WO2006033162A1

WO2006033162A1 - Composition for denture stabilization

Info

Publication number: WO2006033162A1
Application number: PCT/JP2004/013967
Authority: WO
Inventors: Hiromu Takeda; Goichi Howashi; Yoshiharu Noda; Tatsuro Ueki; Suehiro Tsukamoto
Original assignee: Fukuoka Soy Sauce Brewing Cooperation
Priority date: 2004-09-24
Filing date: 2004-09-24
Publication date: 2006-03-30
Also published as: JP4746549B2; JPWO2006033162A1

Abstract

A composition for denture stabilization which can solve problems involved in conventional denture stabilizers, is easy to use, is excellent in tackiness, cushioning properties, durability, and a feeling on use and is safe to the human body. In the composition for denture stabilization, poly-Ϝ-glutamic acid is of an acid type, a salt type, an acid/salt mixture type, and/or a crosslinked product type which are each of a single or mixture type. Antibacterial plant extracts such as fructans and polyphenol or chitosan may also be added. Preferably, the poly-Ϝ-glutamic acid has a molecular weight of not less than 500000 and has been produced by culture of Bacillus natto.

Description

Specification

Denture stabilizing composition

Technical field

[0001] The present invention relates to a denture stabilizing composition that is simple to use in denture attachment and has excellent properties such as adhesiveness, cushioning properties, durability, feeling of use, and safety to the human body. Therefore, the present invention relates to a composition for stabilizing a denture to eliminate or reduce instability and pain due to poor maintenance of the denture and to realize a comfortable denture.

Background art

[0002] Regardless of how precisely the denture fits and makes an occlusal denture, the denture mucous membrane (such as the gums) and palate are subject to uneven pressure due to the rigidity and deformation of the denture material. This may cause problems. In addition, with the passage of time, the resorption of the jaw crest is often seen, resulting in decreased stability, inability to eat satisfactorily, and difficulty in conversation. In this case, it is essentially necessary to readjust the denture by a dentist, but it is often difficult to readjust immediately due to economic or time reasons. For this reason, denture stabilizers are often used as a temporary treatment until readjustment.

[0003] In recent years, in Japan, elderly people are rapidly advancing, and elderly people who need dentures have risen, and the need for denture stabilizers has rapidly increased. There is a strong demand for denture stabilizers that are safe and harmless, especially for elderly people requiring long-term care, even if they are swallowed unexpectedly or insufficiently wiped.

[0004] Currently available denture stabilizers are classified into adhesive type and cushion type depending on the method of denture stabilization. The adhesive type contains water-soluble polymer as the main component and absorbs saliva and Z or water between the denture base and the oral mucosal surface to form sticky and highly viscous substances (including gel-like substances). The denture is fixed using adhesiveness. Substances used include CMC, Kara gum, arabia gum, tragacanth gum, sodium polyacrylate, polyethylene oxide, PVA, methoxymethylene maleic anhydride copolymer, and the like. (See Patent Documents 1 and 2)

The cushion type is a rubbery cushioning material that fills the space between the denture base and the oral mucosal surface. The denture is fixed. Examples of the substance used include vinyl acetate copolymer, partially hydrolyzed butyl acetate copolymer, polyethylene oxide, PVA, and low temperature PVA (see Patent Documents 3 and 4). These are classified into powder type, cream type, tape type, etc.

[0005] A plasticizer is added to these denture stabilizers in order to improve viscoelastic properties and adhesiveness. If necessary, colorants, bactericides, antibacterial agents, bacteriostatic agents, flavoring agents, pH adjusters, etc. are added.

[0006] These existing denture stabilizers are difficult to wipe off dentures and oral mucosa surface force regardless of whether they are adhesive or cushion type. For this reason, there are problems such as the oral mucosa becoming inflamed by the denture stabilizer remaining on the surface of the oral mucosa, and the oral mucosa being damaged by excessive wiping. There are also problems such as remaining on the denture, causing dirt and germs to propagate and worsening the hygienic condition of the denture.

[0007] Further, since the cushion type is a rubbery material and has poor fluidity, it is difficult to cover the denture and the oral mucosal surface thinly and evenly, and the compatibility with the denture and the oral surface deteriorates with continued use. It may change the occlusal relationship. This causes problems such as absorption of the alveolar bone and jawbone.

