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WO2006006691A3 - Nouvelle dispersion solide et son procede d'elaboration - Google Patents

Nouvelle dispersion solide et son procede d'elaboration Download PDF

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Publication number
WO2006006691A3
WO2006006691A3 PCT/JP2005/013099 JP2005013099W WO2006006691A3 WO 2006006691 A3 WO2006006691 A3 WO 2006006691A3 JP 2005013099 W JP2005013099 W JP 2005013099W WO 2006006691 A3 WO2006006691 A3 WO 2006006691A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid dispersion
kinase inhibitor
map kinase
present
drug release
Prior art date
Application number
PCT/JP2005/013099
Other languages
English (en)
Other versions
WO2006006691A2 (fr
Inventor
Yoshihiro Omachi
Takashi Kurasawa
Original Assignee
Takeda Pharmaceutical
Yoshihiro Omachi
Takashi Kurasawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical, Yoshihiro Omachi, Takashi Kurasawa filed Critical Takeda Pharmaceutical
Publication of WO2006006691A2 publication Critical patent/WO2006006691A2/fr
Publication of WO2006006691A3 publication Critical patent/WO2006006691A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne une dispersion solide renfermant (i) un médicament, (ii) des excipients, (iii) des plastifiants et (iv) des composés à libération contrôlée de médicaments. Selon cette invention, la solubilité de médicament insoluble ou peu soluble peut être améliorée et une fonction de contrôle de la libération de médicaments peut être fournie simultanément dans un processus d'élaboration unique. Ladite invention a également pour objet une dispersion solide possédant une composition uniforme permettant la libération soutenue de médicaments.
PCT/JP2005/013099 2004-07-09 2005-07-08 Nouvelle dispersion solide et son procede d'elaboration WO2006006691A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004-203799 2004-07-09
JP2004203799A JP2007223903A (ja) 2004-07-09 2004-07-09 新規な固体分散体およびその製造方法

Publications (2)

Publication Number Publication Date
WO2006006691A2 WO2006006691A2 (fr) 2006-01-19
WO2006006691A3 true WO2006006691A3 (fr) 2006-03-30

Family

ID=34979219

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/013099 WO2006006691A2 (fr) 2004-07-09 2005-07-08 Nouvelle dispersion solide et son procede d'elaboration

Country Status (3)

Country Link
JP (1) JP2007223903A (fr)
TW (1) TW200608996A (fr)
WO (1) WO2006006691A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1992344A1 (fr) 2007-05-18 2008-11-19 Institut Curie P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
WO2011102505A1 (fr) * 2010-02-22 2011-08-25 第一三共株式会社 Préparation solide à libération prolongée pour usage oral
TW201141544A (en) 2010-02-22 2011-12-01 Daiichi Sankyo Co Ltd Oral solid extended release dosage form
CN106232144B (zh) 2014-03-18 2019-12-06 武田药品工业株式会社 固体分散体
CA3144945A1 (fr) * 2019-06-26 2020-12-30 Ricoh Company, Ltd. Composition pharmaceutique comprenant des particules contenant un materiau de base hydrosoluble et un compose peu hydrosoluble

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1180518A1 (fr) * 1999-04-23 2002-02-20 Takeda Chemical Industries, Ltd. Composes 5-pyridyle-1,3-azole, leur procede de fabrication et leur utilisation
US20030077322A1 (en) * 2000-05-20 2003-04-24 Lee Sang Deuk Solid dispersion system of pranlukast with improved dissolution and method for preparing the same
US20030181411A1 (en) * 2002-03-20 2003-09-25 Elan Pharma International Ltd. Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1180518A1 (fr) * 1999-04-23 2002-02-20 Takeda Chemical Industries, Ltd. Composes 5-pyridyle-1,3-azole, leur procede de fabrication et leur utilisation
US20030077322A1 (en) * 2000-05-20 2003-04-24 Lee Sang Deuk Solid dispersion system of pranlukast with improved dissolution and method for preparing the same
US20030181411A1 (en) * 2002-03-20 2003-09-25 Elan Pharma International Ltd. Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors

Also Published As

Publication number Publication date
WO2006006691A2 (fr) 2006-01-19
JP2007223903A (ja) 2007-09-06
TW200608996A (en) 2006-03-16

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