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WO2006083269A3 - Nanocapteurs luminescents - Google Patents

Nanocapteurs luminescents Download PDF

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Publication number
WO2006083269A3
WO2006083269A3 PCT/US2005/016818 US2005016818W WO2006083269A3 WO 2006083269 A3 WO2006083269 A3 WO 2006083269A3 US 2005016818 W US2005016818 W US 2005016818W WO 2006083269 A3 WO2006083269 A3 WO 2006083269A3
Authority
WO
WIPO (PCT)
Prior art keywords
luminescent
biomolecule
biosensor
specific
assembly
Prior art date
Application number
PCT/US2005/016818
Other languages
English (en)
Other versions
WO2006083269A2 (fr
Inventor
Rakesh Mogul
Original Assignee
Univ Florida Atlantic
Rakesh Mogul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida Atlantic, Rakesh Mogul filed Critical Univ Florida Atlantic
Publication of WO2006083269A2 publication Critical patent/WO2006083269A2/fr
Publication of WO2006083269A3 publication Critical patent/WO2006083269A3/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un biocapteur à points quantiques protéique luminescent pouvant être conçu sur mesure pour la détection spécifique de composés présentant un intérêt sur le plan environnemental ou médical. Ce biocapteur comprend un ensemble composé d'une nanoparticule inorganique ou organique et d'une biomolécule, servant d'échafaudage pour un dosage par compétition de fluorescence. La détection spécifique et sensible de poisons chimiques, de contaminants et de biotoxines, peut être réalisée par l'intermédiaire des structures internes à l'ensemble nanoparticule-biomolécule, sans que l'opération n'affecte les propriétés luminescentes de la sonde. Cette technique de biodétection est destinée à des applications d'analyse environnementale, de diagnostic médical et de biodéfense.
PCT/US2005/016818 2004-05-14 2005-05-13 Nanocapteurs luminescents WO2006083269A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57116004P 2004-05-14 2004-05-14
US60/571,160 2004-05-14

Publications (2)

Publication Number Publication Date
WO2006083269A2 WO2006083269A2 (fr) 2006-08-10
WO2006083269A3 true WO2006083269A3 (fr) 2007-02-22

Family

ID=36777635

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/016818 WO2006083269A2 (fr) 2004-05-14 2005-05-13 Nanocapteurs luminescents

Country Status (1)

