WO2006008002A3 - Agents diagnostiques et therapeutiques pour pathologies associees a la kallikreine 1 (klk1) - Google Patents
Agents diagnostiques et therapeutiques pour pathologies associees a la kallikreine 1 (klk1) Download PDFInfo
- Publication number
- WO2006008002A3 WO2006008002A3 PCT/EP2005/007438 EP2005007438W WO2006008002A3 WO 2006008002 A3 WO2006008002 A3 WO 2006008002A3 EP 2005007438 W EP2005007438 W EP 2005007438W WO 2006008002 A3 WO2006008002 A3 WO 2006008002A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- disorders
- klk1
- diseases
- kallikrein
- therapeutics
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 9
- 101710176219 Kallikrein-1 Proteins 0.000 title 1
- 101100180428 Mus musculus Klk1b1 gene Proteins 0.000 title 1
- 101100453992 Rattus norvegicus Ngfg gene Proteins 0.000 title 1
- 102000057032 Tissue Kallikreins Human genes 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 208000035475 disorder Diseases 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 2
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 210000000750 endocrine system Anatomy 0.000 abstract 2
- 230000002496 gastric effect Effects 0.000 abstract 2
- 208000014951 hematologic disease Diseases 0.000 abstract 2
- 229940088597 hormone Drugs 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 208000019423 liver disease Diseases 0.000 abstract 2
- 208000030159 metabolic disease Diseases 0.000 abstract 2
- 208000014001 urinary system disease Diseases 0.000 abstract 2
- 101100453988 Homo sapiens KLK1 gene Proteins 0.000 abstract 1
- 101000605522 Homo sapiens Kallikrein-1 Proteins 0.000 abstract 1
- 102100038297 Kallikrein-1 Human genes 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96455—Kallikrein (3.4.21.34; 3.4.21.35)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention concerne une KLK1 humaine qui est associée à des troubles hormonaux et troubles du système endocrinien, des troubles cardio-vasculaires, des troubles métaboliques, des troubles inflammatoires, des troubles gastro-intestinaux et hépatiques, des troubles cancéreux, des troubles hématologiques, des troubles musculaires et osseux, des troubles de la reproduction et des troubles urologiques. L'invention a également pour objet des essais pour identifier des composés utiles pour la prévention ou le traitement de troubles hormonaux et troubles du système endocrinien, de troubles cardio-vasculaires, de troubles métaboliques, de troubles inflammatoires, de troubles gastro-intestinaux et hépatiques, de troubles cancéreux, de troubles hématologiques, de troubles musculaires et osseux, de troubles de la reproduction et de troubles urologiques. L'invention concerne aussi des composés qui se lient à KLK1 et/ou activent ou inhibent son activité, ainsi que des compositions pharmaceutiques qui comprennent de tels composés.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04017450.0 | 2004-07-23 | ||
| EP04017450 | 2004-07-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2006008002A2 WO2006008002A2 (fr) | 2006-01-26 |
| WO2006008002A3 true WO2006008002A3 (fr) | 2006-04-13 |
Family
ID=35056965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2005/007438 WO2006008002A2 (fr) | 2004-07-23 | 2005-07-09 | Agents diagnostiques et therapeutiques pour pathologies associees a la kallikreine 1 (klk1) |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2006008002A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9364521B2 (en) | 2012-06-04 | 2016-06-14 | Diamedica Inc. | Human tissue kallikrein 1 glycosylation isoforms |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329737B2 (en) | 2004-08-03 | 2008-02-12 | Dyax Corp. | Antibodies that bind hK-1 |
| EP2182978A4 (fr) * | 2007-07-20 | 2012-03-21 | Sanomune Inc | Kallikréine tissulaire destinée au traitement de maladies associées à la protéine amyloïde |
| CA2838984A1 (fr) * | 2011-06-10 | 2012-12-13 | Isis Pharmaceuticals, Inc. | Procedes pour moduler l'expression de la kallicreine (klkb1) |
| EP2726153B1 (fr) | 2011-06-29 | 2018-03-28 | Ionis Pharmaceuticals, Inc. | Procédés de modulation de l'expression de kallicréine (klkb1) |
| US20130315891A1 (en) | 2012-05-25 | 2013-11-28 | Matthew Charles | Formulations of human tissue kallikrein-1 for parenteral delivery and related methods |
| AU2014312196C1 (en) | 2013-08-28 | 2019-12-19 | Ionis Pharmaceuticals, Inc. | Modulation of prekallikrein (PKK) expression |
| BR112016022855B1 (pt) | 2014-05-01 | 2022-08-02 | Ionis Pharmaceuticals, Inc | Compostos e composições para modular a expressão de pkk e seus usos |
| KR20190122706A (ko) | 2017-03-09 | 2019-10-30 | 다이어메디카 인코포레이티드 | 조직 칼리크레인 1의 투약 형태 |
| JP7414281B2 (ja) * | 2017-08-08 | 2024-01-16 | クイーンズランド ユニバーシティ オブ テクノロジー | 初期心不全の診断方法 |
