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WO2006007180A3 - Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia - Google Patents

Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia Download PDF

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Publication number
WO2006007180A3
WO2006007180A3 PCT/US2005/018232 US2005018232W WO2006007180A3 WO 2006007180 A3 WO2006007180 A3 WO 2006007180A3 US 2005018232 W US2005018232 W US 2005018232W WO 2006007180 A3 WO2006007180 A3 WO 2006007180A3
Authority
WO
WIPO (PCT)
Prior art keywords
exhaled breath
breath condensate
gram negative
lipopolysaccharide
negative pneumonia
Prior art date
Application number
PCT/US2005/018232
Other languages
French (fr)
Other versions
WO2006007180A2 (en
Inventor
Jeffrey A Kline
Jackeline Hernandez
John Albert Watts Jr
Original Assignee
Charlotte Mecklenburg Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP05753778A priority Critical patent/EP1761166A4/en
Application filed by Charlotte Mecklenburg Hospital filed Critical Charlotte Mecklenburg Hospital
Priority to MXPA06014248A priority patent/MXPA06014248A/en
Priority to AU2005262701A priority patent/AU2005262701B2/en
Priority to JP2007527565A priority patent/JP4804464B2/en
Priority to BRPI0511846-8A priority patent/BRPI0511846A/en
Priority to CA002566804A priority patent/CA2566804A1/en
Publication of WO2006007180A2 publication Critical patent/WO2006007180A2/en
Priority to IL179137A priority patent/IL179137A/en
Publication of WO2006007180A3 publication Critical patent/WO2006007180A3/en
Priority to IL218191A priority patent/IL218191A0/en
Priority to IL218190A priority patent/IL218190A0/en
Priority to IL218188A priority patent/IL218188A0/en
Priority to IL218189A priority patent/IL218189A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0813—Measurement of pulmonary parameters by tracers, e.g. radioactive tracers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/50—Lipopolysaccharides; LPS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physiology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)

Abstract

A method for determining whether a subject has Gram negative bacterial pneumonia based on the presence of lipopolysaccharide in exhaled breath condensate collected from the subject. The collection devices utilized to collect exhaled breath condensate from both spontaneously breathing and mechanically ventilated subjects and the devices utilized to determine whether lipopolysaccharide is present in the collected exhaled breath condensate.
PCT/US2005/018232 2004-06-07 2005-05-24 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia WO2006007180A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA002566804A CA2566804A1 (en) 2004-06-07 2005-05-24 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
MXPA06014248A MXPA06014248A (en) 2004-06-07 2005-05-24 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia.
AU2005262701A AU2005262701B2 (en) 2004-06-07 2005-05-24 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
JP2007527565A JP4804464B2 (en) 2004-06-07 2005-05-24 Diagnosis of Gram-negative bacterial pneumonia using lipopolysaccharide in exhaled breath condensate
BRPI0511846-8A BRPI0511846A (en) 2004-06-07 2005-05-24 use of exhaled breath condensate lipopolysaccharide to diagnose gram-negative pneumonia
EP05753778A EP1761166A4 (en) 2004-06-07 2005-05-24 USE OF LIPOPOLYSACCHARIDE IN EXHAUSTED BREATHING CONDENSATION FOR THE DIAGNOSIS OF GRAM NEGATIVE PNEUMONIA
IL179137A IL179137A (en) 2004-06-07 2006-11-09 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
IL218191A IL218191A0 (en) 2004-06-07 2012-02-19 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
IL218190A IL218190A0 (en) 2004-06-07 2012-02-19 Reaction chamber assemblies for measuring the lipopolysaccharide in exhaled breath condensate
IL218188A IL218188A0 (en) 2004-06-07 2012-02-19 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
IL218189A IL218189A0 (en) 2004-06-07 2012-02-19 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57764104P 2004-06-07 2004-06-07
US60/577,641 2004-06-07

Publications (2)

Publication Number Publication Date
WO2006007180A2 WO2006007180A2 (en) 2006-01-19
WO2006007180A3 true WO2006007180A3 (en) 2006-11-30

Family

ID=35784291

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/018232 WO2006007180A2 (en) 2004-06-07 2005-05-24 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia

Country Status (8)