[0008] In addition to such problems, depending on the types of existing denture stabilizers and added plasticizers, these substances may dissolve in the mouth and cause abnormal taste, or may be absorbed into the human body and absorbed throughout the body. There are problems such as concern about adverse effects on the environment. It is also known that denture stabilizers harden and the cushioning properties deteriorate significantly when the plasticizer is dissolved.

Patent Document 1: Japanese Patent No. 3179102

Patent Document 2: Japanese Patent No. 3460349

Patent Document 3: Japanese Patent No. 2547276

Patent Document 4: Japanese Patent No. 2568397

Disclosure of the invention

Problems to be solved by the invention

[0009] The present invention is intended to solve the above-mentioned problems of existing denture stabilizers. In particular, in Japan, elderly people are rapidly advancing, and elderly people who need dentures are rising. At the same time, the need for denture stabilizers is growing rapidly. In particular, elderly people requiring care tend to respond to the strong demand for safe and harmless denture stabilizers even with unexpected swallowing or inadequate wiping.

[0010] That is, the denture stabilizing composition according to the present invention is easy to use for denture attachment and has excellent properties such as adhesiveness, cushioning properties, durability, feeling of use, and safety to the human body. Furthermore, instability and pain due to poor maintenance of dentures can be eliminated or relaxed, and comfortable dentures can be mounted.

[0011] More specifically, (1) difficulty in wiping dentures and oral mucosal surface force in existing adhesive-type and cushion-type denture stabilizers (2) difficulty in wiping and insufficient wiping of oral mucosa Oral mucosal troubles such as inflammation and damage (3) Denture hygiene problems such as denture fouling and bacterial growth caused by difficult and insufficient wiping (4) Dentures composed of synthetic polymers Taste abnormalities that are concerned by elution of denture stabilizer components, unreacted monomers, oligomers, plasticizers, etc. in stabilizers and adverse effects on the whole body caused by absorption into the human body (5) —parts of oligomers and plasticizers (6) Poor flow and difficulty in thin and uniform lining caused by it in the cushion-type rubbery denture stabilizer, (7) Occlusion caused by it Changes, especially absorption of alveolar bone and jaw bone (8) is intended to solve the problems such as reduction of click Sshiyon due hardening of elution of the plasticizer causes denture stabilizer.

Means for solving the problem

[0012] The present inventors have solved the problems of existing denture stabilizers as described above by using polyγ-glutamic acid (hereinafter referred to as “「 PGA ”) as a denture stabilizing composition. It was. In other words, it was found that the problem can be solved by using γ-PGA as a highly viscous material (including gel-like material) dissolved in saliva and / or water.

Next, the contents will be described in detail. For example, an appropriate amount of powdery PGA is placed thinly and evenly on the surface of the denture that contacts the oral mucosal surface. Subsequently, when an appropriate amount of water is added dropwise to this, γ-PGΑ absorbs the water, rapidly swells and dissolves, and becomes a highly viscous material exhibiting appropriate fluidity and elasticity. In this state, if the denture is brought into contact with the oral mucosal surface and gently crimped, the denture will adhere to the oral mucosal surface. Adhesive fixed. In this state, the denture was extremely stable for a long time without loosening, and an appropriate tactile effect was obtained, and there was no problem in eating, speaking, chewing and the like.

[0014] Further, an appropriate amount of powdery γ-PGA is placed thinly and evenly on the surface of the denture contacting the oral mucosal surface. Continue to moisten the alveolar ridge and the mucous membrane of the oral cavity in contact with the denture surface with saliva and water, and contact the denture with the mucosa of the oral cavity and the oral mucosa to gently compress the γ-PGA. It absorbs and rapidly swells and dissolves, resulting in a highly viscous material that exhibits moderate fluidity and elasticity. Dentures are adhesively fixed to the oral mucosal surface. In this state, the denture is extremely stable for a long time, does not loosen and has a moderate cushioning effect, and does not feel any trouble in eating, speaking, chewing, etc.

