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WO2006005630A1 - Composition aqueuse photoprotectrice comprenant des nanopigments d'oxydes metalliques hydrophiles et un polyalkyleneglycol de faible masse moleculaire, et ses utilisations - Google Patents

Composition aqueuse photoprotectrice comprenant des nanopigments d'oxydes metalliques hydrophiles et un polyalkyleneglycol de faible masse moleculaire, et ses utilisations Download PDF

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Publication number
WO2006005630A1
WO2006005630A1 PCT/EP2005/007887 EP2005007887W WO2006005630A1 WO 2006005630 A1 WO2006005630 A1 WO 2006005630A1 EP 2005007887 W EP2005007887 W EP 2005007887W WO 2006005630 A1 WO2006005630 A1 WO 2006005630A1
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WIPO (PCT)
Prior art keywords
composition according
derivatives
composition
metal oxide
hydrophilic
Prior art date
Application number
PCT/EP2005/007887
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English (en)
Inventor
Florence L'alloret
Jean-Thierry Simonnet
Original Assignee
L'oreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0451508A external-priority patent/FR2873020A1/fr
Application filed by L'oreal filed Critical L'oreal
Priority to JP2007520785A priority Critical patent/JP2008506662A/ja
Priority to EP05768229A priority patent/EP1773286A1/fr
Publication of WO2006005630A1 publication Critical patent/WO2006005630A1/fr
Priority to US11/653,394 priority patent/US20070166248A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Definitions

  • the present application relates to a photo- protective composition
  • a photo- protective composition comprising, in a physiologically acceptable medium: a) at least one aqueous phase, b) at least hydrophilic inorganic nanopigments based on metal oxides, in an amount ranging from 1 to 25% by weight, with respect to the total weight of the composition, c) at least one polyalkylene glycol with a molecular mass of less than 8000 g/mol.
  • UV-B radiation causes skin burns and erythemas which can harm the development of natural tanning; this UV-B radiation must therefore be screened out.
  • UV-A radiation with wavelengths of between 320 nm and 400 nm, which causes browning of the skin, is capable of leading to a detrimental change in the skin, in particular in the case of sensitive skin or of skin continually exposed to solar radiation.
  • UV-A radiation causes in particular a loss of elasticity of the skin and the appearance of wrinkles, resulting in premature ageing. It promotes the triggering of the erythemal reaction or accentuates this reaction in some subjects and can even be the cause of phototoxic or photoallergic reactions. It is therefore desirable to screen out UV-A radiation as well.
  • nanopigments generally have a mean size for the unit particle of less than 500 nm and preferably of less than 100 nm.
  • the metal oxide nanoparticles generally used in the formulations may be hydrophilic or else may be hydrophobic.
  • Some types of metal oxide nanoparticles and more particularly those of titanium oxide and those of zinc oxide have a tendency to whiten the skin after application. This phenomenon is undesirable from an aesthetic viewpoint.
  • metal oxide nanoparticles are generally difficult to formulate in aqueous compositions and more particularly in vehicles of the emulsion type which are the most commonly used in antisun cosmetic ' s. They have a tendency to produce a phenomenon of sedimentation, to form large aggregates and to destabilize the aqueous formulations comprising them.
  • the Applicant Company has discovered, surprisingly and unexpectedly, that this objective could be achieved by using the combination of hydrophilic metal oxide nanoparticles and of a polyalkylene glycol with a mean molecular mass of less than 8000 g/mol.
  • a subject-matter of the present invention is a photoprotective composition
  • a photoprotective composition comprising, in a physiologically acceptable medium: a) at least one aqueous phase, b) at least hydrophilic metal oxide nanoparticles, in an amount ranging from 1 to 25% by weight, with respect to the total weight of the composition, c) at least one polyalkylene glycol with a mean molecular mass of less than 8000 g/mol.
  • Another subject-matter of the present invention is the use of at least one polyalkylene glycol with a mean molecular mass of less than 8000 g/mol in a photoprotective composition comprising at least one aqueous phase and at least hydrophilic metal oxide nanoparticles for the purpose of reducing the whitening and/or of improving the stability of the said composition (dispersibility of the nanoparticles ' in the aqueous phase) .
  • physiologically acceptable medium is ⁇ understood to mean a nontoxic medium capable of being applied to the skin, lips, hair, eyelashes, eyebrows or nails.
