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WO2006031388A3 - Polymeres dendritiques et gels reticules: utilisations dans des applications orthopediques - Google Patents

Polymeres dendritiques et gels reticules: utilisations dans des applications orthopediques Download PDF

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Publication number
WO2006031388A3
WO2006031388A3 PCT/US2005/029915 US2005029915W WO2006031388A3 WO 2006031388 A3 WO2006031388 A3 WO 2006031388A3 US 2005029915 W US2005029915 W US 2005029915W WO 2006031388 A3 WO2006031388 A3 WO 2006031388A3
Authority
WO
WIPO (PCT)
Prior art keywords
capped
compound
dendritic
isocysteine
cysteine
Prior art date
Application number
PCT/US2005/029915
Other languages
English (en)
Other versions
WO2006031388A2 (fr
Inventor
Mark W Grinstaff
Michael A Carnahan
Original Assignee
Hyperbranch Medical Technology
Mark W Grinstaff
Michael A Carnahan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyperbranch Medical Technology, Mark W Grinstaff, Michael A Carnahan filed Critical Hyperbranch Medical Technology
Publication of WO2006031388A2 publication Critical patent/WO2006031388A2/fr
Publication of WO2006031388A3 publication Critical patent/WO2006031388A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne des compositions, des kits, et des procédés de réparation des tissus cartilagineux. Certains procédés de l'invention font intervenir des macromolécules dendritiques obtenues par phototraitement d'un composé dendritique ou d'un composé de liaison. Dans certains modes de réalisation, les composés dendritiques comportent un résidu de lysine, de cystéine, d'isocystéine ou d'un autre groupe nucléophile fixé à leur périphérie. L'ajout d'un composé contenant au moins deux groupes électrophiles, tels que les aldéhydes, les esters activés ou les acrylates aux dendrimères à extrémité lysine, cystéine, ou isocystéine, permet d'obtenir un composé polymère apte à réparer les défauts du cartilage.
PCT/US2005/029915 2004-08-20 2005-08-22 Polymeres dendritiques et gels reticules: utilisations dans des applications orthopediques WO2006031388A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60350204P 2004-08-20 2004-08-20
US60/603,502 2004-08-20
US60409704P 2004-08-23 2004-08-23
US60/604,097 2004-08-23

Publications (2)

Publication Number Publication Date
WO2006031388A2 WO2006031388A2 (fr) 2006-03-23
WO2006031388A3 true WO2006031388A3 (fr) 2006-10-12

Family

ID=36060499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029915 WO2006031388A2 (fr) 2004-08-20 2005-08-22 Polymeres dendritiques et gels reticules: utilisations dans des applications orthopediques

Country Status (1)

Country Link
WO (1) WO2006031388A2 (fr)

Cited By (14)