[0015] In addition, γ-PGA prepared as a highly viscous material with appropriate fluidity and elasticity by adding water is made into a film, tape, or gel and placed thinly and evenly on the surface of the denture that contacts the oral mucosal surface. Make it. In this state, if the denture is brought into contact with the oral mucosal surface and gently pressed, the denture is adhesively fixed to the oral mucosal surface. In this state, the denture was extremely stable for a long time without loosening, and an appropriate cushioning effect was obtained, and there was no trouble in eating, speaking, chewing and the like.

[0016] y The excellent action of PGA is as follows. That is, γ-PGA molecules form strong hydrogen bonds within and between molecules in aqueous solution. At the same time, a strong hydrogen bond is formed with the solvent water. Γ-PGA molecules take a helical conformation in aqueous solution. In other words, high-viscosity γ-PGA that swells and dissolves with water and / or saliva requires a strong intramolecular γ-PGA molecule, intermolecular hydrogen bonding and helical conformation, and is necessary as a composition for stabilizing dentures. It was found that it exhibited appropriate moderate tackiness, cushioning properties and viscoelasticity.

[0017] In the denture stabilizing composition of the present invention, γ-PGA is a component necessary for developing the adhesiveness, cushioning properties, and viscoelasticity necessary for a denture stabilizing composition. German or γ-PGA added with optional components such as antibacterial plant extract, colorant, bactericidal agent, antibacterial agent, flavoring agent and rhodium adjusting agent as described later within the range that does not impair the properties of γ-PGA. It may be a composition.

[0018] Here, the safety of γ-PGA and saliva and / or water will be described. Saliva is a physiological fluid. Needless to say, water is a safe substance. γ— P AG is the sticky component of natto It exhibits biodegradability, biocompatibility, and physiological activity, and is not only extremely safe for the human body, but also exhibits excellent physiological functions. Also, since no synthetic polymers or plasticizers are used, there is no concern about taste abnormalities caused by unreacted monomers, oligomers, added plasticizers, etc., or adverse effects on the whole body caused by absorption of these into the human body. In addition, there is no danger as an environmental hormone that is concerned about some unreacted monomers, oligomers and plasticizers. That is, it is clear that the denture stabilizing composition shown in the present invention is extremely safe. Here, the inclusion of other substances such as glycerin, lactose, soluble starch and the like within a range not impairing the action of saliva and / or water does not impair the significance of the present invention.

[0019] Although the molecular weight of γ PGA used here is not limited, 500,000 or more are preferable in order to exhibit appropriate adhesiveness and viscoelasticity as a denture stabilizing composition. In particular, it should be 1 million or more. If the molecular weight is appropriate, γ-PGA can be dissolved in saliva and / or water smoothly, and a highly viscous material exhibiting excellent adhesion and suitable viscoelasticity can be obtained. Here, polysaccharides such as fructans may be included as long as yPGA exhibits water solubility and strong adhesiveness. The presence of an appropriate amount of fructans has the effect of increasing the spinnability and fluidity of γ-PGA high-viscosity material, and the γ-PGA high-viscosity material is spread thinly and evenly on the contact surface between the denture and the oral mucosal surface. It is effective.

[0020] Chitosan may be mixed if necessary! Chitosan can be uniformly mixed with γ-PGA at any ratio, and the force of the molecular chain is stiff. An appropriate amount of chitosan force is effective in increasing the elasticity of highly viscous materials. Power! ] Chitosan is antibacterial and biocompatible, so it is as effective and safe as a substance used in the oral cavity, just like γ-PGA.

[0021] If necessary, γ-PGA may be crosslinked within a range without impairing the original properties of the γ-PGA. Crosslinking is effective for controlling swelling, elasticity and strength. Reagents, heat, radiation, etc. can be used as the crosslinking method. Also, mix γ-PGA and cross-linked γ-PGA.

[0022] In addition, γ-PGA may have all side-chain carboxyl groups in acid form, or all side-chain carboxy groups may be in salt form. The salt forms may be mixed, or some or all of these may be mixed. The salt type is not particularly limited as long as it is a cation that forms an ion with a carboxyl group. The In other words, metal ions such as ions of lithium, potassium, sodium, calcium, magnesium, tin, aluminum, iron, nickel, cobalt, etc., or ammonium ions and organic amine cations can be mentioned. In particular, it was found that when the carboxyl group of the side chain is in a salt form of 10 mol% or more, the affinity for saliva and water is improved and the swelling and dissolution becomes smooth. Γ-PGA described in the present invention is a general term for γ-PGA described herein. Further, these γ-PGAs alone or a mixture thereof may be a mixture with fructan or chitosan.