  • the composition of the invention can constitute in particular a cosmetic or dermatological composition.
  • nanoparticles is understood to mean particles for which the mean size of the unit particle is less than 500 nm and preferably less than 100 nm.
  • hydrophilic is understood to mean particles which, introduced into an aqueous phase at 25°C, at a concentration by weight of 1%, make it possible to obtain a solution which is macroscopically homogeneous to the naked eye.
  • the hydrophilic metal oxide nanoparticles used in the present invention are powders composed of particles having a mean size for the unit particle preferably of between 5 nm and 500 nm, preferably between 10 nm and 100 nm and preferentially between 15 nm and 50 nm.
  • the metal oxides forming these nanoparticles are preferably chosen from titanium oxides, zinc oxides or their mixtures, whether treated or untreated.
  • the treated metal oxide nanoparticles are generally subjected to one or more surface treatments of a chemical, electronic, mechanochemical and/or mechanical nature with compounds capable of rendering them hydrophilic, such as those described, for example, in Cosmetics & Toiletries, February 1990, Vol. 105, pp. 53-64. Mention may be made, for example, of amino acids, C 1 -C 5 alkanolamines, silicon oxides (silica) , metal oxides, such as alumina, sodium hexametaphosphate or glycerol or their mixtures.
  • the untreated titanium oxide nanopigments are, for example, those sold by Tayca under the trade names "Microtitanium dioxide MT 500 B” or “Microtitanium dioxide MT600 B", by Degussa under the name “P 25”, by Wacker under the name “Oxyde de titane transparent PW”, by Miyoshi Kasei under the name “UFTR”, by Tomen under the name “ITS” and by Tioxide under the name "Tioveil AQ”.
  • the untreated zinc oxide nanoparticles are for example:
  • Nanophase Technologies those sold under the name “Nanoguard WCD 2025” by Nanophase Technologies.
  • polyalkylene glycols in accordance with the invention are preferably chosen from those with an alkylene group comprising from 1 to 4 carbon atoms, in particular polyethylene glycols, polypropylene glycols and polybutylene glycols.
  • Polyethylene glycols will more particularly be chosen.
  • the concentration by weight of polyalkylene glycol in the composition preferably varies from 0.01% to 10%, more preferably from 0.1% to 5% and better still from 0.2% to 2.5%, with respect to the total weight of the composition.
  • the ratio by weight of the metal oxide nanoparticles to the polyalkylene glycol preferably varies from 1 to 30, more preferably from 5 to 20 and particularly from 8 to 12.
  • the ionic strength of the aqueous phase of the composition, without the metal oxide is less than 0.1 mol/1.
  • the ionic strength is determined using a CDM 230 conductivity meter (Meterlab) resulting in the conductivity of the medium, a parameter related to the ionic strength by the following relationship:
  • compositions in accordance with the invention can comprise other additional organic photoprotective agents active in the UV-A and/or UV-B region which are water-soluble or fat-soluble or else insoluble in the cosmetic solvents commonly used.
  • the additional organic photoprotective agents are chosen in particular from cinnamic derivatives; anthranilates; salicylic derivatives; dibenzoylmethane derivatives; camphor derivatives; benzophenone derivatives; ⁇ , ⁇ -diphenylacrylate derivatives; triazine derivatives; benzotriazole derivatives; benzalmalonate derivatives; benzimidazole derivatives; imidazolines; bis-benzoazolyl derivatives, as disclosed in Patents EP 669 323 and US 2 463 264; p-aminobenzoic acid (PABA) derivatives; methylenebis (hydroxyphenylbenzotriazole) derivatives, as disclosed in Applications US 5 237 071, US 5 166 355, GB 2 303 549, DE 197 26 184 and EP 893 119; benzoxazole derivatives, as disclosed in Patent Applications EP 0 832 642, EP 1 027 883, EP 1 300 137 and DE 10162844; screening polymers and screening silicones
  • Cinnamic derivatives Mention may be made, as examples of additional organic photoprotective agents, of those denoted below under their INCI names : Cinnamic derivatives:
  • Ethylhexyl Methoxycinnamate sold in particular under the trade name "Parsol MCX” by Hoffmann-LaRoche, Isopropyl Methoxycinnamate,
  • Ethyl Dihydroxypropyl PABA Ethylhexyl Dimethyl PABA, sold in particular under the name "Escalol 507" by ISP,
  • PEG-25 PABA sold under the name "Uvinul P25” by BASF.
