved by the invention

[0008] If it becomes possible to increase the neurotrophic factor safely in vivo, the viability inherent in the central or peripheral nerve cells will increase, and nerve damage such as ischemic disease and physical injury will be prevented. It can protect your nerves from various stresses that may come. Furthermore, in relation to the neurite outgrowth promoting effect, it becomes possible to improve brain or nerve functions such as repair of already lost nerve function and memory ability.

That is, healthy people and patients with risk factors for ischemic disease, Patients suffering from blood disorders or trauma and having neurological dysfunction, patients who are addicted to these diseases and who may relapse, patients who have dysfunction in the central or peripheral nervous system due to various causes, and memory Development of in vivo neurotrophic factor production and production methods that can be used on a daily basis for patients with dementia with reduced brain function such as improving the survival of nerve cells and improving nerve function. It was desired.

The present inventor has conducted intensive research on a method for increasing neurotrophic factors in vivo in a reliable and safe manner, and that an AC high potential load that causes a systemic potential change including the brain is in vivo neurotrophic. It has been found that it has a factor-increasing action, and the present invention has been completed.

Means for solving the problem

[0009] The invention according to claim 1 is an in vivo neurotrophic factor production method characterized in that a constant or fluctuating high voltage of alternating current is applied to a living body to produce and increase production of a growth / nutrient factor in the living body. About.

The invention according to claim 2 is a high voltage generation means for generating a constant or variable high voltage of an alternating current with an extremely low current from an input power supply, and a high voltage generated by the high voltage generation means for applying to the organism. And an energizing means, wherein a constant or variable high voltage of alternating current generated by the high voltage generating means is applied to the living body by the energizing means to produce and increase production of growth / nutrient factors in the living body. The present invention relates to an in vivo neurotrophic factor producing device.

The invention according to claim 3 relates to the in vivo neurotrophic factor production device according to claim 2, wherein the AC high voltage generated by the high voltage generation means is 1000 to 30000 V .

The invention according to claim 4 is characterized in that the AC high voltage generated by the high voltage generating means is constant or fluctuates within a range of 500 to 50000 V. The in vivo nerve according to claim 2 It is related with a trophic factor production device.

[0010] The invention according to claim 5 relates to a method for improving cranial nerve function, wherein a constant or variable high voltage of alternating current is applied to a living body to improve cranial nerve functions such as memory ability. The invention according to claim 6 is an AC constant or variable high voltage with an extremely low current from the input power supply. A high voltage generation means for generating a high voltage generated by the high voltage generation means, and an energization means for applying the high voltage generated by the high voltage generation means to the living body. The present invention relates to a cranial nerve function improving apparatus characterized in that a voltage is applied to a living body by the energizing means to improve cranial nerve functions such as memory ability. The invention according to claim 7 relates to the device for improving cranial nerve function according to claim 6, wherein the AC high voltage generated by the high voltage generating means is 1000 to 30000V.

The invention according to claim 8 is the improvement of cranial nerve function according to claim 6, wherein the alternating high voltage generated by the high voltage generating means varies in a constant or within a range of 500 to 50000V. Relates to the device.

[0011] The invention according to claim 9 relates to a method for preventing ischemic injury, characterized in that a constant or variable high voltage of alternating current is applied to a living body to grow and produce 'nutrient factors' in the living body. .

The invention according to claim 10 is a high voltage generating means for generating an AC constant or variable high voltage with an extremely low current from an input power supply, and a high voltage generated by the high voltage generating means for applying to the organism. An energizing means, and applying a constant or fluctuating high voltage of alternating current generated by the high voltage generating means to the living body by the energizing means to produce 'in-vivo growth' produce nutrient factor and increase production. The present invention relates to a device for preventing ischemic injury.

The invention according to claim 11 relates to the apparatus for preventing ischemic injury according to claim 10, wherein the AC high voltage generated by the high voltage generating means is from 1,000 to 30,000 V.

The invention according to claim 12 is the ischemic injury according to claim 10, characterized in that the alternating high voltage generated by the high voltage generating means is constant or fluctuates within a range of 500 to 50000V. It relates to a preventive device.

