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WO2006017353A3 - Treatment of viral infections - Google Patents

Treatment of viral infections Download PDF

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Publication number
WO2006017353A3
WO2006017353A3 PCT/US2005/024922 US2005024922W WO2006017353A3 WO 2006017353 A3 WO2006017353 A3 WO 2006017353A3 US 2005024922 W US2005024922 W US 2005024922W WO 2006017353 A3 WO2006017353 A3 WO 2006017353A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
viral infections
medicaments
pyrimidine
infected
Prior art date
Application number
PCT/US2005/024922
Other languages
French (fr)
Other versions
WO2006017353A2 (en
Inventor
Steven Zeichner
Vyjayanthi Krishnan
Original Assignee
Ices The Secretary Dept Of Hea
Steven Zeichner
Vyjayanthi Krishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ices The Secretary Dept Of Hea, Steven Zeichner, Vyjayanthi Krishnan filed Critical Ices The Secretary Dept Of Hea
Publication of WO2006017353A2 publication Critical patent/WO2006017353A2/en
Publication of WO2006017353A3 publication Critical patent/WO2006017353A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Treatment of cells or humans carrying or infected with a virus capable of causing an immunodeficiency disease with particular compounds, including N-phenyl­2-pyrimidine-amine derivatives of formula I, wherein substituents are defined as indicated in the description and to medicaments comprising those compounds and uses thereof.
PCT/US2005/024922 2004-07-13 2005-07-13 Treatment of viral infections WO2006017353A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58801504P 2004-07-13 2004-07-13
US60/588,015 2004-07-13

Publications (2)

Publication Number Publication Date
WO2006017353A2 WO2006017353A2 (en) 2006-02-16
WO2006017353A3 true WO2006017353A3 (en) 2006-03-30

Family

ID=35462172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/024922 WO2006017353A2 (en) 2004-07-13 2005-07-13 Treatment of viral infections

Country Status (1)

Country Link
WO (1) WO2006017353A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090010941A1 (en) * 2007-04-09 2009-01-08 University Of Massachusetts Methods for treating HIV
CA2689989A1 (en) 2007-06-04 2008-12-11 Avila Therapeutics, Inc. Heterocyclic compounds and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0931544A2 (en) * 1997-12-22 1999-07-28 Kaken Shoyaku Co., Ltd. NF-kB activity inhibitor
US20040102453A1 (en) * 2000-09-13 2004-05-27 Buerger Hans Michael N-phenyl-2-pyrimidine-amine derivatives
US20040126877A1 (en) * 2001-04-20 2004-07-01 Man-Wook Hur Repressors for hiv transcription and methods thereof
WO2005072826A2 (en) * 2004-01-21 2005-08-11 Emory University Compositions and use of tyrosine kinase inhibitors to treat pathogenic infection

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0931544A2 (en) * 1997-12-22 1999-07-28 Kaken Shoyaku Co., Ltd. NF-kB activity inhibitor
US20040102453A1 (en) * 2000-09-13 2004-05-27 Buerger Hans Michael N-phenyl-2-pyrimidine-amine derivatives
US20040126877A1 (en) * 2001-04-20 2004-07-01 Man-Wook Hur Repressors for hiv transcription and methods thereof
WO2005072826A2 (en) * 2004-01-21 2005-08-11 Emory University Compositions and use of tyrosine kinase inhibitors to treat pathogenic infection

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BASKARAN RAJASEKARAN ET AL: "Nuclear c-Abl is a COOH-terminal repeated domain (CTD)-tyrosine kinase-specific for the mammalian RNA polymerase II: Possible role in transcription elongation", CELL GROWTH AND DIFFERENTIATION, vol. 10, no. 6, June 1999 (1999-06-01), pages 387 - 396, XP002361028, ISSN: 1044-9523 *
TSIMBERIDOU APOSTOLIA-MARIA ET AL: "Chronic myeloid leukemia in a patient with acquired immune deficiency syndrome: complete cytogenetic response with imatinib mesylate: report of a case and review of the literature", LEUKEMIA RESEARCH, vol. 28, no. 6, June 2004 (2004-06-01), pages 657 - 660, XP002361027, ISSN: 0145-2126 *

Also Published As

Publication number Publication date
WO2006017353A2 (en) 2006-02-16

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