Country Link
WO (1) WO2006083269A2 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008018894A2 (fr) * 2005-12-19 2008-02-14 The University Of Miami Chimiodétecteurs à base de points quantiques et composés oxazine
EP2137533A2 (fr) * 2007-04-19 2009-12-30 3M Innovative Properties Company Utilisation de nanoparticules de silice dispersibles dans l'eau pour fixer des biomolécules
US8597959B2 (en) 2007-04-19 2013-12-03 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
US20110165689A1 (en) * 2008-08-05 2011-07-07 Agency For Science, Technology And Research 1 Fusionoplis Way Methods, compositions, and articles comprising stabilized gold nanoclusters
RU2414696C2 (ru) * 2008-11-19 2011-03-20 Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет информационных технологий, механики и оптики" Диссоциативный люминесцентный наносенсор
CN101782570A (zh) * 2008-12-25 2010-07-21 国家纳米技术与工程研究院 一种生物分子竞争分析方法及其应用
CN102690349A (zh) * 2011-03-24 2012-09-26 苏州工业园区晨健抗体组药物开发有限公司 乙肝表面抗原的量子点纳米颗粒生物探针及其制备与用途
CN102942935B (zh) * 2012-09-28 2013-12-25 武汉大学 一步合成DNA功能化Zn掺杂CdTe量子点的方法
US10241078B2 (en) 2012-10-29 2019-03-26 University Of Utah Research Foundation Functionalized nanotube sensors and related methods
US9970950B1 (en) 2014-03-09 2018-05-15 Hound Labs, Inc. Method and apparatus for detecting acute use of target substance(s)
US20170058319A1 (en) * 2014-03-26 2017-03-02 Virginia Commonwealth University Nanosensor for assessing thrombin inhibitors
US9726684B1 (en) * 2015-01-18 2017-08-08 Hound Labs, Inc. Compositions for target substance detection and measurement
CN104880424B (zh) * 2015-05-13 2017-12-01 福州市传染病医院 一种用于检测amacr的双功能纳米探针、试剂盒及方法
US9933445B1 (en) 2016-05-16 2018-04-03 Hound Labs, Inc. System and method for target substance identification
US9921234B1 (en) 2016-06-17 2018-03-20 Hound Labs, Inc. Compositions and methods for detection of target constituent in exhaled breath
US11026596B1 (en) 2017-05-19 2021-06-08 Hound Labs, Inc. Detection and measurement of target substance in exhaled breath
CN107449761B (zh) * 2017-08-09 2020-02-18 贵州大学 一种双通道荧光成像检测活性癌细胞中微量Cu2+和Hg2+的方法
US11187711B1 (en) 2017-09-11 2021-11-30 Hound Labs, Inc. Analyte detection from breath samples
PL240252B1 (pl) * 2017-10-10 2022-03-07 Univ Jagiellonski Nanorozmiarowy czujnik jonów rtęci i sposób jego otrzymywania oraz sposób wykrywania jonów Hg2+
CO2018008743A1 (es) 2018-08-21 2019-02-28 Pontificia Univ Javeriana Nanosensor de efecto de campo para la detección de metabolitos simples en organismos vivos
US11426097B1 (en) 2018-10-17 2022-08-30 Hound Labs, Inc. Rotary valve assemblies and methods of use for breath sample cartridge systems
US20200245898A1 (en) 2019-01-31 2020-08-06 Hound Labs, Inc. Single-use Microfluidic Cartridge for Detection of Target Chemical Presence in Human Breath
US11977086B2 (en) 2019-03-21 2024-05-07 Hound Labs, Inc. Biomarker detection from breath samples
US11933731B1 (en) 2020-05-13 2024-03-19 Hound Labs, Inc. Systems and methods using Surface-Enhanced Raman Spectroscopy for detecting tetrahydrocannabinol
CN112201752B (zh) * 2020-08-11 2023-11-10 苏州科技大学 柔性电存储器件的制备方法及其应用
CN112526127B (zh) * 2020-10-28 2022-12-06 四川大学华西医院 一种破伤风抗原的检测方法及其应用
CN112480151A (zh) * 2020-11-25 2021-03-12 辽宁大学 一种新型荧光探针及其制备方法和在检测蜂蜜中磺胺二甲嘧啶的应用
US11806711B1 (en) 2021-01-12 2023-11-07 Hound Labs, Inc. Systems, devices, and methods for fluidic processing of biological or chemical samples using flexible fluidic circuits
WO2022222237A1 (fr) * 2021-04-21 2022-10-27 苏州科技大学 Sonde à base de fluorescéine halogénée-lactone spirocyclique, procédé de préparation associé et son application pour la détection d'ions métalliques
CN114113265B (zh) * 2021-12-14 2023-08-08 郑州轻工业大学 一种适配体传感器及其制备方法
CN114814235B (zh) * 2022-04-01 2025-04-29 中国海洋大学 用于检测卵黄原蛋白浓度的荧光免疫方法及免疫传感器
CN114487401B (zh) * 2022-04-18 2022-06-21 中国农业大学 一种微生物检测的双适配体功能核酸恒温微流控芯片传感器
CN118955414B (zh) * 2024-10-17 2025-03-18 南昌大学 两亲性Eu配合物及其制备方法与在检测四环素中的应用

Citations (6)

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US5521289A (en) * 1994-07-29 1996-05-28 Nanoprobes, Inc. Small organometallic probes
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US6468808B1 (en) * 1998-09-24 2002-10-22 Advanced Research And Technology Institute, Inc. Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US5738453A (en) * 1993-12-30 1998-04-14 Canon Kabushiki Kaisha Sheet supplying apparatus
US5521289A (en) * 1994-07-29 1996-05-28 Nanoprobes, Inc. Small organometallic probes
US5700646A (en) * 1995-09-15 1997-12-23 The United States Of America As Represented By The Secretary Of The Army Comprehensive identification scheme for pathogens
US6468808B1 (en) * 1998-09-24 2002-10-22 Advanced Research And Technology Institute, Inc. Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use
US6344337B1 (en) * 1999-02-19 2002-02-05 Board Of Trustees Of Michigan State University Antigen test to detect equine protozoal myeloencephalitis in horse serum and cerebrospinal fluid

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MAXWELL D.J. ET AL.: "Self-Assembled Nanoparticle Probes for Recognition and Detection of Biomolecules", J. AM. CHEM. SOC., vol. 124, no. 32, 2002, pages 9606 - 9612, XP001179600 *
MEDINTZ I.L. ET AL.: "Self-assembled nanoscale biosensors based on quantum dot FRET donors", NATURE MATERIALS, vol. 2, 2 September 2003 (2003-09-02), pages 630 - 638, XP003005623 *

Also Published As

Publication number Publication date
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