The invention's effect

[0012] According to the in vivo neurotrophic factor production method and in vivo neurotrophic factor production device according to the present invention, an AC constant high voltage potential (AC constant high electric field) or AC fluctuation high piezoelectricity is applied to a living body. By applying a position (AC fluctuation high electric field), it is possible to promote the production of neurotrophic factors in vivo. As a result, the resistance to various diseases and injuries of the nervous system that are healthy or have a reduced function can be enhanced or recovered. Furthermore, it is possible to improve brain function and nerve function such as memory ability that is normal or deteriorated.

The in vivo neurotrophic factor production method and in vivo neurotrophic factor production apparatus according to the present invention can be applied to young and old men and women, animals and plants.

[0013] According to the cranial nerve function improving method and the cranial nerve function improving apparatus according to the present invention, the living body is charged with a constant AC high voltage potential (AC constant high electric field) or an AC variable high voltage potential (AC variable high electric field). Production of neurotrophic factor in vivo can be promoted. Thereby, cranial nerve functions such as memory ability can be improved.

The method for improving cranial nerve function and the device for improving cranial nerve function according to the present invention can be applied to young and old men and women and animals and plants.

According to the method for preventing ischemic injury and the apparatus for preventing ischemic injury according to the present invention, an AC constant high voltage potential (AC constant high electric field) or an AC variable high voltage potential (AC variable high electric field) is applied to the living body. Can promote the production of neurotrophic factors in vivo. As a result, the viability of the central nerve 'peripheral nerve cells is increased, and cerebral ischemic diseases such as cerebral infarction, neurodegenerative diseases and cerebrospinal cord injury can be prevented.

The apparatus for preventing ischemic injury according to the present invention can be applied to young men and women, animals and plants.

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the in vivo neurotrophic factor production method and in vivo neurotrophic factor production apparatus according to the present invention will be described in detail.

The method for producing in vivo neurotrophic factor according to the present invention is the production of in vivo neurotrophic factor by placing the living body in AC constant high voltage electric field (AC constant high potential) or AC variable high voltage electric field (AC variable high potential). It has the effect | action which promotes.

[0016] When the local DC potential in the living body is changed to a certain level or more, cell depolarization occurs. In the brain, a transient reversible depolarizing wave with a specific speed of about 2 to 5 mm / min is focused around the depolarization that occurs locally, like a ripple in the surroundings. Fragment It is known that a phenomenon that propagates through the entire lateral brain occurs. This phenomenon is called propagating depression or spreading depression. This phenomenon does not appear in the normal state of the mature brain, but is known to occur when an epileptic seizure, cerebral infarction, or a temperature stimulus or physical stimulus that damages the brain is applied. Although spread suppression appears with any characteristic pathological condition, spread suppression itself is harmless to the normal brain.

[0017] It is known that spreading suppression, which is a reversible transient cell depolarization phenomenon, increases brain-derived neurotrophic factor, which is a kind of neurotrophic factor, in the brain. This increase in brain-derived neurotrophic factor induces resistance to ischemic stress (ischemic resistance, cerebral infarction resistance). In other words, it is known that electrical potential stimulation by spreading suppression increases the neurotrophic factor in the brain, and has the effect of increasing the viability of the brain.

However, the present inventor has hitherto known known stimuli that have the effect of causing known spread suppression, i.e., epileptogenic stimulation, cerebral ischemic stimulation, or depolarization action. We found that constant or fluctuating alternating high-potential loading increases in vivo neurotrophic factors without using chemical stimuli such as bringing a chemical into contact with the brain.

[0018] The load potential (electric field) level and the fluctuation potential width (electric field fluctuation width) of the AC constant or variable high voltage potential load applied to the living body are not particularly limited. ', 1000 to 10000V, preferably 3000 to 20000V can be displayed. The applied potential level may be constant during the period of loading on the living body, but may vary regularly or irregularly. In the case of AC fluctuation potential, the potential level fluctuation cycle and the potential level fluctuation range are not particularly limited. For the fluctuation period, 1 to 20 times per minute, for example, 500 V to 50000 V for the fluctuation range. Can do. Further, the AC frequency used is not particularly limited, and 50-60 hertz can be exemplified.

[0019] In order to increase the neurotrophic factor in the living body, it is desirable to continuously apply a constant AC voltage or a variable high potential (hereinafter simply referred to as a high potential) load for a certain period. The period during which the high potential load is applied is not particularly limited, but one to several high potential loads per day is given for a total of 5 minutes to 8 hours per day, and this is continuously performed for at least one week to two months. High potential, preferably every day or every other day, for a certain period of time It is desirable to cover the load.

