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WO2006071777A3 - Soft tissue repair and regeneration using postpartum-derived cells and cell products - Google Patents

Soft tissue repair and regeneration using postpartum-derived cells and cell products Download PDF

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Publication number
WO2006071777A3
WO2006071777A3 PCT/US2005/046808 US2005046808W WO2006071777A3 WO 2006071777 A3 WO2006071777 A3 WO 2006071777A3 US 2005046808 W US2005046808 W US 2005046808W WO 2006071777 A3 WO2006071777 A3 WO 2006071777A3
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Prior art keywords
postpartum
soft tissue
derived cells
regeneration
tissue repair
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PCT/US2005/046808
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French (fr)
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WO2006071777A2 (en
Inventor
Laura Brown
Alexander M Harmon
Anna Gosiewska
Original Assignee
Ethicon Inc
Laura Brown
Alexander M Harmon
Anna Gosiewska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Ethicon Inc, Laura Brown, Alexander M Harmon, Anna Gosiewska filed Critical Ethicon Inc
Priority to EP05855379A priority Critical patent/EP1831355A2/en
Publication of WO2006071777A2 publication Critical patent/WO2006071777A2/en
Publication of WO2006071777A3 publication Critical patent/WO2006071777A3/en

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    • C12N5/0603—Embryonic cells ; Embryoid bodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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Abstract

Cells derived from postpartum tissue and products thereof having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such postpartum-derived cells and products related thereto in therapies for conditions of soft tissue.
PCT/US2005/046808 2004-12-23 2005-12-22 Soft tissue repair and regeneration using postpartum-derived cells and cell products WO2006071777A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05855379A EP1831355A2 (en) 2004-12-23 2005-12-22 Soft tissue repair and regeneration using postpartum-derived cells and cell products

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63870204P 2004-12-23 2004-12-23
US60/638,702 2004-12-23

Publications (2)

Publication Number Publication Date
WO2006071777A2 WO2006071777A2 (en) 2006-07-06
WO2006071777A3 true WO2006071777A3 (en) 2007-03-01

Family

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Family Applications (1)

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PCT/US2005/046808 WO2006071777A2 (en) 2004-12-23 2005-12-22 Soft tissue repair and regeneration using postpartum-derived cells and cell products

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EP (1) EP1831355A2 (en)
WO (1) WO2006071777A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US9234172B2 (en) 2003-06-27 2016-01-12 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110280838A1 (en) * 2007-12-27 2011-11-17 Advanced Technologies And Regenerative Medicine, Llc Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
DK1835924T3 (en) 2004-12-23 2013-11-04 Ethicon Inc TREATMENT OF PARKINSON'S DISEASE AND RELATED DISEASES WHEN USING POSTPARTUM OBTAINED CELLS
WO2007070870A1 (en) 2005-12-16 2007-06-21 Ethicon, Inc. Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation
ES2516698T3 (en) * 2006-10-06 2014-10-31 Anthrogenesis Corporation Native placental collagen (telopeptide) compositions
EP2164953A4 (en) 2007-06-18 2010-06-30 Childrens Hosp & Res Ct Oak METHOD FOR ISOLATING PLACENTA FROM STEM AND PROGENITOR CELLS
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
EP2379088B1 (en) 2008-12-19 2018-02-28 DePuy Synthes Products, Inc. Treatment of lung and pulmonary diseases and disorders
US8771677B2 (en) 2008-12-29 2014-07-08 Vladimir B Serikov Colony-forming unit cell of human chorion and method to obtain and use thereof
BRPI1013409A2 (en) 2009-03-26 2018-01-16 Advanced Tech And Regenerative Medicine Llc human umbilical cord tissue cells as therapy for alzheimer's disease
US8574899B2 (en) 2010-12-22 2013-11-05 Vladimir B Serikov Methods for augmentation collection of placental hematopoietic stem cells and uses thereof
SG11201403465PA (en) 2011-12-23 2014-10-30 Atrm Llc Detection of human umbilical cord tissue-derived cells
AU2016227607B2 (en) 2015-03-04 2021-09-30 Mesoblast International Sarl Cell culture method for mesenchymal stem cells
CN110988352B (en) * 2019-11-11 2023-06-27 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） Kit for auxiliary detection of placenta implantation and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919702A (en) * 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
US20030032179A1 (en) * 2000-12-06 2003-02-13 Hariri Robert J. Post-partum mammalian placenta, its use and placental stem cells therefrom
WO2003068937A2 (en) * 2002-02-13 2003-08-21 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells
US20030161818A1 (en) * 2002-02-25 2003-08-28 Kansas State University Research Foundation Cultures, products and methods using stem cells
WO2004072273A1 (en) * 2003-02-11 2004-08-26 Davies John E Progenitor cells from wharton's jelly of human umbilical cord
WO2005001079A2 (en) * 2003-06-27 2005-01-06 Ethicon, Incorporated Soft tissue repair and regeneration using postpartum-derived cells

