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WO2006013367A3 - Chimeric heamaglutinin proteins and uses thereof - Google Patents

Chimeric heamaglutinin proteins and uses thereof Download PDF

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Publication number
WO2006013367A3
WO2006013367A3 PCT/GB2005/003053 GB2005003053W WO2006013367A3 WO 2006013367 A3 WO2006013367 A3 WO 2006013367A3 GB 2005003053 W GB2005003053 W GB 2005003053W WO 2006013367 A3 WO2006013367 A3 WO 2006013367A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
chimeric
heamaglutinin
well
chimeric proteins
Prior art date
Application number
PCT/GB2005/003053
Other languages
French (fr)
Other versions
WO2006013367A2 (en
Inventor
Rodney Stuart Daniels
Kathryn Marie Copeland
Alexander James Elliot
Original Assignee
Medical Res Council
Rodney Stuart Daniels
Kathryn Marie Copeland
Alexander James Elliot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0417390A external-priority patent/GB0417390D0/en
Application filed by Medical Res Council, Rodney Stuart Daniels, Kathryn Marie Copeland, Alexander James Elliot filed Critical Medical Res Council
Publication of WO2006013367A2 publication Critical patent/WO2006013367A2/en
Publication of WO2006013367A3 publication Critical patent/WO2006013367A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to chimeric proteins which comprise an amino acid sequence of a viral protein and which exhibit structural and functional properties of the native parent proteins, as well as nucleic acids and expression vectors encoding such proteins and host cells expressing such proteins. The invention further relates to expression of the chimeric proteins, including in recombinant viruses, as well as uses of the chimeric proteins and recombinant viruses expressing them.
PCT/GB2005/003053 2004-08-04 2005-08-02 Chimeric heamaglutinin proteins and uses thereof WO2006013367A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US59867404P 2004-08-04 2004-08-04
GB0417390.2 2004-08-04
US60/598,674 2004-08-04
GB0417390A GB0417390D0 (en) 2004-08-04 2004-08-04 Chimeric proteins and uses thereof

Publications (2)

Publication Number Publication Date
WO2006013367A2 WO2006013367A2 (en) 2006-02-09
WO2006013367A3 true WO2006013367A3 (en) 2006-04-06

Family

ID=35478750

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/003053 WO2006013367A2 (en) 2004-08-04 2005-08-02 Chimeric heamaglutinin proteins and uses thereof

Country Status (1)

Country Link
WO (1) WO2006013367A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064860A2 (en) * 2000-03-02 2001-09-07 Polymun Scientific Immunbiologische Forschung Gmbh Recombinant influenza a viruses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064860A2 (en) * 2000-03-02 2001-09-07 Polymun Scientific Immunbiologische Forschung Gmbh Recombinant influenza a viruses

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BENTZ J ET AL: "Deployment of membrane fusion protein domains during fusion.", CELL BIOLOGY INTERNATIONAL. 2000, vol. 24, no. 11, 2000, pages 819 - 838, XP002361541, ISSN: 1065-6995 *
BULLOUGH P A ET AL: "Structure of influenza haemagglutinin at the pH of membrane fusion.", NATURE. 1 SEP 1994, vol. 371, no. 6492, 1 September 1994 (1994-09-01), pages 37 - 43, XP002361542, ISSN: 0028-0836 *
COPELAND K M ET AL: "Functional chimeras of human immunodeficiency virus type 1 Gp120 and influenza A virus (H3) hemagglutinin.", JOURNAL OF VIROLOGY. MAY 2005, vol. 79, no. 10, May 2005 (2005-05-01), pages 6459 - 6471, XP002361544, ISSN: 0022-538X *
DATABASE EMBL 2 September 2002 (2002-09-02), VERHOEYEN M.: "Influenza A/aichi/2/68 (h3n2), hemagglutinin (seg 4), cdna.", XP002361634, retrieved from EBI Database accession no. J02090 *
FERKO B ET AL: "CHIMERIC INFLUENZA VIRUS REPLICATING PREDOMINANTLY IN THE MURINE UPPER RESPIRATORY TRACT INDUCES LOCAL IMMUNE RESPONSES AGAINST HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 IN THE GENITAL TRACT", JOURNAL OF INFECTIOUS DISEASES, CHICAGO, IL, US, vol. 178, no. 5, November 1998 (1998-11-01), pages 1359 - 1368, XP001035117, ISSN: 0022-1899 *
HORIMOTO TAISUKE ET AL: "Generation of influenza A viruses with chimeric (type A/B) hemagglutinins.", JOURNAL OF VIROLOGY. JUL 2003, vol. 77, no. 14, July 2003 (2003-07-01), pages 8031 - 8038, XP002361543, ISSN: 0022-538X *
SEGAL M S ET AL: "Disulfide bond formation during the folding of influenza virus hemagglutinin.", THE JOURNAL OF CELL BIOLOGY. JUL 1992, vol. 118, no. 2, July 1992 (1992-07-01), pages 227 - 244, XP002361540, ISSN: 0021-9525 *
WATANABE TOKIKO ET AL: "Exploitation of nucleic acid packaging signals to generate a novel influenza virus-based vector stably expressing two foreign genes", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 77, no. 19, October 2003 (2003-10-01), pages 10575 - 10583, XP002325831, ISSN: 0022-538X *

Also Published As

Publication number Publication date
WO2006013367A2 (en) 2006-02-09

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