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WO2006019427A3 - Compositions et methodes de prophylaxie, de traitement et de detection d'infections paludeennes - Google Patents

Compositions et methodes de prophylaxie, de traitement et de detection d'infections paludeennes Download PDF

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Publication number
WO2006019427A3
WO2006019427A3 PCT/US2005/012248 US2005012248W WO2006019427A3 WO 2006019427 A3 WO2006019427 A3 WO 2006019427A3 US 2005012248 W US2005012248 W US 2005012248W WO 2006019427 A3 WO2006019427 A3 WO 2006019427A3
Authority
WO
WIPO (PCT)
Prior art keywords
prophylaxis
compositions
detection
treatment
methods
Prior art date
Application number
PCT/US2005/012248
Other languages
English (en)
Other versions
WO2006019427A2 (fr
Inventor
Altaf A Lal
Lihua X Xiao
Charles W Todd
Paul K Schnake
Zhiyong Zhou
Ya-Ping Shi
Robert M Wohlhueter
Venkatachalam Udhayakumar
Original Assignee
Governement Of The Us Secretar
Altaf A Lal
Lihua X Xiao
Charles W Todd
Paul K Schnake
Zhiyong Zhou
Ya-Ping Shi
Robert M Wohlhueter
Venkatachalam Udhayakumar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Governement Of The Us Secretar, Altaf A Lal, Lihua X Xiao, Charles W Todd, Paul K Schnake, Zhiyong Zhou, Ya-Ping Shi, Robert M Wohlhueter, Venkatachalam Udhayakumar filed Critical Governement Of The Us Secretar
Publication of WO2006019427A2 publication Critical patent/WO2006019427A2/fr
Publication of WO2006019427A3 publication Critical patent/WO2006019427A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des polypeptides immunogènes chimériques. Lesdits polypeptides immunogènes chimériques comprennent des épitopes peptidiques dérivés de différents stades du cycle biologique du parasite paludéen, et, en particulier, du parasite Plasmodium falciparum. Dans certains modes de réalisation, des séquences d'acides aminés d'espacement sont insérées entre des épitopes. Les polypeptides immunogènes chimériques selon l'invention peuvent être utilisés pour stimuler une réponse immunitaire dirigée contre le parasite P. falciparum chez un sujet.
PCT/US2005/012248 2004-04-14 2005-04-11 Compositions et methodes de prophylaxie, de traitement et de detection d'infections paludeennes WO2006019427A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56269004P 2004-04-14 2004-04-14
US60/562,690 2004-04-14

Publications (2)

Publication Number Publication Date
WO2006019427A2 WO2006019427A2 (fr) 2006-02-23
WO2006019427A3 true WO2006019427A3 (fr) 2006-04-27

Family

ID=35614652

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/012248 WO2006019427A2 (fr) 2004-04-14 2005-04-11 Compositions et methodes de prophylaxie, de traitement et de detection d'infections paludeennes

Country Status (1)

Country Link
WO (1) WO2006019427A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0905729A2 (pt) * 2008-01-18 2015-07-14 Aeras Global Tb Vaccine Found "polipeptídeo antigênico recombinante, peptídeo antigênico recombinante, ácido nucléico e método para imunizar um indivíduo contra malária"
US20150359869A1 (en) * 2012-08-15 2015-12-17 Cyvax, Inc. Methods and compositions for preventing a condition

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000011179A1 (fr) * 1998-08-21 2000-03-02 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Vaccin anti-paludeen recombinant multivalent dirige contre plasmodium falciparum

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000011179A1 (fr) * 1998-08-21 2000-03-02 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Vaccin anti-paludeen recombinant multivalent dirige contre plasmodium falciparum

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GILBERT ET AL: "A protein particle vaccine containing multiple malaria epitopes", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 15, 1 November 1997 (1997-11-01), pages 1280 - 1284, XP002096555, ISSN: 1087-0156 *
HARNYUTTANAKORN PONGCHAI ET AL: "Inhibitory monoclonal antibodies recognise epitopes adjacent to a proteolytic cleavage site on the RAP-1 protein of Plasmodium falciparum", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 55, no. 1-2, 1992, pages 177 - 186, XP002366110, ISSN: 0166-6851 *
RAFI-JANAJREH ASIMAH ET AL: "Influence of adjuvants in inducing immune responses to different epitopes included in a multiepitope, multivalent, multistage Plasmodium falciparum candidate vaccine (FALVAC-1) in outbred mice", EXPERIMENTAL PARASITOLOGY, vol. 101, no. 1, May 2002 (2002-05-01), pages 3 - 12, XP002366111, ISSN: 0014-4894 *
SHI ET AL: "Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 96, no. 4, 16 February 1999 (1999-02-16), pages 1615 - 1620, XP002128164, ISSN: 0027-8424 *
SHI Y P ET AL: "Development, expression, and murine testing of a multistage Plasmodium falciparum malaria vaccine candidate.", VACCINE. 15 JUN 2000, vol. 18, no. 25, 15 June 2000 (2000-06-15), pages 2902 - 2914, XP002365879, ISSN: 0264-410X *

Also Published As

Publication number Publication date
WO2006019427A2 (fr) 2006-02-23

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