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US7943573B2 (en) 2008-02-07 2011-05-17 Biomimetic Therapeutics, Inc. Methods for treatment of distraction osteogenesis using PDGF
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US8114841B2 (en) 2004-10-14 2012-02-14 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix
US8492335B2 (en) 2010-02-22 2013-07-23 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8870954B2 (en) 2008-09-09 2014-10-28 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8986730B2 (en) 2004-11-05 2015-03-24 Incept, Llc Methods for sealing a vascular puncture
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
DE102005051334A1 (de) * 2005-10-25 2007-06-21 Degussa Gmbh Präparate umfassend hyperverzweigte Polymere
CA2627459C (fr) 2005-10-25 2011-08-09 Evonik Degussa Gmbh Preparation comprenant des polymeres hyperramifies
US9393344B2 (en) 2006-01-11 2016-07-19 Hyperbranch Medical Technology, Inc. Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
ES2443581T3 (es) 2006-02-09 2014-02-19 Biomimetic Therapeutics, Llc Composiciones y métodos para el tratamiento de hueso
CA2656278C (fr) 2006-06-30 2016-02-09 Biomimetic Therapeutics, Inc. Compositions et procedes destines au traitement de lesions de la coiffe des rotateurs
US8262608B2 (en) 2007-01-25 2012-09-11 Hyperbranch Medical Technology, Inc. Applicators for multiple component formulations and the like, and methods of use thereof
US7862538B2 (en) 2008-02-04 2011-01-04 Incept Llc Surgical delivery system for medical sealant
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
EP3153194B1 (fr) 2009-05-04 2019-04-10 Incept, LLC Biomatériaux pour fermeture de perforation et de voie
JP5820815B2 (ja) 2009-12-15 2015-11-24 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ インプラントおよび生体分解性基準マーカー
WO2013022801A1 (fr) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Administration de petites molécules à l'aide d'un dispositif thérapeutique implantable
US10617557B2 (en) 2010-08-05 2020-04-14 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
AU2011329656B2 (en) 2010-11-19 2017-01-05 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
WO2013003620A2 (fr) 2011-06-28 2013-01-03 Forsight Vision4, Inc. Procédés et appareil de diagnostic
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
PT2755600T (pt) 2011-09-16 2021-04-19 Forsight Vision4 Inc Aparelhos de troca de fluidos
US9205150B2 (en) 2011-12-05 2015-12-08 Incept, Llc Medical organogel processes and compositions
WO2013116061A1 (fr) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Procédés et instrument pour l'insertion et le retrait de dispositifs thérapeutiques
WO2014152959A1 (fr) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systèmes pour l'administration intra-oculaire entretenue de composés à faible solubilité provenant d'un implant de système de pose d'orifice
EP3169289B1 (fr) 2014-07-15 2020-04-15 ForSight Vision4, Inc. Dispositif de pose d'implant oculaire
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
MX383085B (es) 2014-11-10 2025-03-13 Forsight Vision4 Inc Dispositivo de entrega de fármacos expandibles y método de uso.
EP3229779B1 (fr) 2014-12-10 2021-02-03 Incept, LLC Implants d'administration de médicament à base d'hydrogel
WO2016183296A1 (fr) 2015-05-12 2016-11-17 Incept, Llc Administration de médicament à partir d'hydrogels
MX2018006234A (es) 2015-11-20 2018-08-14 Forsight Vision4 Inc Estructuras porosas para dispositivos de suministro de medicamentos de liberacion prolongada.
CA3006303C (fr) 2015-11-25 2023-11-14 Incept, Llc Dispositifs d'administration de medicaments a changement de forme et procedes
CA3019822A1 (fr) 2016-04-05 2017-10-12 Forsight Vision4, Inc. Dispositifs implantables d'administration de medicaments par voie oculaire
WO2018058048A1 (fr) 2016-09-23 2018-03-29 Incept, Llc Dépôts pour l'administration de médicament en intracaméral
CA3082891A1 (fr) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Appareil d'echange de fluide pour systeme d'administration a port extensible et methodes d'utilisation
CN112166039B (zh) 2018-04-06 2023-09-05 聚合-医药有限公司 用于光致聚合增材制造的方法和组合物
CN112203828B (zh) 2018-04-19 2023-06-09 聚合-医药有限公司 用于光固化过程的大分子单体和组合物
AU2021409576A1 (en) * 2020-12-22 2023-07-13 Fluidx Medical Technology, Inc. In situ solidifying injectable compositions with transient contrast agents and methods of making and using thereof
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device

Citations (1)

* Cited by examiner, † Cited by third party
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US6642363B1 (en) * 1996-09-19 2003-11-04 The Regents Of The University Of Michigan Polymers containing polysaccharides such as alginates or modified alginates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642363B1 (en) * 1996-09-19 2003-11-04 The Regents Of The University Of Michigan Polymers containing polysaccharides such as alginates or modified alginates

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114841B2 (en) 2004-10-14 2012-02-14 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix
US9386969B2 (en) 2004-11-05 2016-07-12 Incept, Llc Methods for sealing a vascular puncture
US8986730B2 (en) 2004-11-05 2015-03-24 Incept, Llc Methods for sealing a vascular puncture
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US8349796B2 (en) 2008-02-07 2013-01-08 Biomimetic Therapeutics Inc. Methods for treatment of distraction osteogenesis using PDGF
US7943573B2 (en) 2008-02-07 2011-05-17 Biomimetic Therapeutics, Inc. Methods for treatment of distraction osteogenesis using PDGF
US8870954B2 (en) 2008-09-09 2014-10-28 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8492335B2 (en) 2010-02-22 2013-07-23 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US9033911B2 (en) 2010-08-05 2015-05-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof

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