WO2006010070A3 - Compositions and methods related to peptides that selectively bind leukemia cells - Google Patents
Compositions and methods related to peptides that selectively bind leukemia cells Download PDFInfo
- Publication number
- WO2006010070A3 WO2006010070A3 PCT/US2005/024414 US2005024414W WO2006010070A3 WO 2006010070 A3 WO2006010070 A3 WO 2006010070A3 US 2005024414 W US2005024414 W US 2005024414W WO 2006010070 A3 WO2006010070 A3 WO 2006010070A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- leukemia cells
- targeting peptides
- compositions
- peptides
- leukemia
- Prior art date
Links
- 208000032839 leukemia Diseases 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000008685 targeting Effects 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides additional methods and compositions for the preparation and use of targeting peptides that are selective and/or specific for leukemia. In some embodiments, the invention concerns particular targeting peptides selective or specific for leukemia cells, including but not limited to SEQ ID NO: 5, SEQ ID NO: 6, or SEQ ID NO: 7. Other embodiments concern such targeting peptides attached to therapeutic agents. In other embodiments, leukemia or other targeting peptides may be used to selectively or specifically deliver therapeutic agents to target cells, such as leukemia cells. In certain embodiments, the subject methods concern the identification, preparation, and use of targeting peptides selective or specific for a given target cell, tissue or organ, such as leukemia cells.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58681404P | 2004-07-10 | 2004-07-10 | |
| US60/586,814 | 2004-07-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2006010070A2 WO2006010070A2 (en) | 2006-01-26 |
| WO2006010070A3 true WO2006010070A3 (en) | 2006-05-26 |
Family
ID=35785773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2005/024414 WO2006010070A2 (en) | 2004-07-10 | 2005-07-11 | Compositions and methods related to peptides that selectively bind leukemia cells |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2006010070A2 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2002036A4 (en) * | 2006-03-09 | 2010-01-27 | Univ Texas | COMPOSITIONS AND METHODS FOR PROFILING A PLURALITY OF CELL LINES AS A FUNCTION OF THEIR LINK TO PEPTIDES |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| US8313729B2 (en) | 2007-03-01 | 2012-11-20 | Medibeacon, LLC | Integrated photoactive small molecules and uses thereof |
| CA2695197C (en) | 2007-07-31 | 2017-08-15 | Mallinckrodt Inc. | Integrated photoactive agents and uses thereof |
| KR100968839B1 (en) * | 2008-02-25 | 2010-07-09 | 경북대학교 산학협력단 | Polypeptides that specifically bind to phosphatidylserine and uses thereof |
| US8241623B1 (en) | 2009-02-09 | 2012-08-14 | David Bermudes | Protease sensitivity expression system |
| WO2011031955A2 (en) * | 2009-09-11 | 2011-03-17 | Mallinckrodt Inc. | Optical monitoring of leukemia |
| WO2011084571A2 (en) | 2009-12-16 | 2011-07-14 | Mallinckrodt Inc. | Azide derivatives for phototherapy |
| US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
| US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
| US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| WO2013038392A1 (en) * | 2011-09-18 | 2013-03-21 | Ariel-University Research And Development Company, Ltd. | Peptides useful for binding to b-cell leukemic cells, conjugates, and compositions comprising same and uses thereof |
| US9593339B1 (en) | 2013-02-14 | 2017-03-14 | David Gordon Bermudes | Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment |
| US9737592B1 (en) | 2014-02-14 | 2017-08-22 | David Gordon Bermudes | Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment |
| US10702803B2 (en) | 2016-11-01 | 2020-07-07 | Northwestern University | Layer-by-layer sorting of rhenium disulfide via high-density isopycnic density gradient ultracentrifugation |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714577A (en) * | 1996-01-26 | 1998-02-03 | University Of Pittsburgh | Antimicrobial peptides |
| US20030054375A1 (en) * | 2000-01-31 | 2003-03-20 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
-
2005
- 2005-07-11 WO PCT/US2005/024414 patent/WO2006010070A2/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714577A (en) * | 1996-01-26 | 1998-02-03 | University Of Pittsburgh | Antimicrobial peptides |
| US20030054375A1 (en) * | 2000-01-31 | 2003-03-20 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006010070A2 (en) | 2006-01-26 |
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