| CN115840039A (zh) * | 2023-02-20 | 2023-03-24 | 南京广祺医药科技有限公司 | 一种测定血清中人源uklk1的elisa方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023100A2 (fr) * | 1998-10-22 | 2000-04-27 | Curagen Corporation | Genes et proteines destines a la prevention et therapie de maladies renales et de troubles associes |
-
2005
- 2005-07-09 WO PCT/EP2005/007438 patent/WO2006008002A2/fr active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023100A2 (fr) * | 1998-10-22 | 2000-04-27 | Curagen Corporation | Genes et proteines destines a la prevention et therapie de maladies renales et de troubles associes |
Non-Patent Citations (3)
| Title |
|---|
| DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1988, PEREZ BLANCO F J ET AL: "EXCRETION OF RENAL KALLIKREIN IN LIVER CIRRHOSIS", XP002349454, Database accession no. PREV198987123831 * |
| REVISTA ESPANOLA DE LAS ENFERMEDADES DEL APARATO DIGESTIVO, vol. 74, no. 5, 1988, pages 505 - 508 * |
| YUKI N ET AL: "RENAL KININ AND KALLIKREIN EXCRETION IN CIRRHOTIC PATIENTS", SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, vol. 26, no. 10, 1991, pages 1075 - 1081, XP008054176 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9364521B2 (en) | 2012-06-04 | 2016-06-14 | Diamedica Inc. | Human tissue kallikrein 1 glycosylation isoforms |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006008002A2 (fr) | 2006-01-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2005075665A3 (fr) | Agents diagnostiques et therapeutiques pour des maladies associees a la kallikreine plasmatique (klkb1) | |
| WO2004104216A3 (fr) | Diagnostics et agents therapeutiques destines a des maladies liees a une dipeptidylpeptidase iv (dpp4) | |
| WO2004104215A3 (fr) | Approches diagnostiques et therapeutiques des maladies associees a la dipeptidylpeptidase 7 (dpp7) | |
| WO2005106492A3 (fr) | Diagnostic et traitement therapeutique des maladies associees au recepteur 3 de la chimiokine c-c (ccr3) | |
| WO2006008002A3 (fr) | Agents diagnostiques et therapeutiques pour pathologies associees a la kallikreine 1 (klk1) | |
| WO2005022164A3 (fr) | Agents diagnostiques et agents therapeutiques destines a des maladies associees a la kallikreine 8 (klk8) | |
| WO2005078117A3 (fr) | Agents diagnostiques et therapeutiques destines a des maladies associees a la kallikreine 6 (klk6) | |
| WO2004097358A3 (fr) | Agents diagnostiques et therapeutiques destines a des maladies associees a la serine protease 2 transmembranaire humaine (tmprss2) | |
| WO2005118840A3 (fr) | Elements diagnostiques therapeutiques pour des maladies associees a la kallikreine 10 (klk10) | |
| WO2005050225A3 (fr) | Outils de diagnostic et de traitement de maladies associees au recepteur 84 couple aux proteines g (gpr84) | |
| WO2004082568A3 (fr) | Diagnostics et traitements contre des maladies associees au recepteur 5a du composant du complement (c5ar) | |
| WO2005106471A3 (fr) | Diagnostics et therapies pour des maladies associees a un recepteur 4 de chimiokine c-c (ccr4) | |
| WO2005095973A3 (fr) | Methodes diagnostiques et therapeutiques pour des maladies associees au recepteur 54 couple a la proteine g (gpr54) | |
| WO2005075662A3 (fr) | Methodes diagnostiques et therapeutiques des maladies associees au kallikrein 2 (klk2) | |
| WO2005103702A3 (fr) | Methodes diagnostiques et therapeutiques pour lutter contre les maladies associees au recepteur 2 de la chimiokine cxc (cxcr2) | |
| WO2004104574A3 (fr) | Agents diagnostiques et therapeutiques destines a des maladies associees au recepteur de chimiokine c-c de type 7 (ccr7) | |
| WO2005040211A3 (fr) | Composes destines au diagnostic et au traitement de maladies associees au recepteur 1 couple aux proteines g (gpr1) | |
| WO2005040825A3 (fr) | Diagnostics et therapeutiques pour maladies liees au recepteur 20 couple a la proteine g (gpr20) | |
| WO2006008008A3 (fr) | Agents diagnostiques et therapeutiques pour pathologies associees au facteur nucleaire d'hepatocyte 4, alpha (hnf4a) | |
| WO2005095984A3 (fr) | Compositions diagnostiques et therapeutiques pour des maladies associees au recepteur adrenergique alpha 2a couple a la proteine g (adra2a) | |
| WO2004106536A3 (fr) | Agents diagnostiques et therapeutiques pour maladies associees a la serine protease 8 (prss8) | |
| WO2005059546A3 (fr) | Diagnostics et therapeutique destines au traitement de maladies associees au recepteur couple aux proteines g 35 (gpr35) | |
| WO2004106935A3 (fr) | Agents diagnostiques et therapeutiques destines a des maladies associees au recepteur 103 couples aux proteines g (gpr103) | |
| WO2005040401A3 (fr) | Diagnostic et traitement de maladies associees a la serine-protease mosaique (msp) | |
| WO2005103711A3 (fr) | Agents diagnostiques et therapeutiques pour des maladies associees au recepteur 1 des chimiokines cxc (cxcr1) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
| AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |