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WO2006026592A3 - Oral administration of poorly absorbed drugs, methods and compositions related thereto - Google Patents

Oral administration of poorly absorbed drugs, methods and compositions related thereto Download PDF

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Publication number
WO2006026592A3
WO2006026592A3 PCT/US2005/030774 US2005030774W WO2006026592A3 WO 2006026592 A3 WO2006026592 A3 WO 2006026592A3 US 2005030774 W US2005030774 W US 2005030774W WO 2006026592 A3 WO2006026592 A3 WO 2006026592A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
poorly absorbed
methods
absorbed drugs
oral administration
Prior art date
Application number
PCT/US2005/030774
Other languages
French (fr)
Other versions
WO2006026592A2 (en
Inventor
Edith Mathiowitz
Avinash Nangia
Jules S Jacob
Mark R Kreitz
Rebecca Doane
Ryan Donnelly
Original Assignee
Spherics Inc
Edith Mathiowitz
Avinash Nangia
Jules S Jacob
Mark R Kreitz
Rebecca Doane
Ryan Donnelly
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/009,327 external-priority patent/US20050201974A1/en
Priority claimed from US11/072,098 external-priority patent/US20050249799A1/en
Application filed by Spherics Inc, Edith Mathiowitz, Avinash Nangia, Jules S Jacob, Mark R Kreitz, Rebecca Doane, Ryan Donnelly filed Critical Spherics Inc
Publication of WO2006026592A2 publication Critical patent/WO2006026592A2/en
Publication of WO2006026592A3 publication Critical patent/WO2006026592A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention provides methods and compositions for the delivery of poorly absorbed drugs. In some embodiments, the drug is administered in the form of microparticles or nanoparticles. In other embodiments, the drug is encapsulated with polymer. In certain embodiments, the drug is administered in combination with an absorption enhancer. The invention further relates to dosing schedules to maintain the oral bioavailability of poorly absorbed drugs, such as paclitaxel. In another embodiment, the method involves administering inhibitors of one or more inhibitors of a drug efflux pump in combination with a poorly absorbed drug.
PCT/US2005/030774 2004-08-27 2005-08-29 Oral administration of poorly absorbed drugs, methods and compositions related thereto WO2006026592A2 (en)

Applications Claiming Priority (26)

Application Number Priority Date Filing Date Title
US60519904P 2004-08-27 2004-08-27
US60499104P 2004-08-27 2004-08-27
US60520104P 2004-08-27 2004-08-27
US60520004P 2004-08-27 2004-08-27
US60499004P 2004-08-27 2004-08-27
US60519804P 2004-08-27 2004-08-27
US60/605,200 2004-08-27
US60/604,990 2004-08-27
US60/605,198 2004-08-27
US60/605,199 2004-08-27
US60/604,991 2004-08-27
US60/605,201 2004-08-27
US60790504P 2004-09-08 2004-09-08
US60/607,905 2004-09-08
US11/009,327 2004-12-09
US11/009,327 US20050201974A1 (en) 2003-12-09 2004-12-09 Bioadhesive polymers with catechol functionality
US63581204P 2004-12-13 2004-12-13
US60/635,812 2004-12-13
US65019105P 2005-02-04 2005-02-04
US65037505P 2005-02-04 2005-02-04
US60/650,375 2005-02-04
US60/650,191 2005-02-04
US11/072,098 US20050249799A1 (en) 2004-03-03 2005-03-03 Polymeric drug delivery system for hydrophobic drugs
US11/072,098 2005-03-03
US67638305P 2005-04-29 2005-04-29
US60/676,383 2005-04-29

Publications (2)

Publication Number Publication Date
WO2006026592A2 WO2006026592A2 (en) 2006-03-09
WO2006026592A3 true WO2006026592A3 (en) 2006-09-14

Family

ID=35703588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/030774 WO2006026592A2 (en) 2004-08-27 2005-08-29 Oral administration of poorly absorbed drugs, methods and compositions related thereto

Country Status (1)