[0023] The production method of γ-PGA used here will be described. As long as the γ-PGA used is obtained by the bacteria that produce it, the type, culture method, and conditions of the bacteria are not questioned. Are preferred.

[0024] γ PGA is not only a substance used for food as a viscous component of natto, but is also well known to have biodegradability, biocompatibility, and physiological activity, and is absorbed into the human body. However, there is a bioactive effect rather than an adverse effect. In other words, there is no risk of adverse effects on the whole body due to absorption into the human body even if it is swallowed with saliva or water or eluted from between the denture and the oral mucosa. Further, as described above, since no plasticizer is added, there is no adverse effect of the plasticizer on the human body, and high safety can be obtained.

[0025] Further, the refined γ-PGA does not impair the taste and aroma of food and drink.

[0026] It should be noted that the addition of an appropriate amount of an optional component such as a colorant, bactericidal agent, antibacterial agent, flavoring agent, and rhodium adjusting agent as required does not change the contents of the present invention. It is also possible to cover natural products such as Kara gum, arabiya gum, tragacanth gum, xanthan gum or the like, CMC and glycerin, as long as they do not impair the characteristics of the present invention. Well then. In particular, an antibacterial plant extract is suitable as an antibacterial agent. Addition of antibacterial plant extract is effective in suppressing the degradation of γ-PGA by oral microorganisms, normalizing the composition of oral microorganisms, increasing the regenerative power of the oral mucosal surface, improving immunity, etc. It was found to show an effect. Antibacterial plant extracts include, for example, al-force, obata, olen, calendula, clara (cushin), cucumber (cucumber leaves), genno shoko, sicon, shokiyo, honeysuckle, seiyozu, thyme, chiya, chijioji, tokinse There are Nka, Ninri, Heath (Erica), Hinokitiol, Buttons, Hops, etc. The effect is particularly remarkable when polyphenol is added. Polyphenol is here Epigalocatechin (

It is at least one selected from EGC), epigallocatechin gallate (ECGg), epicatechin (EC), and epicatechin gallate (ECg).

The invention's effect

[0027] The denture stabilizing composition of the present invention has simple properties for use in denture attachment, and has excellent properties such as adhesiveness, cushioning properties, durability, feeling of use, and safety to the human body. Furthermore, the instability and pain due to poor maintenance of dentures can be eliminated or alleviated, and comfortable dentures can be mounted. In other words, existing adhesive type and cushion type denture stabilizers (1) Difficulty of wiping from denture and oral mucosa surface (2) Inflammation and damage of oral mucosa caused by wiping difficulty and insufficient wiping (3) Denture hygiene problems such as denture fouling and bacterial growth caused by difficulty in wiping and insufficient wiping (4) Dentures in denture stabilizers composed of synthetic polymers Abnormal taste caused by elution of stabilizer components, unreacted monomers, oligomers, plasticizers, etc. and adverse effects on the whole body caused by absorption in the human body (5) —environmental hormones found in some oligomers and plasticizers (6) Poor flow and difficulty in thin and uniform lining due to it, (7) Occlusal changes caused by the cause In particular, resorption of alveolar bone and jaw bone (8) It solves problems such as deterioration of cushioning property due to hardening of denture stabilizer caused by elution of plasticizer.

BEST MODE FOR CARRYING OUT THE INVENTION

[0028] The contents and effects of the present invention will be specifically described below, but it goes without saying that the present invention is not limited to the examples shown here.

Example 1

[0029] (1) Preparation of test piece

An alginate impression material was used to obtain an impression of the toothed palate without pressure, and an upper jaw model was prepared from the impression using plaster. A test plate was prepared from this anhydrite model using an immediate polymerization resin. The test plate was sized to cover the palate with the trailing edge on the line connecting the distal part of the second molar tooth 3 mm away from the tooth neck line and weighed 2.4 g. This palate floor A loop-shaped silk suture (standard GA03SB) was attached to the center of the test plate with an immediate polymerization resin.