[0020] The body part to which the high potential load is applied is not particularly limited. Usually, when a part of the body is in contact with a high electric field, a systemic load is instantaneously applied.

Next, the in vivo neurotrophic factor production device according to the present invention will be described with reference to the drawings.

FIG. 1 is a block diagram showing an outline of an in vivo neurotrophic factor production apparatus (hereinafter sometimes simply referred to as production apparatus) according to the present invention.

[0022] The production apparatus (1) according to the present invention uses the potential generation means (11) and the energization means (17).

The production device (1) is equipped with a high voltage generation circuit (14) that can generate an alternating current with a very low current or a variable high voltage by supplying power from the power supply unit (16). The The energizing means (17) is provided to apply an extremely low current AC constant or variable high voltage generated by the high voltage generating circuit (14) to the living body.

[0023] The power supply unit (16) is provided to supply necessary power to the production apparatus (1). For example, an alkaline ion battery, a lithium ion battery, a 100V AC power supply, a 200V AC power supply, a noku A battery is used.

When a DC power source is used as the power source unit (16), the production device (1) is provided with a conversion unit (not shown) that converts the DC power source into an AC power source.

[0024] The production device (1) is provided with a high voltage generation circuit (14), which can generate a high AC voltage.

The high voltage generation circuit (14) is a constant AC high voltage generation circuit used in a conventional potential therapy device, or an AC fluctuation high voltage generation circuit, specifically, a constant AC voltage of about 1000 to 100000V. Any device that can generate a high voltage or that has a variable function that can change the high voltage regularly or irregularly in the range of 500 to 50,000 V can be used without particular limitation. be able to.

For example, it is possible to illustrate a high voltage generation circuit that can generate a high voltage using a transformer.

[0025] The potential generating means (11) includes a control unit (12) and an operation unit (15).

The control unit (12) is composed of a CPU and the like, and input information from the operation unit (15) is preliminarily determined. The production means (1) is controlled correctly by controlling the ON / OFF switching unit (13), which controls the supply of power from the power supply unit (16), the high voltage generation circuit (14), etc. Control each part so that it always functions.

[0026] The operation unit (15) is provided with various switches and the like, and can perform various operations of the production apparatus (1).

For example, the operation unit (15) is provided with a power switch, a treatment time selection switch for selecting a treatment time, a selection switch for selecting a potential and a fluctuation range, and the like.

The treatment time selection switch selects the treatment time. For example, when the set treatment time elapses, the control unit (12) controls the ON / OFF switching unit (13) to turn off the power. To do.

The selection switch can set the potential applied to the energizing means (17) to an arbitrary value, for example, a constant potential at 1000V, 3000V, 5000V, 10000V, or a regular or irregularly varying potential.

The energization means (17) is provided for applying a high voltage generated by the high voltage generation circuit (14) to the living body. When a high voltage is applied to the living body, the energizing means (17) is insulated from the ground.

As the energizing means (17), an electrode capable of applying a high voltage generated by the high voltage generating circuit (14) to the living body can be exemplified.

[0028] The production device (1) according to the present invention can be applied not only to humans but also to any animals and plants, and particularly preferably to mammals such as sushi, pigs, hidges, horses, sheep and monkeys. be able to.

[0029] Next, a method of using the production apparatus (1) according to the present invention will be described with reference to the drawings. 2 and 3 are diagrams showing the usage state of the in vivo neurotrophic factor production method according to the present invention.

In order to use the production apparatus (1) according to the present invention, a living body (animal or plant or user) is in contact with the current-carrying means (17) insulated from the ground and is located in a constant or variable high-voltage electric field. By doing so, it is possible to produce neurotrophic factors in vivo by the action of these high-voltage electric fields-i: production. [0030] As the posture of the user (M) when using the production apparatus (1), for example, a lying posture as shown in FIG. 2 and a posture sitting on a chair as shown in FIG. 3 are exemplified. be able to. When the user (M) as shown in Fig. 2 lies down, first lay an insulating mat (20) on the floor (Y) to insulate the energizing means (17) from the ground, and then energize it. Lay down means (17). The user (M) lies down in contact with the energizing means (17). The potential generating means (11) is connected to the energizing means (17), and the user (M) can be placed in a constant high-voltage or variable high-voltage electric field by operating the preventive device by the operation unit.