  • TEA Salicylate sold under the name "Neo Heliopan TS” by Haarmann and Reimer.
  • ⁇ , ⁇ -Diphenylacrylate derivatives ⁇ , ⁇ -Diphenylacrylate derivatives:
  • Etocrylene sold in particular under the trade name
  • Benzophenone-1 sold under the trade name "Uvinul 400" by BASF,
  • Benzophenone-2 sold under the trade name "Uvinul D50" by BASF,
  • Benzophenone-4 sold under the trade name "Uvinul MS40" by BASF,
  • Benzophenone-8 sold under the trade name "Spectra-Sorb
  • Camphor Benzalkonium Methosulfate manufactured under the name "Mexoryl SO" by Chimex,
  • Phenylbenzimidazole Sulfonic Acid sold in particular under the trade name "Eusolex 232" by Merck,
  • Ethylhexyl triazone sold in particular under the trade name "Uvinul T150" by BASF,
  • Polyorganosiloxanes with benzalmalonate functional groups such as Polysilicone-15, sold under the trade name "Parsol SLX” by Hoffmann-LaRoche. 4, 4-Diarylbutadiene derivatives:
  • the preferred additional organic photo- protective agents are chosen from: . Ethylhexyl Methoxycinnamate, Ethylhexyl Salicylate, Homosalate, Octocrylene,
  • Phenylbenzimidazole Sulfonic Acid Benzophenone-3, Benzophenone-4, Benzophenone-5, n-Hexyl 2- (4-diethylamino-2-hydroxybenzoyl)benzoate, 4-Methylbenzylidene camphor, Terephthalylidene Dicamphor Sulfonic Acid, Disodium Phenyl Dibenzimidazole Tetrasulfonate, Methylene Bis-Benzotriazolyl Tetramethylbutylphenol, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Ethylhexyl triazone, Diethylhexyl Butamido Triazone, Drometrizole Trisiloxane, Polysilicone-15,
  • aqueous compositions of the invention can be provided in all the forms generally used for a topical application, in particular in the form of an oil-in-water emulsion (direct emulsion) , water-in-oil emulsion (inverse emulsion) , water-in-oil-in-water emulsion (multiple emulsion) or also of an aqueous gel.
  • compositions of the invention can comprise all the additives commonly used in cosmetics and will find applications in the care and makeup field and in the field of antisun products.
  • the additional photoprotective agents are generally present in the compositions according to the invention in proportions ranging from 0.01 to 20% by weight, with respect to the total weight of the composition, and preferably ranging from 0.1 to 10% by weight, with respect to the total weight of the composition.
  • aqueous compositions in accordance with the present invention can additionally comprise conventional cosmetic adjuvants chosen in particular from fatty substances, organic solvents, ionic or nonionic and hydrophilic or lipophilic thickening agents, softening agents, humectants, opacifiers, stabilizers, emollients, silicones, antifoaming agents, fragrances, preservatives, anionic, cationic, nonionic, zwitterionic or amphoteric surfactants, active principles, fillers, polymers, propellants, basifying or acidifying agents or any other ingredient commonly used in the cosmetics and/or dermatological field.
  • conventional cosmetic adjuvants chosen in particular from fatty substances, organic solvents, ionic or nonionic and hydrophilic or lipophilic thickening agents, softening agents, humectants, opacifiers, stabilizers, emollients, silicones, antifoaming agents, fragrances, preservatives, anionic, cati
  • the fatty substances can be composed of an oil or a wax or their mixtures.
  • oil is understood to mean a compound which is liguid at ambient temperature.
  • wax is understood to mean a compound which is solid or substantially solid at ambient temperature and which has a melting point generally of greater than 35°C.