[0030] (2) Measurement of adhesive strength

Place the above-mentioned test plate on the intraoral palate, close the lips and upper and lower jaws, and press lightly for 1 minute with the back of the tongue. Next, the silk suture thread (standard GA03SB) fixed in a loop shape is pulled in parallel to the occlusal plane with the measuring needle of a tension meter (HAAG—STREET (SWITZERLAND)). This tension was used as an index of adhesive force. In the measurement, the oral cavity was cleaned as much as possible to reduce the effects of contamination.

[0031] (3) Measurement results

Measurement: Comparative Example 1: Saliva only, Comparative Example 2: Commercially available fine powder type denture stabilizer, Example 1: Denture stabilizing composition of the present invention (fine powder type γ—PGA ammonia having a molecular weight of 3 million) ) I went to three types.

[0032] The denture stabilizing composition of the present invention and a commercially available denture stabilizer are each spread by 0.1 lg thinly on the surface of the denture that comes into contact with the oral mucosal surface, and 0.9 g of water is uniformly applied in a mist form by spraying. The denture stabilizing composition and commercial denture stabilizer of the present invention that has absorbed moisture rapidly swells and dissolves to become a highly viscous product exhibiting adequate fluidity and elasticity. In this state, when the denture was brought into contact with the oral mucosal surface and gently pressed, the denture was adhered and fixed to the oral mucosal surface.

[0033] Table 1 shows the change in adhesive strength of the denture with saliva, the composition for stabilizing a denture of the present invention, and a denture coated with a commercially available denture stabilizer, when pressure bonding and peeling are repeated. In the case of saliva only in Comparative Example 1, the adhesive strength does not change even after repeated pressing and peeling, but the adhesive strength is low. In the case of the commercially available fine powder type denture stabilizer of Comparative Example 1, the initial adhesive strength is somewhat high, but there is a tendency to decrease with repeated crimping and peeling. On the other hand, in the case of the composition for stabilizing dentures of Example 1 of the present invention, the initial adhesive strength is the highest, and the decrease is small even after repeated pressing and peeling. The composition for stabilizing dentures of the present invention has a high adhesive force and an excellent stability.

[table 1] Repeating power

Sample 1 time 2 times 3 times 4 times 5 times Comparative Example 1 60g 60g 60g 70g 60g Comparative Example 2 350g 200g 1 80g 1 90g 1 40g Example 1 500g 480g 400g 500g 480g

[0034] Table 2 shows the reproducibility of the adhesive strength of the denture stabilizing composition of the present invention and the commercially available denture stabilizer. Both were newly applied to the denture every time and the adhesive strength was measured. Both show adhesive strength and reproducibility, but it is clear that the denture stabilizing composition of the present invention has high adhesive strength and excellent stability.

[Table 2]

Example 2

[0035] An appropriate amount of fine powdery γ-PGA sodium (molecular weight: 3 million) is spread thinly on the denture surface in contact with the oral mucosal surface, and then a small amount of water is dropped. Finely powdered γ-PGA sodium that has absorbed moisture rapidly swells and dissolves, resulting in a highly viscous product exhibiting moderate fluidity and elasticity. The viscosity of the solution was 5000 centipoise. In this state, when the denture was brought into contact with the oral mucosal surface and gently pressed, the denture was adhered and fixed to the oral mucosal surface. In this state, the denture was extremely stable for a long time, did not loosen, and had an appropriate cushioning effect. There was no problem in eating, speaking, chewing, etc.

[0036] Table 3 shows the measurement results of denture maintenance force (adhesive strength) of the denture stabilizing composition of the present invention measured by the same method as in Example 1. After the denture was fixed to the oral mucosa surface, the adhesive strength at the time of peeling was measured after a certain period of time. Adhesive strength is that it is maintained for a long time.

[0037] After use, γ-PGA could be easily wiped away by washing the denture with running water such as tap water or by using light brushing together with running water washing. In addition, γ-PGA adhering to the oral mucosal surface can be washed with clean water such as tap water, or used in combination with light and brushing. Therefore, it was easily wiped away. The oral mucosa showed no inflammation or damage.

The refined sodium γ-PGA was strong enough not to damage the taste and aroma of food and drink. In addition, the γ-PGA sodium elution had no significant adverse effects on the human body.

