WO2006000143A1 - Microcapsule metallique pour la transplantation de cellules et de tissus - Google Patents
Microcapsule metallique pour la transplantation de cellules et de tissus Download PDFInfo
- Publication number
- WO2006000143A1 WO2006000143A1 PCT/CN2005/000804 CN2005000804W WO2006000143A1 WO 2006000143 A1 WO2006000143 A1 WO 2006000143A1 CN 2005000804 W CN2005000804 W CN 2005000804W WO 2006000143 A1 WO2006000143 A1 WO 2006000143A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microcapsule
- metal
- titanium
- microcapsules
- base material
- Prior art date
Links
- 239000003094 microcapsule Substances 0.000 title claims abstract description 64
- 229910052751 metal Inorganic materials 0.000 title claims abstract description 47
- 239000002184 metal Substances 0.000 title claims abstract description 40
- 239000000463 material Substances 0.000 claims abstract description 32
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000010936 titanium Substances 0.000 claims abstract description 26
- 229910052719 titanium Inorganic materials 0.000 claims abstract description 26
- 238000002054 transplantation Methods 0.000 claims abstract description 13
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000956 alloy Substances 0.000 claims abstract description 9
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910052742 iron Inorganic materials 0.000 claims abstract description 5
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 9
- 239000007769 metal material Substances 0.000 claims description 7
- 238000007747 plating Methods 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 5
- 239000010931 gold Substances 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 230000007774 longterm Effects 0.000 abstract description 4
- 239000012528 membrane Substances 0.000 abstract description 3
- 229910045601 alloy Inorganic materials 0.000 abstract description 2
- 238000001727 in vivo Methods 0.000 abstract description 2
- 230000004083 survival effect Effects 0.000 abstract description 2
- 239000004005 microsphere Substances 0.000 abstract 3
- 239000011148 porous material Substances 0.000 abstract 2
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 30
- 238000003466 welding Methods 0.000 description 10
- 238000004381 surface treatment Methods 0.000 description 7
- 238000004140 cleaning Methods 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000006870 function Effects 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 4
- 239000002861 polymer material Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000002788 crimping Methods 0.000 description 2
- 238000009713 electroplating Methods 0.000 description 2
- 210000004153 islets of langerhan Anatomy 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 239000000823 artificial membrane Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000004053 dental implant Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000005323 electroforming Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000002650 immunosuppressive therapy Methods 0.000 description 1
- 238000005495 investment casting Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 241001308709 unidentified virus Species 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
Definitions
- the molecular mass, strength, chemical composition of the polymer material, and the thickness or number of layers of the encapsulating film change the permeability of the film.
- the micro-package is prepared.
- the concentration of the polymer solution used in the capsule, the time of the gelation reaction, the pH of the system, and the type and amount of the additive all have a significant effect on the permeability and biocompatibility of the membrane, allowing the cells to be embedded. Loss of apoptosis or function.
- microencapsulation of such materials often finds problems of excessive volume during the transplantation process.
- the present invention has the following technical effects: (1) using the metal microcapsules to embed biological cells, which can reduce the volume of the transplanted microcapsules, and enable the microcapsules to be transplanted into the human body. It does not cause water swelling in a physiological environment, so that the implanted cells can function normally and have long-term stability in the body; (2)
- the metal microcapsules are harmless to the human body and have good biocompatibility. Made of metal or alloy material, such as titanium metal, due to its light weight, good biocompatibility, non-toxicity, good corrosion resistance, good stability in the body, small thermal expansion coefficient, high melting point, etc., thus avoiding the use of polymer materials. Disadvantages: low mechanical strength, unclear degradation, short service life, exposure of xenogeneic cells to the human body may lead to problems such as unidentified viruses entering the human body and gene transfer. detailed description
- the base material is used as the base material; the base material is used as the base material in the diameter of the base material of the base material;
- the surface is plated with titanium coating, and then cut to obtain a bowl-shaped hemisphere. After cleaning and surface treatment on the hemisphere, the living cells are placed into the titanium hemisphere and assembled into microcapsules. The two hemispheres are spot welded at the seam. Welding is performed. .
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
L'invention concerne un type de microcapsules métalliques qui sont destinées à la transplantation de cellules et de tissus vivants. La microcapsule de l'invention est basée sur un alliage ou un métal biocompatible tel que le titane, l'argent, le fer, etc. Les matières de base de la microcapsule sont enrobées ou recouvertes avec une couche de titane ou d'alliage de titane. Les microcapsules métalliques sont creuses et représentent des microsphères, des cellules ou des tissus actifs destinés à la transplantation étant placés à l'intérieur des microsphères. Le rayon externe de la microsphère est généralement compris entre 0,05 et 5 mm. L'épaisseur de la paroi de membrane de la microsphère est généralement comprise entre 0,001 et 0,5 mm. Les parois de membrane comportent des pores sensiblement ronds, le rayon de chaque pore étant compris entre 0,00005 et 0,01 mm. Le volume de la microcapsule de transplantation est réduit, et les microcapsules métalliques ne vont pas gonfler dans des conditions physiologiques après leur transplantation dans le corps humain, alors que les microcapsules métalliques sont utilisées pour encapsuler des cellules biologiques. Par conséquent, les microcapsules métalliques peuvent maintenir une stabilité à long terme in vivo et prolonger la survie des tissus ou des cellules fonctionnelles.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200410019819.9 | 2004-06-29 | ||
| CNB2004100198199A CN100457900C (zh) | 2004-06-29 | 2004-06-29 | 细胞和组织移植用金属微囊 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2006000143A1 true WO2006000143A1 (fr) | 2006-01-05 |
Family
ID=34663084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2005/000804 WO2006000143A1 (fr) | 2004-06-29 | 2005-06-08 | Microcapsule metallique pour la transplantation de cellules et de tissus |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN100457900C (fr) |
| WO (1) | WO2006000143A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2356227T3 (pl) * | 2008-11-14 | 2018-07-31 | Viacyte, Inc. | Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002070028A1 (fr) * | 2001-03-05 | 2002-09-12 | Bio-Smart, Ltd. | Composition d'element poreux pour une biomatiere |
| WO2003013396A1 (fr) * | 2001-08-11 | 2003-02-20 | Stanmore Implants Worldwide Ltd. | Implant chirurgical |
| US20040167633A1 (en) * | 2003-02-24 | 2004-08-26 | Depuy Products, Inc. | Metallic implants having roughened surfaces and methods for producing the same |
-
2004
- 2004-06-29 CN CNB2004100198199A patent/CN100457900C/zh not_active Expired - Fee Related
-
2005
- 2005-06-08 WO PCT/CN2005/000804 patent/WO2006000143A1/fr active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002070028A1 (fr) * | 2001-03-05 | 2002-09-12 | Bio-Smart, Ltd. | Composition d'element poreux pour une biomatiere |
| WO2003013396A1 (fr) * | 2001-08-11 | 2003-02-20 | Stanmore Implants Worldwide Ltd. | Implant chirurgical |
| US20040167633A1 (en) * | 2003-02-24 | 2004-08-26 | Depuy Products, Inc. | Metallic implants having roughened surfaces and methods for producing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1594561A (zh) | 2005-03-16 |
| CN100457900C (zh) | 2009-02-04 |
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