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WO2006001848A3 - Quantum dots as high-sensitivity optical sensors and biocompatible imaging probes, compositions thereof, and related methods - Google Patents

Quantum dots as high-sensitivity optical sensors and biocompatible imaging probes, compositions thereof, and related methods Download PDF

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Publication number
WO2006001848A3
WO2006001848A3 PCT/US2005/004310 US2005004310W WO2006001848A3 WO 2006001848 A3 WO2006001848 A3 WO 2006001848A3 US 2005004310 W US2005004310 W US 2005004310W WO 2006001848 A3 WO2006001848 A3 WO 2006001848A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
quantum dots
optical sensors
related methods
imaging probes
Prior art date
Application number
PCT/US2005/004310
Other languages
French (fr)
Other versions
WO2006001848A2 (en
Inventor
Christoph A Naumann
Bruce A Young
Eric C Long
Original Assignee
Advanced Res & Tech Inst
Christoph A Naumann
Bruce A Young
Eric C Long
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Res & Tech Inst, Christoph A Naumann, Bruce A Young, Eric C Long filed Critical Advanced Res & Tech Inst
Publication of WO2006001848A2 publication Critical patent/WO2006001848A2/en
Publication of WO2006001848A3 publication Critical patent/WO2006001848A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
    • A61K49/0067—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle quantum dots, fluorescent nanocrystals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Ceramic Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Luminescent Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention provides a semiconductor nanoparticle with improved stability and biocompatibility properties. Accordingly, the present invention provides a nanoparticle that is capped with two separate protective layers: an inner inert layer and an outer inert layer and related in vitro and in vivo methods of use.
PCT/US2005/004310 2004-02-12 2005-02-11 Quantum dots as high-sensitivity optical sensors and biocompatible imaging probes, compositions thereof, and related methods WO2006001848A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54396504P 2004-02-12 2004-02-12
US60/543,965 2004-02-12

Publications (2)

Publication Number Publication Date
WO2006001848A2 WO2006001848A2 (en) 2006-01-05
WO2006001848A3 true WO2006001848A3 (en) 2007-01-25

Family

ID=35782210

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/004310 WO2006001848A2 (en) 2004-02-12 2005-02-11 Quantum dots as high-sensitivity optical sensors and biocompatible imaging probes, compositions thereof, and related methods

Country Status (1)

Country Link
WO (1) WO2006001848A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103554477A (en) * 2008-02-25 2014-02-05 纳米技术有限公司 Semicondcutor nanoparticle capping agents
US8847197B2 (en) 2009-09-23 2014-09-30 Nanoco Technologies Ltd. Semiconductor nanoparticle-based materials
US8957401B2 (en) 2009-09-23 2015-02-17 Nanoco Technologies, Ltd Semiconductor nanoparticle-based materials
US9159590B2 (en) 2010-04-01 2015-10-13 Nanoco Technologies, Ltd. Encapsulated nanoparticles

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0409877D0 (en) 2004-04-30 2004-06-09 Univ Manchester Preparation of nanoparticle materials
GB2429838B (en) 2005-08-12 2011-03-09 Nanoco Technologies Ltd Nanoparticles
US8563348B2 (en) 2007-04-18 2013-10-22 Nanoco Technologies Ltd. Fabrication of electrically active films based on multiple layers
US20080264479A1 (en) 2007-04-25 2008-10-30 Nanoco Technologies Limited Hybrid Photovoltaic Cells and Related Methods
US8784701B2 (en) 2007-11-30 2014-07-22 Nanoco Technologies Ltd. Preparation of nanoparticle material
GB0814458D0 (en) 2008-08-07 2008-09-10 Nanoco Technologies Ltd Surface functionalised nanoparticles
GB0820101D0 (en) 2008-11-04 2008-12-10 Nanoco Technologies Ltd Surface functionalised nanoparticles
GB0821122D0 (en) 2008-11-19 2008-12-24 Nanoco Technologies Ltd Semiconductor nanoparticle - based light emitting devices and associated materials and methods
KR101744904B1 (en) * 2010-03-22 2017-06-21 삼성디스플레이 주식회사 Quantum dot-block copolymer hybrid and fabrication method and dispersion method of the same, and light emitting device having the quantum dot-block copolymer hybrid and fabrication method of the same
WO2021041874A1 (en) 2019-08-29 2021-03-04 Martin David C Biofunctional thiophene monomers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NIEMEYER: "Nanoparticles, Proteins And Nucleic Acids: Biotechnology Meets Materials Science", ANGEWANDTE CHEMIE (INTERNATIONAL EDITION), vol. 40, 2001, pages 4128 - 4158, XP003003923 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103554477A (en) * 2008-02-25 2014-02-05 纳米技术有限公司 Semicondcutor nanoparticle capping agents
US8847197B2 (en) 2009-09-23 2014-09-30 Nanoco Technologies Ltd. Semiconductor nanoparticle-based materials
US8957401B2 (en) 2009-09-23 2015-02-17 Nanoco Technologies, Ltd Semiconductor nanoparticle-based materials
US9543481B2 (en) 2009-09-23 2017-01-10 Nanoco Technologies Ltd. Semiconductor nanoparticle-based materials
US9159590B2 (en) 2010-04-01 2015-10-13 Nanoco Technologies, Ltd. Encapsulated nanoparticles

Also Published As

Publication number Publication date
WO2006001848A2 (en) 2006-01-05

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