[Table 3]

Example 3

[0039] γ— PGA prepared with high viscosity (viscosity 5500 centipoise) with 5% concentration using water as solvent

An appropriate amount (with a molecular weight of 3 million) is spread thinly on the surface of the denture that contacts the oral mucosal surface. In this state, when the denture was brought into contact with the oral mucosal surface and pressed gently, the denture was adhered and fixed to the oral mucosal surface. In this state, the denture was extremely stable for a long time, did not loosen, and had a moderate cushioning effect. There was no problem with eating, talking, or chewing.

[0040] Table 4 shows the relationship between the elapsed time of use and the retention strength of the denture stabilizing composition of the present invention measured by the same method as in Example 1. It is clear that a stable denture maintenance force is maintained.

[0041] After use, γ-PGA could be easily wiped away by washing the denture with running water such as tap water, or using running water washing and light brushing in combination. Γ-PGA adhering to the oral mucosal surface could be easily wiped away with clean water such as tap water, or with a combination of light brushing and soot. The oral mucosa showed no inflammation or damage.

[0042] The refined γ-PGA was strong enough not to damage the taste and aroma of food and drink. Moreover, there was no adverse effect on the human body of the eluted y-PGA.

[Table 4]

Example 4

[0043] Gamma-PGA ammonia with molecular weight of 500,000, 1,000,000, 2 million, 2.5 million, and 3 million was prepared, each was mixed and dissolved in water, and a highly viscous product with a concentration of 6.5% by mass Prepared. This high An appropriate amount of viscous material was spread in a thin film on the side of the denture that contacts the oral mucosal surface. In this state, the denture was adhered to the oral mucosal surface when it was brought into contact with the oral mucosal surface and gently pressed. Dentures are extremely stable for a long time in this state, do not loosen and have a moderate cushioning effect, and are extremely stable for a long time in this state without any trouble in eating, speaking, chewing, etc. It was. γ-PGA ammonia can be used even with a molecular weight of 500,000, but is particularly suitable for molecular weights of 1 million or more.

[0044] Table 5 shows the relationship between the molecular weight and adhesive strength of γ-PGA ammonia measured by the same method as in Example 1. It is clear that a stable denture maintenance force (adhesive strength) is maintained.

[0045] After use, the γ-PGA ammonia could be easily wiped away by washing the denture with running water such as tap water or using a light brushing. In addition, γ-PGA ammonia adhering to the oral mucosal surface could be easily wiped away with clean water such as tap water, or by combining light brushing with scrubbing. There was no inflammation or damage to the oral mucosa. The refined γ-PGA ammonia did not impair the taste and aroma of food and drink. In addition, the γ-PGA ammonia that was eluted had no adverse effects on the human body.

[Table 5]

Example 5

[0046] An appropriate amount of γ-PGA having a carboxyl group in acid form (molecular weight of 3.2 million) was dissolved in water at 80 ° C, and sodium bicarbonate dissolved in a small amount of water was dissolved in a small amount of 10 per unit of structural unit of γ-PGA. Mix evenly by adding 1 mol of water. In addition, 500 gZml of polyphenol was added as an antibacterial agent. The concentration of the highly viscous material was 5% by mass.

[0047] An appropriate amount of this high-viscosity product is spread thinly on a surface that contacts the oral mucosa surface of the denture, and in this state, the denture adheres to the oral mucosa surface when it is brought into contact with the oral mucosa surface and gently pressed. It was done. In this state, the denture was extremely stable for a long time, did not loosen, and provided an appropriate cushioning effect. There was no trouble in eating, talking, and chewing.

[0048] Table 6 shows the time when the composition for stabilizing a denture of the present invention was used, as measured in the same manner as in Example 1. The relationship between the adhesive strength. It is clear that a stable denture maintenance force (adhesive strength) is maintained.

[0049] In addition, the composition for stabilizing dentures of the present invention containing polyphenol shown in the present example has a remarkable effect of suppressing Porphyromonas gingivalis, which is one of oral bacteria, and is a causative agent of bad breath The effect of remarkably suppressing methyl mercabtan hydrogen sulfide, which is the main component of selenium, was also remarkable. In addition, the formation of amorphous calcium phosphate, the causative agent of plaque and calculus, and the transition of amorphous calcium phosphate to crystalline calcium phosphate were suppressed, and the formation of plaque and calculus was less likely to occur. .