Country Link
WO (1) WO2006026592A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101854919B (en) * 2007-08-24 2012-02-15 斯蒂廷海特盖格荷兰协会 Compositions for the treatment of neoplastic diseases
US8911777B2 (en) 2007-04-04 2014-12-16 Sigmoid Pharma Limited Pharmaceutical composition of tacrolimus
US8951570B2 (en) 2007-04-26 2015-02-10 Sigmoid Pharma Limited Manufacture of multiple minicapsules
CN105101950A (en) * 2013-03-05 2015-11-25 安特里斯生物制药公司 Pharmaceuticals for oral delivery
US9220681B2 (en) 2012-07-05 2015-12-29 Sigmoid Pharma Limited Formulations
US9278070B2 (en) 2009-05-18 2016-03-08 Sigmoid Pharma Limited Composition comprising oil drops

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007041079A2 (en) * 2005-09-30 2007-04-12 Alza Corporation Banded controlled release nanoparticle active agent formulation dosage forms and methods
EP2063875A2 (en) * 2007-05-01 2009-06-03 Sigmoid Pharma Limited Combination pharmaceutical compositions
US20100137197A1 (en) 2007-06-26 2010-06-03 Sachin Mittal Lyophilized anti-fungal composition
US9089544B2 (en) 2007-08-24 2015-07-28 Slotervaart Participaties Bv Composition
AU2008291930B2 (en) * 2007-08-24 2014-04-17 Slotervaart Participaties Bv Compositions for the treatment of neoplastic diseases
CN102573802A (en) 2009-08-12 2012-07-11 希格默伊德药业有限公司 Immunomodulatory compositions comprising a polymer matrix and an oil phase
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
EP3215127B1 (en) 2014-11-07 2020-10-28 Sublimity Therapeutics Limited Compositions comprising cyclosporin
DK3244878T3 (en) 2015-01-12 2022-10-17 Enteris Biopharma Inc Solid oral formulations

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228399B1 (en) * 1996-08-22 2001-05-08 Research Triangle Pharmaceuticals Composition and method of preparing microparticles of water-insoluble substances
US6322817B1 (en) * 1999-02-17 2001-11-27 Dabur Research Foundation Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof
US20020013271A1 (en) * 1996-08-22 2002-01-31 Indu Parikh Cyclosporiine particles
US6391335B1 (en) * 1998-04-29 2002-05-21 Cima Labs Inc. Effervescent drug delivery system for oral administration
US6537579B1 (en) * 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537579B1 (en) * 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US6228399B1 (en) * 1996-08-22 2001-05-08 Research Triangle Pharmaceuticals Composition and method of preparing microparticles of water-insoluble substances
US20020013271A1 (en) * 1996-08-22 2002-01-31 Indu Parikh Cyclosporiine particles
US6391335B1 (en) * 1998-04-29 2002-05-21 Cima Labs Inc. Effervescent drug delivery system for oral administration
US6322817B1 (en) * 1999-02-17 2001-11-27 Dabur Research Foundation Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911777B2 (en) 2007-04-04 2014-12-16 Sigmoid Pharma Limited Pharmaceutical composition of tacrolimus
US9114071B2 (en) 2007-04-04 2015-08-25 Sigmoid Pharma Limited Oral pharmaceutical composition
US9387179B2 (en) 2007-04-04 2016-07-12 Sigmoid Pharma Limited Pharmaceutical cyclosporin compositions
US9585844B2 (en) 2007-04-04 2017-03-07 Sigmoid Pharma Limited Oral pharmaceutical composition
US8951570B2 (en) 2007-04-26 2015-02-10 Sigmoid Pharma Limited Manufacture of multiple minicapsules
US9402788B2 (en) 2007-04-26 2016-08-02 Sigmoid Pharma Limited Manufacture of multiple minicapsules
CN101854919B (en) * 2007-08-24 2012-02-15 斯蒂廷海特盖格荷兰协会 Compositions for the treatment of neoplastic diseases
US9278070B2 (en) 2009-05-18 2016-03-08 Sigmoid Pharma Limited Composition comprising oil drops
US9220681B2 (en) 2012-07-05 2015-12-29 Sigmoid Pharma Limited Formulations
CN105101950A (en) * 2013-03-05 2015-11-25 安特里斯生物制药公司 Pharmaceuticals for oral delivery
CN105101950B (en) * 2013-03-05 2019-10-11 安特里斯生物制药公司 The drug of oral delivery

Also Published As

Publication number Publication date
WO2006026592A2 (en) 2006-03-09

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