  • oils of mineral oils (liquid paraffin) ; vegetable oils (sweet almond oil, macadamia oil, blackcurrant seed oil or jojoba oil) ; synthetic oils, such as perhydrosqualene, fatty alcohols, fatty amides (such as isopropyl lauroyl sarcosinate, sold under the name of "Eldew SL-205" by Ajinomoto), fatty acids or esters (such as the benzoate of C 12 -C 15 alcohols sold under the trade name "Finsolv TN” or “Witconol TN” by Witco, octyl palmitate, isopropyl lanolate, triglycerides, including those of capric/caprylic acids, or the dicaprylyl carbonate sold under the name "Cetiol CC” by Cognis), or oxyethylenated or oxypropylenated fatty esters and ethers; silicone oils (cyclomethi
  • Mention may be made, as waxy compounds, of paraffin wax, carnauba wax, beeswax or hydrogenated castor oil.
  • organic solvents of lower alcohols and polyols.
  • the latter can be chosen from glycols and glycol ethers, such as ethylene glycol, propylene glycol, butylene glycol, dipropylene glycol or diethylene glycol.
  • carboxyvinyl polymers such as Carbopols (carbomers) and Pemulens (acrylate/Ci O -C 3 o alkyl acrylate copolymer)
  • polyacrylamides such as, for example, the crosslinked copolymers sold under the names Sepigel 305 (CTFA name: polyacrylamide/C13-14 isoparaffin/Laureth 7) or Simulgel 600 (CTFA name: acrylamide/sodium acryloyldimethyltaurate copolymer/isohexadecane/polysorbate 80) by Seppic
  • lipophilic thickening agents of synthetic polymers, such as the poly(Cio-3o alkyl acrylate) sold under the name "Doresco IPA 13-1" by Landec, or also modified clays, such as hectorite and its derivatives, for example the products sold under the Bentone names.
  • compositions according to the invention can be prepared according to techniques well known to a person skilled in the art. They can in particular be provided in the form of a simple or complex emulsion (0/W, W/0, 0/W/O or W/O/W) , such as a cream, a milk or a cream gel; in the form of an aqueous gel; or in the form of a lotion. They can optionally be packaged in an aerosol and be provided in the form of a foam or spray.
  • the compositions according to the invention are provided in the form of an oil-in-water or water-in-oil emulsion.
  • the emulsions generally comprise at least one emulsifier chosen from amphoteric, anionic, cationic or nonionic emulsifiers, used alone or as a mixture.
  • the emulsifiers are appropriately chosen according to the emulsion to be obtained (W/O .or O/W) .
  • emulsifying surfactants which can be used for the preparation of the W/0 emulsions, of, for example, sorbitan alkyl esters or ethers, glycerol alkyl esters or ethers or sugar alkyl esters or ethers; or silicone surfactants, such as dimethicone copolyols, for example the mixture of cyclomethicone and of dimethicone copolyol sold under the name "DC 5225 C" by Dow Corning, and alkyl dimethicone copolyols, for example lauryl methicone copolyol, sold under the name "Dow Corning 5200 Formulation Aid” by Dow Corning, cetyl dimethicone copolyol, for example the product sold under the name Abil EM 90 ® by Goldschmidt, and the mixture of cetyl dimethicone copolyol, of polyglyceryl (4 mol) isostearate and
  • coemulsifiers which can advantageously be chosen from the group consisting of polyol alkyl esters can also be added thereto. Mention may in particular be made, as polyol alkyl esters, of polyethylene glycol esters, such as PEG-30 dipolyhydroxystearate, for example the product sold under the name Arlacel P135 by ICI.
  • glycerol and/or sorbitan esters for example, of polyglyceryl isostearate, such as the product sold under the name Isolan GI 34 by Goldschmidt; sorbitan isostearate, such as the product sold under the name Arlacel 987 by ICI; the isostearate of sorbitan and of glycerol, such as the product sold under the name Arlacel 986 by ICI, and their mixtures.
  • the mixture of the alkyl polyglucoside as defined above with the corresponding fatty alcohol can be in the form of a self-emulsifying composition, as disclosed, for example, in the document WO-A-92/06778.
  • the aqueous phase of the latter can comprise a nonionic vesicular dispersion prepared according to known processes (Bangham, Standish and Watkins, J. MoI. Biol., 13, 238 (1965), FR 2 315 991 and FR 2 416 008) .
  • compositions according to the invention are applied in a large number of treatments, in particular cosmetic treatments, of the skin, lips and/or hair, including the scalp, in particular for the protection and/or the care of the skin, lips and/or hair and/or for making up the skin and/or lips.
  • Another subject-matter of the present invention is composed of the use of the compositions according to the invention as defined above for the manufacture of products for the cosmetic treatment of the skin, lips, nails, hair, eyelashes, eyebrows and/or scalp, in particular care products, sun protection products and make-up products.
  • the cosmetic compositions according to the invention can, for example, be used as care and/or sun protection product for the face and/or body with a liquid to semi-liquid consistency, such as lotions, milks, relatively smooth creams, gels or cream gels. They can optionally be packaged in an aerosol and be provided in the form of ' a foam or spray.
  • the cosmetic compositions according to the invention can, for example, be used as make-up product.
  • compositions according to the invention in the form of vaporizable fluid lotions in accordance with the invention are applied to the skin or the hair in the form of fine particles using pressurization devices.
  • the devices in accordance with the invention are well known to a person skilled in the art and comprise non-aerosol pumps or "atomizers", aerosol containers comprising a propellant and aerosol pumps using compressed air as propellant. The latter are disclosed in Patents US 4 077 441 and US 4 850 517 (forming an integral part of the content of the description) .
  • compositions packaged in an aerosol in accordance with the invention generally comprise conventional propellants, such as, for example, hydrofluorinated compounds, dichlorodifluoromethane, difluoroethane, dimethyl ether, isobutane, n-butane, propane or trichlorofluoromethane. They are preferably present in amounts ranging from 15 to 50% by weight, with respect to the total weight of the composition.
  • propellants such as, for example, hydrofluorinated compounds, dichlorodifluoromethane, difluoroethane, dimethyl ether, isobutane, n-butane, propane or trichlorofluoromethane.
  • Examples 1 to 4 Aqueous dispersions comprising 20% as AM of hydrophilic titanium oxide nanoparticles (Mirasun TiW 60) in the presence of 2.2% of polymer, at pH 5
  • the polymers used are as follows:
  • A Polyacrylic acid, 2000 g/mol (outside the invention)
  • B Anhydride and diisobutylene copolymer in the sodium salt form supplied under the name of "Orotan 731 DP" by Rohm & Haas (outside the invention)
  • C Polyethylene glycol with a mass of 1450 g/mol, supplied under the name of "Sentry Polyethylene Glycol" from Union Carbide (invention)
  • Dispersion Examples 1, 2, 3 and 4 are prepared according to the following protocol:
  • the viscosity measurements are carried out 24 hours after the preparation of the dispersions using a Haake RS150 rheometer equipped with cone/plate geometry (35 mm, 2°) and with a thermostatically- controlled bath in order to control the temperature.
  • the measurements are carried out in the flow mode, the stress being varied between 0.001 and 1 Pa according to 15 stationary phases of 120 s distributed logarithmically.
  • the value of the viscosity for a shear rate of 10 s "1 i-s then measured. The lower the viscosity, the better the state of dispersion of the nanoparticles in the aqueous phase.
  • Examples 5 and 6 Aqueous dispersions comprising 10% as AM (active material) of titanium oxide (Mirasun TiW 60) in the presence of salt and at pH 5
  • the dispersions are prepared according to the same procedure as for Examples 1 to 4 and the rheological measurements are also carried out in the same way. The state of dispersion is also evaluated by microscopic observation.
  • Examples 7 and 8 Sun milks
  • the emulsion is prepared by rapid introduction of the aqueous phase into the oily phase with stirring using a homogenizer of Moritz type at a stirring speed of 3000 rpm over 15 minutes.
  • the emulsion is then cooled to ambient temperature and then subjected to strong shearing using a homogenizer of Rannie type under a pressure of 600 bar. A white and fluid milk is obtained.
  • Example 7 10 grams of Mirasun TiW 60, the pH of which is adjusted beforehand to 7 with the appropriate amount of citric acid, are introduced into the emulsion.
  • Example 8 the polyethylene glycol is dissolved, with stirring for 1 hour, in 20 grams of deionized water; 10 grams of Mirasun TiW 60, the pH of which is adjusted beforehand to 7 with the appropriate amount of citric acid, are introduced into this solution with simple stirring over 30 minutes. This solution is then introduced with stirring into the emulsion. 2) Measurement of the whitening on the skin
  • each of the formulations 30 mg are applied to an area of 4 cm x 3 cm of the inner face of the forearm and are spread using the finger with 10 rotational movements.
  • the area of the skin treated with each of the formulations is observed with the naked eye after application.