[0050] After use, γ-PGA could be easily wiped away by washing the denture with running water such as tap water or using a light brush. Γ-PGA adhering to the oral mucosal surface could be easily wiped off with clean water such as tap water, or with a combination of light brushing and soot. The oral mucosa showed no inflammation or damage. The refined γ-PGA has no help in damaging the taste and aroma of food and drink. In addition, the γ-PGA that was eluted had no negative effect on the human body.

[Table 6]

Example 6

分散 Disperse PGA (molecular weight 2.5 million) in tetrahydrofuran at a concentration of 5gZl00ml. To this, 1Z50 equivalent of carbodiimide was added per structural unit of γ-PGA, and γ-PGA molecules were cross-linked by reaction between the two. After the reaction, tetrahydrofuran was removed, and further washed with an acidic aqueous solution and pure water to completely remove the unreacted reagent from γ-PGA. Next, γ-PGA was converted to a sodium salt and dissolved in water to prepare a highly viscous product. When an appropriate amount of this high-viscosity material is spread thinly on the surface of the denture that contacts the oral mucosa, and the denture is brought into contact with the surface of the oral mucosa and gently pressed in this state, the denture is adhered and fixed to the surface of the oral mucosa. . In this state, the denture was extremely stable for a long time without loosening and had a moderate cushioning effect, and did not cause any trouble in eating, talking, or chewing. In particular, the improvement in cushioning effect due to cross-linking was remarkable. [0052] Table 7 shows the results of measuring the change in denture maintenance force (adhesive strength) with the elapsed use time of the denture stabilizing composition of the present invention.

[0053] After use, sodium γ-PGA could be easily wiped away by washing the denture with running water such as tap water or using light brushing. In addition, yPGAA sodium adhering to the oral mucosal surface could be easily wiped away with clean water such as tap water, or by using a combination of brushing and soot. There was no inflammation or damage to the oral mucosa. The refined sodium γ PGA was able to damage the taste and aroma of food and drink. In addition, the γ-PGA sodium elution had no significant adverse effect on the human body.

[Table 7]

Example 7

[0054] γ PGA sodium (molecular weight 2.5 million) is added to and mixed with a chitosan solution dissolved in a 60% formic acid aqueous solution. Both are uniformly mixed to obtain a transparent uniform solution. γ-PGA sodium and chitosan were prepared at a mass ratio of 80:20. This solution was dried and solidified, and further pulverized to obtain a fine powder. Subsequently, this fine powdery γ-PGA sodium and chitosan mixture was dissolved in water to prepare a highly viscous product having a concentration of 5%. When an appropriate amount of this high-viscosity material is spread thinly on the side of the denture that comes into contact with the oral mucosa surface, and in this state the denture is brought into contact with the oral mucosal surface and gently pressed, the denture is adhered and fixed to the oral mucosal surface. . In this state, the denture is extremely stable for a long time, does not loosen, and has a moderate cushioning effect. It has no power to feel any trouble in eating, speaking, and chewing. In particular, the improvement of the cushioning effect by chitosan was remarkable.

[0055] Table 8 shows the results of measuring the denture retention force (adhesive strength) of the denture stabilizing composition of this example according to the method of Example 1.

[0056] After use, γ-PGA sodium and chitosan could be easily removed and wiped by washing the denture with running water such as tap water or using a light brushing together. In addition, γ-PGA sodium and chitosan adhering to the oral mucosal surface can be easily removed by using 嗽 V or light brushing and 嗽 in combination with clean water such as tap water. I was able to wipe it off. There was no inflammation or damage to the oral mucosa.

[0057] Purified sodium γ-PGA and chitosan are tasteless and odorless, and even during use, the taste and scent of food and drink were impaired. In addition, the γ-PGA sodium and chitosan that was eluted had no significant adverse effects on the human body.

