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WO2006002563A3 - Technique de dosage pour trouble neurodegeneratif chez un animal - Google Patents

Technique de dosage pour trouble neurodegeneratif chez un animal Download PDF

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Publication number
WO2006002563A3
WO2006002563A3 PCT/CH2005/000360 CH2005000360W WO2006002563A3 WO 2006002563 A3 WO2006002563 A3 WO 2006002563A3 CH 2005000360 W CH2005000360 W CH 2005000360W WO 2006002563 A3 WO2006002563 A3 WO 2006002563A3
Authority
WO
WIPO (PCT)
Prior art keywords
animal
disease
neurodegenerative disorder
identifying
protein
Prior art date
Application number
PCT/CH2005/000360
Other languages
English (en)
Other versions
WO2006002563A2 (fr
Inventor
Adriano Aguzzi
Harald Seeger
Gino Miele
Original Assignee
Univ Zuerich
Adriano Aguzzi
Harald Seeger
Gino Miele
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zuerich, Adriano Aguzzi, Harald Seeger, Gino Miele filed Critical Univ Zuerich
Publication of WO2006002563A2 publication Critical patent/WO2006002563A2/fr
Publication of WO2006002563A3 publication Critical patent/WO2006002563A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne une technique de diagnostic permettant d'identifier un trouble neurodégénératif, en particulier d'identifier une encéphalopathie spongiforme transmissible, une maladie de Parkinson, une maladie de Huntington, une sclérose en plaques ou une maladie d'Alzheimer chez un animal, un échantillon prélevé sur cet animal permettant de déterminer la protéine et/ou le(s) niveau(x) d'ARN de protéine(s) spécifique(s) exprimée(s) de manière différenciée dans des tissus et/ou des fluides anatomiques d'animaux souffrant de troubles neurodégénératifs à des stades précoces de la maladie. Par ailleurs, cette invention concerne un kit d'éléments permettant d'identifier un trouble neurodégénérative chez un animal, comprenant un organe de détection spécifique qui permet de déterminer la protéine et/ou le(s) niveau(x) d'ARN d'un ou de plusieurs des composés susmentionnés.
PCT/CH2005/000360 2004-07-06 2005-06-30 Technique de dosage pour trouble neurodegeneratif chez un animal WO2006002563A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04405423 2004-07-06
EP04405423.7 2004-07-06

Publications (2)

Publication Number Publication Date
WO2006002563A2 WO2006002563A2 (fr) 2006-01-12
WO2006002563A3 true WO2006002563A3 (fr) 2006-07-13

Family

ID=35169811

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH2005/000360 WO2006002563A2 (fr) 2004-07-06 2005-06-30 Technique de dosage pour trouble neurodegeneratif chez un animal

Country Status (1)

Country Link
WO (1) WO2006002563A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11214835B1 (en) 2017-06-06 2022-01-04 University Of South Florida Methods and compositions for diagnosis and management of neurodegerative diseases
CN107881178B (zh) * 2017-11-20 2021-03-30 辽宁师范大学 八目鳗口腔腺CystatinF、制备方法及应用
CN111965353B (zh) * 2020-08-18 2022-08-19 四川农业大学 绵羊痒螨半胱氨酸蛋白酶抑制剂的应用以及一种elisa试剂盒

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576745B1 (en) * 1996-04-03 2003-06-10 Human Genome Sciences, Inc. Human cystatin F antibodies
WO2004040316A2 (fr) * 2002-10-30 2004-05-13 Proteome Sciences Plc. Methodes destinees a diagnostiquer une encephalopathie spongiforme transmissible

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576745B1 (en) * 1996-04-03 2003-06-10 Human Genome Sciences, Inc. Human cystatin F antibodies
WO2004040316A2 (fr) * 2002-10-30 2004-05-13 Proteome Sciences Plc. Methodes destinees a diagnostiquer une encephalopathie spongiforme transmissible

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAKER CHRISTOPHER A ET AL: "Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. 2, 21 January 2003 (2003-01-21), pages 675 - 679, XP002353413, ISSN: 0027-8424 *
MARES JAN ET AL: "Use of cystatin C determination in clinical diagnostics.", BIOMEDICAL PAPERS (OLOMOUC), vol. 147, no. 2, December 2003 (2003-12-01), pages 177 - 180, XP002353412, ISSN: 1213-8118 *
MIELE G ET AL: "A NOVEL ERYTHROID-SPECIFIC MARKER OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 7, no. 3, March 2001 (2001-03-01), pages 361 - 364, XP001009933, ISSN: 1078-8956 *
RIEMER C ET AL: "Gene expression profiling of scrapie-infected brain tissue", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 323, no. 2, 15 October 2004 (2004-10-15), pages 556 - 564, XP004562763, ISSN: 0006-291X *

Also Published As

Publication number Publication date
WO2006002563A2 (fr) 2006-01-12

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