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WO2006009435A3 - Method for detecting and measuring a ligand - Google Patents

Method for detecting and measuring a ligand Download PDF

Info

Publication number
WO2006009435A3
WO2006009435A3 PCT/NL2005/000517 NL2005000517W WO2006009435A3 WO 2006009435 A3 WO2006009435 A3 WO 2006009435A3 NL 2005000517 W NL2005000517 W NL 2005000517W WO 2006009435 A3 WO2006009435 A3 WO 2006009435A3
Authority
WO
WIPO (PCT)
Prior art keywords
ligand
measuring
detecting
detection
liquid
Prior art date
Application number
PCT/NL2005/000517
Other languages
French (fr)
Other versions
WO2006009435A2 (en
WO2006009435A8 (en
Inventor
Rentje Frederik Witkamp
Wouter Henricus Johannes Vaes
Micha Manuele Mueller
Original Assignee
Schappelijk Onderzoek Tno Nl O
Rentje Frederik Witkamp
Wouter Henricus Johannes Vaes
Micha Manuele Mueller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schappelijk Onderzoek Tno Nl O, Rentje Frederik Witkamp, Wouter Henricus Johannes Vaes, Micha Manuele Mueller filed Critical Schappelijk Onderzoek Tno Nl O
Publication of WO2006009435A2 publication Critical patent/WO2006009435A2/en
Publication of WO2006009435A3 publication Critical patent/WO2006009435A3/en
Publication of WO2006009435A8 publication Critical patent/WO2006009435A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to a method for the detection of binding between a ligand and its binding partner and thus provides an improved competitive binding assay for detecting and measuring a ligand. The present invention further provides a liquid container for detecting and measuring a ligand in a liquid, which, in addition to an extracting phase with the capability to extract a ligand from the liquid phase, is provided with detection means for detection of ligands or analogs thereof.
PCT/NL2005/000517 2004-07-19 2005-07-18 Method for detecting and measuring a ligand WO2006009435A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1026678 2004-07-19
NL1026678A NL1026678C2 (en) 2004-07-19 2004-07-19 Method for detecting and measuring a ligand.

Publications (3)

Publication Number Publication Date
WO2006009435A2 WO2006009435A2 (en) 2006-01-26
WO2006009435A3 true WO2006009435A3 (en) 2006-04-27
WO2006009435A8 WO2006009435A8 (en) 2006-08-24

Family

ID=34974013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2005/000517 WO2006009435A2 (en) 2004-07-19 2005-07-18 Method for detecting and measuring a ligand

Country Status (2)

Country Link
NL (1) NL1026678C2 (en)
WO (1) WO2006009435A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030109067A1 (en) 2001-12-06 2003-06-12 Immunetech, Inc. Homogeneous immunoassays for multiple allergens

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366143A (en) * 1979-09-24 1982-12-28 Amersham International Public Limited Company Assay for the free portion of substances in biological fluids
WO1998041855A1 (en) * 1997-03-14 1998-09-24 Pawliszyn Janusz B Method and device for solid phase microextraction and desorption
WO2002101084A2 (en) * 2001-06-11 2002-12-19 Applied Research Systems Ars Holding N.V. Scintillation proximity assays for aminoglycoside binding molecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366143A (en) * 1979-09-24 1982-12-28 Amersham International Public Limited Company Assay for the free portion of substances in biological fluids
WO1998041855A1 (en) * 1997-03-14 1998-09-24 Pawliszyn Janusz B Method and device for solid phase microextraction and desorption
WO2002101084A2 (en) * 2001-06-11 2002-12-19 Applied Research Systems Ars Holding N.V. Scintillation proximity assays for aminoglycoside binding molecules

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
M. B. HERINGA ET AL.: "Negligible depletion solid-phase microextraction with radiolabelled analytes to study free concentrations and protein binding: an example with [3H]estradiol.", ANALYTICAL CHEMISTRY, vol. 74, no. 23, 1 December 2002 (2002-12-01), pages 5993 - 5997, XP002325261 *
P. ÖNNERFJORD ET AL.: "High sample throughput flow immunoassay utilising restricted access columns for the separation of bound and free label", JOURNAL OF CHROMATOGRAPHY A, vol. 800, 1998, ELSEVIER, NL, pages 219 - 230, XP002325262 *
R. F. MASSEYEFF (EDITOR-IN-CHIEF): "Methods of Immunological Analysis, Vol. 1, Fundamentals", 1993, VCH VERLAGSGESELLSCHAFT MBH, WEINHEIN, DE, XP002325263 *
RATCLIFF J G: "SEPARATION TECHNIQUES IN SATURATION ANALYSIS", BRITISH MEDICAL BULLETIN, CHURCHILL LIVINGSTONE, LONDON, GB, vol. 30, 1974, pages 32 - 37, XP002105008, ISSN: 0007-1420 *

Also Published As

Publication number Publication date
NL1026678C2 (en) 2006-01-23
WO2006009435A2 (en) 2006-01-26
WO2006009435A8 (en) 2006-08-24

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