[Table 8]

Example 8

[0058] A sample of γ-PGA sodium (molecular weight 3 million) with a viscosity of 5% (viscosity 5500 centipoise) with water as a solvent (sample 1), sample containing 0.5% by mass of fructan (sample) 2 >> (viscosity 5200 centipoise) and 4% by mass of a sample << Sample 3 >> (viscosity 6500 centipoise) were prepared. Appropriate amounts of these samples are spread thinly on the surface of the denture that contacts the oral mucosal surface. All of << Sample 1 >> << Sample 2 >> << Sample 3 >> have sufficient extensibility, but << Sample 2 >> << Sample 3 >> are particularly excellent in extensibility. In this state, when the denture was brought into contact with the oral mucosal surface and gently crimped, the denture was adhered and fixed to the oral mucosal surface. In this state, the denture was extremely stable for a long time without loosening, and had a moderate cushioning effect. It had the power to feel no trouble in eating, speaking, and chewing.

[0059] Table 9 shows the relationship between the elapsed time of use and the retention strength of the denture stabilizing composition of the present invention measured by the same method as in Example 1. It is clear that a stable denture maintenance force is maintained. Fractans not only improve the spreadability of high-viscosity products, but also have the effect of improving denture retention.

[0060] After use, the γ-PGA high-viscosity samples 1, 2, and 3 could be easily wiped away by washing the denture with running water such as tap water or by using running water washing and light brushing in combination. In addition, γ-PGA high-viscosity samples 1, 2, and 3 adhering to the oral mucosal surface were easily wiped away by rinsing with clean water such as tap water or by using light brushing and a combination of scissors. . The oral mucosa was strong and showed no inflammation or damage.

[0061] The purified γ-PGA high-viscosity samples 1, 2, and 3 did not impair the taste and aroma of food and drink. In addition, the γ-PGA and fractane that were eluted had a strong negative effect on the human body. [Table 9]

Example 9

[0062] γ- PGA ammonium - © beam (molecular weight 2.5 million) 4.6 Weight ^_0/0, mixed gum arabic 0.7 wt ^_0/0, glycerin 20% by mass, the tea catechins 0.5 wt% in water A highly viscous homogeneous solution (viscosity 6 000 centipoise) was prepared by dissolution. Spread an appropriate amount of this solution thinly on the surface of the denture that contacts the oral mucosa. In this state, when the denture was brought into contact with the oral mucosal surface and pressed gently, the denture was adhered and fixed to the oral mucosal surface. In this state, the denture was extremely stable for a long time, did not loosen, and provided an appropriate cushioning effect. It did not cause any trouble in eating, talking, and chewing.

[0063] Table 10 shows the relationship between the elapsed time of use and the retention strength of the denture stabilizing composition of the present invention measured by the same method as in Example 1. It is clear that a stable denture maintenance force is maintained.

[0064] After use, γ-PGA could be easily wiped away by washing the denture with running water such as tap water, or with running water washing and brushing together. Moreover, the γ-PGA high-viscosity solution adhering to the oral mucosal surface could be easily wiped off with clean water such as tap water, or with light, brushing and scrubbing. No inflammation or damage was observed in the oral mucosa.

[0065] The refined γ-PGA highly viscous solution was able to damage the taste and aroma of food and drink. In addition, the γ-PGA high viscosity solution that was eluted had no adverse effect on the human body.

[Table 10] Elapsed time 0 hours 3 hours 4 hours 6 hours Sample 1 Adhesive strength 490 g 360 g 280 g 1 70 g

Claims

The scope of the claims

[1] A denture stabilizing composition comprising poly γ-glutamic acid.

[2] Poly γ-glutamic acid is an acid form, a salt form, a mixed form of acid and salt, and / or a cross-linked product, and these are single or a mixture thereof. The composition for stabilizing a denture according to claim 1.

[3] The denture-stabilizing composition according to claim 1 or 2, comprising a fructan.

[4] The denture stabilizing composition according to any one of claims 1 to 3, comprising an antibacterial plant extract.

[5] The denture stabilizing composition according to any one of claims 1 to 4, which comprises polyphenol as an antibacterial plant extract.

[6] The denture-stabilizing composition according to any one of claims 1 to 5, further comprising chitosan.

7. The denture stabilizing composition according to any one of claims 1 to 6, wherein the molecular weight of poly-γ-glutamic acid is 500,000 or more.

8. The denture stabilizing composition according to any one of claims 1 to 7, wherein the poly-γ-glutamic acid comprises poly-γ-glutamic acid obtained by culture of Bacillus natto.