Country Link
EP (1) EP1761166A4 (en)
JP (2) JP4804464B2 (en)
AU (1) AU2005262701B2 (en)
BR (1) BRPI0511846A (en)
CA (1) CA2566804A1 (en)
IL (5) IL179137A (en)
MX (1) MXPA06014248A (en)
WO (1) WO2006007180A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0316872B1 (en) 2002-12-20 2014-02-18 Breathing condensation collector.
US7828741B2 (en) 2002-12-20 2010-11-09 The Charlotte-Mecklenburg Hospital Authority Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
WO2004073497A2 (en) 2003-02-14 2004-09-02 The Charlotte-Mecklenburg Hospital Authority Device and method for collection of exhaled alveolar breath condensate
US9976944B2 (en) 2007-10-02 2018-05-22 Pexa Ab Collection and measurement of exhaled particles
BRPI0909536A2 (en) * 2008-06-04 2019-03-06 Kci Licensing Inc. "method for detecting infection in a wound caused by an infecting organism at a wound site, system detecting an infection in a wound in a wound region, porous pad adapted to distribute reduced pressure to a wound region and system use"
GB201312635D0 (en) * 2013-07-15 2013-08-28 Univ Plymouth Water testing
US10413216B2 (en) * 2016-02-03 2019-09-17 Quintron Instrument Company, Inc. Breath testing apparatus
CN106018362B (en) * 2016-05-16 2018-06-08 江苏国恒检测有限公司 A kind of picric analyzer of detection
CN108871908B9 (en) * 2018-09-06 2024-07-26 杭州优思达生物技术股份有限公司 Biological sample processing device
CN114449957B (en) * 2019-08-26 2023-11-24 泽特奥科技公司 Diagnosis of tuberculosis and other diseases using exhaled breath
WO2023038582A2 (en) * 2021-09-10 2023-03-16 National University Of Singapore Exhaled breath condensate collection kit
GB2612897B (en) * 2021-09-20 2024-05-29 Vosbio Inc Devices, methods and kits for biological sample capture and processing

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349626A (en) * 1980-10-28 1982-09-14 The Monell Chemical Senses Center Method of detecting Pseudomonas aeruginosa infections utilizing selected ketone and/or sulfur metabolites
US5541057A (en) * 1989-09-18 1996-07-30 Biostar, Inc. Methods for detection of an analyte
US20040234971A1 (en) * 2001-02-01 2004-11-25 Joany Jackman Diagnosis of pathogen infections using mass spectral analysis of immune system modulators in post-exposure biological samples

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59383A (en) * 1980-02-14 1983-03-31 Technion Res & Dev Foundation Micromethod for the determination of endotoxins with limulus amebocyte lysate
SE9704329D0 (en) * 1997-11-25 1997-11-25 Siemens Elema Ab Gas meters
AU776296B2 (en) * 1998-12-18 2004-09-02 University Of Virginia Patent Foundation Device and method for monitoring asthma
DE60020823T2 (en) * 1999-03-09 2006-05-18 Osmetech Plc, Crewe DIAGNOSTIC METHOD THROUGH ANALYSIS OF CONDENSATION FROM BREATHING GAS
WO2001084112A1 (en) * 2000-05-01 2001-11-08 Respiratory Research, Inc. Method and device for collecting and analyzing exhaled breath

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349626A (en) * 1980-10-28 1982-09-14 The Monell Chemical Senses Center Method of detecting Pseudomonas aeruginosa infections utilizing selected ketone and/or sulfur metabolites
US5541057A (en) * 1989-09-18 1996-07-30 Biostar, Inc. Methods for detection of an analyte
US20040234971A1 (en) * 2001-02-01 2004-11-25 Joany Jackman Diagnosis of pathogen infections using mass spectral analysis of immune system modulators in post-exposure biological samples

Also Published As

Publication number Publication date
BRPI0511846A (en) 2008-01-15
IL218189A0 (en) 2012-04-30
JP2009186487A (en) 2009-08-20
EP1761166A2 (en) 2007-03-14
IL218190A0 (en) 2012-04-30
JP4852121B2 (en) 2012-01-11
JP2008501976A (en) 2008-01-24
JP4804464B2 (en) 2011-11-02
IL179137A0 (en) 2007-03-08
EP1761166A4 (en) 2009-11-11
IL179137A (en) 2012-07-31
IL218188A0 (en) 2012-04-30
IL218191A0 (en) 2012-04-30
CA2566804A1 (en) 2006-01-19
MXPA06014248A (en) 2007-06-25
AU2005262701A1 (en) 2006-01-19
AU2005262701B2 (en) 2011-12-01
WO2006007180A2 (en) 2006-01-19

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