[0031] In order to use the production apparatus (1) with the user (M) sitting on a chair as shown in Fig. 3, an insulating mat (20) for insulating the energizing means (17) from the ground is used. Lay the chair (C) on it. The energization means (17) may be arranged at a position in contact with the user (M). For example, the energizing means (17) may be arranged on the seat surface of the chair as shown in FIG. In addition, it may be placed on the back of the chair.

The energizing means (17) is connected to the production device (1), and the user (M) can be placed in the high-voltage electric field by operating the potential generating means.

[0032] The production method according to the present invention can increase neurotrophic factors in vivo. Therefore, the production method according to the present invention increases the neurotrophic factor in the living body, and as a result, the viability of the central nerve 'peripheral nerve cells can be increased. Therefore, the cerebral ischemic disease such as cerebral infarction, It can be used as a preventive method against neurodegenerative diseases and nerve injury caused by cerebrospinal injury. That is, the method for preventing ischemic injury according to the present invention can be configured in the same manner as the in vivo neurotrophic factor production method described above.

Further, the production increase method according to the present invention increases neurotrophic factors in the living body, and as a result, the growth of neuronal neurites is promoted, so that the nerve plasticity increases and the cranial nerve function improves the cranial nerve functions such as memory ability. It can be used as an improvement method. That is, the method for improving cranial nerve function according to the present invention can be configured in the same manner as the above-described in vivo neurotrophic factor production method.

Furthermore, the method for increasing production according to the present invention increases the neurotrophic factor in the living body and, as a result, can promote the growth of new nerves, and therefore can be used as a method for promoting new nerve growth. That is, the method for promoting the growth of new nerves is the above-mentioned in vivo neurotrophic factor production. It can be configured in the same way as the raw method.

[0033] The production device according to the present invention can increase neurotrophic factors in a living body. Therefore, the production apparatus according to the present invention increases the neurotrophic factor in the living body, and as a result, the viability of the central nerve 'peripheral nerve cell can be enhanced, so that the cerebral ischemic disease such as cerebral infarction

It can be used as a preventive device for neurodegenerative diseases and nerve injury caused by cerebrospinal injury. That is, the ischemic injury preventing apparatus according to the present invention can be configured in the same manner as the in vivo neurotrophic factor producing apparatus described above.

In addition, the production apparatus according to the present invention increases neurotrophic factors in the living body, and as a result, the growth of neuronal neurites is promoted, so that the nerve plasticity is increased and the cranial nerve function is improved to improve the cranial nerve functions such as memory ability. It can be used as an improvement device. That is, the cranial nerve function improving apparatus according to the present invention can be configured in the same manner as the in vivo neurotrophic factor producing apparatus described above.

Furthermore, since the production apparatus according to the present invention increases the neurotrophic factor in the living body and, as a result, can promote the growth of new nerves, it can be used as a new nerve growth promotion apparatus. That is, the new nerve growth promoting device can be configured in the same manner as the in vivo neurotrophic factor producing device described above.

Example

Hereinafter, the present invention will be described based on examples, but the present invention is not limited to these examples.

[0035] [Example 1]

C57BL / 6J male mice aged 8-9 weeks are subjected to various alternating constant or variable high potential loads once a day for 5 hours by the in vivo neurotrophic factor producing device according to the present invention: for 3 weeks I was loaded every day. The brain was removed under general anesthesia, and the brain content of brain-derived neurotrophic factor, a kind of neurotrophic factor, was measured. The results are shown in Fig. 4.

As shown in the results in Fig. 4, the brain-derived neurotrophic factor content in the group with constant AC or variable high-potential load increased significantly in the brain compared with the untreated group. It was.

[Example 2] A local cerebral ischemic load was applied to a mouse loaded with a constant alternating or variable high potential load under the conditions shown in Example 1, and then the cerebral infarct volume produced was measured. The results are shown in FIG. 5. As shown in FIG. 5, cerebral infarction was significantly reduced in the group subjected to high potential load compared to the untreated group.

[0037] [Example 3]

Evaluation of spatial cognition / memory was performed on mice loaded with constant AC or variable high potential load under the conditions shown in Example 1 using a water maze test. That is, the mouse was released into the water tank, and the time required to find the scaffold in the water tank was measured. The experiment was conducted every day for 5 days. The result is shown in FIG.

As shown in Fig. 6, a significant increase in memory was confirmed in the group with high potential load compared to the untreated group.

Industrial applicability

[0038] The in vivo neurotrophic factor production method and production apparatus according to the present invention can produce and increase neurotrophic factor in vivo, and can enhance or restore neural function by acting on neurites. . In addition, by increasing the viability of nerve cells, it is difficult to cause ischemic injury such as cerebral infarction or other cerebral nerve 'peripheral nerve injury' damage. It can be repaired and brain functions such as memory can be improved. Therefore, the in vivo neurotrophic factor production method having these actions can be used for various animals including humans.

On the other hand, it is possible to produce and increase in vivo growth factors in young living organisms by using this in vivo neurotrophic factor production method, which should be used to accelerate the growth of various animals and plants. Can do.

Brief Description of Drawings

FIG. 1 is a block diagram showing an outline of an in vivo neurotrophic factor production apparatus according to the present invention.

FIG. 2 is a diagram showing a use state of the in vivo neurotrophic factor production device according to the present invention.

FIG. 3 is a diagram showing a use state of the in vivo neurotrophic factor production device according to the present invention.

FIG. 4 is a graph showing the results of Example 1. FIG. 5 is a graph showing the results of Example 2.

FIG. 6 is a graph showing the results of Example 3. Explanation of symbols

1 In vivo neurotrophic factor generator 11 Potential generation means

12 Control unit

13 ON / OFF switching section

14 High voltage generator

15 Operation unit

16 Power supply

17 Energizing means

20 Insulation mat

C chair

M user

Y floor

Claims

The scope of the claims

[1] An in vivo neurotrophic factor production method characterized by applying a constant or fluctuating high voltage of alternating current to a living body to increase production of 'growing nutritional factor' in the living body.

[2] A high voltage generating means for generating a constant or fluctuating high voltage with an extremely low current from an input power source, an energizing means for applying the high voltage generated by the high voltage generating means to the living body, An in-vivo growth / nutrient factor is generated and increased by applying a constant or fluctuating high voltage of alternating current generated by the high-voltage generating means to the living body by the energizing means. Neurotrophic factor production device.

[3] The in vivo neurotrophic factor producing device according to [2], wherein the AC high voltage generated by the high voltage generating means is 1000 to 30000V.

4. The in vivo neurotrophic factor producing device according to claim 2, wherein the alternating high voltage generated by the high voltage generating means is constant or fluctuates in a range of 500 to 50000V.

[5] A method for improving cranial nerve function, comprising applying a constant or fluctuating high voltage of alternating current to a living body to improve cranial nerve functions such as memory ability.

[6] A high voltage generation means for generating a constant or variable high voltage of alternating current with an extremely low current from an input power source, an energization means for applying the high voltage generated by the high voltage generation means to the living body, A device for improving cranial nerve function comprising: applying a constant or fluctuating high voltage of alternating current generated by the high voltage generating means to a living body by the energizing means to improve cranial nerve functions such as memory ability.

7. The cranial nerve function improving apparatus according to claim 6, wherein the AC high voltage generated by the high voltage generating means is 1000 to 30000V.

8. The cranial nerve function improving apparatus according to claim 6, wherein the AC high voltage generated by the high voltage generating means is constant or fluctuates in a range of 500 to 50000V.

[9] A method for preventing ischemic injury, comprising applying a constant or fluctuating high voltage of alternating current to a living body to produce and increase production of nutrient factors in the living body.

[10] A high voltage generating means for generating a very constant or variable high voltage with an extremely low current from an input power source, and a current supplying means for applying the high voltage generated by the high voltage generating means to a living body A constant or fluctuating high voltage generated by the high voltage generating means is applied to the living body by the energizing means to produce and increase the growth / nutrient factors in the living body. To prevent ischemic injury.

11. The ischemic injury prevention device according to claim 10, wherein the AC high voltage generated by the high voltage generating means is 1000 to 30000V.

12. The ischemic injury prevention device according to claim 10, wherein the alternating high voltage generated by the high voltage generation means varies at a constant value or in a range of 500 to 50000V.