  • the whitening of the skin is also measured using a spectrocolorimeter (CM 2002 from Minolta) which makes it possible to determine the brightness B of the deposit.
  • CM 2002 spectrocolorimeter
  • composition 8 according to the invention comprising hydrophilic TiO 2 nanoparticles in the presence of polyethylene glycol, produces a substantially lower whitening in comparison with the composition 7, which does not comprise polyethylene glycol.
  • Examples 9 to 12 Aqueous lotions comprising 1% as AM of hydrophilic titanium oxide nanoparticles in the presence of polyethylene glycols having different molecular masses
  • the TiO 2 nanoparticles used are:
  • the polyethylene glycols used are:
  • the stability of the aqueous lotions obtained is evaluated by measuring their viscosity according to the same test procedure described above for Examples 1 to 4.

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Abstract

La présente invention concerne une composition photoprotectrice comprenant, dans un milieu physiologiquement acceptable: a) au moins une phase aqueuse; b) au moins des nanopigments inorganiques hydrophiles à base d'oxydes métalliques selon une quantité comprise entre 1 et 25 % en poids relativement au poids total de la composition; c) au moins un polyalkylèneglycol de masse moléculaire inférieure à 8000 g/mol. L'invention concerne également l'utilisation d'au moins un polyalkylèneglycol de masse moléculaire inférieure à 8000 g/mol présent dans une composition photoprotectrice comprenant au moins une phase aqueuse et au moins des nanoparticules hydrophiles d'oxydes métalliques servant à réduire le blanchiment et/ou à améliorer la stabilité de ladite composition (la dispersabilité des nanoparticules dans la phase aqueuse).
PCT/EP2005/007887 2004-07-13 2005-06-13 Composition aqueuse photoprotectrice comprenant des nanopigments d'oxydes metalliques hydrophiles et un polyalkyleneglycol de faible masse moleculaire, et ses utilisations WO2006005630A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2007520785A JP2008506662A (ja) 2004-07-13 2005-06-13 親水性金属酸化物ナノ顔料と低分子量のポリアルキレングリコールとを含む水性光保護組成物；その使用
EP05768229A EP1773286A1 (fr) 2004-07-13 2005-06-13 Composition aqueuse photoprotectrice comprenant des nanopigments d'oxydes metalliques hydrophiles et un polyalkyleneglycol de faible masse moleculaire, et ses utilisations
US11/653,394 US20070166248A1 (en) 2004-07-13 2007-01-16 Aqueous photoprotective compositions comprising hydrophilic metal oxide nanopigments and polyalkylene glycols of low molecular mass

Applications Claiming Priority (4)

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FR0451508 2004-07-13
FR0451508A FR2873020A1 (fr) 2004-07-13 2004-07-13 Composition photoprotectrice aqueuse contenant des nanopigments d'oxyde metallique hydrophiles et un polyalkylglycol de faible masse moleculaire; utilisations
US59986704P 2004-08-10 2004-08-10
US60/599,867 2004-08-10

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DE102006062480A1 (de) 2006-12-28 2008-07-03 Carl Zeiss Smt Ag Optisches Element mit hydrophober Beschichtung, Projektionsobjektiv und Projektionsbelichtungsanlage damit
DE102008002193A1 (de) 2007-08-29 2009-03-05 Carl Zeiss Smt Ag Optisches Element mit hydrophober Oberfläche und Projektionsbelichtungsanlage für die Immersionslithographie damit
DE102015223260A1 (de) * 2015-11-25 2017-06-01 Beiersdorf Ag Titandioxid-haltiges Sonnenschutzmittel
DE102015223261A1 (de) * 2015-11-25 2017-06-01 Beiersdorf Ag Sonnenschutzmittel enthaltend Titandioxid

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DE102008002193A1 (de) 2007-08-29 2009-03-05 Carl Zeiss Smt Ag Optisches Element mit hydrophober Oberfläche und Projektionsbelichtungsanlage für die Immersionslithographie damit
DE102015223260A1 (de) * 2015-11-25 2017-06-01 Beiersdorf Ag Titandioxid-haltiges Sonnenschutzmittel
DE102015223261A1 (de) * 2015-11-25 2017-06-01 Beiersdorf Ag Sonnenschutzmittel enthaltend Titandioxid

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