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919702A (en) * 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
US20030032179A1 (en) * 2000-12-06 2003-02-13 Hariri Robert J. Post-partum mammalian placenta, its use and placental stem cells therefrom
WO2003068937A2 (en) * 2002-02-13 2003-08-21 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells
US20030161818A1 (en) * 2002-02-25 2003-08-28 Kansas State University Research Foundation Cultures, products and methods using stem cells
WO2004072273A1 (en) * 2003-02-11 2004-08-26 Davies John E Progenitor cells from wharton's jelly of human umbilical cord
WO2005001079A2 (en) * 2003-06-27 2005-01-06 Ethicon, Incorporated Soft tissue repair and regeneration using postpartum-derived cells

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ISHII M ET AL: "Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 332, no. 1, 24 June 2005 (2005-06-24), pages 297 - 303, XP004892979, ISSN: 0006-291X *
JACKSON K A ET AL: "Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 107, no. 11, June 2001 (2001-06-01), pages 1395 - 1402, XP002976368, ISSN: 0021-9738 *
LODIE T A ET AL: "Systematic analysis of reportedly distinct populations of multipotent bone marrow-derived stem cells reveals a lack of distinction", TISSUE ENGINEERING, LARCHMONT, NY, US, vol. 8, no. 5, October 2002 (2002-10-01), pages 739 - 751, XP002306489, ISSN: 1076-3279 *
MITCHELL K E ET AL: "Matrix cells from Wharton's jelly form neurons and glia", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 21, no. 1, January 2003 (2003-01-01), pages 50 - 60, XP002281007, ISSN: 1066-5099 *
QIAN YE ET AL: "RECOVERY OF PLACENTAL-DERIVED ADHERENT CELLS WITH MESENCHYMAL STEM CELL CHARACTERISTICS", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 98, no. 11, PART 2, 7 December 2001 (2001-12-07), pages 147B, XP009026843, ISSN: 0006-4971 *
RABBANY SINA Y ET AL: "Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization.", TRENDS IN MOLECULAR MEDICINE, vol. 9, no. 3, March 2003 (2003-03-01), pages 109 - 117, XP002312847, ISSN: 1471-4914 *
RAFII SHAHIN ET AL: "Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration.", NATURE MEDICINE, vol. 9, no. 6, June 2003 (2003-06-01), pages 702 - 712, XP002312846, ISSN: 1078-8956 *
TREMAIN N ET AL: "MICROSAGE ANALYSIS OF 2,353 EXPRESSED GENES IN A SINGLE CELL-DERIVED COLONY OF UNDIFFERENTIATED HUMAN MESENCHYMAL STEM CELLS REVEALS MRNAS OF MULTIPLE CELL LINEAGES", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 19, 2001, pages 408 - 418, XP002907879, ISSN: 1066-5099 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9234172B2 (en) 2003-06-27 2016-01-12 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US9585918B2 (en) 2005-12-28 2017-03-07 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells

Also Published As

Publication number Publication date
EP1831355A2 (en) 2007-09-12
WO2006071777A2 (en) 2006-07-06

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